EKS-XET-00618

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00618

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	348.3	3.3E-104	148	419	272

Status

Unreviewed

Ensembl Protein

ENSXETP00000027352

UniProt Accession

B0JZD9;

Protein Name

Protein Synonyms/Alias

Nlk protein;

Gene Name

nlk

Gene Synonyms/Alias

nlk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000012503	ENSXETP00000027352	ENSXETT00000027352
ENSXETG00000012503	ENSXETP00000060656	ENSXETT00000061820
ENSXETG00000012503	ENSXETP00000058708	ENSXETT00000064789

Organism

Xenopus tropicalis

Functional Description

Protein Length

419

Protein Sequence
(FASTA)

MSLCGTSSNA NMMAAYNGGT STAAGGHHHH HHHHLAHLPP PHLHHHHHLH PQHHLHPGSA 60

AAVHPVQQHV SSSSASTSSS AAAAAAAAAA AAAMLNPGQA QSYFPSPAPG QAPGPAAAVA 120

PAQVQAAAVK AHHHQHSHHA QQLDIEPDRP IGYGAFGVVW SVTDPRDGKR VALKKMPNVF 180

QNLVSCKRVF RELKMLCFFK HDNVLSALDI LQPPHIDYFE EIYVVTELMQ SDLHKIIVSP 240

QPLSSDHVKV FLYQILRGLK YLHSAGILHR DIKPGNLLVN SNCVLKICDF GLARVEELDE 300

SRHMTQEVVT QYYRAPEILM GSRHYTNAID VWSVGCIFAE LLGRRILFQA QSPIQQLDLI 360

TDLLGTPSLE AMRTACEGAK AHILRGPHKQ PSLPVLYTLS SQATHEAVHL LCRMLVFDP 419

Nucleotide Sequence
(FASTA)

ATGTCTCTTT GTGGCACATC TTCCAATGCA AATATGATGG CGGCATATAA TGGGGGCACA 60

TCAACAGCAG CTGGGGGGCA CCACCACCAT CATCACCATC ACCTTGCCCA TTTGCCCCCT 120

CCCCACCTAC ACCATCATCA TCACCTCCAT CCTCAGCATC ATCTGCACCC AGGCTCAGCA 180

GCAGCTGTGC ACCCTGTTCA GCAACATGTC TCCTCTTCAT CAGCTTCCAC TTCCTCCTCA 240

GCTGCCGCAG CTGCTGCGGC AGCGGCGGCA GCAGCAGCAA TGCTAAATCC AGGGCAGGCC 300

CAGTCCTACT TTCCATCTCC AGCTCCAGGC CAAGCTCCAG GTCCTGCAGC AGCAGTGGCC 360

CCTGCTCAGG TTCAGGCTGC TGCTGTAAAG GCTCACCACC ATCAGCACTC TCATCATGCC 420

CAGCAACTGG ATATTGAACC TGATCGGCCC ATTGGTTATG GCGCATTTGG AGTTGTCTGG 480

TCAGTAACAG ATCCAAGAGA TGGAAAAAGA GTTGCTCTAA AAAAGATGCC CAACGTCTTC 540

CAGAATCTAG TCTCTTGCAA GAGGGTCTTC CGAGAACTGA AGATGTTGTG TTTTTTTAAA 600

CATGACAACG TACTCTCAGC ACTTGATATT CTCCAGCCAC CTCATATTGA TTATTTTGAA 660

GAAATATATG TTGTCACAGA ATTAATGCAG AGTGACCTCC ATAAGATCAT TGTCTCTCCT 720

CAGCCGCTTA GTTCAGATCA TGTCAAGGTT TTTTTGTATC AGATTTTAAG AGGTCTGAAG 780

TATTTGCATT CAGCTGGCAT TTTACATCGA GATATTAAAC CAGGGAATCT ACTTGTGAAC 840

AGCAACTGCG TTCTTAAGAT CTGTGATTTT GGATTGGCAA GGGTTGAAGA ACTTGATGAA 900

TCTCGGCATA TGACTCAGGA AGTTGTCACT CAGTATTATC GGGCTCCAGA AATCCTCATG 960

GGGAGTCGAC ATTATACCAA CGCTATAGAC GTCTGGTCTG TAGGATGCAT TTTTGCAGAG 1020

TTACTTGGGC GAAGAATATT GTTTCAGGCT CAAAGTCCAA TCCAACAGTT GGACTTAATC 1080

ACTGATTTGT TGGGTACACC GTCACTAGAA GCAATGAGAA CGGCTTGTGA AGGAGCCAAG 1140

GCACACATAC TCAGGGGTCC TCATAAACAG CCATCTCTTC CTGTCCTGTA CACACTGTCC 1200

AGCCAGGCAA CTCACGAAGC TGTCCATCTA CTCTGCAGGA TGTTGGTCTT TGATCCA 1257

Domain Profile

S: 4     lkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiikl  63

          +p+g Ga+gvv+s++d r+++rva+kk+ ++fq+ +s+kr++RElk+l  +kh+N+++

Q: 148   DRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSA  207

         689*********************************************************

S: 64    ldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylHsan  122

         ld+++p + ++ ++++Y+vtelm++dL+k+i s   ls++h+k++lyqilrglkylHsa+

Q: 208   LDILQPPH-IDYFEEIYVVTELMQSDLHKIIVSPqPLSSDHVKVFLYQILRGLKYLHSAG  266

         *******9.**********************99879************************

S: 123   viHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslkeyt  182

         ++HrD+KP+Nllvn++c lki+dFGlar+++ ++++++t++v+t++YraPeil+ +++yt

Q: 267   ILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYT  326

         *********************************999************************

S: 183   kavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyiks  242

         +a+D+WsvGCI+aEll +++lf++++ i+ql++i+++lgtps e +++ ++  a+++i +

Q: 327   NAIDVWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEG-AKAHILR  385

         ************************************************9996.7777777

S: 243   lpkkkkk..dfeelfpkaseealdLleklLvldp  274

          p+k+     + +l ++a++ea++Ll ++Lv+dp

Q: 386   GPHKQPSlpVLYTLSSQATHEAVHLLCRMLVFDP  419

         77666644457788888***************98

Domain Sequence
(FASTA)

DRPIGYGAFG VVWSVTDPRD GKRVALKKMP NVFQNLVSCK RVFRELKMLC FFKHDNVLSA 60

LDILQPPHID YFEEIYVVTE LMQSDLHKII VSPQPLSSDH VKVFLYQILR GLKYLHSAGI 120

LHRDIKPGNL LVNSNCVLKI CDFGLARVEE LDESRHMTQE VVTQYYRAPE ILMGSRHYTN 180

AIDVWSVGCI FAELLGRRIL FQAQSPIQQL DLITDLLGTP SLEAMRTACE GAKAHILRGP 240

HKQPSLPVLY TLSSQATHEA VHLLCRMLVF DP 272

Keyword

ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

xtr:100144638

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013