EPS-XET-00013
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-XET-00013
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/aDSP135.91.0E-392136135
StatusReviewed
Ensembl ProteinENSXETP00000024913
UniProt AccessionQ5XHB2;
Protein NameDual specificity protein phosphatase 22
Protein Synonyms/Alias
Gene Namedusp22
Gene Synonyms/Alias dusp22; TEgg009e03.1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000011414ENSXETP00000024913ENSXETT00000024913
OrganismXenopus tropicalis
Functional DescriptionActivates the Jnk signaling pathway. Dephosphorylatesand deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity).
Protein Length205
Protein Sequence
(FASTA)
MNKILPSLFI GNFKDARDVE QLHKNNITHI LSIHDSARPM LEGMKYLCIP ASDSPSQNLI 60
QHFKDSIAFI HECRLKGEGC LVHCLAGVSR SVTLVVAYVM TVTDFGWEDA LSAVRGARTC 120
ANPNMGFQKQ LEDFGKHDVY QFRTWLKETY GENPFNDKDD AKQLLDKHKQ QEAAESQSAT 180
SSGRQWSSHL TSLSSMSYSN YTTET 205
Nucleotide Sequence
(FASTA)
ATGAATAAGA TTCTTCCCAG TTTGTTTATT GGAAACTTTA AAGATGCTCG AGATGTTGAA 60
CAGCTGCACA AAAACAACAT TACTCATATA CTCTCAATCC ATGATAGTGC AAGGCCTATG 120
CTGGAGGGCA TGAAATATCT CTGCATTCCA GCCTCAGATT CACCAAGTCA GAACTTGATA 180
CAGCATTTTA AGGACAGCAT AGCATTTATA CACGAATGCC GGCTAAAGGG GGAAGGCTGC 240
CTTGTTCACT GTTTGGCTGG AGTCTCCAGA AGTGTAACAT TAGTAGTAGC CTATGTTATG 300
ACAGTCACAG ATTTTGGATG GGAAGATGCT TTGTCTGCCG TGAGAGGAGC AAGGACATGC 360
GCCAACCCAA ATATGGGCTT CCAGAAGCAG CTTGAGGACT TTGGAAAACA TGATGTCTAC 420
CAGTTCAGGA CGTGGCTGAA AGAAACTTAT GGGGAGAATC CTTTTAACGA TAAAGATGAT 480
GCAAAACAGC TACTTGACAA ACATAAACAG CAGGAAGCGG CAGAATCCCA AAGTGCCACA 540
AGTTCTGGAA GGCAGTGGAG TAGCCACCTT ACGTCTCTTT CATCCATGTC TTATAGCAAC 600
TACACTACAG AGACTTAA 618
Domain Profile
S: 3     teilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdD  62
         ++ilp+l++g+ ++a d  +L+k++it+++   ++  +    P   + +g++y+ ip++D
Q: 2     NKILPSLFIGNFKDARDVEQLHKNNITHILSI-HDSAR----P---MLEGMKYLCIPASD  53
         79**********************99999975.44555....3...458***********
S: 63    sdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAiea  122
         s++++l+q+f+  ++fi+e++ kg+ +lvHC aGvsRS+tlv+aY+m+v+++ ++dA++a
Q: 54    SPSQNLIQHFKDSIAFIHECRLKGEGCLVHCLAGVSRSVTLVVAYVMTVTDFGWEDALSA  113
         ************************************************************
S: 123   vkrkrpsiepnegfleQLlelek  145
         v+  r +++pn gf +QL  + k
Q: 114   VRGARTCANPNMGFQKQLEDFGK  136
         ******************99977
Domain Sequence
(FASTA)
NKILPSLFIG NFKDARDVEQ LHKNNITHIL SIHDSARPML EGMKYLCIPA SDSPSQNLIQ 60
HFKDSIAFIH ECRLKGEGCL VHCLAGVSRS VTLVVAYVMT VTDFGWEDAL SAVRGARTCA 120
NPNMGFQKQL EDFGK 135
KeywordComplete proteome; Cytoplasm; Hydrolase; Nucleus; Protein phosphatase; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EPS-AIM-00016
EPS-ANC-00019
EPS-BOT-00010
EPS-CAJ-00009
EPS-CAF-00016
EPS-CAP-00011
EPS-CII-00046
EPS-CIS-00036
EPS-DAR-00020
EPS-DRM-00041
EPS-ECT-00010
EPS-EQC-00009
EPS-FEC-00017
EPS-GAM-00082
EPS-GAG-00016
EPS-GAA-00021
EPS-GOG-00016
EPS-HOS-00010
EPS-ICT-00011
EPS-LAC-00018
EPS-LOA-00010
EPS-MAM-00009
EPS-MEG-00019
EPS-MOD-00013
EPS-MUM-00010
EPS-MUP-00010
EPS-MYL-00012
EPS-NOL-00014
EPS-OCP-00004
EPS-ORC-00010
EPS-ORL-00021
EPS-OTG-00012
EPS-PAT-00010
EPS-PES-00016
EPS-PEM-00006
EPS-POA-00016
EPS-PTV-00010
EPS-RAN-00013
EPS-SAH-00010
EPS-TAG-00013
EPS-TAR-00022
EPS-TEN-00018
EPS-TUT-00010
EPS-XIM-00026
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0035335; P:peptidyl-tyrosine dephosphorylation
GO:0046330; P:positive regulation of JNK cascade
GO:0042127; P:regulation of cell proliferation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
xtr:496452;
InterPros
IPR020417; Atypical_DUSP.
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR020422; Dual-sp_phosphatase_subgr_cat.
IPR024950; DUSP.
IPR000387; Tyr/Dual-specificity_Pase.
Pfam
PF00782; DSPc; 1.
SMARTs
SM00195; DSPc; 1.
Prosites
PS00383; TYR_PHOSPHATASE_1; FALSE_NEG.
PS50056; TYR_PHOSPHATASE_2; 1.
PS50054; TYR_PHOSPHATASE_DUAL; 1.
Prints
PR01908; ADSPHPHTASE.
Created Date20-Feb-2013