EKS-XET-00165

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00165

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	406.3	6.6E-122	246	511	266

Status

Unreviewed

Ensembl Protein

ENSXETP00000020225

UniProt Accession

F7DVL1;

Protein Name

Protein Synonyms/Alias

Gene Name

prkci

Gene Synonyms/Alias

prkci;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000009210	ENSXETP00000020223	ENSXETT00000020223
ENSXETG00000009210	ENSXETP00000020225	ENSXETT00000020225

Organism

Xenopus tropicalis

Functional Description

Protein Length

585

Protein Sequence
(FASTA)

MPTQRDNTMS QPSDHSHQVR VKAYFKGDIM ITHFEPSITF DGLCNEVRDM CSFENDQPFT 60

MKWIDEEGDP CTVSSQLELE EAFRLYELNK DSELLIHVFP CIPERPGMPC AGEDKSIYRR 120

GARRWRKLYC ANGHTFQAKR FNRRAHCAIC TDRIWGLGRQ GYKCINCKLL VHKKCHKLVS 180

IECGRHTIAE PVIPMDPPGM HSDHSEPELP YRPRSQDNLD QVGEEKEAMN SRESGKTPSS 240

LGLQDFDLMR VIGRGSYAKV LLVRLKKTER IYAMKVVKKE LVNDDEDIDW VQTEKHVFEQ 300

ASNHPFLVGL HSCFQTESRL FFVIEYVNGG DLMFHMQRQR KLPEEHARFY SAEISLALNY 360

LHERGIIYRD LKLDNVLLDS EGHIKLTDYG MCKEGLRPGD TTSTFCGTPN YIAPEILRGE 420

DYGFSVDWWA LGVLMFEMMA GRSPFDIVGS SDNPDQNTED FLFQVINKAI YYKCNINVSA 480

ANEHIIKSDP KDRLGCHPQT GFADIQGHQF FRNVDWDLME QKQVVPPFKP NISGEFGLDN 540

FDAQFTNEPV QLTPDDEDVV RKIDQSEFEG FEYINPLLMS AEECV 585

Nucleotide Sequence
(FASTA)

