EKS-XET-00356

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00356

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	386.2	1.0E-115	198	491	294

Status

Unreviewed

Ensembl Protein

ENSXETP00000031689

UniProt Accession

F6U8C1;

Protein Name

Protein Synonyms/Alias

Gene Name

tgfbr2

Gene Synonyms/Alias

tgfbr2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000014480	ENSXETP00000031689	ENSXETT00000031689

Organism

Xenopus tropicalis

Functional Description

Protein Length

521

Protein Sequence
(FASTA)

LCRFCDVKET TCENQGYCTS VCNIASVCEH QEEVCIAIWR NKDGNITEET MCHDPKKELY 60

GYKLDDYNEK ECIMKEKKTS EGIMSMCSCR GKLCTERFYF PPANETNIDP SKDILLKVLL 120

ITLLPLVWIT IAVIVGFYFY RVQRTKKLKK KWEKNPKCMR HPDMDCSDAC AIMIDDDRSD 180

ISSTCANNLN HNTELLPIEL DTLVGKGRFA EVYKAKLKQN TSEQYETVAV KIFHFEEYAS 240

WKMEKDIFSD MNLKHENVLQ FLTAEERKTD TGKQYWLITA FHSKGNLQEY LSKHIISWED 300

LMKLGGSLAR GVAHLHSDHT PCGRPKTPIV HRDIKSSNIL VKNDLTCCLC DFGLSLWLEP 360

SLSVDDLANS GQVGTARYMA PEVLESRINL ENIESFKQTD VYSMALVLWE ITSRCNAIGD 420

VKDYEPPFGT KVREHPCVES MKDNVLRDRG RPEISNSWLS HQGIQLVCET ITECWDQDPE 480

ARLTAQCVEE RFSEMETLDR LSERSCSEEK IPEDCSENAS K 521

Nucleotide Sequence
(FASTA)

TTGTGTAGGT TTTGTGATGT GAAAGAGACA ACATGCGAAA ACCAAGGCTA CTGTACCAGT 60

GTGTGCAACA TAGCCTCCGT TTGTGAGCAC CAAGAAGAAG TGTGCATAGC TATATGGAGG 120

AATAAGGATG GCAACATCAC CGAGGAAACA ATGTGTCATG ACCCAAAAAA GGAACTGTAT 180

GGCTATAAAC TGGATGACTA TAATGAGAAA GAGTGCATCA TGAAGGAGAA AAAGACAAGT 240

GAGGGAATAA TGTCCATGTG TTCGTGTAGA GGAAAACTTT GTACTGAGAG ATTTTATTTT 300

CCTCCAGCAA ATGAGACAAA TATAGACCCA TCTAAAGACA TACTCCTGAA AGTTCTTCTC 360

ATCACTCTTC TTCCACTGGT CTGGATCACC ATTGCAGTCA TCGTCGGCTT CTACTTCTAC 420

CGTGTTCAGA GAACAAAGAA ACTGAAAAAG AAATGGGAAA AGAATCCAAA GTGCATGCGC 480

CATCCCGATA TGGACTGCAG CGATGCCTGT GCGATTATGA TAGACGATGA TCGTTCTGAC 540

ATCAGTTCAA CATGTGCCAA CAACCTAAAC CACAATACTG AGCTTCTCCC AATTGAATTA 600

GACACTTTGG TTGGGAAAGG TCGATTTGCT GAAGTGTACA AGGCCAAGCT AAAACAAAAT 660

ACATCAGAAC AGTATGAAAC AGTGGCTGTC AAAATTTTCC ATTTTGAAGA ATATGCATCT 720

TGGAAGATGG AAAAAGATAT TTTTTCTGAC ATGAATCTGA AACATGAGAA CGTACTGCAG 780

TTCCTGACAG CAGAAGAGAG GAAAACTGAC ACTGGCAAAC AGTATTGGCT CATCACTGCT 840

TTCCACTCTA AAGGCAATCT ACAAGAATAT TTATCCAAGC ATATCATCAG CTGGGAAGAC 900

CTTATGAAGC TTGGAGGCTC TTTGGCCCGT GGCGTTGCTC ATTTGCACAG TGATCACACA 960

CCCTGTGGCA GACCAAAGAC ACCAATTGTT CACCGCGACA TTAAGAGCTC AAATATTTTG 1020

GTTAAAAATG ATCTCACATG TTGCTTGTGT GACTTCGGTC TGTCTCTTTG GCTTGAACCT 1080

TCACTTTCAG TGGATGATCT TGCAAACAGT GGCCAGGTCG GAACTGCTAG GTATATGGCT 1140

CCAGAGGTTC TAGAGTCTAG AATCAATCTG GAGAACATAG AATCATTTAA GCAAACTGAT 1200

GTTTATTCAA TGGCGCTTGT CCTTTGGGAA ATCACATCCC GCTGCAATGC CATTGGAGAT 1260

GTAAAGGACT ACGAGCCTCC ATTTGGCACA AAAGTGCGGG AGCACCCATG TGTTGAAAGC 1320

ATGAAGGACA ATGTATTGAG GGATAGAGGG AGACCTGAAA TCTCCAACAG CTGGCTTAGC 1380

CATCAGGGGA TCCAGCTTGT ATGTGAGACT ATAACAGAAT GTTGGGACCA AGACCCAGAA 1440

GCCCGTCTCA CTGCTCAGTG TGTAGAGGAA AGGTTCAGTG AAATGGAGAC CCTCGACAGA 1500

CTCTCAGAGA GAAGCTGTTC TGAAGAGAAG ATACCAGAGG ACTGTTCAGA GAATGCAAGC 1560

AAATAG 1566

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif+ e+ aswk Ek+i++ ++l+hen

Q: 198   IELDTLVGKGRFAEVYKAKLKQntseqyETVAVKIFHFEEYASWKMEKDIFSDMNLKHEN  257

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         +lqf++a+++++d+ ++++l+t++h kg+L++yL+++++++e+l++l  sla+G+ahLH+

Q: 258   VLQFLTAEERKTDTGKQYWLITAFHSKGNLQEYLSKHIISWEDLMKLGGSLARGVAHLHS  317

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K  i+HRD+ks Nilvk+dltcc++D+GL+l le + ++ dla++ qvGt

Q: 318   D-HTPCGRPKTPIVHRDIKSSNILVKNDLTCCLCDFGLSLWLEPSLSVDDLANSGQVGTA  376

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  + v++y++pf ++v+++

Q: 377   RYMAPEVLESRINLENIESFKQTDVYSMALVLWEITSRCNA-IGDVKDYEPPFGTKVREH  435

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+i+++w +++ ++ ++++++ecWd+dpeaRlta++v++r

Q: 436   PCVESMKDNVLRDRGRPEISNSWLSHQGIQLVCETITECWDQDPEARLTAQCVEER  491

         *****************************************************998

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQYET VAVKIFHFEE YASWKMEKDI FSDMNLKHEN 60

VLQFLTAEER KTDTGKQYWL ITAFHSKGNL QEYLSKHIIS WEDLMKLGGS LARGVAHLHS 120

DHTPCGRPKT PIVHRDIKSS NILVKNDLTC CLCDFGLSLW LEPSLSVDDL ANSGQVGTAR 180

YMAPEVLESR INLENIESFK QTDVYSMALV LWEITSRCNA IGDVKDYEPP FGTKVREHPC 240

VESMKDNVLR DRGRPEISNS WLSHQGIQLV CETITECWDQ DPEARLTAQC VEER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013