EKS-XET-00220

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00220

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ryk	483.0	2.4E-145	253	519	267

Status

Unreviewed

Ensembl Protein

ENSXETP00000053547

UniProt Accession

F6SBQ2;

Protein Name

Protein Synonyms/Alias

Gene Name

ryk

Gene Synonyms/Alias

ryk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000011818	ENSXETP00000025844	ENSXETT00000025844
ENSXETG00000011818	ENSXETP00000053547	ENSXETT00000053547

Organism

Xenopus tropicalis

Functional Description

Protein Length

530

Protein Sequence
(FASTA)

ELYYIRNDII NHYALSFNLL VPSETNSLHF TWHAKSKVEY KLGFQVDNPM AMTMPLTNIS 60

MQGEVPSSLT VFRVDLYCSG KMDSEVLFLM QLNITISSAK NITVLNFKRR KMCYRKLEDI 120

KVPVLQDKNN TRIHFDPVNV APTTSTRVFY ISVGVCCAVI FLVAIILAVL HLHSMKRVEL 180

DDSMSDSSSS QGLSQPSTQT TQYLRADTPN NATPVTISSG YPTLRIEKND LKSVTLQEAK 240

AKVKDIAISR ERVTLKDVLQ EGTFGRIFHG ILVDEKDPNK EKAVFVKTVK DQASEVQITM 300

MLTESCKLRG LHHRNLLPIG HVCTEDGEKP MVLLPYMNWG NLKLFLRQCK LVEANNPQAI 360

SQQDLVHMAI QIACGMSYLA RREVIHKDLA ARNCVIDESL QVKITDNALS RDLFPMDYHC 420

LGDNENRPVR WMALESLVNK EFSSAGDVWA FGVTLWELMT LGQTPYVDID PFEMAAYLKD 480

GYRIAQPINC PDELFAVMAC CWALDPEERP KFQQLVQCLT EFHSALGAYV 530

Nucleotide Sequence
(FASTA)

