EKS-XET-00540

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00540

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Aur	457.1	1.3E-137	146	396	251

Status

Unreviewed

Ensembl Protein

ENSXETP00000026285

UniProt Accession

Q28HZ5;

Protein Name

Protein Synonyms/Alias

Serine/threonine kinase 6;

Gene Name

aurka

Gene Synonyms/Alias

aurka; stk6; TEgg021k02.1-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000012032	ENSXETP00000026285	ENSXETT00000026285

Organism

Xenopus tropicalis

Functional Description

Protein Length

415

Protein Sequence
(FASTA)

MERAVKENLP SNVKVFHPTM EGPKRIPVTQ PPSTQVRPPG TAVSAQRILG PSNVPQRVVS 60

QAQKPVMSAQ KPVMSTQKPM TQGPLRPVTH GHQAGKPQGP NENRTPQQTS HSSTPNVEKK 120

GSTDQGKTLA VPKEEGKKKQ WCLEDFEIGR PLGKGKFGNV YLARERESKF ILALKVLFKT 180

QLEKAGVEHQ LRREVEIQSH LRHPNILRLY GYFHDAARVY LILDYAPGGE LFRELQKVTR 240

FDEQKSALYI KQLAEALLYC HSKNVIHRDI KPENLLLGAN GELKIADFGW SVHAPSSRRT 300

TLCGTLDYLP PEMIEGRMHD EKVDLWSLGV LCYEFLVGKP PFETDTHQET YRRISKVEFQ 360

YPSYVSEGAR DLVSKLLKHN PNHRLSLKGV LEHPWIIDNS AQKPKRKEGP VTGAQ 415

Nucleotide Sequence
(FASTA)

ATGGAACGGG CTGTTAAAGA GAATCTTCCT TCTAATGTCA AGGTTTTCCA CCCCACAATG 60

GAGGGTCCCA AACGTATCCC AGTTACCCAG CCTCCGAGCA CCCAGGTTAG ACCTCCTGGG 120

ACTGCCGTCT CTGCCCAGAG GATATTGGGT CCCTCCAATG TGCCACAGCG AGTCGTGTCT 180

CAGGCTCAGA AACCTGTTAT GTCCGCTCAG AAACCTGTTA TGTCCACTCA GAAGCCAATG 240

ACTCAGGGGC CACTGAGGCC AGTAACTCAT GGGCATCAGG CTGGCAAACC ACAGGGACCA 300

AATGAGAATC GTACTCCACA GCAGACCAGC CATTCCTCCA CTCCAAACGT GGAGAAGAAA 360

GGAAGCACCG ATCAAGGAAA GACTCTGGCT GTTCCCAAAG AGGAGGGCAA AAAGAAACAG 420

TGGTGCCTGG AAGACTTTGA GATTGGGCGC CCCCTGGGCA AAGGGAAGTT TGGGAACGTG 480

TATCTGGCGC GCGAGCGGGA GAGTAAATTC ATCCTGGCGC TGAAAGTCCT GTTTAAAACT 540

CAGCTGGAGA AGGCAGGGGT AGAGCACCAA CTGCGGAGGG AGGTGGAAAT TCAGTCCCAT 600

CTCAGGCATC CAAACATCCT CCGGCTATAT GGGTACTTCC ATGATGCCGC CCGAGTCTAC 660

CTAATCCTGG ATTATGCCCC CGGCGGGGAG CTGTTCCGAG AGCTGCAGAA AGTCACCAGA 720

TTTGATGAGC AGAAGAGCGC CTTGTACATC AAACAGCTGG CAGAAGCCCT CCTGTACTGT 780

CACTCCAAGA ACGTGATACA CCGGGATATC AAGCCAGAGA ACTTGCTGCT CGGTGCCAAC 840

GGGGAACTGA AGATCGCTGA CTTTGGTTGG TCTGTGCACG CGCCGTCCTC CAGGAGGACC 900

ACTCTGTGCG GAACCCTGGA CTATCTCCCT CCTGAGATGA TTGAGGGCCG AATGCACGAC 960

GAGAAGGTGG ACTTGTGGAG CCTGGGAGTC CTCTGTTATG AGTTCCTTGT AGGGAAACCT 1020

CCATTTGAGA CTGACACCCA CCAGGAAACC TACAGACGTA TTTCAAAGGT TGAATTTCAG 1080

TATCCTTCGT ATGTATCGGA AGGAGCCAGA GATCTCGTAT CGAAGCTGTT AAAGCACAAC 1140

CCAAACCACA GGCTGTCCCT GAAGGGGGTT CTCGAACATC CGTGGATCAT AGATAATTCT 1200

GCTCAAAAGC CCAAGAGGAA AGAGGGGCCG GTTACAGGGG CTCAATAG 1248

Domain Profile

S: 1     feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn  60

         feiGr+lGkGkfGnvylare++skfi+alkvlfk+qlek+gve+qlrre+eiqshl+hpn

Q: 146   FEIGRPLGKGKFGNVYLARERESKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPN  205

         9***********************************************************

S: 61    ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv  120

         ilrlygyfhd+ rvylil+yap Gel++elqk +++deq++a yi++la+al y+h+k+v

Q: 206   ILRLYGYFHDAARVYLILDYAPGGELFRELQKVTRFDEQKSALYIKQLAEALLYCHSKNV  265

         ************************************************************

S: 121   ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl  180

         ihrdikpenlllg +gelk+adfGwsvhapss+r+tlcGtldylppem+egr++dekvdl

Q: 266   IHRDIKPENLLLGANGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDL  325

         ************************************************************

S: 181   walGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepkerl  240

         w+lGvlcye+lvGkppfe+++++ety+ri+kv++++ps vs+ga+dl+skllk++p++rl

Q: 326   WSLGVLCYEFLVGKPPFETDTHQETYRRISKVEFQYPSYVSEGARDLVSKLLKHNPNHRL  385

         ************************************************************

S: 241   tladvlahpwi  251

         +l+ vl+hpwi

Q: 386   SLKGVLEHPWI  396

         **********8

Domain Sequence
(FASTA)

FEIGRPLGKG KFGNVYLARE RESKFILALK VLFKTQLEKA GVEHQLRREV EIQSHLRHPN 60

ILRLYGYFHD AARVYLILDY APGGELFREL QKVTRFDEQK SALYIKQLAE ALLYCHSKNV 120

IHRDIKPENL LLGANGELKI ADFGWSVHAP SSRRTTLCGT LDYLPPEMIE GRMHDEKVDL 180

WSLGVLCYEF LVGKPPFETD THQETYRRIS KVEFQYPSYV SEGARDLVSK LLKHNPNHRL 240

SLKGVLEHPW I 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

xtr:549324

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013