EKS-XET-00360

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00360

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	429.0	7.8E-129	562	823	262

Status

Unreviewed

Ensembl Protein

ENSXETP00000022749

UniProt Accession

F6TMX1;

Protein Name

Protein Synonyms/Alias

Gene Name

ern2

Gene Synonyms/Alias

ern2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000010337	ENSXETP00000022749	ENSXETT00000022749

Organism

Xenopus tropicalis

Functional Description

Protein Length

958

Protein Sequence
(FASTA)

SMAPLASHPW LWLILAFFSA HLLQCDAGAS VSLPESLLFV STLDGNLHAV SKRSGTVLWT 60

LKDDPVIQVP LYVSEMTFIK KPAVLLKYLS DPMEKYDTVK LPFTIPELVQ SSPCRSSDGI 120

LYTGKKQDAW FVVDPKSGEK QTTLSTESSE GLCPSSPLLY IGRTQYMITM YDTKSRELRW 180

NATFHDYSAP MCDETYDYKM AHFTSTGDGL LVTADRNSGE VLWMQNYGSP VIGLFLWHQD 240

SLRRIPHLNV ASETLRYLTF HSHDIRLIKW NYQAVQQLSS TKTHLLPSLY VGKHVTGFYA 300

TSSMIHEGVA VVPRGITLAR VDGPTTQDVT LKESTKFDVT SNTDVKYPQG SVISAHQWLL 360

IGHHELPPVV HTTMLRAFPE TLRRDTETII RGSSPRTLFD DFLTPQNQDG LSQGDTERRI 420

KVDTSKEEAN MVPTDSSVMN VLLGIIFTLL LGGWVLFAFT YPKMQEQQRR QQQELQQELE 480

KKLQLLQNQQ NLASEVPPSP GHSGSAQTSF LSEEQDSRQS SGSRASGQLD GVQTNGTRKL 540

RKESVESEVN DGDEIRVGKI SFSPKDVLGH GAGGTCVFRG KFDDRAVAVK RILSESFTLA 600

DREVQLLRES DEHPNVIRYY CTESDKLFCY IALELCATTL QEYMKNPDLH RSGLDSVTLL 660

HQTMSGLAHL HSLNIVHRDL KPCNILISYP SAHGKVRAVI SDFGLCKKLS VGRNSFSLRS 720

GIPGTEGWIA PEVLRDRPKQ NPTAAVDIFS AGCVFYYVLS KGQHPFGDNL RRQSNILSGS 780

YSLPKLQEDT HENVVARHLV EMMINCDSLL RPTAEHVLIH PFFWAPAKRL QFFQDVSDRI 840

EKEPAESPIV VALESDARSV VRVNWRLHIS VPLQTDLRKF RSYRGNSVRD LLRAMRNKKH 900

HYHELPADVQ ETLGSIPDEF VSYFSSRFPY LLLHTYQALE QCSPERQFQT YYHWVQSS 958

Nucleotide Sequence
(FASTA)

