EKS-XET-00032

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00032

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	294.9	6.9E-88	601	870	270

Status

Unreviewed

Ensembl Protein

ENSXETP00000025411

UniProt Accession

F7CMB7;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

tyk2

Gene Synonyms/Alias

tyk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000011623	ENSXETP00000025411	ENSXETT00000025411

Organism

Xenopus tropicalis

Functional Description

Protein Length

1188

Protein Sequence
(FASTA)

PLPEMALCQC AVKHSESDMD GCSFTPAGLR VFLYWSNGKE HYVTYSQGEI TAEDVCIHIS 60

ERLGITPLCY TFFALYDVHG KYWYPPDHVF TVTKDMKLFL HFRMRYYFRN WHGMNEKEPV 120

VFRNVPKSRD GSEDRSRIEQ AGAILDLASF EYLFEQGKFD FVNDVVSLKD FSMEQDIHRF 180

KNESLGMAVL HLSHIAIKKK VSLEEVAKQI SFKECIPKSF CRQIQQNNYL TKFRMKNVFK 240

KFVRRFHLHT VSPGKLNEED IMYKYLSTLE NLAPRLGCEV FKALSLELPA EGEKLPFYLN 300

GGYMEHTDTV NREPTSTHQV MVSGMEGIQY RISKEEELST QPSWGESNES DQLGRKPKSR 360

VKGQKALKSQ QLPGKSEPKW VTFCDFQDIT HIVISKSRVS VSCQDNRCLE IALHSCEDAL 420

SFVSLVDGYF RLTTDSNHYL CHEVAPPRLV LSVANGIHGP LQEQYVAQKL KREEQEEGLY 480

IIRWSAFSFN IIIMAVKSVT QSKGFTYKQF KIEKKGGVFS LEDWDREFHS VKELVESLRG 540

CTLKSGKDTF TVKKCILPKS GEVSNLTISR RGKNNRERTV SKNLNLSQLS FHQIRKHEIL 600

QKSHLGQGTR TNIYDGMLLV TEGSEHESDY ESGELNNNSH DLRVVLKVLD PSHRDIALAF 660

FETASLMSQV SHIHLVFVHG VCVRESENIM VEEFIEHGPL DVCLRKDKLK IKAEWKFTVA 720

RQLASALSYL EDKNLVHGNV CAKNILLARK GLEENSSPFI KLSDPGVTFT VLSREERVER 780

IPWIAPECVR NISSLSTTAD KWSFGTTLLE ICFNGEVPLK ERTPPEKERF YEKELGLPEP 840

SCKELADLIG QCHNYNPEGR PSFRTILREL TQLQPDVLPD IATISPVSIT DPTVFQKRYL 900

KKIRELGEGH FGKVSLYCYD PNNDGTGEMV AVKSLKSGCS QQLESSWKGE IKILKTLYHE 960

NIVKYKGCCS EQGDKIVQLI MEYVPLGSLR DYLPKHNVSL AQILLFAQQI CEGMAYLHSQ 1020

HYIHRDLAAR NVLVENENVV KIGDFGLAKA VPEGHEYYRV REDGDSPVFW YSGSELMETK 1080

HASLLMRFCP TLFSARWHCQ TKMSHHVKFI EMIGVTQGQM TVVRLIDLLE RGQRLPCPSD 1140

CPLEIYKLMK NCWETEANFR PTFNHLIPIL KSFVNTYSTQ APSVFSLC 1188

Nucleotide Sequence
(FASTA)

