EKS-XET-00309

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00309

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	396.6	5.3E-119	84	367	284

Status

Reviewed

Ensembl Protein

ENSXETP00000029916

UniProt Accession

Q66I46;

Protein Name

MAP kinase-interacting serine/threonine-protein kinase 2

Protein Synonyms/Alias

MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2;

Gene Name

mknk2

Gene Synonyms/Alias

mknk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000013667	ENSXETP00000029916	ENSXETT00000029916

Organism

Xenopus tropicalis

Functional Description

May play a role in the response to environmental stressand cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap (By similarity).

Protein Length

468

Protein Sequence
(FASTA)

MVQKKTTEMK GFHRSFKGQN PFDAAYEMES RNMASVFNFD CPSRPDVPSS APIDIPDAKK 60

RTKKKKRCRA TDSFTGRFED MYQLQQEILG EGAYAKVQSC INLITNKEYA VKIIEKRPGH 120

SRSRVFREVE MLYQCQGHSN VLELIEFFEE EDKFYLVFEK MCGGSILNHI HRRRHFNERE 180

ASFVVRDIAE ALNYLHNKGI AHRDLKPENI LCESPHQVSP VKICDFDLGS GIKLNSDCSP 240

ISTPELLTPC GSAEYMAPEV VEAFNEEASI YDKRCDLWSL GVILYIMLSG YPPFVGHCGS 300

DCGWDRGEAC PACQNMLFVS IQEGKYEFPE KDWAHISSGA KDLISKLLLR DAKKRLSAAQ 360

VLQHPWVQGN APDNTLPTPI ILQRHRNSSA KDLTSFAAEA IAMNRQLMER EEEEEGTESS 420

SSCPIVVKAT SCSMQLSPPS ESKLAKRRHG SKGGISPPSL APLLIVSD 468

Nucleotide Sequence
(FASTA)

