EKS-XET-00510

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00510

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	518.1	5.1E-156	498	762	265

Status

Unreviewed

Ensembl Protein

ENSXETP00000030197

UniProt Accession

A0JP83; F6YK41;

Protein Name

Protein Synonyms/Alias

Axl protein;

Gene Name

axl

Gene Synonyms/Alias

axl;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000013781	ENSXETP00000030197	ENSXETT00000030197

Organism

Xenopus tropicalis

Functional Description

Protein Length

897

Protein Sequence
(FASTA)

TVRNIAVSEH KDVKFNCSIV VPNTDNGDQI TWWKDGKLLP SSDRISIQSF EIPDLTVTSM 60

SSSCSIAGVQ RLDNGTYNCK LTVEGEEVVS EPIYIQVEGL PYFIQQPERL NVTKNMPFNL 120

TCEAVGPPEP VEIYWIQNST KINTIPEVSP AVFTVSGLEE PAIFSCEAHN KKGLTVSNDV 180

RINIKGIPSP PIKVDVINRT AHGILISWIP GFDGYSPLSV CIIKMKEMLQ SNASNTRYFN 240

TPVPPYEYQI GGLKASSKYN FSISCKNEVG WSSSSLWIVN STTEGPPSAA PQNLTVGVNN 300

SHSVLEVSWV SPPVAEMNGQ LLGYTIIHKW KVYGRKKDLL DEEDEYSVYS NSTAAFLPIK 360

ATNATCTVTV AARTNGGVGP YSLPVQLLIP GDGSVTSATS STPAPGNVSP YVILLGFICS 420

LMILLLLIYG VVMCLRRKKE TEFGHAFIHS EDSDIVVNFK AKKSYNRRAI EITLSTLGIN 480

QDLQQKLEDV MVERNLLNLG KVLGEGEFGS VMEGELQYSD GTNHKVAVKT MKMDNFSQRE 540

IEEFLSEAAC MKDFNHPNVI RLLGVCLEVG PRRIPKPMVI LPFMKYGDLH SFLLSSRIGS 600

GPQHVPLRTL VKFMIDIATG MEYLSSRNFL HRDLAARNCM LRDDMTVCVA DFGLSKKIYS 660

GDYYRQGRIA KMPVKWIAVE SLADRIYTVK SDVWAFGVTM WEISTRGMTP YPGVQNHEIY 720

DYLLVGHRLK QPPECLDDLY TVMYQCWLSD PTCRPSFTAL RENLEKIVEG LPPATDKEVL 780

YINTSLPEES EHLTQDPEVN EINVDPSYVQ ISPSNSETTT VTVEVHENHC SEERYILEGL 840

GEEHDGDFEQ SSTPLLQDNN ARSRAPWCEN NTFLACSAKT DDNQYTDDSA EDTEIMV 897

Nucleotide Sequence
(FASTA)

