EKS-XET-00076

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00076

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	438.6	1.1E-131	82	365	284

Status

Unreviewed

Ensembl Protein

ENSXETP00000026360

UniProt Accession

B1H3G0;

Protein Name

Protein Synonyms/Alias

Gsk3a protein;

Gene Name

gsk3a

Gene Synonyms/Alias

gsk3a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000012072	ENSXETP00000026360	ENSXETT00000026360

Organism

Xenopus tropicalis

Functional Description

Protein Length

434

Protein Sequence
(FASTA)

IQRLYLSLLS MSAANRARGG GEAFVEQVQA GTNKGPVTSA AASGGASVPG AFMKIGRDNG 60

KVTTVVATPG QGPDRPQEVS YTDIKVIGNG SFGVVYQARL VGCGEMVAIK KVLQDKRFKN 120

RELQIMRRLD HCNIVRLRYF FYSSGEKKDE VYLNLVLDFV PETVYRVARH FAKAKTSLPS 180

IYVKVYMYQL FRSLAYIHSQ GVCHRDIKPQ NLLVDPDTAV LKLCDFGSAK QLVRGEPNVS 240

YICSRYYRAP ELIFGATDYT ANIDIWSAGC VLAELLLGQP IFPGDSGVDQ LVEIIKVLGT 300

PTREQIREMN PNYTEFKFPQ IKAHPWTKVF KPRTCPEAIT LCSRLLEYTP DTRLSPLQAC 360

AHSYFDELRD PNTRLPSGRE LPPIFNFSSV ELSIQPSLNS ILIPPHLQSS HLHGDGRPGS 420

DRLKSGDVAE LNSS 434

Nucleotide Sequence
(FASTA)

ATTCAGCGCT TGTACTTGTC GCTCCTCAGT ATGAGCGCCG CCAACCGGGC CCGGGGCGGG 60

GGCGAGGCCT TCGTGGAGCA GGTACAAGCG GGGACAAATA AAGGACCCGT GACTTCCGCG 120

GCTGCATCTG GCGGAGCGTC CGTGCCCGGG GCCTTTATGA AGATAGGGAG AGACAATGGA 180

AAAGTTACAA CAGTGGTAGC AACCCCTGGT CAGGGACCAG ACCGCCCACA GGAGGTTTCT 240

TATACAGACA TCAAAGTCAT TGGTAATGGC TCCTTCGGGG TGGTATACCA GGCTCGGCTG 300

GTGGGCTGTG GAGAAATGGT GGCTATCAAG AAAGTTCTAC AGGATAAGAG GTTCAAGAAC 360

CGGGAGCTGC AGATCATGCG CAGGCTGGAT CACTGTAACA TTGTGCGCCT GAGATATTTC 420

TTCTACTCCA GTGGGGAGAA GAAAGACGAG GTTTACCTAA ACCTGGTCCT GGATTTTGTC 480

CCGGAGACTG TCTATCGTGT AGCTCGTCAC TTTGCAAAAG CCAAAACCTC ATTACCGTCC 540

ATTTATGTGA AGGTATACAT GTATCAGCTG TTCCGCAGCT TGGCTTATAT CCATTCTCAG 600

GGTGTCTGTC ACAGAGACAT TAAACCACAG AACTTGCTGG TAGATCCAGA CACTGCTGTA 660

CTTAAGCTTT GTGACTTTGG CAGTGCAAAG CAGCTTGTTC GTGGGGAGCC AAATGTGTCC 720

TATATATGTT CGAGGTATTA CAGAGCCCCA GAGCTCATTT TTGGAGCCAC AGACTACACT 780

GCAAATATTG ACATATGGTC AGCAGGTTGT GTCCTTGCCG AGCTGCTCCT GGGCCAGCCT 840

ATCTTTCCCG GAGATAGTGG AGTGGACCAG CTGGTGGAAA TTATCAAGGT TTTGGGGACT 900

CCCACACGGG AACAAATAAG AGAGATGAAC CCAAACTACA CAGAGTTCAA ATTCCCACAG 960

ATCAAAGCAC ATCCTTGGAC AAAGGTCTTT AAACCCCGAA CCTGCCCTGA AGCCATAACA 1020

TTGTGCAGCC GGCTATTGGA GTACACACCA GACACTCGCC TCTCCCCACT GCAGGCCTGC 1080

GCACACTCCT ACTTTGATGA GCTCCGTGAC CCTAACACAC GCCTCCCTAG TGGACGCGAG 1140

TTACCCCCTA TCTTCAACTT CAGCTCTGTA GAGCTCTCCA TTCAGCCTTC GCTGAACTCC 1200

ATCCTCATAC CCCCCCACCT GCAGTCTTCT CATTTGCATG GTGACGGGAG ACCTGGATCA 1260

GACAGACTGA AAAGCGGCGA TGTGGCAGAG CTGAATAGCT CCTGA 1305

Domain Profile

S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61

         +++k+ig+GsFg+Vyqa+l+   e+ vaiKkvlqdk++kn+El+i+r+l+H+nivrL+yf

Q: 82    TDIKVIGNGSFGVVYQARLVGCGEM-VAIKKVLQDKRFKNRELQIMRRLDHCNIVRLRYF  140

         789**********************.**********************************

S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121

         f++s ekkd+vylnlvl+++Pet+++v+r+++++k++l+ ++vk+y+yQlfr+lay+hs+

Q: 141   FYSSGEKKDEVYLNLVLDFVPETVYRVARHFAKAKTSLPSIYVKVYMYQLFRSLAYIHSQ  200

         ************************************************************

S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181

         +++HrDiKPqNllvd++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++yt

Q: 201   GVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT  260

         ************************************************************

S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241

         ++iD+WsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf++

Q: 261   ANIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ  320

         ************************************************************

S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         ik+++++kv+k ++ +ea+ l++++l+y+p +Rls+l+++ah++f

Q: 321   IKAHPWTKVFKPRTCPEAITLCSRLLEYTPDTRLSPLQACAHSYF  365

         ********************************************9

Domain Sequence
(FASTA)

TDIKVIGNGS FGVVYQARLV GCGEMVAIKK VLQDKRFKNR ELQIMRRLDH CNIVRLRYFF 60

YSSGEKKDEV YLNLVLDFVP ETVYRVARHF AKAKTSLPSI YVKVYMYQLF RSLAYIHSQG 120

VCHRDIKPQN LLVDPDTAVL KLCDFGSAKQ LVRGEPNVSY ICSRYYRAPE LIFGATDYTA 180

NIDIWSAGCV LAELLLGQPI FPGDSGVDQL VEIIKVLGTP TREQIREMNP NYTEFKFPQI 240

KAHPWTKVFK PRTCPEAITL CSRLLEYTPD TRLSPLQACA HSYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013