ATGGTACAGA AGAAAACTAC TGAAATGAAA GGATTTCACC GTTCTTTTAA GGGTCAGAAC 60

CCTTTTGATG CAGCTTATGA GATGGAATCC AGAAACATGG CGTCAGTGTT CAATTTTGAC 120

TGTCCCTCAC GTCCTGATGT GCCTTCCAGT GCCCCCATTG ACATCCCTGA TGCCAAAAAA 180

AGAACCAAGA AGAAAAAACG CTGCAGGGCA ACAGATAGCT TCACTGGGCG GTTTGAAGAT 240

ATGTACCAAC TGCAGCAAGA AATTCTTGGT GAAGGCGCTT ATGCAAAAGT TCAGAGCTGC 300

ATTAATCTCA TCACCAATAA GGAGTATGCT GTGAAGATAA TTGAGAAAAG GCCTGGCCAC 360

AGTAGAAGCA GAGTTTTCAG GGAGGTGGAG ATGTTGTATC AGTGTCAGGG TCATAGTAAT 420

GTATTGGAAC TAATAGAATT CTTTGAAGAA GAAGATAAAT TCTACCTGGT GTTTGAGAAG 480

ATGTGTGGTG GTTCCATACT GAATCATATC CACAGACGCA GGCATTTCAA TGAACGAGAG 540

GCCAGTTTTG TGGTGCGGGA CATTGCAGAA GCTCTGAACT ATTTGCACAA CAAAGGCATA 600

GCACATAGGG ATCTGAAACC TGAAAATATC CTTTGTGAAA GCCCTCATCA AGTATCACCA 660

GTGAAGATTT GTGATTTCGA CCTTGGAAGT GGTATAAAGC TGAACAGCGA TTGCTCCCCA 720

ATCTCCACGC CAGAGCTGCT TACACCTTGT GGATCTGCAG AGTACATGGC CCCTGAAGTG 780

GTAGAAGCTT TTAATGAAGA AGCATCAATA TATGACAAAC GTTGTGACTT GTGGAGCCTT 840

GGAGTGATCT TGTACATCAT GTTGAGTGGA TATCCTCCAT TTGTGGGACA CTGTGGCAGT 900

GACTGTGGAT GGGATCGAGG CGAGGCTTGT CCTGCATGCC AGAACATGCT GTTTGTAAGT 960

ATCCAGGAAG GAAAATATGA ATTCCCTGAG AAAGATTGGG CTCACATCTC ATCTGGAGCA 1020

AAAGATCTTA TCTCAAAACT GCTGCTTCGA GATGCCAAGA AGAGACTGAG TGCAGCGCAA 1080

GTCCTGCAGC ACCCATGGGT TCAGGGGAAT GCACCTGACA ACACACTTCC CACTCCAATT 1140

ATCTTGCAAC GGCACAGGAA CAGTAGTGCC AAAGATCTTA CTTCATTTGC GGCAGAAGCC 1200

ATTGCAATGA ACCGCCAGCT AATGGAACGG GAGGAGGAAG AAGAAGGAAC CGAAAGCTCC 1260

TCATCCTGCC CCATTGTGGT GAAAGCTACC TCTTGCTCCA TGCAACTATC TCCACCTTCA 1320

GAGTCAAAAC TGGCAAAAAG GAGACACGGC AGCAAGGGGG GAATATCCCC TCCCAGTTTG 1380

GCGCCCCTGC TAATTGTCAG TGACTAA 1407

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghknive  56

         l++e+lGeG+++kv++c++  t+++ya+ki+     ++r++v+reve+++q++gh+n++e

Q: 84    LQQEILGEGAYAKVQSCINLITNKEYAVKIIekrpgHSRSRVFREVEMLYQCQGHSNVLE  143

         789*********************************************************

S: 57    lidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhskn  116

         li++fe    +e++++lv+ek+ GG++l++i++r++f+e+eas vv+dia+al++lh+k+

Q: 144   LIEFFE----EEDKFYLVFEKMCGGSILNHIHRRRHFNEREASFVVRDIAEALNYLHNKG  199

         ******....9*************************************************

S: 117   iahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyvaPe  168

         iahrDlkpen+L+es+++++pvk+cDf+l+++++ +        +el tpc++aey+aPe

Q: 200   IAHRDLKPENILCESPHQVSPVKICDFDLGSGIKLNsdcspistPELLTPCGSAEYMAPE  259

         ********************************944446999999****************

S: 169   vleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklke  217

         v+ea++eea++ydk+CDlWslGvilyi+l+GypPf++++g            a++++l+

Q: 260   VVEAFNEEASIYDKRCDLWSLGVILYIMLSGYPPFVGHCGsdcgwdrgeacPACQNMLFV  319

         ***************************************99*********99********

S: 218   riqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         +iqegkyefPe++W+++s+ akdli+klL rd+k+rl++++vl+hpwv

Q: 320   SIQEGKYEFPEKDWAHISSGAKDLISKLLLRDAKKRLSAAQVLQHPWV  367

         ***********************************************8

Domain Sequence
(FASTA)

LQQEILGEGA YAKVQSCINL ITNKEYAVKI IEKRPGHSRS RVFREVEMLY QCQGHSNVLE 60

LIEFFEEEDK FYLVFEKMCG GSILNHIHRR RHFNEREASF VVRDIAEALN YLHNKGIAHR 120

DLKPENILCE SPHQVSPVKI CDFDLGSGIK LNSDCSPIST PELLTPCGSA EYMAPEVVEA 180

FNEEASIYDK RCDLWSLGVI LYIMLSGYPP FVGHCGSDCG WDRGEACPAC QNMLFVSIQE 240

GKYEFPEKDW AHISSGAKDL ISKLLLRDAK KRLSAAQVLQ HPWV 284

Keyword

ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Translation regulation; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006417	; P:regulation of translation

KEGG

xtr:780232

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013