EKS-XET-00373

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00373

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	418.3	1.2E-125	683	945	263

Status

Unreviewed

Ensembl Protein

ENSXETP00000020879

UniProt Accession

F7EBK6;

Protein Name

Protein Synonyms/Alias

Gene Name

erbb3

Gene Synonyms/Alias

erbb3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000009463	ENSXETP00000020879	ENSXETT00000020879

Organism

Xenopus tropicalis

Functional Description

Protein Length

1295

Protein Sequence
(FASTA)

VCSGTMNGLS VSGDSDYQLF TLKNMYSNCQ IVMGNLEIVL IDNKGDLSFL TSIREVTGYV 60

LIAVNIFTYL PLENLRVIRG AHLYDKKYAL YMSLNNQING SLGIEKLGFH KLTEILAGGV 120

HITKNDHLCF TDTINWKDIV QDSKAAIEIE SNSKACKPCD QACDGNCWGP EKTDCQTLTK 180

TVCAEQCNGR CFGKNPTECC HDECAGGCTD SSNLKCFVCR HFNDSEACVP HCPQPLIYNK 240

LTFQLEPNPD AKYQYGGSCV KSCPRNFVVD QSSCVRACPS NKMEVEKNGV KMCEPCSGLC 300

PKACEGTLHG STYQTVDSSN IDKFINCTKI LGNLDFLTIG IDGDLWRNIT ALDPKKLSVF 360

KTVKEITGYL NIQSWPKSLT DFSVFSSLST IGGRTLHTRG FSLLVMKNSN VTSLGFRSLQ 420

EISAGKVYIA ENQNLCYCDT VNWTSLFPTY PRQSTEIKGN RKKNKCVEEG KVCDPLCSNN 480

GCWGSGPDQC LSCRNYSRNG VCLQSCNFTE GDEREYAKAG VCLKCHEECQ KMEGRLSCNG 540

SGPDGCVQCV NYRDGLHCVS QCPNGILGKD RPIFKYPDAN KDCQPCHENC THGCTGPEIK 600

HCTGIAAPII SSNTPTVVVA AVVATFFVLC CCALLGTLYW RGQKIRNKRA MRRYLERGEC 660

LDMLDPSEKT NTVQARLFKD TELKKLKILG SGVFGTVHKG VWIPDGESIK IPVCIKVILD 720

RTGRQTFHAV TDHMLAIGSL DHTYIVRLLG ICPGSQLQLV TAYLPMGSLL QHVRKNKDSG 780

AIGPQLLLNW CVQIAKGMCY LEEHRMVHRN LSARNVLMKS VNQVQVSDYG VADLLYPDDK 840

KFCYNEIKTP VKWMALESIH FGKYTHQSDV WSYVPQKGVT LWEMMTFGAE PYTGIRLSEV 900

PDLLEKGERL SQPQICTIDV YMVMVKCWMI DENIRPTFKE LGNEFTRMAR DPPRYLVVTR 960

NSDALQSPLP GDPPPLSEKQ VSDLESDVDT DLESEDMAMQ PKTPTTLYAS RQRIDYSRSQ 1020

SALSSIAGYL PMNQSLCSSS RKVGCFQGTM TSAEPIPRHG TRRREDSLGR TVSESSEGCC 1080

TSSDLETIED NSYGGGSLSH ISRSRLDSAY RSQRESLLVG TPDDDSEYIM PGLSQSEISR 1140

DGTLTSQGSR SLTPCLVNAT DEEDEEYEYM NKKKPSSKEK LEYEYMDIRG TGDASNECIA 1200

FSPAEGDKEG DYEYGNKEDY EYMNEKGKYT SRESLGDGDL EEYTYMNRSG KTCHREALQK 1260

GYHQPLRALE AKDCAFDNPD YWHSRLFSKT DLQMT 1295

Nucleotide Sequence
(FASTA)

