EKS-XET-00159

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00159

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	447.7	1.6E-134	356	615	260

Status

Unreviewed

Ensembl Protein

ENSXETP00000031627

UniProt Accession

F6VT32;

Protein Name

Protein Synonyms/Alias

Gene Name

prkch

Gene Synonyms/Alias

prkch;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000014450	ENSXETP00000031627	ENSXETT00000031627

Organism

Xenopus tropicalis

Functional Description

Protein Length

695

Protein Sequence
(FASTA)

FMAVTMRFNG SLKLKIGEAV ELQPTRWSLR HSVFKKGSCL LDPYITINVD ECRIGQTSIK 60

HRTNKPTYNE EFCVTVSEGS KVELAVFHET PIGYDDFVAH CTLSFEELIK AAGPPTRLKG 120

WMDLEPEGKL FVVITLIGTF TEGTMRDGRL IKHFTRKRQR AMRRRVHQVN GHKFMATYLK 180

QPTYCSHCKD FIWGVFGKQG YQCQVCTCVV HKRCHQLIVT ACTCKSTTSK VEKQIFEQRF 240

GINLPHKFRY HNYKVPTFCD HCGSLLWGLV KQGLQCKICK MNVHKRCEAN VAHNCGVNSV 300

DLANALAGMG LHPGNIPFKQ LALKSLLQYN IKNNNHLEED SISNTSSQYK FGIDDFTFLR 360

VLGKGSFGKV MLAKSKESDS LYAVKVLKKD VILQDDDVEC TMTEKRILSL ACNHPFLTQL 420

FCCFQTLDRL FFVMEFVNGG DLMFHIQKSR RFDEARACFY SAEITSALMF LHDKGVIYRD 480

LKLDNVLLDH EGHCKLADFG MCKEGIREGC TTSTFCGTPD YIAPEILQEM QYGPLVDWWA 540

MGVLLYEMLC GHAPFEAENE DDLFEAILND EVVYPGWLSQ DAVEILQAFM KKKPAKRLGS 600

LSLGGEKAIL WHPFFKDINW DELNKKTIEP PFRPRIKARE DVSNFDPEFI KEDAVLTPID 660

ESLLPLINQE EFRNFSYTAP ELQNTFQDGS AQMPQ 695

Nucleotide Sequence
(FASTA)