CCCCTCCCAG AGATGGCTCT TTGTCAGTGT GCCGTGAAAC ACAGTGAGTC AGACATGGAC 60

GGCTGCAGCT TCACCCCGGC CGGGCTCAGA GTCTTTCTCT ATTGGAGCAA TGGCAAGGAG 120

CACTATGTCA CGTATAGCCA GGGAGAGATC ACGGCCGAGG ATGTCTGCAT CCACATATCA 180

GAGAGGCTTG GGATCACACC TCTTTGTTAC ACATTTTTTG CTCTTTATGA TGTGCATGGA 240

AAATACTGGT ATCCTCCCGA CCATGTGTTT ACTGTCACAA AGGATATGAA ACTGTTTCTC 300

CATTTTCGCA TGAGGTACTA TTTCAGGAAC TGGCATGGTA TGAATGAGAA GGAGCCTGTT 360

GTTTTTCGCA ATGTTCCAAA GAGCAGAGAT GGCAGTGAGG ACAGGAGCCG CATTGAGCAG 420

GCAGGAGCTA TCCTGGATTT GGCTTCTTTT GAATACCTTT TTGAACAGGG AAAGTTTGAC 480

TTTGTGAATG ATGTGGTGTC CCTGAAGGAT TTCTCGATGG AGCAGGATAT CCACAGATTT 540

AAGAACGAGA GTCTTGGCAT GGCCGTGCTT CACTTGTCTC ATATCGCCAT AAAGAAGAAA 600

GTGTCTCTGG AAGAGGTGGC AAAGCAAATT AGCTTCAAGG AGTGCATCCC AAAGTCATTC 660

TGCCGCCAAA TCCAGCAGAA CAATTACCTC ACCAAATTCC GCATGAAGAA TGTGTTCAAG 720

AAATTCGTCC GCCGTTTCCA CCTTCATACC GTAAGCCCCG GAAAGCTGAA CGAGGAAGAC 780

ATCATGTACA AGTACTTGTC AACCTTGGAG AACTTGGCAC CTCGCTTAGG CTGCGAGGTT 840

TTCAAGGCAT TGTCATTGGA ACTGCCAGCC GAGGGAGAGA AGCTGCCATT TTACTTAAAC 900

GGGGGCTACA TGGAACATAC AGACACTGTG AACAGGGAAC CAACCAGCAC TCATCAGGTT 960

ATGGTGAGCG GGATGGAAGG AATCCAATAC AGAATCAGCA AAGAGGAGGA ATTAAGTACT 1020

CAGCCATCAT GGGGGGAGTC TAATGAGTCT GACCAGCTAG GGAGAAAGCC AAAAAGCCGG 1080

GTAAAAGGCC AGAAGGCATT AAAGTCCCAG CAGCTTCCAG GAAAGAGCGA ACCCAAATGG 1140

GTGACATTTT GTGACTTTCA GGATATCACG CACATTGTCA TCAGCAAGAG CAGAGTCAGC 1200

GTCAGCTGTC AGGATAACCG CTGTCTGGAG ATTGCTCTGC ATTCCTGTGA AGATGCCTTG 1260

TCGTTTGTAT CGCTGGTAGA TGGATATTTT AGGCTGACAA CTGATTCTAA CCACTACCTT 1320

TGCCACGAGG TCGCCCCCCC ACGTTTAGTG TTGAGCGTGG CAAATGGAAT TCATGGACCC 1380

TTGCAGGAGC AGTATGTTGC CCAGAAGCTG AAGCGAGAGG AGCAGGAGGA GGGACTGTAC 1440

ATTATTAGAT GGAGTGCCTT CAGTTTCAAC ATCATAATCA TGGCTGTAAA GAGTGTTACC 1500

CAGAGCAAAG GGTTCACCTA CAAGCAGTTC AAGATTGAGA AGAAGGGTGG AGTGTTCTCA 1560

CTCGAGGATT GGGATCGTGA GTTCCACAGT GTAAAAGAAT TAGTGGAAAG TCTTCGGGGC 1620

TGCACCCTGA AATCTGGAAA GGACACCTTT ACAGTGAAGA AGTGCATCTT GCCAAAGTCT 1680

GGAGAAGTTT CCAACTTGAC TATCTCCAGG AGAGGGAAGA ACAATAGGGA GAGAACAGTG 1740

TCCAAGAACC TCAATCTGAG CCAACTCAGT TTCCACCAGA TCCGCAAACA CGAGATTTTG 1800

CAGAAATCCC ACCTAGGGCA GGGCACTCGC ACTAATATTT ATGACGGGAT GCTCCTGGTG 1860

ACCGAAGGAA GTGAGCACGA GTCTGATTAT GAGTCAGGGG AACTGAATAA CAATTCTCAT 1920

GATCTGAGGG TGGTTCTGAA AGTTCTGGAT CCCAGCCACA GAGACATAGC GCTGGCTTTC 1980

TTTGAGACGG CAAGTTTAAT GAGCCAGGTC TCCCACATCC ATCTTGTGTT TGTCCATGGA 2040

GTTTGTGTTC GAGAGTCTGA GAATATCATG GTGGAAGAGT TCATTGAACA CGGACCTCTA 2100

GATGTTTGTT TGCGGAAAGA CAAATTAAAG ATCAAAGCAG AATGGAAGTT CACTGTAGCC 2160

AGACAACTAG CAAGCGCCTT GAGCTACCTG GAAGATAAGA ATTTGGTTCA TGGAAATGTC 2220

TGTGCAAAAA ATATTCTGCT GGCCAGAAAG GGTTTGGAAG AGAACTCCTC TCCGTTCATC 2280

AAACTGAGTG ATCCCGGAGT GACATTCACA GTCTTGTCCA GAGAAGAACG TGTGGAGAGG 2340

ATCCCATGGA TTGCGCCAGA GTGTGTCCGA AACATCTCTA GTCTTAGCAC CACCGCTGAT 2400

AAATGGAGCT TTGGGACAAC CCTGCTGGAA ATATGTTTTA ATGGAGAAGT CCCTCTGAAA 2460

GAAAGGACGC CCCCTGAGAA AGAGCGTTTT TATGAGAAAG AGCTGGGTCT TCCAGAGCCT 2520

TCCTGCAAGG AGCTTGCTGA CCTTATTGGC CAGTGCCACA ATTACAACCC AGAGGGAAGA 2580

