EKS-XET-00318

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00318

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	360.3	5.3E-108	20	271	252

Status

Unreviewed

Ensembl Protein

ENSXETP00000022415

UniProt Accession

F7AB54;

Protein Name

Protein Synonyms/Alias

Gene Name

sik2

Gene Synonyms/Alias

sik2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000010165	ENSXETP00000022415	ENSXETT00000022415

Organism

Xenopus tropicalis

Functional Description

Protein Length

897

Protein Sequence
(FASTA)

MVMADCQKPV QRGPVRVGFY DIERTLGKGN FAVVKLARHR ITKTEVAIKI IDKSQLDSVN 60

LEKIYREVQI MKMLDHPHII KLYQVMETKN MLYLVTEYAK NGEIFDYLAN HGRLNEPEAR 120

RKFWQILSAV EYCHGRNIVH RDLKAENLLL DNHMNIKIAD FGFGNFYKNG EPLATWCGSP 180

PYAAPEVFEG QQYEGPQLDI WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM 240

SEECEHLIRR MLVLEPSKRL SIAQIKEHKW MMAEVPVHRP VLYSQTQDKA ASIGEYNEQV 300

LRLMHSLGID QQKTIESLQN RSYNHFAAIY YLLVERLKSH RSSFPVESRI DARQRRPSTV 360

AEQTVTKAST IVPPVNLLPQ NMRLLRAPIL PEASPAETFS YPQISSQAES TFLEEESVNT 420

PPVNGCLLDP LPPVTIRKGC QSLPCNMMET SIDEGIETED DTEEDPAQAF AACQGRRSGQ 480

RRHTLSEVTN QMVMLPTAGK LFTIGNNPSL GSVDSEYDMG SIQSDLSFQD DGTMNEVVMA 540

NQSVTRLTPP FIGLRPTNLA MPTLPSQKRE AHNRSPVSFR EGRRASDTSL TQGIVAFRQH 600

LQNLARTKGI LELNKIQMFY EQMGPDEEQN VTSVPNQLQD HNHHPSLQLD MSAQLSNVST 660

FPNGIHPHLL SRRQSLETQY LQHRLQKANL LAKAQNSCQL YCKETPRSLE QQLQEHRLHQ 720

KRLFLQKQPQ LQAYFKQMQI AETSYPMQTQ QLPLSHQETV QPAQFGLSQP LSPVMEPASD 780

EMQYDPFLSQ YHKLHSQQMQ NLVQPSQPQI PVQQPPLQYA YQTCEISGVP SHEPEYTNQC 840

QYSMNSTQQG VMTLPENQSH LAGHDPQSSY ETLALSEPCD CEMMETVDSH SGYVLVN 897

Nucleotide Sequence
(FASTA)