ACAGTGCGGA ATATTGCTGT TTCAGAGCAT AAAGATGTCA AGTTCAATTG CTCCATTGTG 60

GTCCCAAATA CAGATAATGG GGACCAGATC ACCTGGTGGA AGGATGGGAA GCTACTACCT 120

TCATCTGATC GCATTTCCAT CCAGTCTTTT GAAATCCCTG ATCTGACTGT AACATCTATG 180

TCATCCTCCT GCAGTATTGC AGGCGTTCAG AGGTTGGACA ATGGGACATA CAACTGTAAA 240

CTGACAGTAG AGGGGGAAGA AGTTGTTTCA GAGCCTATCT ACATCCAAGT GGAAGGTCTG 300

CCATATTTCA TTCAGCAACC TGAGAGATTA AATGTCACCA AGAACATGCC ATTTAATCTT 360

ACCTGTGAAG CAGTGGGACC CCCAGAACCT GTAGAGATTT ACTGGATCCA GAATAGTACA 420

AAAATCAATA CAATTCCAGA AGTTTCACCA GCAGTTTTTA CTGTATCGGG TCTGGAAGAA 480

CCTGCAATAT TCAGCTGTGA AGCACACAAC AAGAAAGGCC TGACTGTGTC CAATGATGTA 540

AGGATCAATA TAAAAGGTAT CCCATCGCCA CCAATTAAGG TCGATGTTAT AAATAGAACG 600

GCACATGGTA TTTTAATATC CTGGATTCCT GGATTTGATG GTTATTCTCC ACTGAGTGTC 660

TGCATTATAA AGATGAAGGA AATGCTACAA AGCAATGCTA GCAACACAAG GTACTTTAAC 720

ACCCCAGTGC CTCCCTATGA ATATCAGATT GGTGGATTAA AGGCATCTTC CAAATATAAC 780

TTTAGCATCT CCTGTAAGAA TGAAGTGGGC TGGTCTTCTT CAAGCTTGTG GATTGTTAAT 840

AGTACAACAG AAGGGCCTCC ATCGGCTGCT CCCCAGAATT TAACAGTGGG AGTAAATAAC 900

TCCCATTCCG TTCTTGAAGT GTCGTGGGTC AGTCCTCCAG TTGCGGAGAT GAACGGACAA 960

CTCCTGGGTT ATACAATAAT ACACAAATGG AAAGTGTATG GACGTAAAAA AGATCTGTTA 1020

GATGAGGAAG ATGAATATTC TGTGTACTCC AATTCTACTG CTGCATTTCT TCCCATCAAA 1080

GCCACCAATG CAACCTGCAC TGTAACTGTT GCAGCTCGTA CAAATGGAGG CGTTGGGCCC 1140

TACAGTCTGC CAGTGCAACT TCTCATCCCA GGAGATGGTT CAGTAACTTC AGCCACTTCT 1200

TCTACTCCAG CTCCAGGAAA TGTCAGTCCT TATGTGATTT TGCTTGGCTT CATCTGCAGC 1260

CTAATGATTC TCTTGCTGCT CATATATGGA GTGGTCATGT GTCTTAGAAG GAAGAAGGAA 1320

ACAGAATTTG GGCATGCTTT TATCCACTCA GAAGATTCTG ACATTGTAGT AAACTTCAAA 1380

GCTAAAAAGT CCTATAATAG GAGAGCAATT GAAATCACAC TGAGTACTTT AGGTATCAAT 1440

CAGGATCTGC AACAGAAACT GGAAGACGTC ATGGTTGAAA GGAACCTGTT AAACCTTGGG 1500

AAGGTGTTGG GTGAAGGTGA ATTTGGATCA GTGATGGAGG GGGAGCTCCA GTATTCTGAT 1560

GGAACCAATC ACAAAGTAGC TGTGAAAACT ATGAAGATGG ATAATTTTTC TCAGAGGGAA 1620

ATAGAGGAAT TCTTAAGCGA AGCGGCCTGC ATGAAAGACT TCAATCACCC AAACGTCATT 1680

AGATTGCTAG GTGTTTGTTT AGAAGTTGGA CCTCGGCGAA TCCCAAAGCC TATGGTGATT 1740

TTACCATTTA TGAAGTATGG AGATCTGCAC AGTTTTCTGC TGTCATCCAG AATTGGTTCT 1800

GGCCCTCAGC ATGTTCCCTT GAGGACCCTA GTAAAGTTTA TGATTGACAT TGCTACGGGC 1860

ATGGAGTATC TCAGCAGCAG AAACTTCCTA CACAGAGATT TAGCTGCTCG AAACTGCATG 1920

TTACGAGACG ACATGACTGT TTGTGTAGCT GATTTTGGTC TATCTAAGAA AATCTACAGC 1980

GGAGACTATT ATCGTCAGGG ACGTATCGCT AAGATGCCAG TGAAATGGAT TGCAGTGGAG 2040

AGCCTCGCTG ATCGCATCTA TACAGTCAAA AGTGATGTGT GGGCTTTTGG CGTCACAATG 2100

TGGGAAATAT CAACCAGAGG AATGACTCCT TATCCTGGGG TACAGAACCA TGAAATATAT 2160