GTGTGTTCTG GAACAATGAA TGGTCTCAGT GTGTCTGGTG ACTCCGACTA CCAGCTCTTC 60

ACCTTGAAGA ACATGTACAG TAACTGCCAA ATTGTCATGG GCAACCTGGA GATTGTACTA 120

ATTGATAACA AAGGGGACTT GTCCTTTCTA ACGTCCATAC GGGAGGTGAC TGGATATGTT 180

CTGATTGCTG TAAATATTTT CACTTACCTG CCACTCGAAA ATCTACGTGT GATCCGAGGG 240

GCCCACCTCT ACGACAAAAA GTATGCTCTG TACATGTCAC TCAACAACCA GATTAATGGC 300

TCGTTGGGCA TAGAAAAACT TGGCTTCCAC AAGCTGACAG AAATCCTGGC TGGAGGAGTT 360

CACATAACCA AAAATGATCA CCTGTGCTTC ACTGACACTA TTAACTGGAA AGACATTGTA 420

CAAGATTCTA AAGCAGCGAT TGAGATCGAG TCTAATTCAA AAGCATGCAA ACCCTGTGAC 480

CAGGCGTGTG ATGGAAATTG TTGGGGACCA GAAAAGACAG ATTGTCAAAC ATTGACAAAG 540

ACCGTTTGTG CAGAGCAGTG TAACGGACGT TGCTTTGGCA AGAACCCTAC TGAGTGCTGT 600

CATGATGAGT GTGCTGGGGG CTGCACAGAT TCCTCAAACC TGAAGTGCTT CGTATGTCGT 660

CACTTTAATG ATAGCGAAGC CTGTGTCCCA CACTGTCCTC AGCCACTGAT TTACAACAAA 720

CTAACCTTTC AACTGGAACC CAATCCAGAT GCCAAATATC AATATGGAGG CTCGTGCGTC 780

AAAAGTTGCC CTCGAAATTT TGTGGTAGAC CAAAGCTCCT GTGTTCGTGC GTGTCCCAGT 840

AACAAAATGG AAGTTGAAAA AAATGGGGTT AAGATGTGTG AGCCATGTTC AGGGCTGTGC 900

CCCAAAGCCT GTGAGGGGAC TCTGCATGGA AGTACATACC AGACTGTGGA TTCCAGTAAT 960

ATTGACAAGT TCATTAACTG CACCAAAATC CTGGGGAATC TGGACTTCCT TACTATTGGA 1020

ATTGATGGAG ATTTGTGGAG AAATATCACA GCTCTAGACC CCAAAAAACT AAGCGTCTTC 1080

AAGACAGTGA AGGAAATCAC TGGGTACCTG AACATTCAGT CTTGGCCAAA GAGCCTGACA 1140

GACTTTAGTG TGTTCTCCAG CCTCAGTACG ATTGGTGGAC GGACTCTCCA TACCCGAGGC 1200

TTCTCACTAC TTGTGATGAA AAACAGCAAC GTGACCTCAT TGGGGTTCCG CTCACTGCAG 1260

GAAATCAGCG CGGGGAAAGT ATATATTGCA GAGAACCAGA ATCTCTGCTA TTGTGACACT 1320

GTGAACTGGA CATCTTTGTT CCCAACATAC CCTCGCCAGA GCACTGAAAT CAAGGGAAAC 1380

AGAAAGAAGA ATAAGTGTGT GGAGGAAGGG AAGGTATGTG ACCCTCTCTG CTCTAACAAT 1440

GGATGCTGGG GTTCTGGGCC AGACCAGTGT TTATCCTGCA GAAATTACAG CAGAAATGGA 1500

GTATGCCTGC AATCCTGTAA CTTCACTGAA GGAGATGAAC GGGAATATGC CAAGGCAGGT 1560

GTATGCCTTA AATGCCACGA AGAGTGTCAG AAAATGGAGG GAAGGTTGTC TTGCAATGGA 1620

TCTGGCCCTG ATGGTTGTGT GCAATGTGTT AACTATAGGG ATGGTCTACA CTGTGTGAGC 1680

CAATGTCCCA ATGGGATTTT AGGAAAAGAC AGGCCAATCT TCAAGTACCC AGATGCCAAC 1740

