EKS-XET-00372
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00372
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR481.37.1E-145710966257
StatusUnreviewed
Ensembl ProteinENSXETP00000033165
UniProt AccessionF6SK42;
Protein Name
Protein Synonyms/Alias
Gene NameLOC100492078
Gene Synonyms/Alias LOC100492078;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000015145ENSXETP00000033165ENSXETT00000033165
OrganismXenopus tropicalis
Functional Description
Protein Length1294
Protein Sequence
(FASTA)
CIHFICANWL CCLSYAVMGE VCTGTDMKLL HPFSQRNHYE TLSTIYRDCQ VIQGNLEITY 60
LKEDNDVSFL KDIKEVQGYV LIAHNLLSYV PLENLRIIRG TQLYQERYAL AVLSNSDPSG 120
TAGLRELRMK NLTEILKGGV IMENNTQLCF QDTVLWADIL SQSNSQRNEV VLGSSNRQCP 180
TCSPGCGSLP SGKSGFCWGE GQEYCQILTS TICNSGCQRC KGNHSTHCCH EQCAAGCTGP 240
KNSDCLACLH FNHNGVCGLH CPPLRTYNPE TYESVHNEGG RYTFGASCVT SCPYNYLATE 300
VGSCTLFCPQ DNQEVIVGNV QKCEKCDKQC SKVCYGLGRD FLRTTQAVNA SIIHHFQGCT 360
KIFGSLVFLS ESFKPDPNKP NSVLNAQSLE VFKTLEEITG YIYIESWPEE LKSLNVFENL 420
RVIHGRMLQN GAYSLVLRNL SISHLGLRSL TEVSSGLVLI EGNPDLCFLE SAPWASLFRN 480
PRQTILKTIN KPQEACDQEG QNCFSRCDGN KCWGPGPSQC VRCNGFLRGH DCIESCNVPL 540
RYPREHVNGS QCVPCHPQCL PQNGTLTCNG TEAHQCMECA HYLDGEDCVE QCPSGVKGNS 600
FVPIWKYPDK DRICQLCNVN CSHSCNQLDE RGCPILPDNS QVYMVASIVI SILIVITIST 660
AIVLYIRRRK QLKKKHTMRR LLQDELVEPL TPSGAIPNQA QMRILKETEL KKMMILGSGA 720
FGTVYKGIWI PDGENIKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP YVCRLLGICL 780
TSTVQLVTQL MPYGCLLDYV RENKDRIASR DLLNWCVQIA KGMTYLEDVR LVHRDLAARN 840
VLVKSPSHVK ITDFGLARLL DVDETEYHAD GGKVPIKWMA LESILHRRFT HQSDVWSYGV 900
TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPVCTID VYMIMVKCWM IDSEFRPKFR 960
DLVGELSRMA RDPSRYVVIE NEEFLAQASP MTTQFYSALL QEVGMDDLVD AEEYLVPQRG 1020
FFPSEDVTSE HRSRISSTRS ATEMQAEQAL LQETAPSGAA LARTMSERSG GSGSDALSEG 1080
EYVFDPPQNE ESGSPHRYTD DPLHSGEDET DSCFFEGDCI SPSIPLHLPA EYVNQKDGER 1140
NHSPVKSQRT SVSTLERQKS TQERQKNTLE RQKSTLERQK SSLDRQKSTL ERQKSTLERQ 1200
KAQQCKNGLV RELRSPPALS SLDNPDYLPP PGLILPNGFP QAFDNPYYWN HELNLAKADG 1260
DPAQGHNGFT TPTAENPEYL GLDETMIRPR DITV 1294
Nucleotide Sequence
(FASTA)
TGTATACATT TTATATGTGC TAATTGGCTC TGCTGTCTCT CTTACGCAGT AATGGGGGAG 60
GTTTGCACTG GCACCGATAT GAAGCTGCTT CATCCCTTCA GCCAGAGAAA CCACTATGAG 120
ACTCTCTCTA CTATCTACCG TGACTGCCAA GTCATCCAAG GGAATTTAGA GATAACCTAC 180
CTAAAAGAAG ATAATGACGT ATCCTTTCTT AAGGACATTA AAGAAGTACA GGGCTATGTC 240
CTAATTGCGC ATAACCTGTT GAGTTATGTG CCCTTGGAGA ATTTACGGAT TATCCGTGGC 300
ACTCAGCTGT ACCAGGAACG ATACGCCCTC GCCGTACTGT CCAATTCAGA CCCCAGTGGG 360
ACGGCCGGCT TGCGGGAACT GCGCATGAAG AACCTAACAG AAATCCTAAA AGGCGGCGTG 420
ATCATGGAGA ATAACACCCA GTTATGTTTC CAGGACACAG TCTTGTGGGC AGATATCCTG 480
AGCCAAAGCA ACAGCCAGAG AAATGAGGTG GTCCTAGGCT CCAGCAACCG CCAATGCCCA 540
ACCTGCTCCC CTGGATGTGG CTCCCTTCCC TCAGGCAAAT CTGGATTTTG TTGGGGAGAG 600
GGACAGGAGT ACTGTCAGAT CTTAACCAGC ACTATCTGCA ACAGTGGATG CCAGAGATGT 660
