EKS-XET-00385
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00385
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20343.77.3E-1031251251
StatusUnreviewed
Ensembl ProteinENSXETP00000020078
UniProt AccessionF7DKI7; F7B9M0;
Protein Name
Protein Synonyms/Alias
Gene Nametnik
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000009142ENSXETP00000020078ENSXETT00000020078
OrganismXenopus tropicalis
Functional Description
Protein Length1283
Protein Sequence
(FASTA)
VLQGRHVKTG QLAAIKVMDV TGDEEEEIKQ EINMLKKYSH HRNIATYYGA FIKKNPPGMD 60
DQLWLVMEFC GAGSVTDLIK NTKGNTLKEE WIAYICREIL RGLSHLHQHK VIHRDIKGQN 120
VLLTENAEVK LVDFGVSAQL DRTVGRRNTF IGTPYWMAPE VIACDENPDA TYDFKSDLWS 180
LGITAIEMAE GAPPLCDMHP MRALFLIPRN PAPRLKSKKW SKKFQSFIES CLVKNHSQRP 240
TTEQLMKHPF IRDQPNERQV RIQLKDHIDR TKKKRGEKDE TEYEYSGSEE EEEDNDSGEP 300
SSILNLPGES TLRRDFLRLQ LANKERSEAL RRQQLEQQQR ENEEHKRQLL AERQKRIEEQ 360
KEQRRRLEEE QQQRREKEMR KQQERDQRRR YEEQMRREEE RRRAEHEKEY KRKQLEEQRQ 420
AERLQRQLQQ ERDYLVSLQQ QQQQQQRSSE KKPLYHYKEG LNPAEKPAWA KEVEERSRLN 480
RQSSPAMPHK VANRISDPNL PPRSESFSIS GVQPARTPPM HRPIDPQIRP RKFRALHQVS 540
VKTQGSSLSA SQSVHEQSAK GMSAFQEGII SHRPEMPRQN SDPTSENPPL PPRIEKFDRS 600
SWLRQEEDLP PKVPQRTTSI SPALARKNCA GNGNSLGNSL ATQPVRARLP QSHGLWYIYK 660
CNPDLRRTET VIENPIQRIS SGSSSSSSTP SSQPSSQGGS QPGSQAGSSE RNRARGNNKP 720
EGSPLLPHET SNSKPEENRD VTRPSRPADL TALAKELREL RIEETNRPIK KVTDYSSSSE 780
ESESSEEEEG ENQREYLEMS HITQGHRLCM ITHSACTLLV KCLSHLLCVS LCLQTSGDKK 840
RTGHAESNGF AGHINLPDLV QQSHSPVGTP TEALGRGPTH AQEMDTVNEY GVANNTKASF 900
TPFVDPRVYQ TSPKSLKCCP FVSKVGCELL RQEQAKLNEA RKISVVNVNP TNIRPHSDTP 960
EIRKYKKRFN SEILCAALWG VNLLVGTENG LMLLDRSGQG KVYNLINRRR FQQMEVLEGL 1020
NVLVTISGKK NKLRVYYLSW LRNRILHNDP EVEKKQGWIT VGELEGCVHY KVAMPSNQIC 1080
LLLQAHFSLN VNSFALTTYN KKMYIKSFTD LQHRPLLCDL TVEEGQRLKV IFGSSTGFHV 1140
IDVDSGNTYD IYIPSHIQGN ITPHAIVILP KTDGMEMLVC YEDEGVYVNT YGRITKDVVL 1200
QWGEMPTSVA YIHSNQIMGW GEKAIEIRSV ETGHLDGVFM HKRAQRLKFL CERNDKVFFA 1260
SVRSGGSSQV FFMTLNRNSM MNW 1283
Nucleotide Sequence
(FASTA)
GTGTTACAGG GTCGCCATGT TAAAACTGGA CAGCTTGCAG CTATTAAAGT CATGGACGTC 60
ACAGGGGATG AAGAAGAAGA GATCAAACAA GAGATTAATA TGCTGAAGAA ATACTCACAT 120
CACAGAAATA TTGCCACATA TTATGGGGCA TTTATAAAAA AGAACCCTCC TGGAATGGAT 180
