EKS-XET-00223

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00223

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	432.8	4.9E-130	316	572	257

Status

Unreviewed

Ensembl Protein

ENSXETP00000022723

UniProt Accession

F6RZQ1;

Protein Name

Protein Synonyms/Alias

Gene Name

limk1

Gene Synonyms/Alias

limk1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000010324	ENSXETP00000043489	ENSXETT00000043489
ENSXETG00000010324	ENSXETP00000022723	ENSXETT00000022723

Organism

Xenopus tropicalis

Functional Description

Protein Length

615

Protein Sequence
(FASTA)

MRLMLLCCSW SEEHMGEEEG NGLPVCASCG QSIYDGCYLQ ALALDWHSDC FRCSDCGVSL 60

SHRYYEKDGR LFCKKHYWAR FGGMCQGCSE NITKGLVMVA GEHKYHPECF MCSRCKAYIG 120

DGETYALVER SKLYCGPCYY QFSVTPVIDS PGSRSPHTVT LVSLPASDGK RGLSVSITPS 180

CAEHSHTVRV SQLDTDCLSP DIQSTIHIGD RILEINGTPI RSVPLDEIDV LIQETSRLLQ 240

LTIEHDPHET PTLPSPCTEI TVRRQRPIMR SCSIDRSPGS SCVGSPSCSR RDMSRSESVR 300

TVTGVHRIFR PSDLMPGEVL GRGCFGQAIK VTHRVTGEVM VMKELIRFDE ETQRTFLKEV 360

KVMRCLEHPN VLKFIGVLYK DKRLNFITEY IPGGTLRRVI KSMDAHYPWN QRVSFARDIA 420

AGMTYLHSMN IIHRDLNSHN CLVREDGSLV VADFGLARLV TDETRDLRKD RRKRYTVVGN 480

PYWMAPEMIN GRSYDESVDV FSCGIVICEI IGRVNADPDY LPRTMDFGLN VRAFLDRFCP 540

PNCPPGFFPS AVLCCDLDPE KRPRFSQLQL WLDSLLRHLN LQLPLSSHLE QLERNFWENY 600

RRGDSTLHVH PEIPE 615

Nucleotide Sequence
(FASTA)