TTCATGGCTG TCACTATGAG GTTTAACGGC AGTCTAAAGT TAAAAATTGG GGAGGCGGTG 60

GAACTGCAGC CCACCCGGTG GTCCCTGAGA CACTCCGTGT TCAAAAAAGG TTCCTGCTTG 120

CTGGACCCCT ATATCACCAT CAATGTGGAC GAGTGCCGGA TCGGCCAGAC CAGCATCAAG 180

CACCGGACCA ACAAGCCCAC GTATAACGAG GAGTTCTGTG TGACTGTGAG TGAGGGCAGC 240

AAGGTGGAGC TGGCCGTCTT CCATGAGACC CCCATCGGCT ACGATGATTT CGTGGCTCAC 300

TGCACTCTCA GCTTCGAGGA GCTCATCAAG GCTGCGGGAC CACCGACTCG TTTGAAGGGT 360

TGGATGGATT TGGAACCAGA AGGCAAGTTG TTCGTTGTGA TAACCCTAAT AGGCACCTTT 420

ACCGAAGGTA CCATGAGAGA TGGAAGGCTT ATCAAGCACT TTACCCGAAA ACGTCAGAGA 480

GCTATGAGAA GGAGGGTACA CCAGGTCAAT GGGCACAAAT TTATGGCAAC ATATCTCAAG 540

CAACCAACAT ACTGCTCTCA CTGTAAAGAC TTCATTTGGG GTGTGTTTGG AAAGCAGGGC 600

TACCAGTGCC AAGTGTGCAC GTGTGTTGTA CACAAGCGCT GCCACCAGCT GATTGTCACA 660

GCTTGCACGT GCAAGAGCAC CACCAGCAAA GTGGAGAAAC AGATTTTTGA ACAGAGGTTT 720

GGGATCAATT TGCCACACAA ATTCCGGTAT CACAATTACA AAGTACCAAC CTTTTGCGAC 780

CATTGTGGAT CTTTACTCTG GGGTTTGGTG AAGCAAGGAC TGCAATGCAA AATATGTAAA 840

ATGAATGTAC ATAAACGCTG TGAAGCAAAT GTGGCACATA ACTGTGGAGT GAATTCGGTG 900

GATCTGGCAA ATGCTCTGGC TGGGATGGGC CTTCACCCTG GCAATATTCC TTTCAAGCAG 960

TTAGCCTTAA AAAGTCTGCT TCAATATAAT ATCAAGAATA ACAATCACCT TGAAGAGGAC 1020

TCTATATCAA ATACATCTTC TCAGTACAAA TTTGGCATTG ATGATTTCAC ATTCCTTCGT 1080

GTTTTGGGCA AGGGCAGTTT TGGGAAGGTA ATGCTTGCTA AGTCAAAGGA GTCTGACAGT 1140

CTCTATGCAG TGAAGGTTCT AAAGAAGGAT GTGATTCTTC AGGATGACGA TGTGGAATGC 1200

ACTATGACAG AGAAGCGAAT TCTATCCCTG GCTTGCAATC ACCCCTTCCT CACCCAACTC 1260

TTCTGCTGCT TTCAGACTCT GGACAGGTTA TTTTTCGTCA TGGAGTTTGT AAATGGTGGA 1320

GACCTGATGT TTCACATTCA GAAATCTCGG CGATTTGATG AAGCTCGTGC CTGCTTTTAC 1380

AGTGCTGAAA TCACATCTGC ACTCATGTTT CTTCACGACA AAGGAGTCAT TTACAGAGAT 1440

CTGAAATTAG ACAATGTACT TCTCGATCAT GAAGGTCACT GCAAACTGGC CGACTTTGGT 1500

ATGTGCAAAG AGGGTATCCG GGAAGGCTGT ACAACATCGA CATTCTGCGG AACTCCTGAT 1560

TACATTGCAC CAGAGATATT ACAGGAGATG CAGTATGGAC CTCTAGTAGA TTGGTGGGCA 1620

ATGGGTGTTC TTTTGTACGA GATGCTCTGC GGCCATGCAC CTTTTGAAGC AGAAAATGAG 1680

GATGACCTCT TTGAAGCCAT ACTGAATGAT GAAGTAGTGT ATCCAGGCTG GCTGTCCCAG 1740

GATGCAGTAG AAATTCTACA AGCTTTCATG AAGAAAAAGC CGGCCAAGCG TTTAGGAAGT 1800

TTGTCTTTGG GGGGTGAGAA GGCAATTTTG TGGCACCCTT TCTTTAAAGA CATCAACTGG 1860

GATGAGCTGA ACAAGAAGAC GATTGAGCCA CCTTTTAGAC CCAGGATTAA AGCTAGAGAG 1920

GATGTCAGCA ACTTTGACCC GGAGTTTATC AAGGAGGATG CAGTGTTGAC CCCTATTGAT 1980

GAGAGCCTCC TGCCACTGAT CAATCAGGAG GAATTTAGAA ACTTTTCCTA TACTGCTCCA 2040

GAGCTTCAGA ACACTTTTCA GGACGGCAGT GCTCAGATGC CTCAGTAA 2088

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlGkGsfgkv+la++k++d+lya+kvlkkdv+lqdddve+t++ekr+l+la ++p

Q: 356   FTFLRVLGKGSFGKVMLAKSKESDSLYAVKVLKKDVILQDDDVECTMTEKRILSLACNHP  415

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+qlf+cfqt drlffv+e+vnGGdlmfhiqk+r+++e+ra fy+aei++al+flh+kg

Q: 416   FLTQLFCCFQTLDRLFFVMEFVNGGDLMFHIQKSRRFDEARACFYSAEITSALMFLHDKG  475

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         +iyrdlkldnvlld+eGh+kladfG+cke+i eg ttstfcGtPdyiaPeil+e++yg

Q: 476   VIYRDLKLDNVLLDHEGHCKLADFGMCKEGIREGCTTSTFCGTPDYIAPEILQEMQYGPL  535

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyeml+g++Pfe+e+ed+lfe+il++ev+yP +ls++aveil+++++k+p+

Q: 536   VDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPGWLSQDAVEILQAFMKKKPA  595

         ************************************************************

S: 241   krlGvk.eegeedikehaff  259

         krlG+    ge++i  h+ff

Q: 596   KRLGSLsLGGEKAILWHPFF  615

         *****648999********9

Domain Sequence
(FASTA)

FTFLRVLGKG SFGKVMLAKS KESDSLYAVK VLKKDVILQD DDVECTMTEK RILSLACNHP 60

FLTQLFCCFQ TLDRLFFVME FVNGGDLMFH IQKSRRFDEA RACFYSAEIT SALMFLHDKG 120

VIYRDLKLDN VLLDHEGHCK LADFGMCKEG IREGCTTSTF CGTPDYIAPE ILQEMQYGPL 180

VDWWAMGVLL YEMLCGHAPF EAENEDDLFE AILNDEVVYP GWLSQDAVEI LQAFMKKKPA 240

KRLGSLSLGG EKAILWHPFF 260

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013