GATCAGCTAT GGCTGGTAAT GGAATTCTGT GGCGCTGGAT CCGTCACTGA TTTGATCAAA 240
AACACCAAAG GCAATACTTT AAAAGAAGAG TGGATTGCTT ACATCTGCAG GGAGATCTTA 300
CGGGGCCTGA GTCATCTGCA CCAGCACAAA GTGATTCATC GAGATATTAA GGGGCAGAAT 360
GTCTTGCTGA CAGAAAACGC AGAAGTTAAA CTGGTGGATT TTGGTGTTAG TGCCCAGCTT 420
GACAGAACAG TTGGCAGGAG AAATACGTTT ATTGGAACAC CATATTGGAT GGCTCCTGAA 480
GTTATTGCCT GTGATGAAAA CCCTGATGCA ACCTATGACT TTAAGAGCGA CTTGTGGTCT 540
TTAGGAATAA CAGCCATAGA AATGGCAGAG GGAGCTCCCC CACTCTGCGA CATGCACCCA 600
ATGAGAGCCC TCTTTCTTAT CCCTCGCAAT CCAGCCCCAA GATTGAAATC AAAGAAATGG 660
TCTAAAAAAT TTCAGTCATT TATTGAGAGC TGCCTTGTGA AGAATCACAG CCAAAGACCC 720
ACAACAGAGC AGTTAATGAA ACATCCCTTT ATCCGGGACC AGCCTAACGA AAGGCAGGTT 780
CGAATCCAAC TTAAGGATCA CATTGACAGA ACAAAGAAAA AAAGAGGGGA AAAGGATGAA 840
ACTGAGTATG AATATAGTGG AAGCGAAGAA GAAGAGGAAG ACAATGATTC CGGAGAGCCA 900
AGCTCAATTT TAAATCTGCC TGGGGAATCA ACATTAAGAA GGGATTTCTT GAGGCTGCAG 960
TTGGCAAATA AGGAGCGTTC AGAAGCCCTG AGACGCCAGC AGCTGGAACA GCAGCAACGG 1020
GAAAATGAAG AGCACAAAAG GCAGCTGCTG GCAGAGAGGC AAAAACGCAT TGAGGAGCAG 1080
AAGGAACAAA GGAGAAGGCT AGAAGAGGAA CAGCAGCAAA GAAGGGAAAA AGAAATGAGA 1140
AAGCAACAGG AGAGAGACCA AAGACGGCGG TATGAGGAGC AGATGCGCAG GGAGGAAGAA 1200
CGAAGGCGAG CAGAACATGA GAAGGAGTAT AAGCGTAAGC AGTTGGAAGA ACAGAGACAA 1260
GCAGAGCGAC TTCAGAGACA GCTTCAGCAA GAGCGAGATT ACCTAGTTTC TCTCCAGCAA 1320
CAACAACAGC AGCAACAGAG GTCATCTGAG AAGAAACCAC TCTATCATTA CAAAGAAGGG 1380
CTAAACCCTG CAGAGAAACC AGCATGGGCA AAAGAGGTAG AGGAACGCTC CAGACTCAAT 1440
CGTCAGAGTT CCCCTGCAAT GCCCCATAAA GTAGCAAACA GGATATCCGA TCCAAATCTG 1500
CCTCCAAGAT CAGAATCTTT TAGCATTAGT GGAGTACAGC CTGCCCGAAC ACCGCCAATG 1560
CACAGACCGA TTGATCCACA GATCAGACCT AGAAAATTCA GAGCTCTACA CCAAGTCTCT 1620
GTGAAAACCC AAGGATCATC CCTGTCTGCC TCCCAGTCAG TGCATGAGCA GTCTGCCAAG 1680
GGAATGTCTG CTTTTCAGGA GGGGATTATT TCTCATCGCC CAGAGATGCC ACGGCAGAAT 1740
TCTGACCCAA CATCTGAAAA TCCTCCTCTA CCTCCTCGCA TTGAAAAATT TGATCGAAGT 1800
TCATGGTTGC GCCAGGAGGA AGACCTTCCA CCAAAGGTGC CTCAACGGAC AACTTCTATC 1860
TCCCCCGCGT TAGCCCGAAA GAACTGTGCT GGCAATGGTA ATTCACTGGG AAACAGCTTG 1920
GCAACTCAAC CAGTTAGAGC AAGGCTCCCC CAGTCTCATG GGCTCTGGTA CATATATAAA 1980
TGCAACCCTG ATTTGAGAAG AACTGAAACG GTCATTGAAA ACCCCATCCA AAGAATAAGC 2040