GAACTGTATT ACATAAGGAA CGACATAATT AATCACTATG CTCTGTCCTT CAACCTTCTG 60

GTGCCAAGCG AGACCAACAG CCTCCACTTT ACTTGGCATG CCAAGTCTAA GGTGGAGTAT 120

AAATTGGGAT TTCAGGTGGA CAACCCAATG GCCATGACCA TGCCACTGAC CAACATCTCC 180

ATGCAGGGGG AGGTCCCTTC CTCCTTAACT GTGTTTAGGG TTGATCTTTA CTGCTCAGGA 240

AAAATGGACT CGGAAGTCTT GTTTCTCATG CAGCTGAACA TCACCATCAG CTCTGCCAAA 300

AACATCACAG TTCTCAACTT TAAACGGAGG AAAATGTGCT ACAGGAAACT GGAGGACATC 360

AAGGTGCCCG TGCTCCAGGA CAAAAACAAC ACCAGGATTC ATTTTGATCC TGTCAATGTA 420

GCCCCTACAA CTTCAACACG TGTGTTCTAC ATCAGCGTGG GTGTCTGCTG TGCAGTGATT 480

TTCCTGGTAG CCATCATTTT GGCAGTTCTG CATCTCCACA GCATGAAACG AGTGGAACTT 540

GATGACAGCA TGAGTGACAG CAGCAGTTCC CAGGGTCTCT CTCAGCCCTC GACGCAGACA 600

ACACAGTACC TCAGAGCGGA CACCCCCAAC AATGCAACGC CTGTCACCAT TTCCTCAGGT 660

TATCCAACAC TACGGATCGA GAAGAATGAC CTGAAAAGTG TAACTCTTCA GGAAGCCAAG 720

GCAAAGGTGA AGGACATCGC CATCTCTCGG GAGAGGGTCA CTCTGAAGGA CGTCCTGCAG 780

GAAGGCACGT TTGGCAGAAT ATTCCATGGA ATCCTAGTGG ATGAGAAAGA TCCGAACAAG 840

GAGAAAGCGG TTTTTGTTAA GACTGTAAAA GATCAGGCCT CGGAAGTTCA GATCACCATG 900

ATGTTGACTG AAAGCTGCAA ACTTCGAGGT CTGCACCATA GGAACCTGCT GCCCATTGGC 960

CACGTGTGTA CAGAAGATGG CGAGAAGCCC ATGGTGCTGC TGCCTTATAT GAACTGGGGC 1020

AACCTGAAAC TGTTTCTTAG ACAGTGCAAG TTGGTGGAAG CAAATAACCC ACAGGCCATT 1080

TCCCAGCAAG ATCTTGTGCA TATGGCCATT CAGATCGCCT GTGGGATGAG TTACTTGGCG 1140

CGACGGGAAG TTATTCACAA AGACCTTGCT GCTAGAAATT GTGTGATTGA CGAGTCCCTT 1200

CAGGTAAAGA TTACAGACAA CGCTCTCTCT CGAGACCTCT TCCCCATGGA TTATCACTGT 1260

CTCGGAGACA ATGAGAACCG ACCTGTACGC TGGATGGCTC TTGAGAGTCT AGTGAACAAA 1320

GAGTTCTCCA GTGCAGGGGA TGTGTGGGCT TTTGGCGTGA CCCTGTGGGA GCTTATGACA 1380

CTGGGACAAA CTCCATACGT TGATATTGAT CCTTTTGAAA TGGCCGCATA CTTAAAAGAT 1440

GGCTACAGAA TAGCCCAGCC AATCAACTGC CCTGATGAGC TGTTTGCTGT CATGGCCTGT 1500

TGCTGGGCCC TGGACCCAGA AGAAAGACCA AAGTTCCAGC AGTTAGTCCA GTGCTTGACA 1560

GAATTTCACT CTGCCCTGGG AGCCTACGTA TGA 1593

Domain Profile

S: 1     lrlkellqeGtfGriyrGkledekdtnkekavlvktvkdqaseiqvalllqealllygvs  60

         ++lk++lqeGtfGri++G+l dekd+nkekav+vktvkdqase+q++++l+e+++l+g++

Q: 253   VTLKDVLQEGTFGRIFHGILVDEKDPNKEKAVFVKTVKDQASEVQITMMLTESCKLRGLH  312

         5799********************************************************

S: 61    hrnilsvllvsieeaekPlvvypalnkgnlkkflricklkdkekaqalstkqlvelaiqi  120

         hrn+l++ +v++e+ ekP+v++p++n+gnlk flr+ckl++++++qa+s+++lv++aiqi

Q: 313   HRNLLPIGHVCTEDGEKPMVLLPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQI  372

         ************************************************************

S: 121   asalaylhkrevvhkdiaarncviddelqvkltdsalsrdlfPadydclGdnenrPlkWl  180

         a++++yl++rev+hkd+aarncvid+ lqvk+td+alsrdlfP+dy+clGdnenrP++W+

Q: 373   ACGMSYLARREVIHKDLAARNCVIDESLQVKITDNALSRDLFPMDYHCLGDNENRPVRWM  432

         ************************************************************

S: 181   slealqkeeyssasdvWalGvllWelvtlgksPyaeidpfeleaylkdGyrlaqPvncPd  240

         +le+l+++e+ssa+dvWa+Gv+lWel+tlg++Py++idpfe++aylkdGyr+aqP+ncPd

Q: 433   ALESLVNKEFSSAGDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPD  492

         ************************************************************

S: 241   elftvmaccWallpeerPsfeqlvscl  267

         elf+vmaccWal+peerP+f+qlv+cl

Q: 493   ELFAVMACCWALDPEERPKFQQLVQCL  519

         **************************8

Domain Sequence
(FASTA)

VTLKDVLQEG TFGRIFHGIL VDEKDPNKEK AVFVKTVKDQ ASEVQITMML TESCKLRGLH 60

HRNLLPIGHV CTEDGEKPMV LLPYMNWGNL KLFLRQCKLV EANNPQAISQ QDLVHMAIQI 120

ACGMSYLARR EVIHKDLAAR NCVIDESLQV KITDNALSRD LFPMDYHCLG DNENRPVRWM 180

ALESLVNKEF SSAGDVWAFG VTLWELMTLG QTPYVDIDPF EMAAYLKDGY RIAQPINCPD 240

ELFAVMACCW ALDPEERPKF QQLVQCL 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR003306	; WIF.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF02019	; WIF; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50814	; WIF; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013