AAGGACTGTC AGCCATGCCA TGAAAACTGT ACTCATGGGT GTACAGGACC TGAAATTAAA 1800

CACTGCACTG GAATCGCTGC CCCTATAATT TCAAGTAACA CTCCCACAGT GGTGGTAGCA 1860

GCAGTAGTGG CCACTTTCTT TGTCCTGTGC TGCTGTGCCC TGCTTGGTAC ACTTTACTGG 1920

AGAGGACAGA AAATCCGCAA TAAACGTGCT ATGAGGAGGT ACCTGGAGAG GGGTGAGTGT 1980

TTGGATATGC TGGATCCTTC AGAAAAAACA AACACCGTGC AGGCTCGGCT CTTCAAAGAC 2040

ACAGAACTGA AGAAACTGAA GATCTTGGGC TCCGGAGTAT TTGGCACAGT GCATAAGGGT 2100

GTCTGGATAC CCGATGGTGA GTCGATCAAG ATACCTGTCT GTATTAAAGT TATACTAGAC 2160

CGGACCGGTC GCCAGACCTT CCATGCAGTT ACTGATCACA TGCTAGCGAT TGGAAGCCTG 2220

GACCATACCT ACATTGTGCG TTTGTTGGGG ATATGCCCAG GCTCACAGCT CCAGCTGGTC 2280

ACAGCATACC TGCCAATGGG ATCGCTGCTT CAACACGTGC GCAAAAACAA GGATTCTGGT 2340

GCCATTGGTC CTCAGCTCCT TCTTAACTGG TGTGTGCAAA TTGCAAAGGG TATGTGTTAC 2400

TTGGAGGAAC ATCGAATGGT TCATAGGAAC CTATCTGCTC GGAATGTCCT TATGAAAAGT 2460

GTCAATCAGG TGCAGGTATC AGACTATGGA GTGGCAGACT TGCTGTACCC AGATGACAAG 2520

AAGTTTTGCT ACAATGAGAT CAAGACTCCC GTGAAATGGA TGGCTCTGGA AAGTATACAC 2580

TTTGGGAAGT ACACTCATCA GAGTGACGTA TGGAGCTATG TTCCTCAAAA AGGTGTTACT 2640

CTATGGGAAA TGATGACATT CGGTGCAGAA CCATACACAG GGATTCGTTT GTCAGAAGTT 2700

CCTGACCTCC TAGAGAAAGG GGAGCGACTA TCCCAACCAC AAATATGCAC CATTGATGTC 2760

TACATGGTAA TGGTGAAATG CTGGATGATT GATGAAAATA TTCGCCCTAC GTTTAAAGAA 2820

CTCGGAAATG AATTCACCCG TATGGCTAGG GATCCACCTC GCTACCTGGT TGTTACGCGC 2880

AATAGTGATG CGCTTCAGTC CCCACTCCCA GGGGATCCAC CACCTCTGTC TGAGAAACAA 2940

GTGAGTGATC TGGAGTCTGA CGTGGACACT GACCTTGAGT CTGAAGACAT GGCAATGCAG 3000

CCTAAAACTC CAACTACCCT ATATGCCTCA CGACAAAGAA TTGACTACTC TAGGAGTCAG 3060

AGTGCACTGA GCTCTATCGC TGGGTACCTG CCTATGAACC AGAGTCTTTG CAGCTCCTCA 3120

AGAAAGGTGG GCTGTTTTCA GGGAACAATG ACCTCTGCAG AACCAATTCC AAGACATGGG 3180

ACACGCAGAA GAGAAGACTC ACTTGGCCGA ACAGTGTCAG AGTCATCAGA GGGCTGTTGT 3240

ACTTCTTCAG ACCTGGAGAC AATAGAGGAT AATTCCTATG GCGGAGGGAG CCTGAGCCAC 3300

ATTTCTCGCT CTCGCCTTGA CAGTGCATAC CGATCCCAAA GGGAGAGCCT CCTTGTTGGG 3360

ACCCCTGATG ATGACAGCGA GTATATCATG CCAGGGCTCA GTCAAAGTGA AATTTCACGG 3420

GATGGAACAC TAACATCCCA AGGATCCAGA TCCCTGACAC CATGCCTGGT CAATGCCACT 3480