GACTATTTGC TTGTGGGACA CAGGTTGAAG CAGCCCCCAG AGTGTTTGGA TGATCTTTAC 2220

ACAGTGATGT ACCAGTGCTG GTTATCCGAC CCTACTTGCC GCCCCTCTTT CACAGCACTA 2280

AGAGAGAACC TGGAGAAGAT CGTTGAGGGC TTGCCTCCTG CAACGGACAA AGAAGTTCTT 2340

TATATTAACA CAAGCTTACC TGAGGAGAGT GAGCATCTCA CTCAAGATCC AGAAGTGAAT 2400

GAAATAAATG TGGATCCAAG CTATGTTCAG ATCAGTCCCT CAAATTCTGA AACCACCACA 2460

GTTACAGTGG AGGTGCATGA AAATCATTGC AGTGAAGAAA GATATATTTT GGAAGGTTTA 2520

GGTGAAGAGC ATGATGGAGA TTTTGAGCAA TCAAGCACCC CCCTTTTGCA GGACAATAAT 2580

GCACGTAGCA GAGCTCCTTG GTGTGAAAAC AATACTTTTC TAGCCTGCAG CGCAAAGACT 2640

GATGACAATC AGTATACAGA TGACTCTGCT GAAGATACAG AAATCATGGT ATAG 2694

Domain Profile

S: 2     vlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdhp  61

          lgkvlgegefgsvmeg+l+  dg+  kvavkt+k+d+++++eieeflseaacmk+f+hp

Q: 498   NLGKVLGEGEFGSVMEGELQYSDGTNHKVAVKTMKMDNFSQREIEEFLSEAACMKDFNHP  557

         69**********************************************************

S: 62    nvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmvd  121

         nvirl+gv+le+  +  +pkp+vilpfmkygdlh+fll sr+g++p+++pl+tlvkfm+d

Q: 558   NVIRLLGVCLEVGPRR-IPKPMVILPFMKYGDLHSFLLSSRIGSGPQHVPLRTLVKFMID  616

         ************9997.*******************************************

S: 122   iasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvkw  181

         ia+gmeylssrnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvkw

Q: 617   IATGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW  676

         ************************************************************

S: 182   iaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedcl  241

         ia+esladr+yt+ksdvwafgvtmwei trg+tpy+gv+n+eiydyll g+rlkqp++cl

Q: 677   IAVESLADRIYTVKSDVWAFGVTMWEISTRGMTPYPGVQNHEIYDYLLVGHRLKQPPECL  736

         ************************************************************

S: 242   delydlmyrcweadpkdrpsfsvlre  267

         d+ly +my+cw  dp  rpsf+ lre

Q: 737   DDLYTVMYQCWLSDPTCRPSFTALRE  762

         ***********************996

Domain Sequence
(FASTA)

NLGKVLGEGE FGSVMEGELQ YSDGTNHKVA VKTMKMDNFS QREIEEFLSE AACMKDFNHP 60

NVIRLLGVCL EVGPRRIPKP MVILPFMKYG DLHSFLLSSR IGSGPQHVPL RTLVKFMIDI 120

ATGMEYLSSR NFLHRDLAAR NCMLRDDMTV CVADFGLSKK IYSGDYYRQG RIAKMPVKWI 180

AVESLADRIY TVKSDVWAFG VTMWEISTRG MTPYPGVQNH EIYDYLLVGH RLKQPPECLD 240

DLYTVMYQCW LSDPTCRPSF TALRE 265

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

xtr:100036629	;
xtr:100497963	;

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00409	; IG; 2.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013