EKS-XET-00345
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00345
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK407.44.7E-122158419262
StatusUnreviewed
Ensembl ProteinENSXETP00000028566
UniProt AccessionF6QKT7;
Protein Name
Protein Synonyms/Alias Dual-specificity tyrosine-phosphorylation-regulated kinase 1A;
Gene Namedyrk1a
Gene Synonyms/Alias dyrk1a;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000013037ENSXETP00000028566ENSXETT00000028566
OrganismXenopus tropicalis
Functional Description
Protein Length719
Protein Sequence
(FASTA)
TGGETSACKP SSVRLAPSFS FHAAGLQMAG QMSHSHQQYS DRRQQNLNDQ QASALPYNDQ 60
IQQPLPNQYA LYCLVLQRRM PQTFRDPATA PLRKLSVDLI KTYKHINEVY YAKKKRRHQQ 120
GQGDDSSHKK ERKVYNDGYD DDNYDYIVKN GEKWMDRYEI DSLIGKGSFG QVVKAYDRAE 180
QEWVAIKIIK NKKAFLNQAQ IEVRLLELMN KHDTEMKYYI VHLKRHFMFR NHLCLVFEML 240
SYNLYDLLRN TNFRGVSLNL TRKFAQQMCT ALLFLATPEL SIIHCDLKPE NILLCNPKRS 300
AIKIVDFGSS CQLGQRIYQY IQSRFYRSPE VLLGMPYDLA IDMWSLGCIL VEMHTGEPLF 360
SGANEVDQMS KIVEVLGIPP AHILDQAPKA RKFFEKMPEG TWNLKKTKDG KKVIWEWKRN 420
QRLCMFLMRF KPKRHIWLYS AVQYTCIKLS LDTLGCIICI QLSNLPLCLH SRPSGQVVNA 480
GTYIYVSGGS SGTSNSGRAR SDPTHQHRHS GGHFTAAVQA MDCETHSPQV RQQFPPGWTV 540
PEAPTQVTIE THPVQETTFH VPPSQQNVPH HHGNGGQHVL SNRTRTRIYN SPSTSSSTQD 600
SMDVGHSHHS MTSLSSSTTS SSTSSSSTGN QGNQAYQNRP VAANTLDFGQ NGTMDVNLTA 660
FSNPRQETGI TGHPDYQYSA NTGPGHYVTE GHLTMRQGMD REDSPMTGVC VQQSPVASS 719
Nucleotide Sequence
(FASTA)
ACAGGAGGAG AGACTTCAGC ATGCAAACCA TCATCTGTCC GGCTTGCACC ATCCTTTTCA 60
TTCCATGCTG CCGGCCTTCA GATGGCTGGA CAAATGTCCC ATTCACATCA GCAGTACAGT 120
GACCGCCGTC AGCAGAACCT AAACGACCAA CAAGCATCTG CCTTACCGTA TAATGACCAG 180
ATTCAGCAAC CGTTGCCCAA CCAGTATGCT CTATATTGTC TTGTTTTGCA GCGGCGGATG 240
CCACAAACAT TTCGTGATCC GGCCACAGCA CCATTAAGAA AACTGTCAGT CGACTTGATC 300
AAAACATACA AACATATTAA TGAGGTCTAC TATGCAAAAA AGAAACGGCG GCATCAGCAA 360
GGACAAGGGG ATGACTCCAG TCACAAGAAG GAGAGGAAGG TTTACAACGA TGGCTATGAT 420
GATGACAACT ACGACTATAT CGTTAAGAAT GGGGAAAAAT GGATGGATAG ATATGAAATC 480
GATTCTTTAA TTGGCAAAGG TTCATTCGGC CAGGTTGTAA AGGCATATGA TCGCGCGGAG 540
CAAGAGTGGG TGGCAATTAA AATCATAAAG AACAAGAAAG CTTTCCTAAA CCAAGCCCAA 600
ATTGAAGTAC GGCTTCTCGA GCTGATGAAC AAACATGACA CGGAAATGAA GTACTATATT 660
GTGCATTTGA AGCGGCATTT TATGTTCAGA AACCACCTTT GTTTAGTGTT CGAAATGCTC 720
TCGTACAACC TCTACGACTT ACTGCGCAAC ACCAATTTCC GCGGCGTTTC GCTCAACCTG 780
ACACGAAAGT TTGCACAGCA GATGTGCACT GCACTACTCT TCCTGGCGAC TCCAGAACTT 840
AGTATCATTC ACTGTGACCT GAAGCCTGAG AATATCTTGC TTTGTAACCC AAAACGAAGC 900
GCCATTAAGA TTGTGGACTT TGGAAGCTCG TGCCAGCTAG GGCAGAGGAT ATACCAGTAT 960
ATTCAGAGTC GCTTCTACCG GTCTCCTGAG GTTTTACTAG GAATGCCTTA TGACCTTGCA 1020
ATTGACATGT GGTCCCTTGG CTGCATTTTG GTAGAAATGC ACACTGGGGA GCCCCTCTTC 1080
AGTGGAGCCA ATGAGGTTGA TCAAATGAGT AAAATTGTGG AAGTTTTAGG AATACCACCT 1140
GCTCACATCC TTGACCAAGC ACCAAAAGCT AGAAAGTTCT TTGAGAAGAT GCCAGAAGGC 1200
ACTTGGAACT TAAAGAAGAC CAAAGATGGA AAAAAGGTAA TTTGGGAATG GAAAAGGAAT 1260
CAACGGCTTT GCATGTTTCT AATGAGGTTT AAGCCCAAAA GGCACATTTG GTTATACAGT 1320
GCAGTTCAAT ATACATGTAT AAAACTGTCA CTAGATACAC TGGGTTGTAT TATATGTATA 1380
