EKS-XET-00337

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00337

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	407.0	3.6E-122	60	312	253

Status

Unreviewed

Ensembl Protein

ENSXETP00000029784

UniProt Accession

F6ZDC6;

Protein Name

Protein Synonyms/Alias

Gene Name

plk3

Gene Synonyms/Alias

plk3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000013590	ENSXETP00000029784	ENSXETT00000029784

Organism

Xenopus tropicalis

Functional Description

Protein Length

661

Protein Sequence
(FASTA)

METACYIQSH PYQCNALGAD LYRTTHQHGP AVPRSPKPEP QRSPQQPCKL ITDPLTGKAY 60

TKGRLLGKGG FARCYEMTEV ATNKTYAVKV IPHSRVAKPH QREKIVNEID LHRELHHKHV 120

VKFSHHFEDS ENIYIFLEIC SRKSLAHIWK ARHTLLEPEV RYFLKQIISG LKYLHLKGIL 180

HRDLKLGNFF INESMELKVG DFGLAARLEP PEQRKKTICG TPNYLAPEVL YRQGHGPESD 240

IWSLGCVMYT LLCGTPPFET SDLKETYRCI KQVKYTLPAC LSSAAKHLLM GILKRTPGER 300

LTLDQILEHE FFTKGYTPDK LPPSSCVMVP DLHPPNPAKS LFTKVAKSLF GKTKSKTKKS 360

PTEEKDDISK IVTGLVKTSI CRQLSYKTVD GNEVAPVTSH AVSANSSPVD TLTEEASGKS 420

VSRSIRGSLV SSSDAFEDCV TASGVIETAL AVLKDSLSSM PAVEGNPPSL AKPEHFVWVS 480

KWVDYSNKYG FGYQLSNRSI GVLFNSGTHM VLPAHRRHVH YNLTNSRHFV FPTSAVPEQL 540

QGQMSILQYF ATYMEKNLMK GGDLPCHEEG SQTPLLLLQW VKTEHALLML FSNGTLQVNF 600

YNDHTKIILC KPQDAYLLTY INRDRNSQTF LLNTLTQTGC SSEMYHRLRY TVKLLQQKAE 660

S 661

Nucleotide Sequence
(FASTA)

