EKS-XET-00351

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00351

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	448.2	1.3E-134	211	498	288

Status

Unreviewed

Ensembl Protein

ENSXETP00000022799

UniProt Accession

F6SV95;

Protein Name

Protein Synonyms/Alias

Gene Name

acvr1

Gene Synonyms/Alias

acvr1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000010380	ENSXETP00000022799	ENSXETT00000022799

Organism

Xenopus tropicalis

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MVDGVMILPI LMMVAFSSPS MEDEEMKLNA GQYKCVCEGM SCGSGDHCYG QQCFASLSNN 60

DGVLVSQKGC FQVYEQGKMT CKTPPSQDQA VECCQSDLCN MNITVKITDL TGRTKQGEAP 120

NYSVETLTIF ILAPVIVLVV LSVLAVLIFR KIQQRHMQML SNRDAEYGTI DGLIASNVGD 180

STLAVSLDHS CTSGSGSGLP FLVQRTVARQ ITLAECVGKG RYGEVWRGLW QGESVAVKIF 240

SSRDEKSWFR ETELYNTVLL RHENILGFIA SDMTSRNSST QLWLITHYHE LGSLYDYLQV 300

TTLDSVTCLR IVLSIASGLA HLHVEIFGTQ GKPAISHRDL KSKNVLVKKN GQCCIADLGL 360

AVMHSQTTNQ LDVGNNPRVG TKRYMAPEVL DETIQVDCFD SYKRVDIYAF GLVLWEVARR 420

MVSNGIVEEY KPPFYDVVPN DPSFEDMKKV VCVDQQRPNI PNRWFSDPTL TALAKLMKEC 480

WYQNPSARLT ALRIKKTLTK IDNSLDKLKS DC 512

Nucleotide Sequence
(FASTA)