ATGGTCATGG CGGACTGTCA GAAGCCTGTA CAGAGGGGTC CTGTCCGGGT CGGATTTTAT 60

GACATAGAAC GCACTTTAGG GAAAGGGAAT TTCGCGGTGG TGAAGCTGGC GAGGCACCGG 120

ATCACCAAAA CCGAGGTTGC AATAAAGATC ATTGACAAGT CTCAGCTGGA CTCTGTGAAT 180

TTGGAGAAGA TCTATAGAGA GGTGCAGATA ATGAAGATGC TGGATCATCC CCACATTATC 240

AAGCTTTACC AGGTCATGGA AACCAAAAAC ATGCTGTATC TTGTGACAGA ATATGCCAAA 300

AATGGAGAGA TTTTTGATTA CTTGGCTAAT CACGGGCGTC TCAATGAGCC AGAGGCTAGG 360

CGGAAATTCT GGCAGATCCT CTCTGCAGTT GAATACTGCC ACGGCCGAAA CATAGTGCAC 420

AGAGATTTAA AAGCTGAAAA TCTGCTGCTG GACAACCACA TGAACATTAA AATTGCAGAT 480

TTTGGGTTTG GCAACTTTTA CAAGAATGGA GAACCTCTGG CCACGTGGTG CGGAAGTCCA 540

CCTTATGCAG CCCCAGAAGT TTTTGAGGGT CAGCAGTATG AAGGACCACA GCTGGATATA 600

TGGAGCATGG GAGTAGTACT GTATGTCTTG GTGTGTGGTG CATTACCTTT TGACGGACCT 660

ACGCTGCCTA TCTTGAGACA GCGAGTTCTA GAAGGGAGAT TCCGGATTCC TTATTTTATG 720

TCTGAAGAAT GTGAACACTT AATACGAAGG ATGCTTGTGC TGGAGCCTTC AAAACGTCTC 780

TCTATTGCAC AAATAAAAGA GCATAAATGG ATGATGGCTG AAGTCCCTGT GCACAGGCCA 840

GTTCTCTACT CACAGACCCA GGATAAAGCG GCTTCGATTG GTGAATACAA TGAACAGGTT 900

TTGCGACTCA TGCACAGCCT GGGGATCGAC CAGCAGAAGA CTATCGAGTC ACTGCAGAAC 960

CGTAGCTACA ACCACTTTGC TGCTATATAT TACCTGTTAG TGGAAAGGCT AAAATCTCAC 1020

CGCAGCAGCT TCCCTGTGGA GTCCAGAATT GACGCACGGC AACGTCGGCC AAGCACAGTC 1080

GCTGAGCAGA CAGTCACCAA GGCCAGCACT ATCGTCCCTC CCGTGAATCT GCTACCCCAG 1140

AATATGAGGT TACTGAGGGC TCCGATTCTC CCAGAAGCCT CCCCTGCAGA AACATTCTCC 1200

TATCCTCAGA TCAGCAGCCA GGCTGAGTCC ACATTCCTAG AGGAGGAAAG TGTAAACACA 1260

CCCCCAGTTA ATGGCTGCCT TTTGGACCCA TTGCCTCCGG TTACAATAAG GAAAGGATGC 1320

CAATCATTGC CCTGCAACAT GATGGAGACA TCTATCGATG AAGGCATTGA GACAGAGGAC 1380

GACACTGAGG AGGACCCAGC TCAAGCATTT GCAGCTTGTC AGGGCAGGCG TAGTGGACAG 1440

AGGCGACATA CTCTTTCTGA AGTGACCAAT CAAATGGTTA TGCTACCAAC TGCAGGCAAA 1500

CTGTTCACCA TTGGTAACAA CCCATCTCTG GGAAGTGTTG ATTCTGAATA TGACATGGGA 1560

TCTATTCAGA GTGATCTCAG TTTCCAAGAT GATGGGACCA TGAATGAAGT TGTTATGGCA 1620

AATCAGTCAG TCACCAGGCT AACACCACCA TTCATAGGAC TGCGACCAAC AAATTTAGCT 1680

ATGCCCACAC TTCCCTCCCA AAAACGGGAG GCTCATAACA GATCTCCAGT CAGTTTCCGA 1740

GAAGGCAGAC GGGCATCAGA TACCTCTTTA ACACAAGGTA TTGTGGCCTT TCGTCAGCAT 1800

CTGCAGAACC TGGCCAGGAC AAAGGGCATT CTAGAGCTCA ACAAGATTCA GATGTTTTAT 1860

GAACAGATGG GACCTGATGA GGAGCAAAAT GTCACTAGCG TTCCAAACCA ACTCCAGGAC 1920

CACAACCATC ACCCGTCTTT GCAGCTGGAT ATGTCTGCGC AACTTTCAAA TGTATCCACG 1980

TTCCCCAATG GCATACACCC ACATTTACTC TCTAGACGCC AGAGTTTGGA GACACAGTAT 2040

TTACAGCACA GGTTACAGAA AGCAAATTTG CTGGCCAAAG CCCAGAACAG CTGCCAGTTG 2100

TATTGTAAAG AAACACCAAG GAGCCTGGAA CAGCAGTTAC AAGAACACAG ACTGCATCAG 2160

AAGCGTCTTT TCCTTCAGAA GCAACCACAA CTGCAGGCTT ATTTCAAACA GATGCAGATA 2220

GCTGAAACCT CTTATCCCAT GCAGACACAG CAGCTGCCCT TGTCTCATCA GGAAACCGTG 2280

CAGCCCGCGC AATTTGGCTT GTCACAGCCA CTTAGCCCTG TTATGGAGCC TGCTTCTGAT 2340

GAAATGCAAT ATGACCCCTT CTTAAGCCAG TATCACAAGT TACATTCCCA GCAGATGCAG 2400

AACCTGGTGC AACCTAGCCA GCCACAGATA CCTGTGCAGC AACCACCTTT GCAGTATGCT 2460

TATCAGACCT GTGAAATATC AGGAGTGCCA TCCCATGAGC CTGAATACAC AAACCAGTGT 2520

CAGTATTCTA TGAACTCAAC GCAACAAGGT GTTATGACTT TGCCTGAAAA CCAGAGTCAT 2580

CTAGCAGGGC ATGACCCACA GTCATCATAT GAAACATTGG CTCTCAGTGA GCCATGTGAC 2640

TGTGAGATGA TGGAGACTGT TGACTCGCAC AGCGGATATG TCTTGGTCAA TTAG 2694

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +tlG+g+f+ Vkla+h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 20    YDIERTLGKGNFAVVKLARHRITKTEVAIKIIDKSQLDSVNLEKIYREVQIMKMLDHPHI  79

         899*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e ear+ f q++sav+Y+h ++iv

Q: 80    IKLYQVMETKNMLYLVTEYAKNGEIFDYLANHGRLNEPEARRKFWQILSAVEYCHGRNIV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n++k+g+ l t+cGsppYaaPe+++g++Yegp++D

Q: 140   HRDLKAENLLLDNHMNIKIADFGFGNFYKNGEPLATWCGSPPYAAPEVFEGQQYEGPQLD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +s+e+e+L+r++Lv +p+kR

Q: 200   IWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEECEHLIRRMLVLEPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

         ++i +i++h+w+

Q: 260   LSIAQIKEHKWM  271

         ***********8

Domain Sequence
(FASTA)

YDIERTLGKG NFAVVKLARH RITKTEVAIK IIDKSQLDSV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK NMLYLVTEYA KNGEIFDYLA NHGRLNEPEA RRKFWQILSA VEYCHGRNIV 120

HRDLKAENLL LDNHMNIKIA DFGFGNFYKN GEPLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PTLPILRQRV LEGRFRIPYF MSEECEHLIR RMLVLEPSKR 240

LSIAQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013