AGTGGAAGCT CCTCCAGTTC CAGTACTCCA AGCTCCCAGC CTAGCTCTCA AGGGGGATCT 2100
CAGCCTGGAT CTCAAGCAGG TTCAAGTGAG AGGAACAGGG CACGAGGTAA CAATAAACCT 2160
GAAGGCTCCC CGTTGCTGCC ACATGAAACA TCTAACTCGA AACCAGAGGA AAACAGAGAT 2220
GTGACACGGC CAAGCCGACC AGCTGATCTG ACAGCGCTGG CCAAAGAGCT TAGAGAACTG 2280
CGCATTGAAG AGACTAACCG ACCAATCAAA AAAGTGACTG ACTATTCTTC ATCTAGTGAA 2340
GAGTCAGAAA GCAGTGAGGA AGAAGAGGGT GAAAACCAAC GGGAATATCT GGAAATGAGC 2400
CATATAACGC AGGGACACAG GCTGTGCATG ATAACCCATT CTGCTTGCAC TCTTCTAGTG 2460
AAGTGCTTAA GTCACTTGCT TTGTGTCTCT TTGTGTCTGC AGACGTCCGG AGATAAAAAA 2520
CGCACTGGCC ATGCTGAGAG TAATGGTTTT GCCGGCCATA TTAATCTTCC TGACCTTGTC 2580
CAGCAAAGTC ACTCCCCGGT GGGTACACCA ACTGAGGCTT TGGGACGAGG TCCTACGCAT 2640
GCACAAGAGA TGGATACTGT GAATGAATAT GGCGTGGCAA ACAACACCAA AGCCTCCTTC 2700
ACTCCTTTTG TTGATCCAAG AGTTTATCAG ACTTCCCCCA AATCACTTAA ATGCTGTCCT 2760
TTTGTGTCAA AGGTAGGTTG CGAACTTCTT AGACAAGAAC AAGCCAAGCT GAATGAGGCC 2820
AGAAAAATAT CTGTGGTAAA CGTGAACCCT ACCAATATTC GTCCTCACAG CGATACTCCA 2880
GAGATCCGGA AATACAAGAA ACGCTTTAAT TCTGAGATAC TTTGTGCAGC ACTATGGGGT 2940
GTAAACTTAC TGGTGGGAAC AGAGAATGGA CTAATGTTGT TGGATCGAAG CGGACAAGGA 3000
AAGGTCTACA ACCTTATCAA CAGGAGGAGG TTTCAGCAGA TGGAAGTCCT AGAAGGACTC 3060
AATGTCCTTG TCACCATTTC AGGGAAAAAG AACAAGTTAA GAGTGTACTA CCTTTCCTGG 3120
CTGCGAAACC GGATCTTGCA CAATGACCCA GAAGTAGAGA AGAAGCAGGG CTGGATTACC 3180
GTGGGGGAAC TGGAAGGCTG TGTACATTAT AAAGTTGCCA TGCCAAGCAA TCAGATTTGT 3240
TTACTTTTAC AGGCCCACTT CAGTCTGAAT GTAAACTCTT TTGCTTTGAC AACATATAAT 3300
AAAAAAATGT ACATTAAGTC CTTTACAGAC CTCCAGCATA GACCATTGCT ATGTGATCTC 3360
ACTGTAGAAG AAGGTCAGAG ATTAAAAGTG ATTTTTGGAT CAAGCACCGG CTTCCATGTA 3420
ATTGATGTTG ATTCTGGCAA TACATATGAC ATCTATATTC CATCTCATAT TCAGGGTAAC 3480
ATCACCCCAC ATGCTATTGT TATATTACCA AAAACAGATG GCATGGAGAT GCTCGTGTGC 3540
TATGAGGATG AGGGTGTTTA TGTGAATACC TATGGTCGAA TAACTAAAGA TGTGGTGCTT 3600
CAATGGGGGG AAATGCCCAC ATCGGTTGCA TATATCCATT CCAATCAGAT AATGGGCTGG 3660
GGAGAGAAAG CAATTGAAAT CCGTTCTGTG GAAACTGGGC ATCTGGATGG GGTGTTCATG 3720
CATAAGAGAG CCCAGCGCTT AAAATTCCTA TGTGAAAGGA ATGATAAGGT TTTCTTTGCA 3780
TCTGTACGAT CAGGAGGCAG CAGCCAAGTC TTTTTTATGA CGCTCAACAG AAATTCCATG 3840
ATGAACTGGT AA 3852
Domain Profile
