EKS-XET-00054

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00054

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	441.3	1.5E-132	4	286	283

Status

Unreviewed

Ensembl Protein

ENSXETP00000020815

UniProt Accession

F7E1G7;

Protein Name

Protein Synonyms/Alias

Gene Name

cdk2

Gene Synonyms/Alias

cdk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000009444	ENSXETP00000063160	ENSXETT00000061554
ENSXETG00000009444	ENSXETP00000020815	ENSXETT00000020815

Organism

Xenopus tropicalis

Functional Description

Protein Length

297

Protein Sequence
(FASTA)

MENFQKVEKI GEGTYGVVYK ARNRETGEIV ALKKIRLDTE TEGVPSTAIR EISLLKELNH 60

PNIVKLLDVI HTENKLYLVF EFLNQDLKKF MDGSNISGIS LALVKSYLFQ LLQGLAFCHS 120

HRVLHRDLKP QNLLINSEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKFY 180

STAVDIWSLG CIFAEMITRR ALFPGDSEID QLFRIFRTLG TPDEVSWPGV TTMPDYKSTF 240

PKWVRQDFSK VVPPLDDDGR DLLAQMLQYD SNKRISAKAA LTHAFFRDVS RPTPHLI 297

Nucleotide Sequence
(FASTA)

ATGGAGAATT TCCAGAAGGT GGAGAAGATC GGGGAGGGCA CGTACGGGGT GGTGTACAAA 60

GCGCGGAACC GAGAGACCGG GGAGATTGTG GCTCTGAAAA AGATTCGCTT GGACACTGAG 120

ACAGAAGGAG TTCCAAGCAC AGCCATCCGG GAAATTTCCC TCCTCAAAGA ATTGAACCAT 180

CCCAATATTG TGAAGCTTCT TGATGTCATT CATACAGAAA ACAAGCTCTA CCTTGTATTT 240

GAGTTCCTTA ACCAAGATCT GAAGAAATTC ATGGACGGTT CAAACATTTC TGGAATTTCA 300

CTAGCCCTAG TTAAAAGCTA TCTGTTCCAG TTGCTCCAAG GTTTGGCTTT CTGCCACTCA 360

CATCGTGTCT TACATCGTGA CTTAAAACCA CAGAACCTGC TTATTAATTC TGAGGGTGCC 420

ATCAAACTTG CCGACTTTGG ACTAGCTCGG GCATTTGGTG TGCCTGTGAG AACCTATACT 480

CATGAGGTTG TCACCCTGTG GTACAGAGCA CCAGAAATTC TTCTTGGCTG CAAGTTCTAC 540

TCCACGGCTG TAGATATCTG GAGCCTGGGA TGTATATTTG CAGAAATGAT CACTAGGAGA 600

GCACTTTTTC CTGGAGATTC TGAAATTGAT CAGCTCTTTC GCATCTTTCG AACACTGGGG 660

ACCCCTGATG AAGTGTCCTG GCCAGGAGTG ACAACTATGC CAGATTACAA GTCAACCTTT 720

CCTAAGTGGG TCCGACAGGA CTTTAGCAAA GTGGTGCCAC CTTTGGATGA TGATGGTAGA 780

GACCTTTTAG CTCAAATGCT TCAGTATGAC TCCAACAAGC GGATTTCTGC TAAAGCAGCG 840

CTGACCCATG CTTTCTTCCG AGATGTGAGC AGACCAACTC CGCATCTGAT TTAG 894

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++k+ekigeGtyg+vyka+++etge+vAlKkirl++e+egvp+ta+rEisllkel+h+ni

Q: 4     FQKVEKIGEGTYGVVYKARNRETGEIVALKKIRLDTETEGVPSTAIREISLLKELNHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         vkLl+v++ +++klyLvfefl+qdLkk+++ ++++++sl+ vks+l+qll+gla++Hs++

Q: 64    VKLLDVIH-TENKLYLVFEFLNQDLKKFMDGSNISGISLALVKSYLFQLLQGLAFCHSHR  122

         ********.99*************************************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi++eg +klaDfGlaraf++p++tyt+evvTlwYraPe+Llg+k Yst

Q: 123   VLHRDLKPQNLLINSEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKFYST  182

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfpk  240

         avDiWs+gci+ae++tr++lf+g+seidql+rif++lgtp+e +wp+v+++p+yk++fpk

Q: 183   AVDIWSLGCIFAEMITRRALFPGDSEIDQLFRIFRTLGTPDEVSWPGVTTMPDYKSTFPK  242

         ************************************************************

S: 241   kkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         + +++++++v+ l+++++dll ++l++d +kRisak+al+h +f

Q: 243   WVRQDFSKVVPPLDDDGRDLLAQMLQYDSNKRISAKAALTHAFF  286

         ******************************************98

Domain Sequence
(FASTA)

FQKVEKIGEG TYGVVYKARN RETGEIVALK KIRLDTETEG VPSTAIREIS LLKELNHPNI 60

VKLLDVIHTE NKLYLVFEFL NQDLKKFMDG SNISGISLAL VKSYLFQLLQ GLAFCHSHRV 120

LHRDLKPQNL LINSEGAIKL ADFGLARAFG VPVRTYTHEV VTLWYRAPEI LLGCKFYSTA 180

VDIWSLGCIF AEMITRRALF PGDSEIDQLF RIFRTLGTPD EVSWPGVTTM PDYKSTFPKW 240

VRQDFSKVVP PLDDDGRDLL AQMLQYDSNK RISAKAALTH AFF 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013