ATGGTGGATG GTGTTATGAT TCTTCCTATC CTTATGATGG TGGCTTTTTC CTCTCCCAGC 60

ATGGAAGACG AGGAGATGAA GCTGAACGCA GGGCAGTATA AATGCGTATG TGAAGGGATG 120

TCCTGTGGCA GTGGGGACCA CTGTTACGGG CAGCAGTGTT TCGCTTCGCT CAGCAACAAC 180

GATGGTGTCC TGGTGTCCCA AAAGGGCTGC TTCCAAGTCT ATGAACAAGG CAAAATGACC 240

TGCAAAACCC CTCCATCTCA GGACCAGGCC GTGGAGTGCT GCCAGAGTGA CCTCTGTAAC 300

ATGAACATCA CTGTAAAAAT AACAGATTTA ACAGGGAGAA CAAAGCAAGG GGAGGCACCA 360

AATTACAGCG TGGAGACGCT AACGATCTTC ATCTTGGCCC CTGTGATTGT GCTAGTGGTA 420

CTTTCTGTCT TGGCCGTGCT GATCTTCCGG AAAATCCAAC AGCGTCACAT GCAGATGCTA 480

AGCAATCGAG ATGCAGAATA CGGAACCATT GACGGGCTCA TCGCATCCAA TGTTGGAGAC 540

AGTACGCTGG CAGTAAGTCT CGATCATTCC TGTACATCGG GCAGTGGTTC TGGGCTTCCA 600

TTCCTGGTAC AAAGAACAGT GGCTCGGCAG ATCACACTAG CAGAGTGTGT GGGAAAAGGG 660

CGATACGGCG AAGTATGGCG GGGTCTCTGG CAAGGAGAAA GCGTCGCAGT GAAGATCTTT 720

TCATCTCGAG ACGAAAAATC CTGGTTCAGG GAGACGGAGC TGTACAACAC TGTGTTACTG 780

CGGCACGAGA ATATTCTGGG TTTTATTGCC TCAGATATGA CTTCCAGAAA CTCCAGCACG 840

CAGTTGTGGC TAATAACTCA CTACCACGAG CTGGGCTCTC TCTACGACTA CTTGCAGGTC 900

ACCACGCTGG ATTCGGTCAC CTGTCTGCGC ATCGTGCTGT CCATAGCCAG CGGCCTGGCG 960

CATCTGCACG TGGAGATATT TGGCACTCAG GGGAAGCCGG CCATTTCCCA CAGAGACCTG 1020

AAGAGCAAGA ATGTCCTTGT GAAAAAGAAC GGCCAGTGCT GCATTGCGGA TCTAGGGCTT 1080

GCCGTCATGC ATTCACAAAC AACCAACCAG CTGGATGTTG GCAATAACCC CCGCGTGGGA 1140

ACGAAGCGCT ACATGGCCCC CGAAGTTCTG GACGAGACCA TCCAAGTGGA CTGTTTTGAC 1200

TCCTACAAGC GAGTGGATAT TTATGCATTT GGTCTTGTCC TCTGGGAGGT GGCCAGGCGA 1260

ATGGTCAGCA ATGGCATCGT AGAAGAATAC AAGCCTCCTT TTTATGATGT TGTACCCAAT 1320

GACCCAAGTT TTGAAGACAT GAAGAAGGTT GTCTGCGTGG ATCAGCAAAG ACCAAACATT 1380

CCCAATAGAT GGTTCTCAGA TCCAACTCTC ACAGCGCTCG CTAAGCTGAT GAAGGAATGC 1440

TGGTATCAGA ACCCCTCGGC AAGACTCACA GCCTTACGCA TCAAAAAGAC TTTAACCAAA 1500

ATTGACAATT CTTTAGATAA ACTGAAATCT GACTGTTGA 1539

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+e+y+tvllrhenil+fia

Q: 211   ITLAECVGKGRYGEVWRGLWQGESVAVKIFSSRDEKSWFRETELYNTVLLRHENILGFIA  270

         7899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe gsL+dyL+ +tld  ++lr++ls+asGlahLH ei+gt+

Q: 271   SDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVTCLRIVLSIASGLAHLHVEIFGTQ  330

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kpai+HRDlkskN+lvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 331   G--KPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQLDVGNNPRVGTKRYMAPE  388

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D+Y++gLvlWEva+R+ + +++veeyk+pf++vv++dPs+e+m

Q: 389   VLDETIQVDCFDSYKRVDIYAFGLVLWEVARRMVS-NGIVEEYKPPFYDVVPNDPSFEDM  447

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         k+vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 448   KKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSARLTALRIKKTL  498

         *************************************************97

Domain Sequence
(FASTA)

ITLAECVGKG RYGEVWRGLW QGESVAVKIF SSRDEKSWFR ETELYNTVLL RHENILGFIA 60

SDMTSRNSST QLWLITHYHE LGSLYDYLQV TTLDSVTCLR IVLSIASGLA HLHVEIFGTQ 120

GKPAISHRDL KSKNVLVKKN GQCCIADLGL AVMHSQTTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIYAF GLVLWEVARR MVSNGIVEEY KPPFYDVVPN DPSFEDMKKV 240

VCVDQQRPNI PNRWFSDPTL TALAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0070724	; C:BMP receptor complex
GO:0005938	; C:cell cortex
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0030509	; P:BMP signaling pathway
GO:0003230	; P:cardiac atrium development
GO:0051216	; P:cartilage development
GO:0021556	; P:central nervous system formation
GO:0035462	; P:determination of left/right asymmetry in diencephalon
GO:0003140	; P:determination of left/right asymmetry in lateral mesoderm
GO:0048264	; P:determination of ventral identity
GO:0060030	; P:dorsal convergence
GO:0035124	; P:embryonic caudal fin morphogenesis
GO:0035162	; P:embryonic hemopoiesis
GO:0003146	; P:heart jogging
GO:0001947	; P:heart looping
GO:0001889	; P:liver development
GO:0048332	; P:mesoderm morphogenesis
GO:0046588	; P:negative regulation of calcium-dependent cell-cell adhesion
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0003342	; P:proepicardium development
GO:0051260	; P:protein homooligomerization
GO:0030510	; P:regulation of BMP signaling pathway
GO:0001944	; P:vasculature development

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013