S: 15    vylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniveylesflk......  67
         v ++r++ktg+l+aik+++++  +++ee+++ei++lkk++h +ni +y+++f+k      
Q: 1     VLQGRHVKTGQLAAIKVMDVTG-DEEEEIKQEINMLKKYSHhRNIATYYGAFIKknppgm  59
         67899****************8.999*************998******************
S: 68    eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdikak  127
         +++lwlvme++ +Gs++dl+k+++ ++lkEe+iayi+re+l++L++lH++kviHrdik++
Q: 60    DDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQ  119
         ************************************************************
S: 128   niLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgYdekaDiw  184
         n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++   + +Yd k+D+w
Q: 120   NVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDenpDATYDFKSDLW  179
         **********************************************999999********
S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244
         slGItaie+aeg+pP++d++p++al++i++n++p+lksk k+sk+f++f+e+cl kn ++
Q: 180   SLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKFQSFIESCLVKNHSQ  238
         ************************************888.********************
S: 245   RpsasellkhkFl  257
         Rp++++l+kh+F+
Q: 239   RPTTEQLMKHPFI  251
         ************7
Domain Sequence
(FASTA)
VLQGRHVKTG QLAAIKVMDV TGDEEEEIKQ EINMLKKYSH HRNIATYYGA FIKKNPPGMD 60
DQLWLVMEFC GAGSVTDLIK NTKGNTLKEE WIAYICREIL RGLSHLHQHK VIHRDIKGQN 120
VLLTENAEVK LVDFGVSAQL DRTVGRRNTF IGTPYWMAPE VIACDENPDA TYDFKSDLWS 180
LGITAIEMAE GAPPLCDMHP MRALFLIPRN PAPRLKSKKW SKKFQSFIES CLVKNHSQRP 240
TTEQLMKHPF I 251
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00288
EKS-ANC-00307
EKS-BOT-00325
EKS-CAJ-00314
EKS-CAF-00329
EKS-CAP-00343
EKS-DAR-00667
EKS-EQC-00300
EKS-FEC-00295
EKS-GAG-00270
EKS-GAA-00381
EKS-GOG-00305
EKS-HOS-00315
EKS-ICT-00307
EKS-LAC-00328
EKS-LOA-00329
EKS-MAM-00312
EKS-MOD-00303
EKS-MUM-00340
EKS-MUP-00305
EKS-MYL-00320
EKS-NOL-00284
EKS-ORN-00400
EKS-ORA-00286
EKS-ORC-00291
EKS-ORL-00382
EKS-OTG-00324
EKS-PAT-00292
EKS-PES-00274
EKS-PEM-00170
EKS-POA-00300
EKS-SUS-00290
EKS-TAG-00323
EKS-TAR-00403
EKS-TAS-00031
EKS-TEN-00400
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013