AAAGGGAACC ATTCTACTCA CTGCTGTCAT GAGCAGTGTG CTGCAGGCTG CACTGGACCC 720
AAGAACTCTG ACTGCCTGGC CTGCCTTCAC TTTAACCACA ATGGAGTTTG TGGGTTGCAC 780
TGCCCGCCTC TCAGAACCTA CAATCCAGAG ACCTACGAGT CTGTACACAA TGAAGGTGGC 840
CGGTACACAT TTGGTGCAAG CTGTGTCACC TCTTGCCCAT ATAACTACCT TGCCACCGAG 900
GTTGGCTCGT GCACACTCTT TTGCCCTCAG GATAATCAGG AAGTGATTGT GGGCAATGTG 960
CAAAAATGTG AGAAATGTGA CAAGCAGTGC AGTAAAGTGT GTTATGGACT TGGAAGGGAC 1020
TTCTTGAGAA CGACACAAGC AGTTAATGCC TCTATCATCC ATCATTTCCA AGGCTGCACT 1080
AAGATCTTTG GGAGCCTGGT ATTCCTTTCT GAGTCGTTCA AACCAGATCC CAACAAACCC 1140
AACTCAGTCC TCAATGCACA GAGCCTTGAG GTCTTCAAGA CCCTTGAAGA AATCACAGGA 1200
TATATATATA TTGAGTCTTG GCCAGAAGAA CTCAAGAGTC TCAATGTTTT CGAAAACCTG 1260
CGGGTGATTC ACGGACGAAT GCTACAGAAC GGGGCGTATT CATTGGTCCT GAGGAACCTT 1320
TCAATCTCAC ACCTTGGCTT GCGCTCCCTG ACGGAAGTCA GCAGCGGGTT GGTGCTGATA 1380
GAAGGTAACC CAGACCTGTG CTTTTTGGAA AGCGCTCCGT GGGCTTCACT CTTTAGAAAC 1440
CCAAGACAAA CTATACTGAA GACAATCAAC AAACCCCAGG AAGCCTGCGA CCAAGAAGGG 1500
CAGAATTGCT TCAGTCGCTG TGATGGCAAC AAATGCTGGG GTCCTGGGCC ATCCCAATGT 1560
GTTCGGTGCA ATGGATTTCT GAGAGGCCAT GACTGCATTG AGTCTTGCAA TGTTCCCCTC 1620
AGATACCCAA GAGAGCACGT TAATGGAAGT CAGTGTGTGC CTTGCCACCC TCAGTGCCTC 1680
CCACAGAATG GAACTCTGAC ATGCAATGGC ACGGAAGCTC ACCAGTGTAT GGAGTGTGCT 1740
CACTATTTGG ACGGAGAAGA CTGTGTGGAG CAATGCCCTA GTGGGGTGAA GGGAAATTCC 1800
TTTGTACCCA TTTGGAAATA CCCTGACAAG GATCGGATCT GCCAGTTATG CAATGTCAAC 1860
TGCTCCCATT CGTGCAATCA GCTGGATGAA AGGGGCTGCC CAATTTTACC AGACAACAGC 1920
CAAGTGTACA TGGTAGCTTC AATTGTGATT AGCATTCTGA TTGTGATAAC CATATCAACT 1980
GCCATTGTGC TGTATATCCG GCGCCGAAAG CAGCTGAAGA AGAAGCACAC CATGCGCCGC 2040
CTTTTACAGG ATGAGCTTGT GGAACCGCTG ACTCCAAGTG GGGCTATTCC CAACCAAGCC 2100
CAGATGAGGA TCCTTAAGGA GACAGAACTT AAGAAAATGA TGATCCTAGG ATCTGGGGCA 2160
TTTGGTACTG TGTACAAGGG TATTTGGATT CCAGATGGTG AAAACATCAA AATCCCAGTT 2220
GCCATCAAAG TTTTGAGGGA GAACACGTCA CCTAAAGCCA ACAAAGAGAT CCTTGATGAA 2280
GCCTATGTGA TGGCAGGGGT GGGCAGCCCT TACGTTTGTC GGCTGCTAGG GATCTGCCTT 2340
ACATCCACCG TACAGCTTGT CACCCAACTC ATGCCGTACG GCTGCTTACT GGACTATGTG 2400
AGGGAGAACA AAGACCGCAT TGCCTCCAGA GATCTCCTCA ACTGGTGTGT GCAGATAGCA 2460
AAGGGGATGA CCTACCTGGA GGATGTGCGC TTGGTGCACA GAGACCTAGC TGCACGCAAT 2520
GTACTGGTGA AGAGCCCGTC ACATGTGAAA ATCACAGACT TTGGCCTGGC CCGACTATTG 2580
GATGTGGATG AGACTGAGTA CCATGCTGAT GGTGGAAAGG TCCCCATCAA ATGGATGGCT 2640
TTAGAGTCCA TTTTGCATAG AAGATTCACC CACCAGAGTG ATGTCTGGAG CTACGGTGTA 2700
ACAGTTTGGG AGCTCATGAC CTTTGGGGCA AAACCCTATG ATGGAATCCC GGCCCGAGAA 2760
ATCCCGGACC TTTTGGAAAA AGGGGAGAGG CTTCCACAGC CGCCAGTCTG CACCATAGAT 2820
GTTTATATGA TCATGGTTAA GTGCTGGATG ATAGACTCAG AATTCAGACC CAAGTTTCGG 2880
GACCTCGTTG GTGAACTCTC TCGTATGGCT CGGGATCCGT CACGTTATGT GGTCATTGAG 2940
AATGAAGAGT TCCTGGCTCA GGCGAGCCCG ATGACCACCC AGTTTTACAG TGCCTTGCTG 3000
CAGGAAGTCG GGATGGATGA CCTGGTGGAT GCAGAGGAAT ATCTGGTGCC CCAGAGGGGA 3060
