EKS-XET-00655

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00655

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/BRD	N/A	N/A	N/A	N/A	N/A

Status

Reviewed

Ensembl Protein

ENSXETP00000049781

UniProt Accession

F7DRV9;

Protein Name

Bromodomain testis-specific protein

Protein Synonyms/Alias

Gene Name

brdt

Gene Synonyms/Alias

brdt;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000008571	ENSXETP00000049781	ENSXETT00000049781

Organism

Xenopus tropicalis

Functional Description

Testis-specific chromatin protein that specificallybinds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (By similarity).

Protein Length

933

Protein Sequence
(FASTA)

MSMSSRHLHS SIVNPPPPEY INRKKTGRLT NQLQYLEKVV LKALWRHHFS WPFQQPVDAA 60

KLNLPDYYQI IKNPMDLSTI RKRLEYNYYS KALDCIQDFN TMFTNCYIYN KPGDDIVVMS 120

QELEKVFMEK IAEMPHEEIE LSVVGNRGVK SRIKISAVAA EVCKKKMVSQ KMHRRTFPCP 180

VIAMMPKRTT LVPLSVIRSS TSSHSASSVS KVNKGIKRKA DTTTPAVSLI ATSCESSPTL 240

SEPKPNKILS GTEKTRSAET SAVDLPDSQH HIHFIKSNQI CEQLKHCNNI LNEMMSKKHA 300

EYAWPFYKTV IPTSLLDCSD AIKHPMDLAT IRDKMENGLY KDTQDFASDV RLMFMNSYKY 360

NPPDNEVVNM ARKMQDVFEG MFAKIPDDPL ATQSMVERYK TSTEESSSSS SSEQSSSSDS 420

EDERAQHLAL LQEQLRAVQE QLKALTETPI FSKIQPKSAV GVYDKYKQWV KCIEPMGKLL 480

KRKKNYDAKK KKLHVSDEEE DVKPMSYDEK RQLSLDINKL PGEKLGRIVH IIQSREPSLK 540

DSNPNEIEID FETLKQSTLR HLEKYVMVCL RKRPKKPSSI KSLKSKEQLN KEKKQELEKR 600

LRDVSGQLSS AKKPKIQGFL YPMQSIGGPS RLSESSTSSS ASDVSNSSDS SSSDSSDSES 660

ATFPKNILAK KQTSTNYEVP LLLYYGCFVN KPRTSIPQNG LCIGSQSLAY TTISTIVHPT 720

PMALMPLHPG STNYTSLQLL LKYGLHVPLI IENPLGNSVL FENYLEVLHP SQIEQTFAIK 780

EECLKPKYKN AKVKTSFCWE VFSKSLATTH VTIKSSSNSF QQFRKAAIAK EERERALKAQ 840

ELRRLEDSKA GMQEKLSPSL PMETKVHEMQ AQTIDEATKG EPTCNPVHEG ITEEERNLAR 900

MREQERRRRE AMAGTIDMYL QSDIMATFEE HLC 933

Nucleotide Sequence
(FASTA)

