EKS-XET-00371

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00371

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	485.8	2.9E-146	715	971	257

Status

Unreviewed

Ensembl Protein

ENSXETP00000034519

UniProt Accession

F6UFM4;

Protein Name

Protein Synonyms/Alias

Gene Name

egfr

Gene Synonyms/Alias

egfr;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000015826	ENSXETP00000034519	ENSXETT00000034519

Organism

Xenopus tropicalis

Functional Description

Protein Length

1211

Protein Sequence
(FASTA)

MKTSILNQTA SLISILSLKY QPSYCFSFFL VCLGNNNRLN QLGNTDEHYA SLKRMYDGCE 60

IVLGNLEITY LDRLNDTSFL RNIQEVGGYV LIAINSVRSI HLENLQIVRG NMLYKSTYAL 120

AIVSNESLNT TNALEELHMG RLTEILNGGV LISKNRKLCY LNTIQWNDIV HTDNPINKIS 180

VDKSFSPQCP KCDAESCNGS CWGPGQGNCQ KLTKLTCAQQ CSGRCRGPLP SDCCHSQCAS 240

GCTGPRENNC LACRKFRDGE TCKEGCPQLQ IYNPATYQMD LNPDGKYSFG ASCVKKCPHN 300

YVVTDHGSCV RTCNSDSQEV EENGIRICKK CDGSCNKDKV CDGINMGKLK SVLSVNASNI 360

DLFQNCTKVN GDVAILHVAG YGDPFTNTSK LDPAKLSVFK SVREITGSLL IQWWPDNYTD 420

LSVFENLETI RGRTKQHGIY SLAIVKRSIT SLGLRSLKEV SDGDVIIKTN KNLCFVNTIN 480

FTNIFRIPKQ ARIIEDNKSP EQCESEGNVC DPLCSEEGCW GPGPFQCVSC RKYMRGRECV 540

ENCNFLSGEP REYTEDGKCF ACNAECLQLN ETQTCSGPGA DECFKCGHNS DGPFCVKTCP 600

AGIQGENSTL IWKYPDETGA CQLCHPECKL GCVGHGLDGC PLPWSSHSVA AGVVGGILGA 660

VVIGLVAFFF IRRSRINRKR TLRRILQERE LVEPVTPSGE APNQALLRIL KETEFKKIKV 720

LGSGAFGTVY QGLWIPEGEG IKIPVAIKEL REATSPKANK EILDEAYVMA SVENPYVCRL 780

LGICLTSTVQ LITQLMPFGC LLDYVRDNKD NIGSQHLLNW CVQIAKGMNY LEERRLVHRD 840

LAARNVLVKG PQHVKITDFG LAKLLGADEK AYHAEGGKVP IKWMALESIL HRTYTHQSDV 900

WSYGVTVWEL MTFGLKPYDG IPASEISNIL EKGERLPQPP ICTIDVYMIM VKCWMIDAES 960

RPKFRELSAE FTKMARDPTR YLVIQGDDRM HLPSPVESKI HPALVQEGLG DIVDAEEYLL 1020

PHQGFFTSPS NSRTPLLSTM SSTSNNSPVI CTMRNGGPPV REDSFVQRYS TDPTVILEDS 1080

IDDEFLPVPE YVNQMVPKPI VETQTNAVYQ NLVPLGNTVS PKETLYQNSH SNGLNNPEYL 1140

NTGHTLVPKT DFDYSSIWDQ KANLQINLDN PDYQQDFFPK EPKTNGHFKI PAAQNPEYLG 1200

LAPVSDYIEA S 1211

Nucleotide Sequence
(FASTA)