TTCTTCCCAT CAGAGGATGT TACTTCCGAG CATCGCAGCC GGATTTCATC AACGCGGAGT 3120
GCTACAGAGA TGCAGGCAGA GCAGGCGCTG CTGCAGGAGA CTGCCCCCAG TGGTGCTGCA 3180
CTGGCTCGTA CCATGTCAGA GAGGTCGGGG GGCAGTGGCT CAGATGCATT AAGCGAAGGG 3240
GAATATGTGT TTGACCCACC CCAAAATGAA GAGAGCGGCT CTCCACACAG ATATACTGAT 3300
GACCCACTGC ACTCCGGCGA GGATGAGACT GACAGTTGTT TCTTTGAAGG AGACTGCATT 3360
TCCCCAAGCA TTCCCCTACA CCTACCAGCT GAGTACGTGA ACCAAAAGGA CGGAGAAAGG 3420
AACCATTCGC CTGTAAAATC CCAGAGAACA TCTGTTTCGA CCCTAGAGAG GCAGAAGTCC 3480
ACGCAGGAGA GGCAGAAGAA CACGCTGGAG AGGCAGAAGT CCACGCTGGA GAGACAGAAG 3540
TCCAGTTTGG ATAGACAAAA GTCCACCCTT GAAAGGCAGA AGTCCACATT AGAGAGGCAG 3600
AAGGCTCAGC AGTGCAAGAA CGGCCTTGTC CGAGAGCTGA GGAGCCCTCC TGCCTTGTCT 3660
TCTCTGGACA ATCCCGACTA CCTGCCCCCA CCGGGACTCA TCCTGCCAAA CGGCTTTCCC 3720
CAGGCCTTCG ACAATCCCTA TTACTGGAAC CACGAACTCA ACTTGGCTAA GGCTGACGGG 3780
GATCCTGCGC AGGGACATAA CGGATTCACC ACACCCACAG CCGAAAACCC CGAGTACTTG 3840
GGGCTGGATG AAACCATGAT CCGACCTCGG GACATAACTG TGTAA 3885
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkk+ +lGsGafGtvykGiwip+gen+kipvaikvl+e+t++kanke+ldea+v+a + +
Q: 710   LKKMMILGSGAFGTVYKGIWIPDGENIKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  769
         69999*******************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclldyvre+kd++ s++llnwcvqiakGm+yle+ 
Q: 770   PYVCRLLGICLTSTVQLVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDV  829
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvksp+hvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 830   RLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDETEYHADGGKVPIKWMALESILHRRF  889
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qpp+ctidvym++vkcw
Q: 890   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCW  949
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid+e rpkf++l+ e+
Q: 950   MIDSEFRPKFRDLVGEL  966
         *************9775
Domain Sequence
(FASTA)
LKKMMILGSG AFGTVYKGIW IPDGENIKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVCRLLGIC LTSTVQLVTQ LMPYGCLLDY VRENKDRIAS RDLLNWCVQI AKGMTYLEDV 120
RLVHRDLAAR NVLVKSPSHV KITDFGLARL LDVDETEYHA DGGKVPIKWM ALESILHRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPVCTI DVYMIMVKCW 240
MIDSEFRPKF RDLVGEL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XIM-00379
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007413; P:axonal fasciculation
GO:0001837; P:epithelial to mesenchymal transition
GO:0031101; P:fin regeneration
GO:0048914; P:myelination of anterior lateral line nerve axons
GO:0048932; P:myelination of posterior lateral line nerve axons
GO:0001755; P:neural crest cell migration
GO:0032285; P:non-myelinated axon ensheathment
GO:0048919; P:posterior lateral line neuromast development
GO:0014044; P:Schwann cell development
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013