ATGGAAACCG CTTGTTATAT TCAGTCCCAC CCGTATCAAT GCAACGCGCT GGGCGCGGAT 60

CTGTATCGGA CTACTCACCA GCACGGTCCC GCTGTGCCCC GCTCACCCAA GCCTGAGCCC 120

CAGCGCTCTC CGCAGCAGCC CTGTAAGCTC ATAACAGACC CGCTGACCGG CAAGGCGTAC 180

ACTAAGGGCA GGCTCCTTGG CAAGGGTGGG TTTGCACGCT GTTATGAAAT GACAGAGGTT 240

GCCACCAACA AAACATATGC AGTCAAAGTT ATTCCACACA GCCGTGTCGC AAAACCTCAC 300

CAGAGGGAGA AGATTGTAAA TGAAATAGAC CTTCACAGAG AGCTTCATCA CAAACATGTG 360

GTCAAATTCT CACATCATTT TGAAGACTCT GAGAATATCT ACATTTTTCT TGAAATTTGC 420

AGCCGAAAAT CTCTTGCCCA CATCTGGAAA GCCCGGCACA CACTACTGGA ACCAGAAGTG 480

CGGTATTTTT TGAAGCAGAT CATTTCTGGG TTGAAGTATC TGCACCTTAA AGGCATCCTG 540

CACAGAGACT TGAAACTAGG TAATTTCTTC ATCAATGAGA GCATGGAACT AAAAGTTGGT 600

GACTTCGGAT TAGCTGCCCG TTTGGAGCCC CCTGAGCAGA GAAAGAAGAC CATATGTGGA 660

ACACCAAACT ACTTGGCACC TGAAGTTCTT TACAGGCAGG GGCATGGACC TGAATCTGAC 720

ATATGGTCTC TAGGATGTGT CATGTATACC TTGCTCTGTG GCACTCCACC GTTTGAGACC 780

TCAGATCTAA AGGAGACCTA CCGCTGTATC AAACAGGTGA AATATACCTT ACCAGCATGT 840

CTGTCCTCTG CTGCCAAACA CCTTCTCATG GGAATCCTAA AACGCACCCC TGGAGAGCGA 900

CTTACACTTG ACCAGATTCT AGAACATGAA TTCTTCACAA AGGGTTATAC TCCAGACAAG 960

CTTCCCCCAA GCAGCTGTGT GATGGTCCCT GACCTACATC CTCCCAATCC TGCAAAGAGC 1020

CTCTTCACTA AAGTTGCCAA AAGCTTGTTT GGCAAAACCA AATCAAAAAC AAAGAAAAGT 1080

CCCACTGAGG AGAAAGATGA TATTTCTAAG ATAGTCACAG GACTGGTTAA AACGTCCATC 1140

TGCAGACAGC TGAGTTATAA GACTGTGGAT GGGAATGAGG TTGCCCCAGT AACTAGTCAT 1200

GCTGTAAGTG CCAACTCCAG TCCTGTGGAC ACTTTGACAG AAGAAGCTTC TGGGAAATCT 1260

GTGTCACGTT CTATCCGTGG CAGTTTGGTC AGCAGTAGTG ATGCATTTGA AGACTGTGTC 1320

ACAGCTTCTG GAGTGATAGA GACTGCCCTT GCAGTTTTAA AGGATTCTCT GTCCTCTATG 1380

CCAGCAGTAG AGGGGAATCC TCCCAGTCTG GCAAAACCTG AGCATTTTGT CTGGGTTAGC 1440

AAATGGGTTG ATTACTCTAA CAAATATGGC TTTGGCTATC AGCTGTCCAA CCGCAGTATA 1500

GGCGTTCTCT TTAACAGTGG AACCCATATG GTGCTTCCTG CTCATCGCAG ACATGTGCAC 1560

TACAACCTCA CAAATAGCCG CCATTTTGTT TTTCCAACGT CTGCTGTTCC GGAGCAGCTG 1620

CAGGGTCAGA TGAGCATTTT ACAGTACTTT GCCACATATA TGGAAAAAAA TCTGATGAAG 1680

GGAGGAGACC TTCCATGCCA TGAGGAAGGA AGCCAGACTC CATTGCTACT TTTGCAATGG 1740

GTGAAAACGG AACATGCACT GCTGATGCTC TTCAGCAATG GTACCCTACA GGTGAACTTT 1800

TACAACGACC ACACTAAAAT TATCCTCTGC AAGCCTCAGG ATGCATACCT GCTAACCTAC 1860

ATAAATAGAG ACCGTAATTC TCAGACATTC CTACTGAATA CTCTAACACA AACTGGCTGT 1920

AGTTCAGAAA TGTACCATCG CTTAAGATAC ACTGTGAAAC TGCTTCAGCA AAAGGCAGAG 1980

TCCTAG 1986

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y++g+llGkGgfa+cye++++ t++++avkv+p+s++ak++qrek+ +ei++hr+l+hk+

Q: 60    YTKGRLLGKGGFARCYEMTEVATNKTYAVKVIPHSRVAKPHQREKIVNEIDLHRELHHKH  119

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +vk++++fed+en+y++le+csr+sla+++k+r++l epevry+l+qi+sglkylh k i

Q: 120   VVKFSHHFEDSENIYIFLEICSRKSLAHIWKARHTLLEPEVRYFLKQIISGLKYLHLKGI  179

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle++e+rkkt+cGtPny+aPevl ++gh+ e+

Q: 180   LHRDLKLGNFFINESMELKVGDFGLAARLEPPEQRKKTICGTPNYLAPEVLYRQGHGPES  239

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diWslGc++ytll+G+PPfet++lkety++ik+ +y+lP+ ls++ak+l+  +lk++P e

Q: 240   DIWSLGCVMYTLLCGTPPFETSDLKETYRCIKQVKYTLPACLSSAAKHLLMGILKRTPGE  299

         ************************************************************

S: 241   rpsleevlkdefl  253

         r++l+++l++ef+

Q: 300   RLTLDQILEHEFF  312

         ************8

Domain Sequence
(FASTA)

YTKGRLLGKG GFARCYEMTE VATNKTYAVK VIPHSRVAKP HQREKIVNEI DLHRELHHKH 60

VVKFSHHFED SENIYIFLEI CSRKSLAHIW KARHTLLEPE VRYFLKQIIS GLKYLHLKGI 120

LHRDLKLGNF FINESMELKV GDFGLAARLE PPEQRKKTIC GTPNYLAPEV LYRQGHGPES 180

DIWSLGCVMY TLLCGTPPFE TSDLKETYRC IKQVKYTLPA CLSSAAKHLL MGILKRTPGE 240

RLTLDQILEH EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013