AGTATGGCAC CTTTAGCCTC ACATCCCTGG CTCTGGCTGA TCCTCGCCTT CTTCTCTGCA 60

CACCTGCTGC AGTGTGATGC TGGGGCATCT GTTTCTCTCC CAGAGTCCCT GCTCTTCGTG 120

TCCACATTGG ATGGGAACCT CCATGCTGTC AGTAAGCGGA GCGGGACTGT GCTGTGGACT 180

CTCAAAGATG ATCCGGTTAT TCAAGTGCCA CTGTATGTGT CAGAAATGAC TTTTATTAAG 240

AAGCCAGCAG TTCTGCTGAA ATATTTATCT GACCCCATGG AGAAATATGA CACAGTCAAA 300

TTACCATTCA CTATCCCAGA ATTAGTGCAG TCTTCTCCAT GCCGCAGCTC AGATGGAATT 360

CTGTATACAG GGAAGAAGCA AGATGCCTGG TTTGTTGTGG ATCCAAAGTC AGGAGAGAAG 420

CAGACAACTC TATCCACAGA GTCCTCTGAA GGCCTGTGCC CTTCTTCCCC TCTTCTTTAC 480

ATTGGGCGCA CACAGTACAT GATCACAATG TATGACACAA AGTCTCGGGA GCTGCGCTGG 540

AACGCCACAT TTCATGACTA CTCTGCCCCG ATGTGTGATG AAACGTACGA CTACAAGATG 600

GCTCACTTTA CCTCTACTGG AGACGGACTT CTGGTCACAG CCGACCGGAA CAGTGGGGAG 660

GTGCTATGGA TGCAGAATTA TGGCTCCCCC GTCATTGGAC TCTTTTTGTG GCACCAGGAC 720

AGCCTGAGGC GTATCCCGCA TCTAAATGTC GCCTCAGAAA CCCTACGTTA CCTGACCTTC 780

CATTCCCATG ACATCCGTCT CATTAAATGG AACTATCAAG CTGTCCAGCA ACTGAGCAGC 840

ACCAAAACCC ATCTGCTGCC ATCGCTGTAT GTCGGGAAAC ATGTGACAGG ATTCTATGCC 900

ACTAGTTCTA TGATTCACGA GGGGGTCGCT GTCGTGCCCC GTGGTATCAC TCTAGCCCGG 960

GTAGACGGAC CCACAACTCA GGATGTCACC CTGAAAGAAT CCACCAAGTT TGACGTGACA 1020

TCCAATACAG ATGTCAAGTA CCCACAGGGC AGCGTAATCT CAGCACACCA GTGGCTACTC 1080

ATAGGTCACC ATGAATTGCC ACCTGTTGTA CACACAACCA TGCTGCGCGC CTTCCCCGAG 1140

ACCCTGCGGA GGGATACAGA GACAATTATC CGAGGATCTT CTCCAAGGAC ACTCTTTGAT 1200

GATTTCCTGA CCCCTCAGAA TCAGGATGGG CTCTCCCAAG GGGATACTGA GAGGCGTATA 1260

AAGGTGGATA CAAGCAAGGA AGAAGCAAAC ATGGTTCCTA CGGACTCCTC AGTTATGAAT 1320

GTTCTCCTTG GGATCATCTT CACCCTGCTT TTGGGAGGCT GGGTCCTCTT TGCATTTACG 1380

TACCCCAAGA TGCAGGAGCA GCAGCGTCGG CAGCAGCAAG AATTGCAGCA AGAGCTGGAA 1440

AAGAAACTGC AGCTTCTTCA GAACCAGCAG AATCTGGCGT CTGAGGTCCC ACCATCTCCA 1500

GGGCATTCTG GTTCAGCCCA GACATCGTTC CTCTCAGAAG AGCAGGACAG TCGGCAGAGC 1560

AGTGGCAGTA GGGCAAGTGG GCAGCTGGAT GGAGTACAAA CTAATGGCAC CAGGAAACTG 1620

AGGAAGGAGA GTGTTGAGTC AGAAGTCAAT GATGGCGATG AGATCCGAGT TGGGAAAATC 1680

TCCTTCTCCC CTAAAGATGT TTTGGGCCAT GGTGCTGGTG GGACCTGTGT ATTTCGAGGC 1740

AAGTTTGACG ACAGGGCAGT GGCAGTGAAG AGGATTCTGT CGGAGAGCTT CACCCTTGCG 1800

GATCGGGAGG TTCAGTTGCT GCGGGAATCT GACGAGCACC CGAATGTGAT TCGCTACTAT 1860

TGCACCGAGA GTGACAAGCT CTTTTGTTAT ATTGCCCTGG AGCTGTGTGC AACCACTCTG 1920

CAGGAGTACA TGAAGAACCC CGATTTACAT CGATCTGGTC TTGATTCAGT AACACTCCTG 1980

CATCAGACGA TGTCTGGACT CGCCCACCTA CACTCCCTTA ATATTGTGCA CAGGGACCTG 2040

AAGCCATGCA ACATCCTCAT CTCTTACCCC AGTGCCCACG GCAAGGTACG AGCCGTTATA 2100

TCGGACTTTG GTCTGTGCAA GAAGCTGAGT GTTGGACGGA ACAGCTTCAG CCTGCGCTCT 2160

GGTATCCCCG GCACTGAGGG ATGGATTGCT CCAGAGGTCC TGCGGGATAG ACCCAAGCAA 2220