GATGAAGAGG ATGAAGAGTA TGAATACATG AACAAAAAGA AGCCCAGCTC AAAAGAGAAG 3540

CTAGAGTATG AATATATGGA CATACGTGGA ACAGGAGATG CAAGCAATGA ATGCATAGCT 3600

TTCTCCCCTG CGGAGGGTGA CAAAGAGGGA GACTATGAGT ATGGAAACAA GGAGGACTAC 3660

GAGTATATGA ATGAAAAAGG GAAATACACA AGTAGGGAAA GCTTAGGAGA TGGCGACCTG 3720

GAGGAGTACA CTTATATGAA CCGGAGTGGG AAAACCTGCC ATAGAGAGGC ATTGCAAAAA 3780

GGGTATCACC AGCCCCTTAG GGCTTTAGAA GCTAAAGACT GTGCATTTGA CAATCCAGAC 3840

TACTGGCACA GCCGGTTGTT TTCTAAGACT GACCTACAGA TGACATAA 3888

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lkklk+lGsG+fGtv+kG+wip+ge++kipv+ikv+ ++tg++++++++d++l+++sldh

Q: 683   LKKLKILGSGVFGTVHKGVWIPDGESIKIPVCIKVILDRTGRQTFHAVTDHMLAIGSLDH  742

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkd..klGsqellnwcvqiakGmsyle  118

         +++vrllg+c  s+lqlvt +lp+G+ll++vr++kd  ++G+q llnwcvqiakGm yle

Q: 743   TYIVRLLGICPGSQLQLVTAYLPMGSLLQHVRKNKDsgAIGPQLLLNWCVQIAKGMCYLE  802

         **********************************98446*********************

S: 119   ekrlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkr  178

         e+r+vhr+l+arnvl+ks n+v+++d+G+a+ll  d+k++ +++ k+p+kw+alesi++

Q: 803   EHRMVHRNLSARNVLMKSVNQVQVSDYGVADLLYPDDKKFCYNEIKTPVKWMALESIHFG  862

         ************************************************************

S: 179   kythqsdvwsy....GvtvwelltfGakpydgipakeipdllekGerlaqppictidvym  234

         kythqsdvwsy    Gvt+we++tfGa+py gi+++e+pdllekGerl+qp+ictidvym

Q: 863   KYTHQSDVWSYvpqkGVTLWEMMTFGAEPYTGIRLSEVPDLLEKGERLSQPQICTIDVYM  922

         ***********99999********************************************

S: 235   vlvkcwmidaesrpkfkelaeef  257

         v+vkcwmid+++rp+fkel +ef

Q: 923   VMVKCWMIDENIRPTFKELGNEF  945

         ********************999

Domain Sequence
(FASTA)

LKKLKILGSG VFGTVHKGVW IPDGESIKIP VCIKVILDRT GRQTFHAVTD HMLAIGSLDH 60

TYIVRLLGIC PGSQLQLVTA YLPMGSLLQH VRKNKDSGAI GPQLLLNWCV QIAKGMCYLE 120

EHRMVHRNLS ARNVLMKSVN QVQVSDYGVA DLLYPDDKKF CYNEIKTPVK WMALESIHFG 180

KYTHQSDVWS YVPQKGVTLW EMMTFGAEPY TGIRLSEVPD LLEKGERLSQ PQICTIDVYM 240

VMVKCWMIDE NIRPTFKELG NEF 263

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013