EKS-XET-00547
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00547
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Syk438.76.1E-132324571248
StatusUnreviewed
Ensembl ProteinENSXETP00000020939
UniProt AccessionF6Z0W0;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene Namezap70
Gene Synonyms/Alias zap70;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000009491ENSXETP00000020939ENSXETT00000020939
ENSXETG00000009491ENSXETP00000058411ENSXETT00000063530
OrganismXenopus tropicalis
Functional Description
Protein Length606
Protein Sequence
(FASTA)
MPDAAGHLPF YYGSISRADA EEYLKLGGMM DGLFLLRQCL RTLGGYVLSM VYNLHFHHYP 60
VERQLNGTYA IAGGKAHCGP AELCEYYSKD ADGLCCTLRR PCNRPAGVEC QAGVFDNMRD 120
NMMREYVRQT WKLEGDALEQ AIISQAPQVE KLIATTAHER MAWYHGTISR DEAERKLYSG 180
AQPDGKFLQK QWRERAVKSS LYVNFYVRPF SDAVGGSYSI RLLNILFLFL KLVEYLKLKS 240
DGIMAVLKES CPNSCTFSIA PAAAPPSLPK IRQAASNSDG YTPEPFIGKS RILPMDTSVY 300
ESPYSDPEEL KERKLFVKRE LLLIDEVELG SGNFGCVKKG VYKLKKRQID VAIKVLKVQD 360
EKNVRDEMMK EAEIMHQLDN PYIVRMIGVC EAENLMLVME MASGGPLNKF LGAKKDVIPM 420
SNIVELMHQV SIGMKYLEGK NFVHRDLAAR NVLMVNQHYA KISDFGLSKA LAADDSYYKA 480
KSFGKWPLKW YAPECINYRK FSSRSDVWSY GITMWEAFTY GQKPYKKLKG TEVMSFIERN 540
ERLACPAGCP PEMYQVMLDC WIFKMEDRPN FDNVEYRMRM YYYSIADKPD KEGKEAAAAA 600
EASGKV 606
Nucleotide Sequence
(FASTA)
ATGCCAGATG CTGCTGGTCA CTTGCCCTTT TACTATGGCA GTATATCTCG TGCTGATGCA 60
GAGGAATATC TCAAACTAGG TGGAATGATG GATGGGCTTT TCTTGCTGAG GCAATGCCTA 120
CGGACTCTAG GTGGCTATGT GCTTTCTATG GTATACAACC TGCACTTTCA CCATTACCCT 180
GTGGAACGAC AACTGAATGG CACTTATGCT ATAGCAGGAG GAAAAGCTCA CTGTGGCCCA 240
GCCGAACTAT GTGAATACTA CTCTAAAGAT GCAGATGGAT TGTGCTGTAC CCTGCGGCGG 300
CCATGTAACC GGCCAGCTGG TGTGGAGTGC CAGGCAGGAG TGTTTGATAA TATGCGGGAT 360
AACATGATGA GAGAATATGT AAGGCAGACA TGGAAGCTAG AGGGGGATGC CCTGGAACAG 420
GCAATAATTA GCCAGGCCCC ACAAGTTGAA AAGCTCATAG CCACTACTGC CCATGAGAGG 480
ATGGCCTGGT ATCATGGAAC TATTTCCAGG GATGAAGCAG AACGCAAACT GTACTCAGGA 540
GCGCAACCTG ATGGCAAATT TCTGCAAAAG CAATGGAGGG AAAGAGCAGT AAAGTCTTCA 600
CTGTATGTGA ATTTTTATGT CAGACCATTT TCTGATGCTG TAGGGGGCTC TTATTCCATA 660
AGATTATTAA ACATTTTGTT CCTTTTCTTA AAGCTTGTGG AGTACCTAAA ACTCAAGTCT 720
GATGGAATTA TGGCTGTCTT AAAGGAATCC TGTCCTAATT CCTGCACATT TTCAATAGCA 780
CCAGCTGCCG CACCACCTTC CCTTCCTAAA ATTAGGCAGG CGGCATCCAA CTCTGATGGT 840
TACACCCCCG AACCTTTCAT TGGAAAGTCC CGAATATTGC CAATGGACAC CAGTGTGTAC 900
GAGAGTCCTT ACAGTGACCC AGAGGAGTTA AAGGAACGAA AGCTATTTGT TAAAAGAGAA 960
CTCCTTTTGA TAGATGAAGT GGAATTAGGC TCTGGGAACT TTGGATGTGT TAAGAAGGGT 1020
GTCTATAAGC TAAAGAAACG TCAGATTGAT GTAGCGATAA AGGTGCTGAA AGTACAGGAT 1080
GAAAAAAACG TTAGAGATGA AATGATGAAA GAAGCTGAAA TCATGCATCA ACTGGACAAT 1140
CCTTATATTG TGAGGATGAT AGGAGTGTGT GAGGCAGAGA ACCTTATGCT AGTCATGGAA 1200
ATGGCATCAG GGGGGCCCCT TAACAAGTTC CTGGGAGCTA AGAAGGATGT AATACCTATG 1260
AGTAATATAG TAGAGCTCAT GCACCAGGTA TCCATTGGAA TGAAATACCT TGAAGGAAAG 1320
AATTTTGTGC ATCGTGATCT TGCAGCTCGT AATGTTCTCA TGGTCAACCA ACATTATGCC 1380
AAAATCAGTG ACTTTGGACT TTCAAAAGCT CTTGCAGCTG ATGATAGCTA TTACAAGGCT 1440