ATGAGGTTGA TGTTACTGTG CTGCTCCTGG AGTGAGGAAC ACATGGGAGA GGAGGAAGGG 60

AATGGACTGC CAGTGTGTGC CAGTTGTGGA CAGAGTATTT ATGATGGGTG CTATTTGCAG 120

GCATTGGCAT TGGATTGGCA CTCTGATTGC TTCAGATGTA GTGACTGCGG TGTGTCCTTG 180

TCCCACCGAT ATTACGAGAA GGATGGGAGG TTGTTCTGCA AGAAGCACTA CTGGGCACGC 240

TTTGGGGGCA TGTGCCAAGG CTGTTCTGAA AATATCACCA AAGGCCTAGT CATGGTAGCA 300

GGGGAGCACA AGTACCACCC AGAATGCTTC ATGTGCTCCC GATGTAAAGC TTACATTGGG 360

GATGGAGAGA CATATGCCCT GGTGGAAAGA TCCAAGCTTT ATTGTGGGCC TTGTTACTAT 420

CAGTTCTCTG TAACTCCAGT GATTGACTCC CCGGGTTCTC GATCACCTCA TACAGTCACG 480

CTTGTGTCTC TCCCAGCCTC AGATGGGAAA CGTGGCTTGT CTGTTTCTAT CACGCCATCA 540

TGCGCAGAGC ACTCTCACAC TGTGCGAGTC AGTCAGCTTG ATACAGATTG TTTGAGTCCT 600

GACATCCAAA GCACAATCCA TATTGGAGAT CGAATCCTTG AGATTAATGG TACCCCAATT 660

CGTAGTGTTC CCTTGGATGA GATTGATGTT CTGATACAGG AAACAAGCCG CCTTCTGCAG 720

CTGACTATCG AGCATGACCC TCACGAGACC CCCACATTGC CGAGCCCTTG CACCGAGATT 780

ACAGTGAGGC GGCAAAGGCC AATAATGCGC AGCTGTAGTA TAGACAGGTC ACCTGGATCC 840

AGCTGCGTGG GATCACCTTC CTGTTCTCGC AGAGACATGA GCCGCTCTGA GTCTGTCCGT 900

ACTGTCACTG GTGTCCACCG TATCTTCCGA CCCTCAGATC TTATGCCAGG AGAGGTGCTG 960

GGAAGGGGAT GCTTTGGTCA AGCTATAAAG GTTACTCACC GGGTGACTGG GGAAGTGATG 1020

GTAATGAAGG AGTTAATTAG GTTTGATGAA GAAACACAAA GAACCTTCTT AAAAGAGGTG 1080

AAGGTGATGA GGTGCTTGGA GCACCCCAAT GTGCTGAAGT TTATTGGAGT GCTATACAAA 1140

GACAAAAGGC TAAATTTTAT CACTGAGTAC ATCCCAGGTG GAACCTTGCG CAGAGTTATA 1200

AAGAGCATGG ATGCACACTA CCCATGGAAC CAGAGGGTTA GCTTTGCCAG AGACATTGCA 1260

GCTGGAATGA CATATCTTCA TTCTATGAAT ATTATCCACC GGGACTTGAA CTCTCATAAT 1320

TGTCTTGTGC GTGAGGATGG AAGTCTGGTG GTGGCAGATT TTGGCCTGGC ACGTTTGGTT 1380

ACAGATGAGA CTCGTGATCT ACGGAAAGAC AGAAGGAAGC GTTACACAGT GGTGGGGAAT 1440

CCCTATTGGA TGGCACCGGA GATGATAAAT GGGAGAAGCT ACGACGAATC TGTGGATGTC 1500

TTTTCCTGTG GCATTGTAAT TTGTGAGATA ATTGGACGCG TAAATGCTGA CCCTGATTAT 1560

CTCCCTCGCA CCATGGATTT TGGCCTCAAT GTCCGTGCAT TCTTGGATAG ATTTTGCCCC 1620

CCAAATTGCC CACCAGGATT TTTCCCCAGT GCTGTGTTGT GCTGTGACCT GGATCCTGAA 1680

AAGAGGCCAA GGTTCTCACA GTTGCAGCTT TGGCTGGATT CCCTACTTAG GCACTTAAAT 1740

CTTCAGCTGC CCCTCAGTTC ACATCTTGAA CAACTGGAAC GGAATTTCTG GGAGAACTAC 1800

AGGAGGGGTG ATAGCACACT TCACGTGCAC CCCGAAATCC CCGAATAA 1848

Domain Profile

S: 3     vgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfi  62

          ge+lG+G+f++++kvthr +Gevmv+kelir+dee+++++lkevk++r+lehpnvlkfi

Q: 316   PGEVLGRGCFGQAIKVTHRVTGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFI  375

         68**********************************************************

S: 63    GvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiihrd  121

         Gvl+kdk+l+++teyi gGtl+ ++ks++  +pw+qrv++a+dia+G++ylhs++iihrd

Q: 376   GVLYKDKRLNFITEYIPGGTLRRVIKSMDAhYPWNQRVSFARDIAAGMTYLHSMNIIHRD  435

         ****************************999*****************************

S: 122   lnsknclvredksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPev  181

         lns+nclvred s vvadfGlarlv++e       r+l+k dr+kr+tvvG+PywmaPe+

Q: 436   LNSHNCLVREDGSLVVADFGLARLVTDE------TRDLRK-DRRKRYTVVGNPYWMAPEM  488

         **********************999876......455554.699****************

S: 182   lkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeafl  241

         ++g+syde vdvfs Giv+ceii+rv+adPdylPrt+dfgl+v+af +++++ +cP+ f+

Q: 489   INGRSYDESVDVFSCGIVICEIIGRVNADPDYLPRTMDFGLNVRAFLDRFCPPNCPPGFF  548

         ************************************************************

S: 242   klavvccdldpesrpsfeelekkl  265

         + av ccdldpe+rp f++l+ +l

Q: 549   PSAVLCCDLDPEKRPRFSQLQLWL  572

         *******************99876

Domain Sequence
(FASTA)

PGEVLGRGCF GQAIKVTHRV TGEVMVMKEL IRFDEETQRT FLKEVKVMRC LEHPNVLKFI 60

GVLYKDKRLN FITEYIPGGT LRRVIKSMDA HYPWNQRVSF ARDIAAGMTY LHSMNIIHRD 120

LNSHNCLVRE DGSLVVADFG LARLVTDETR DLRKDRRKRY TVVGNPYWMA PEMINGRSYD 180

ESVDVFSCGI VICEIIGRVN ADPDYLPRTM DFGLNVRAFL DRFCPPNCPP GFFPSAVLCC 240

DLDPEKRPRF SQLQLWL 257

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 2.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013