ATGTCCATGT CAAGCAGACA TCTTCATTCT TCAATTGTGA ACCCACCTCC TCCAGAGTAC 60

ATAAACCGCA AGAAGACAGG ACGCTTAACT AACCAACTGC AGTACCTAGA AAAGGTGGTC 120

TTGAAGGCTT TATGGAGGCA TCACTTTTCT TGGCCATTTC AGCAACCTGT AGATGCAGCG 180

AAGCTAAATC TTCCTGATTA CTATCAAATT ATTAAGAATC CAATGGATTT GAGTACCATA 240

AGAAAGAGAC TGGAATACAA TTATTATTCA AAAGCTCTAG ATTGCATACA AGATTTCAAT 300

ACAATGTTCA CAAACTGTTA CATCTATAAT AAGCCAGGTG ATGATATTGT AGTAATGTCA 360

CAAGAACTGG AAAAAGTGTT CATGGAAAAG ATTGCAGAAA TGCCACATGA AGAAATAGAA 420

TTATCCGTTG TGGGAAATCG AGGAGTCAAA AGCAGAATAA AAATTTCGGC AGTAGCAGCA 480

GAAGTTTGTA AGAAGAAGAT GGTATCACAG AAAATGCATA GGCGTACATT TCCTTGTCCT 540

GTAATTGCCA TGATGCCCAA ACGTACAACC CTTGTTCCCT TGTCTGTTAT TCGGTCAAGT 600

ACTTCTTCCC ATTCTGCATC TTCAGTTAGC AAAGTCAATA AAGGAATTAA AAGGAAAGCT 660

GATACAACAA CTCCTGCTGT ATCGCTCATT GCAACCAGCT GTGAATCTTC TCCAACTTTA 720

TCTGAACCCA AACCAAACAA AATACTGTCT GGAACAGAGA AAACTAGGTC AGCTGAAACT 780

TCAGCTGTGG ACCTGCCTGA TTCTCAGCAT CACATCCACT TTATCAAAAG CAATCAAATA 840

TGTGAACAGC TAAAGCATTG CAACAATATA CTTAATGAGA TGATGTCAAA AAAACATGCA 900

GAGTACGCAT GGCCTTTCTA TAAAACTGTG ATCCCTACAT CCTTGCTTGA TTGTAGTGAT 960

GCCATCAAAC ACCCCATGGA CCTTGCAACC ATCAGAGACA AAATGGAAAA TGGACTCTAT 1020

AAGGACACCC AAGATTTTGC TTCTGATGTC CGGTTAATGT TCATGAATTC TTATAAGTAC 1080

AATCCGCCTG ACAATGAAGT GGTAAACATG GCTCGAAAGA TGCAGGACGT TTTTGAGGGC 1140

ATGTTTGCTA AAATACCAGA TGATCCACTT GCTACTCAGA GTATGGTAGA GAGATACAAG 1200

ACATCTACTG AAGAAAGTAG TAGTTCTAGC TCTTCTGAAC AAAGTTCTTC CTCTGATTCC 1260

GAAGATGAAC GTGCACAACA CCTTGCTTTG CTGCAAGAGC AACTCAGGGC AGTTCAAGAA 1320

CAGCTAAAAG CTTTAACAGA AACACCCATA TTTTCAAAGA TTCAACCAAA AAGTGCTGTG 1380

GGGGTGTATG ACAAATACAA ACAGTGGGTG AAATGCATTG AACCAATGGG GAAGTTATTA 1440

AAGAGGAAAA AAAACTATGA TGCAAAGAAA AAGAAATTAC ATGTTTCTGA TGAAGAAGAG 1500

GATGTTAAAC CAATGAGTTA TGATGAGAAA AGACAGCTGA GTTTGGATAT CAATAAATTG 1560

CCAGGAGAAA AGCTAGGTCG CATTGTTCAT ATCATACAGT CCAGAGAGCC ATCGTTGAAA 1620

GACTCTAATC CTAATGAAAT TGAAATTGAT TTTGAGACCT TGAAACAATC AACACTGAGG 1680

CATCTGGAAA AATATGTAAT GGTTTGCTTG AGAAAAAGAC CTAAAAAGCC AAGCAGTATA 1740

AAATCTTTAA AATCAAAGGA ACAGCTGAAT AAAGAAAAAA AGCAAGAATT AGAAAAGCGG 1800

CTTCGGGATG TCAGTGGCCA GCTAAGCTCT GCCAAGAAAC CGAAAATCCA AGGTTTCCTA 1860

TATCCTATGC AATCAATTGG AGGACCTAGC CGACTGAGTG AGAGTAGTAC TAGCTCTTCT 1920

GCCTCTGACG TGAGCAACAG CAGTGATTCC AGTTCTTCAG ATAGCAGCGA CTCTGAATCA 1980

GCAACGTTTC CAAAAAATAT TCTGGCAAAA AAACAGACAA GCACAAACTA TGAAGTCCCA 2040

CTTTTGCTGT ATTATGGATG TTTTGTAAAT AAACCTCGAA CATCAATTCC ACAGAATGGC 2100

CTTTGTATCG GAAGCCAAAG CTTGGCATAC ACAACAATTA GCACCATAGT CCATCCCACT 2160

CCAATGGCGC TCATGCCATT ACACCCAGGC AGTACAAACT ATACATCACT GCAATTGCTG 2220

CTGAAATACG GACTGCATGT GCCACTGATC ATTGAAAATC CCTTAGGTAA TTCTGTTTTA 2280

TTTGAAAATT ATTTAGAGGT TTTGCACCCC TCACAAATAG AGCAGACATT TGCTATAAAG 2340

GAAGAATGTC TCAAACCAAA GTACAAAAAT GCAAAAGTAA AAACTTCCTT CTGCTGGGAA 2400

GTTTTTTCAA AATCTCTGGC TACCACCCAT GTAACCATAA AGTCTTCAAG CAACAGCTTC 2460

CAGCAGTTCA GAAAAGCAGC AATAGCAAAA GAAGAGCGAG AAAGAGCCTT AAAGGCGCAA 2520

GAGTTGAGAC GTCTTGAAGA CTCCAAAGCT GGTATGCAGG AGAAACTAAG CCCCAGTTTA 2580

CCTATGGAAA CTAAAGTTCA TGAAATGCAA GCACAGACTA TAGATGAGGC AACCAAGGGA 2640

GAGCCAACCT GTAATCCTGT ACATGAGGGA ATTACAGAAG AAGAACGAAA CTTGGCAAGA 2700

ATGAGAGAAC AGGAACGCCG CAGACGAGAG GCTATGGCGG GGACTATAGA TATGTACCTT 2760

CAGAGTGATA TCATGGCAAC GTTTGAAGAA CATTTGTGTT GA 2802

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

Activator; Bromodomain; Chromatin regulator; Coiled coil; Complete proteome; Differentiation; Meiosis; Nucleus; Reference proteome; Repeat; Spermatogenesis; Transcription; Transcription regulation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0070577	; F:histone acetyl-lysine binding
GO:0030154	; P:cell differentiation
GO:0016568	; P:chromatin modification
GO:0001207	; P:histone displacement
GO:0007141	; P:male meiosis I
GO:0051039	; P:positive regulation of transcription during meiosis
GO:0043484	; P:regulation of RNA splicing
GO:0007283	; P:spermatogenesis
GO:0006351	; P:transcription, DNA-dependent

KEGG

InterPros

IPR001487	; Bromodomain.
IPR018359	; Bromodomain_CS.

Pfam

PF00439

; Bromodomain; 2.

SMARTs

SM00297

; BROMO; 2.

Prosites

PS00633	; BROMODOMAIN_1; 1.
PS50014	; BROMODOMAIN_2; 2.
PS51525	; NET; 1.

Prints

PR00503

; BROMODOMAIN.

Created Date

20-Feb-2013