AACCCAACGG CAGCAGTGGA CATATTCTCT GCAGGGTGTG TGTTTTATTA TGTCCTTTCC 2280

AAGGGACAGC ATCCATTTGG GGACAATTTG AGAAGGCAGA GCAACATCCT GAGCGGATCT 2340

TACAGCCTTC CTAAGCTCCA GGAAGATACC CATGAGAACG TGGTGGCACG TCACCTGGTC 2400

GAAATGATGA TCAACTGCGA CTCTTTGCTC CGACCCACAG CCGAGCACGT CCTTATACAT 2460

CCGTTCTTCT GGGCACCAGC AAAGCGCTTG CAGTTCTTTC AGGATGTAAG TGACCGCATT 2520

GAAAAGGAAC CTGCAGAGAG CCCCATTGTG GTCGCCCTGG AGTCAGATGC TCGTTCTGTT 2580

GTCCGAGTAA ACTGGCGTTT GCACATATCT GTCCCACTCC AGACAGATCT CAGAAAATTC 2640

CGATCCTACA GAGGAAATTC TGTGAGGGAC CTTCTTAGAG CCATGAGGAA CAAGAAACAC 2700

CATTACCATG AGCTGCCAGC TGATGTCCAA GAAACCCTGG GTTCCATCCC TGACGAGTTT 2760

GTGTCATATT TCTCTTCCCG ATTCCCATAT TTGCTCCTCC ACACGTACCA GGCCTTGGAG 2820

CAGTGCTCCC CCGAGAGGCA GTTCCAGACC TACTACCACT GGGTGCAAAG TTCCTGA 2877

Domain Profile

S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60

         fspkdvlG+Ga+Gt vfrG+f++r+vavkr+lse ++la+rev+llresdehpnviry+c

Q: 562   FSPKDVLGHGAGGTCVFRGKFDDRAVAVKRILSESFTLADREVQLLRESDEHPNVIRYYC  621

         799*********************************************************

S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120

         te+d+ f yialelca +lq+y++++dl+ + +l+ ++ll+q++sGlahlhsl+ivhrdl

Q: 622   TESDKLFCYIALELCATTLQEYMKNPDLH-RSGLDSVTLLHQTMSGLAHLHSLNIVHRDL  680

         *****************************.9*****************************

S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180

         kp nilis p+a+gk+r++isdfGlckkl+vG++sfs rsg++GteGwiape+l++ +k+

Q: 681   KPCNILISYPSAHGKVRAVISDFGLCKKLSVGRNSFSLRSGIPGTEGWIAPEVLRDRPKQ  740

         ************************************************************

S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240

         ++t avdifs+GcvfyyvlskG+hpfGd+l+rq+nilsg++sl kl+e+++e+v+a++l+

Q: 741   NPTAAVDIFSAGCVFYYVLSKGQHPFGDNLRRQSNILSGSYSLPKLQEDTHENVVARHLV  800

         ************************************************************

S: 241   skmidkdplkrpsakkvlkhplf  263

         + mi+ d l rp+a++vl hp+f

Q: 801   EMMINCDSLLRPTAEHVLIHPFF  823

         **********************9

Domain Sequence
(FASTA)

FSPKDVLGHG AGGTCVFRGK FDDRAVAVKR ILSESFTLAD REVQLLRESD EHPNVIRYYC 60

TESDKLFCYI ALELCATTLQ EYMKNPDLHR SGLDSVTLLH QTMSGLAHLH SLNIVHRDLK 120

PCNILISYPS AHGKVRAVIS DFGLCKKLSV GRNSFSLRSG IPGTEGWIAP EVLRDRPKQN 180

PTAAVDIFSA GCVFYYVLSK GQHPFGDNLR RQSNILSGSY SLPKLQEDTH ENVVARHLVE 240

MMINCDSLLR PTAEHVLIHP FF 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006397	; P:mRNA processing

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 4.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013