CCCTCTTTTC GAACAATCCT CAGAGAGCTG ACTCAGCTGC AGCCTGACGT TCTTCCAGAC 2640

ATTGCCACCA TCAGCCCAGT CTCCATCACG GATCCCACAG TGTTTCAGAA GCGCTACCTG 2700

AAAAAAATCA GAGAGCTGGG AGAGGGCCAC TTCGGCAAAG TCAGCCTCTA CTGCTACGAC 2760

CCCAACAACG ATGGCACGGG AGAAATGGTG GCTGTGAAGT CCCTAAAGTC TGGCTGCAGC 2820

CAACAACTGG AATCCAGCTG GAAAGGAGAG ATCAAGATCC TGAAGACTCT TTACCACGAG 2880

AACATTGTCA AGTACAAGGG ATGCTGCAGT GAACAAGGGG ATAAGATAGT TCAGCTTATT 2940

ATGGAATATG TGCCACTGGG AAGCCTTCGA GATTATCTCC CCAAACACAA TGTGAGCCTG 3000

GCCCAAATAC TACTGTTTGC ACAACAGATC TGTGAGGGAA TGGCCTATCT CCACTCTCAG 3060

CACTACATAC ACCGTGATCT CGCTGCCCGC AATGTCCTCG TCGAAAATGA AAATGTGGTG 3120

AAAATTGGAG ATTTTGGGCT GGCCAAAGCT GTCCCAGAAG GCCATGAATA TTACAGGGTC 3180

AGAGAGGATG GAGACAGCCC GGTTTTCTGG TATAGCGGCT CAGAGCTGAT GGAGACCAAG 3240

CATGCAAGCC TGCTAATGCG TTTTTGTCCT ACTCTATTTT CTGCCAGATG GCACTGTCAA 3300

ACAAAAATGT CCCATCATGT GAAATTCATA GAGATGATCG GGGTCACCCA GGGACAGATG 3360

ACGGTAGTGC GGCTGATTGA CCTGCTGGAG AGAGGTCAGA GGTTACCGTG TCCTAGCGAC 3420

TGCCCGCTGG AGATCTATAA GCTGATGAAA AACTGCTGGG AGACAGAAGC AAATTTCCGT 3480

CCAACGTTTA ATCACCTTAT TCCAATCCTG AAATCTTTTG TCAATACCTA CTCCACCCAG 3540

GCCCCATCCG TGTTTAGCCT GTGCTAG 3567

Domain Profile

S: 3     qiesLgkgtftkvfevre...............daegdsteeevalkvLkesgedisrdf  47

         q+++Lg+gt+t+++ + +               + +++s++  v+lkvL++s++di+ +f

Q: 601   QKSHLGQGTRTNIYDGMLlvtegsehesdyesgELNNNSHDLRVVLKVLDPSHRDIALAF  660

         689**************99999999988665433666677777*****************

S: 48    kreaeilsqlshehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldva  107

         +++a+++sq+sh h+v+++gvcv+e+en++V+e++e+G+Ld+ Lrk k ++++++++ va

Q: 661   FETASLMSQVSHIHLVFVHGVCVRESENIMVEEFIEHGPLDVCLRKDKLKIKAEWKFTVA  720

         ************************************************************

S: 108   kqlakameYLedkklvhrdvaarnvLveresn.egtppfvklsdpglakavnqdeYylvr  166

         +qla+a++YLedk+lvh++v+a+n+L++r++  e+++pf+klsdpg++ +v      l+r

Q: 721   RQLASALSYLEDKNLVHGNVCAKNILLARKGLeENSSPFIKLSDPGVTFTV------LSR  774

         *******************************988899**************......***

S: 167   eerdsripwlapeclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelle  226

         eer +ripw+apec+++  +lst +d+WsFg+tl+e+  c +ge pl+++++ +k++++e

Q: 775   EERVERIPWIAPECVRNISSLSTTADKWSFGTTLLEI--CFNGEVPLKERTPPEKERFYE  832

         *************************************..*********************

S: 227   ekerlpkpkcpaelaelmtnclsyepsqrpsFrailedl  265

         ++  lp+p+c+ ela+l+ +c +y+p+ rpsFr+il++l

Q: 833   KELGLPEPSCK-ELADLIGQCHNYNPEGRPSFRTILREL  870

         ***********.***********************9987

Domain Sequence
(FASTA)

QKSHLGQGTR TNIYDGMLLV TEGSEHESDY ESGELNNNSH DLRVVLKVLD PSHRDIALAF 60

FETASLMSQV SHIHLVFVHG VCVRESENIM VEEFIEHGPL DVCLRKDKLK IKAEWKFTVA 120

RQLASALSYL EDKNLVHGNV CAKNILLARK GLEENSSPFI KLSDPGVTFT VLSREERVER 180

IPWIAPECVR NISSLSTTAD KWSFGTTLLE ICFNGEVPLK ERTPPEKERF YEKELGLPEP 240

SCKELADLIG QCHNYNPEGR PSFRTILREL 270

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR01823	; JANUSKINASE.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013