EKS-XET-00127

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00127

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	503.0	1.9E-151	155	413	259

Status

Unreviewed

Ensembl Protein

ENSXETP00000018817

UniProt Accession

F6XP81;

Protein Name

Protein Synonyms/Alias

Gene Name

akt1

Gene Synonyms/Alias

akt1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000008603	ENSXETP00000018817	ENSXETT00000018817

Organism

Xenopus tropicalis

Functional Description

Protein Length

485

Protein Sequence
(FASTA)

HNSVSALKST YRHCSVCRTG EYIKTWRPRY FLLKTDGTFI GYKERPQDVD QLETPLNNFS 60

VAKCQLMKTE RPKPNTFIIR CLQWTTVIER TFHVDSPEER EEWIQVIQHV ADNLKKQEEE 120

MMEVRSGDSP SDNSGAEEME VSHSKPKHKV TMNEFEYLKL LGKGTFGKVI LVKEKATGRY 180

YAMKILKKEV IVAKDEVAHT LTENRVLQNS RHPFLTALKY SFQTHDRLCF VMEYANGGEL 240

FFHLSRERIF SEDRARFYGA EIVSALDYLH SEKNVVYRDL KLENLMLDKD GHIKITDFGL 300

CKEGIKDGAT MKTFCGTPEY LAPEVLEDND YGRAVDWWGL GVVMYEMMCG RLPFYNQDHE 360

KLFELILMEE IRFPRTLLPE AKSLLSGLLK KDPKQRLGGG PDDAKEIMQH KFFAGIVWQD 420

VYEKKLIPPF KPQVTSETDT RYFDEEFTAQ MITITPPDQD DNLEFVDNER RPHFPQFSYS 480

ASGNA 485

Nucleotide Sequence
(FASTA)

CACAATTCAG TTTCTGCACT TAAAAGTACC TATAGGCATT GCTCTGTCTG CCGTACAGGT 60

GAATACATCA AGACCTGGCG TCCCCGCTAC TTCCTCCTCA AAACTGACGG TACTTTCATT 120

GGGTACAAAG AGCGTCCACA GGATGTTGAC CAGTTGGAAA CTCCTTTAAA TAATTTCTCT 180

GTAGCCAAAT GTCAGCTGAT GAAGACAGAA CGACCAAAAC CAAACACATT TATCATTCGG 240

TGCCTCCAGT GGACCACAGT AATTGAAAGA ACATTTCATG TGGATTCTCC TGAGGAGCGG 300

GAAGAATGGA TTCAGGTTAT ACAACATGTA GCCGACAACC TTAAGAAACA GGAAGAAGAA 360

ATGATGGAGG TTCGGTCTGG CGACTCCCCA AGCGATAACT CTGGAGCCGA GGAAATGGAA 420

GTTTCTCATT CGAAACCAAA ACATAAAGTA ACAATGAATG AATTTGAGTA TCTCAAGCTT 480

TTGGGGAAAG GAACATTTGG GAAAGTTATT TTAGTCAAAG AGAAAGCAAC AGGAAGATAT 540

TACGCTATGA AAATTTTAAA AAAAGAAGTT ATTGTTGCAA AGGATGAAGT AGCTCACACG 600

CTAACAGAAA ACCGCGTCCT GCAGAATTCT AGGCATCCCT TCCTAACAGC ACTGAAATAT 660

TCCTTTCAGA CACATGATCG CTTATGTTTT GTCATGGAGT ATGCCAATGG AGGAGAGTTA 720

TTCTTCCACT TATCAAGAGA ACGTATATTC TCTGAAGATC GTGCCCGGTT TTATGGGGCA 780

GAGATTGTTT CTGCTTTAGA TTATCTTCAT TCTGAGAAAA ATGTAGTTTA CAGAGACTTA 840

AAGTTGGAAA ATCTAATGCT GGACAAAGAT GGACACATAA AGATAACTGA TTTTGGCCTG 900

TGCAAGGAAG GAATAAAAGA CGGAGCAACC ATGAAGACGT TCTGTGGCAC ACCAGAATAT 960

CTCGCTCCTG AGGTGCTAGA AGATAATGAC TATGGCCGTG CTGTAGACTG GTGGGGCTTG 1020

GGCGTAGTGA TGTACGAGAT GATGTGTGGG CGCCTCCCTT TCTACAATCA AGACCATGAA 1080

AAATTGTTTG AACTTATCCT TATGGAAGAG ATTAGATTTC CACGCACTTT ATTGCCAGAA 1140

GCAAAGTCTT TGCTGTCTGG TTTGTTGAAG AAGGACCCTA AGCAAAGGTT AGGCGGCGGG 1200

CCAGACGATG CTAAAGAAAT CATGCAACAC AAATTTTTTG CTGGAATTGT ATGGCAAGAT 1260

GTTTATGAGA AGAAGCTTAT ACCTCCATTT AAGCCACAAG TAACGTCAGA AACAGACACA 1320

AGGTATTTTG ATGAGGAATT CACAGCGCAA ATGATCACCA TAACACCACC TGACCAAGAT 1380

GACAATTTAG AATTTGTTGA CAACGAGAGA AGACCGCACT TCCCCCAGTT TTCATACTCT 1440

GCTAGTGGAA ATGCTTAG 1458

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         f++lkllGkGtfGkvilv+ekat+++ya+kilkkevivakdevahtlte+rvl++++hpf

Q: 155   FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPF  214

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhs.kd  119

         l+alkysfqt+++lc+v+ey+nGGelffhls+er+fsedrarfygaeivsaldylhs k+

Q: 215   LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERIFSEDRARFYGAEIVSALDYLHSeKN  274

         ********************************************************9789

S: 120   vvyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygka  179

         vvyrdlklenl+ldkdGhikitdfGlcke+ikdg+++ktfcGtpeylapevled+dyg+a

Q: 275   VVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRA  334

         ************************************************************

S: 180   vdwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpk  239

         vdwwglGvv+yem+cGrlpfyn+dheklfelil+ee++fpr+l +eaksllsGllkkdpk

Q: 335   VDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLLPEAKSLLSGLLKKDPK  394

         ************************************************************

S: 240   krlGggkddakeireheff  258

         +rlGgg+ddakei++h+ff

Q: 395   QRLGGGPDDAKEIMQHKFF  413

         ******************9

Domain Sequence
(FASTA)

FEYLKLLGKG TFGKVILVKE KATGRYYAMK ILKKEVIVAK DEVAHTLTEN RVLQNSRHPF 60

LTALKYSFQT HDRLCFVMEY ANGGELFFHL SRERIFSEDR ARFYGAEIVS ALDYLHSEKN 120

VVYRDLKLEN LMLDKDGHIK ITDFGLCKEG IKDGATMKTF CGTPEYLAPE VLEDNDYGRA 180

VDWWGLGVVM YEMMCGRLPF YNQDHEKLFE LILMEEIRFP RTLLPEAKSL LSGLLKKDPK 240

QRLGGGPDDA KEIMQHKFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013