ATGCCGACAC AGAGGGACAA CACCATGTCC CAGCCATCAG ATCATTCCCA CCAGGTCCGG 60

GTCAAAGCGT ATTTTAAGGG TGACATCATG ATTACACATT TCGAACCCTC TATAACCTTT 120

GATGGGCTGT GCAATGAGGT GCGGGACATG TGCTCTTTTG AAAACGACCA GCCTTTCACC 180

ATGAAGTGGA TTGATGAAGA AGGAGATCCA TGCACAGTTT CCTCTCAGTT GGAACTGGAA 240

GAAGCTTTCC GTCTGTATGA ATTGAATAAG GATTCTGAGC TGCTTATCCA CGTGTTCCCA 300

TGTATACCAG AGAGGCCTGG CATGCCCTGC GCAGGGGAAG ACAAGTCCAT ATATCGACGT 360

GGAGCCAGAA GATGGAGAAA ACTCTATTGT GCAAATGGTC ACACTTTCCA GGCCAAGAGA 420

TTTAACAGGC GAGCGCACTG CGCCATCTGC ACTGACCGAA TATGGGGGCT GGGACGTCAG 480

GGCTATAAAT GCATCAACTG TAAACTGCTT GTTCATAAGA AATGTCACAA GCTTGTTTCC 540

ATTGAATGTG GCCGACACAC AATAGCGGAA CCTGTTATAC CAATGGATCC ACCAGGCATG 600

CACTCTGATC ACAGCGAACC AGAACTGCCA TACAGACCAA GAAGCCAAGA CAATCTAGAT 660

CAAGTTGGTG AAGAGAAAGA GGCAATGAAC AGCAGGGAGA GTGGAAAGAC CCCGTCTAGC 720

CTGGGACTGC AAGACTTTGA CCTTATGCGG GTCATTGGAA GAGGCAGCTA TGCTAAAGTT 780

CTGCTTGTCC GGTTAAAGAA AACAGAGAGA ATCTATGCAA TGAAAGTTGT CAAAAAGGAG 840

CTTGTTAATG ATGATGAGGA TATTGACTGG GTGCAGACAG AGAAGCATGT GTTCGAGCAG 900

GCCTCAAACC ACCCTTTCCT AGTTGGGCTA CACTCCTGCT TCCAGACAGA GAGCAGGCTA 960

TTTTTTGTAA TTGAATATGT GAATGGTGGG GATCTGATGT TTCACATGCA GCGCCAAAGG 1020

AAGCTTCCCG AGGAGCATGC AAGGTTTTAT TCTGCAGAAA TCAGTCTGGC ATTAAACTAC 1080

CTTCACGAGC GTGGTATTAT TTATAGAGAT TTAAAGCTAG ACAATGTCTT ATTGGATTCT 1140

GAAGGGCACA TAAAACTTAC TGACTACGGC ATGTGTAAGG AGGGGTTGAG GCCTGGAGAT 1200

ACAACTAGTA CATTCTGTGG CACTCCAAAT TATATCGCTC CTGAGATCCT ACGAGGAGAG 1260

GATTATGGTT TCAGCGTTGA TTGGTGGGCT CTTGGGGTCT TGATGTTTGA GATGATGGCC 1320

GGAAGGTCAC CTTTTGATAT CGTTGGAAGC TCAGACAATC CAGACCAAAA CACAGAAGAT 1380

TTTCTTTTCC AAGTCATAAA TAAAGCCATT TACTATAAAT GTAATATAAA TGTCTCTGCT 1440

GCTAATGAGC ATATCATCAA ATCTGATCCA AAGGATCGCC TTGGCTGTCA CCCTCAGACA 1500

GGATTTGCAG ATATCCAGGG ACATCAGTTT TTCCGCAATG TAGACTGGGA TCTTATGGAG 1560

CAAAAACAGG TGGTGCCTCC ATTTAAGCCC AATATATCGG GGGAATTTGG TTTGGATAAC 1620

TTTGATGCTC AGTTCACTAA TGAACCAGTG CAGCTTACCC CTGATGATGA GGATGTGGTG 1680

AGGAAGATTG ACCAGTCAGA GTTTGAAGGC TTTGAATATA TCAACCCACT ACTGATGTCT 1740

GCTGAAGAAT GTGTATAA 1758

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+l++v+G+Gs++kvll++lkkt+++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 246   FDLMRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  305

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 306   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  365

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 366   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  425

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvl++em+ag+sPf+         +++ed lf++i +k ++y  ++++ a++

Q: 426   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDFLFQVI-NKAIYYKCNINVSAAN--  482

         *****************************999******988.5789999999888775..

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         + +++ dp++rlG++ ++g +di+ h+ff

Q: 483   EHIIKSDPKDRLGCHpQTGFADIQGHQFF  511

         88999*********989***********9

Domain Sequence
(FASTA)

FDLMRVIGRG SYAKVLLVRL KKTERIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDFLFQV INKAIYYKCN INVSAANEHI 240

IKSDPKDRLG CHPQTGFADI QGHQFF 266

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0031226	; C:intrinsic to plasma membrane
GO:0005915	; C:zonula adherens
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0034334	; P:adherens junction maintenance
GO:0045217	; P:cell-cell junction maintenance
GO:0007502	; P:digestive tract mesoderm development
GO:0048546	; P:digestive tract morphogenesis
GO:0021744	; P:dorsal motor nucleus of vagus nerve development
GO:0035050	; P:embryonic heart tube development
GO:0000132	; P:establishment of mitotic spindle orientation
GO:0016332	; P:establishment or maintenance of polarity of embryonic epithelium
GO:0035556	; P:intracellular signal transduction
GO:0045199	; P:maintenance of epithelial cell apical/basal polarity
GO:0008078	; P:mesodermal cell migration
GO:0001738	; P:morphogenesis of a polarized epithelium
GO:0001841	; P:neural tube formation
GO:0007405	; P:neuroblast proliferation
GO:0007097	; P:nuclear migration
GO:0042476	; P:odontogenesis
GO:0060042	; P:retina morphogenesis in camera-type eye

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR012233	; PKC_zeta.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013