CAGCTTAGCA ACCTGCCCTT ATGCCTTCAT AGCCGCCCTT CAGGACAAGT AGTAAATGCA 1440
GGCACATATA TTTATGTATC AGGTGGCTCG TCTGGTACAA GCAACAGTGG AAGAGCAAGG 1500
TCTGACCCTA CTCATCAACA TCGACACAGT GGTGGCCATT TCACAGCTGC TGTTCAGGCT 1560
ATGGATTGTG AGACGCACAG TCCTCAGGTT CGACAACAGT TTCCTCCTGG TTGGACCGTC 1620
CCTGAAGCCC CTACGCAGGT CACCATTGAA ACACACCCTG TCCAAGAAAC AACATTTCAT 1680
GTCCCCCCTT CCCAGCAAAA TGTACCGCAT CACCATGGGA ATGGCGGACA GCATGTCTTG 1740
AGTAACAGGA CGAGGACCAG GATCTACAAT TCTCCATCAA CTAGCTCCTC CACCCAGGAT 1800
TCTATGGATG TCGGTCACAG CCACCACTCC ATGACATCCT TGTCTTCCTC AACTACTTCT 1860
TCCTCAACAT CTTCCTCTTC TACTGGCAAC CAAGGCAATC AGGCCTACCA GAATCGTCCT 1920
GTGGCTGCTA ACACCTTGGA CTTTGGACAG AATGGAACTA TGGATGTTAA TTTAACTGCC 1980
TTTTCAAACC CTCGCCAAGA GACTGGCATC ACTGGACATC CAGATTACCA ATATTCTGCA 2040
AATACAGGCC CCGGCCACTA CGTAACGGAA GGACACTTAA CGATGAGGCA AGGGATGGAC 2100
CGAGAAGACT CTCCCATGAC AGGAGTTTGT GTTCAGCAGA GTCCTGTGGC AAGCTCGTGA 2160
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k
Q: 158   YEIDSLIGKGSFGQVVKAYDRAEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  217
         9***********************************************************
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119
         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+ 
Q: 218   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  277
         **********************************************************99
S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++
Q: 278   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  336
         99*************************************.********************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238
         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+kff+k
Q: 337   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMSKIVEVLGIPPAHILDQAPKARKFFEK  396
         ************************************************************
S: 239   keapkyilktkksdrkkklvlnv  261
         + + ++ lk++k+ +k++ + ++
Q: 397   MPEGTWNLKKTKDGKKVIWEWKR  419
         ********998776666555444
Domain Sequence
(FASTA)
YEIDSLIGKG SFGQVVKAYD RAEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60
YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120
PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180
DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMSKIVEVLG IPPAHILDQA PKARKFFEKM 240
PEGTWNLKKT KDGKKVIWEW KR 262
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00251
EKS-ANC-00258
EKS-BOT-00269
EKS-CAE-00239
EKS-CAJ-00275
EKS-CAF-00276
EKS-CAP-00304
EKS-CIS-00040
EKS-DAR-00605
EKS-EQC-00261
EKS-FEC-00255
EKS-GAM-00164
EKS-GAG-00226
EKS-GAA-00327
EKS-GOG-00271
EKS-HOS-00275
EKS-ICT-00253
EKS-LAC-00280
EKS-LOA-00279
EKS-MAM-00271
EKS-MEG-00214
EKS-MOD-00266
EKS-MUM-00300
EKS-MUP-00266
EKS-MYL-00271
EKS-NOL-00246
EKS-ORN-00345
EKS-ORA-00233
EKS-ORC-00254
EKS-ORL-00322
EKS-OTG-00275
EKS-PAT-00254
EKS-PES-00239
EKS-PEM-00139
EKS-RAN-00284
EKS-SAH-00253
EKS-SUS-00231
EKS-TAG-00283
EKS-TAR-00341
EKS-TAS-00016
EKS-TEN-00340
EKS-TUT-00034
EKS-VIP-00013
EKS-XIM-00336
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013