AAGTCCTTTG GAAAGTGGCC GCTGAAGTGG TACGCACCAG AGTGCATCAA CTACCGCAAG 1500
TTTTCAAGTC GTAGTGATGT GTGGAGCTAT GGTATAACCA TGTGGGAAGC TTTTACCTAT 1560
GGGCAAAAGC CCTATAAGAA ACTCAAGGGA ACAGAAGTAA TGAGTTTCAT TGAGAGAAAT 1620
GAGCGTCTGG CCTGCCCTGC AGGCTGCCCA CCTGAGATGT ATCAAGTTAT GTTGGATTGC 1680
TGGATATTCA AGATGGAGGA CCGCCCTAAT TTTGATAATG TGGAATACCG TATGCGCATG 1740
TATTACTATA GCATTGCTGA CAAACCAGAC AAAGAAGGCA AAGAAGCAGC AGCAGCAGCA 1800
GAAGCATCTG GAAAAGTGTG A 1821
Domain Profile
S: 2     vedkelGsGnfGsvkkGyyrmkkkrlevaikvlkeadekadkdellreasvmqqldnkyi  61
         + + elGsGnfG+vkkG+y+ kk++++vaikvlk  dek  +de+++ea++m+qldn+yi
Q: 324   IDEVELGSGNFGCVKKGVYKLKKRQIDVAIKVLKVQDEKNVRDEMMKEAEIMHQLDNPYI  383
         7789********************************************************
S: 62    vrliGiakaealmlvmelaelGpllkylldkreeikaknvlelvhqvamGmkyleeknfv  121
         vr+iG+++ae lmlvme+a++Gpl+k+l  k++ i+ +n++el+hqv++Gmkyle knfv
Q: 384   VRMIGVCEAENLMLVMEMASGGPLNKFLGAKKDVIPMSNIVELMHQVSIGMKYLEGKNFV  443
         ************************************************************
S: 122   hrdlaarnvllvarhyakisdfGlskalradesyykarsaGkwpvkwyapecinlrkfss  181
         hrdlaarnvl+v++hyakisdfGlskal ad+syyka+s Gkwp+kwyapecin+rkfss
Q: 444   HRDLAARNVLMVNQHYAKISDFGLSKALAADDSYYKAKSFGKWPLKWYAPECINYRKFSS  503
         ************************************************************
S: 182   ksdvwsfGvtlweafsyGqkpykelkgsevlalvekGerlecpaecpaelyalmsscwky  241
         +sdvws+G+t+weaf+yGqkpyk+lkg+ev++++e+ erl cpa+cp+e+y++m +cw+ 
Q: 504   RSDVWSYGITMWEAFTYGQKPYKKLKGTEVMSFIERNERLACPAGCPPEMYQVMLDCWIF  563
         ************************************************************
S: 242   kvedrpdf  249
         k+edrp+f
Q: 564   KMEDRPNF  571
         ******99
Domain Sequence
(FASTA)
IDEVELGSGN FGCVKKGVYK LKKRQIDVAI KVLKVQDEKN VRDEMMKEAE IMHQLDNPYI 60
VRMIGVCEAE NLMLVMEMAS GGPLNKFLGA KKDVIPMSNI VELMHQVSIG MKYLEGKNFV 120
HRDLAARNVL MVNQHYAKIS DFGLSKALAA DDSYYKAKSF GKWPLKWYAP ECINYRKFSS 180
RSDVWSYGIT MWEAFTYGQK PYKKLKGTEV MSFIERNERL ACPAGCPPEM YQVMLDCWIF 240
KMEDRPNF 248
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00407
EKS-BOT-00437
EKS-CAP-00470
EKS-DAR-00833
EKS-DIO-00086
EKS-EQC-00428
EKS-ERE-00039
EKS-FEC-00418
EKS-GAG-00368
EKS-GAA-00534
EKS-GOG-00429
EKS-ICT-00420
EKS-LAC-00453
EKS-MAM-00436
EKS-MEG-00362
EKS-MIM-00075
EKS-MOD-00427
EKS-MUM-00469
EKS-MUP-00431
EKS-NOL-00398
EKS-OCP-00104
EKS-ORN-00558
EKS-ORC-00410
EKS-ORL-00508
EKS-OTG-00441
EKS-PAT-00413
EKS-POA-00428
EKS-PRC-00042
EKS-RAN-00450
EKS-SAH-00406
EKS-SUS-00387
EKS-TAG-00504
EKS-TAR-00548
EKS-TEN-00552
EKS-XIM-00548
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
GO:0001946; P:lymphangiogenesis
GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR023420; Kinase_SYK/ZAP-70_inter-SH2.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR012234; Tyr_kinase_non-rcpt_SYK/ZAP70.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 2.
SMARTs
SM00252; SH2; 2.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 2.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013