ATGAAAACAT CTATCCTCAA TCAGACTGCT TCTCTGATAT CTATATTGTC TTTAAAATAC 60

CAGCCTTCAT ATTGTTTTTC TTTCTTTCTA GTCTGCCTGG GCAATAACAA CAGATTAAAT 120

CAGCTGGGTA ACACAGACGA ACACTATGCC AGCCTTAAAA GGATGTATGA TGGTTGTGAA 180

ATTGTGCTTG GTAATCTGGA AATCACTTAT TTAGACCGCC TGAACGATAC CTCCTTCCTG 240

CGGAACATAC AAGAAGTAGG AGGTTATGTG CTCATAGCAA TCAACTCTGT TAGATCCATT 300

CATCTTGAAA ACCTTCAAAT TGTTCGTGGG AATATGTTGT ACAAAAGCAC ATATGCTCTA 360

GCTATAGTGA GTAATGAATC ACTGAATACC ACTAATGCTT TGGAGGAACT GCATATGGGA 420

CGTTTGACAG AAATTCTTAA TGGCGGAGTC CTTATTTCAA AAAATCGGAA ACTTTGCTAC 480

TTGAATACCA TCCAGTGGAA TGATATTGTG CATACAGACA ATCCCATCAA TAAAATATCT 540

GTGGATAAAA GCTTTTCTCC CCAATGTCCT AAATGTGATG CAGAAAGCTG CAATGGATCG 600

TGCTGGGGAC CTGGACAAGG AAACTGTCAG AAATTAACAA AGCTCACCTG TGCCCAGCAG 660

TGTTCCGGTC GTTGCAGAGG TCCACTGCCA AGTGATTGCT GCCACAGCCA ATGTGCTTCT 720

GGCTGTACAG GGCCAAGGGA AAATAACTGC TTGGCTTGCC GTAAGTTTCG AGATGGTGAG 780

ACATGCAAAG AAGGCTGCCC TCAGCTGCAG ATATATAATC CTGCAACATA CCAAATGGAT 840

CTAAATCCTG ATGGAAAGTA CAGTTTTGGA GCTTCATGTG TGAAAAAGTG CCCACATAAC 900

TATGTTGTGA CAGATCATGG ATCATGTGTT CGAACTTGCA ACTCAGATTC CCAAGAAGTA 960

GAGGAGAATG GTATCCGAAT ATGTAAAAAG TGTGATGGGT CATGTAATAA AGATAAGGTT 1020

TGTGATGGAA TCAACATGGG AAAGCTGAAA AGTGTCTTGT CAGTAAACGC CTCAAATATA 1080

GATTTATTCC AGAACTGTAC CAAAGTAAAT GGAGATGTGG CCATTTTACA TGTGGCAGGA 1140

TATGGTGACC CTTTTACCAA CACTAGTAAA CTGGATCCTG CAAAGTTATC TGTATTTAAA 1200

TCTGTCCGAG AAATAACAGG TTCCTTATTG ATTCAGTGGT GGCCAGATAA TTACACAGAC 1260

CTGAGTGTGT TTGAAAATCT CGAGACTATC CGAGGCAGAA CAAAGCAGCA TGGCATTTAT 1320

TCTCTTGCTA TTGTGAAAAG ATCCATAACT TCCTTGGGTC TACGATCGCT CAAAGAAGTG 1380

AGTGATGGAG ATGTTATCAT TAAAACAAAC AAAAATCTCT GCTTTGTTAA CACCATCAAC 1440

TTTACAAACA TCTTTAGAAT ACCGAAACAG GCAAGGATAA TTGAAGACAA CAAAAGTCCT 1500

GAGCAGTGTG AAAGTGAAGG CAATGTTTGT GATCCTTTGT GCTCTGAGGA GGGATGTTGG 1560

GGACCTGGGC CTTTTCAATG TGTTTCCTGC CGTAAATATA TGCGTGGAAG GGAATGTGTA 1620

GAAAACTGCA ACTTTCTTAG TGGGGAGCCA CGAGAATACA CAGAAGATGG CAAGTGCTTT 1680

GCCTGTAACG CAGAGTGTTT ACAGCTGAAT GAAACCCAAA CTTGCTCGGG TCCTGGTGCA 1740

GATGAATGTT TTAAATGTGG CCACAATAGT GATGGTCCAT TCTGTGTCAA GACTTGCCCA 1800

GCTGGAATCC AAGGAGAAAA TAGCACTTTA ATTTGGAAGT ATCCTGATGA AACAGGAGCA 1860

TGTCAGCTCT GTCATCCAGA ATGCAAACTG GGATGTGTGG GACATGGCCT AGATGGATGC 1920

CCTCTTCCTT GGTCCAGCCA CTCTGTTGCT GCAGGTGTTG TTGGAGGCAT TCTTGGAGCT 1980

GTCGTGATTG GACTTGTTGC TTTCTTCTTT ATTAGAAGGA GTCGAATCAA TAGGAAACGA 2040

ACCCTACGTA GGATACTTCA AGAAAGAGAG CTGGTTGAAC CTGTCACCCC CAGTGGAGAG 2100

GCACCAAATC AAGCTCTTCT CCGGATCTTA AAGGAGACAG AGTTCAAGAA AATAAAAGTT 2160

CTTGGCTCTG GGGCGTTTGG GACAGTTTAC CAGGGGCTAT GGATTCCTGA GGGGGAGGGC 2220

ATCAAGATCC CAGTTGCCAT TAAGGAGTTG CGAGAAGCCA CGTCCCCTAA AGCCAACAAA 2280

GAAATTCTAG ATGAAGCATA CGTCATGGCC AGCGTGGAGA ATCCCTATGT TTGCCGTTTG 2340

CTAGGAATCT GCCTGACCTC CACTGTCCAG CTGATCACCC AGTTAATGCC ATTTGGTTGC 2400

CTCCTCGACT ATGTTCGAGA TAACAAAGAC AACATTGGGT CACAACATCT TCTCAACTGG 2460

TGTGTGCAGA TTGCCAAGGG AATGAATTAT CTTGAAGAAA GACGTTTGGT GCATCGTGAT 2520

TTAGCTGCCA GGAATGTTCT AGTTAAAGGC CCACAGCATG TCAAAATCAC AGATTTTGGG 2580

CTAGCAAAGC TTCTGGGAGC AGATGAGAAA GCGTATCATG CAGAAGGGGG CAAAGTGCCT 2640

ATCAAGTGGA TGGCATTAGA GTCCATCTTG CACAGAACCT ACACCCATCA AAGTGATGTT 2700

TGGAGTTATG GGGTCACAGT TTGGGAATTA ATGACATTCG GTTTGAAGCC CTATGATGGA 2760

ATTCCAGCCA GTGAAATCTC AAATATTTTA GAAAAAGGGG AGCGTCTTCC ACAGCCTCCA 2820

ATCTGCACCA TTGATGTCTA TATGATTATG GTGAAATGCT GGATGATTGA TGCAGAGAGT 2880

CGCCCAAAGT TCCGGGAACT GAGCGCTGAA TTTACCAAAA TGGCTCGTGA CCCAACCCGC 2940

TACTTGGTCA TACAGGGGGA TGATAGAATG CATTTGCCTA GTCCTGTTGA ATCCAAGATC 3000

CATCCTGCAT TGGTTCAAGA GGGTCTGGGT GACATTGTTG ATGCTGAAGA GTATCTGTTG 3060

CCACATCAAG GATTCTTCAC AAGTCCCTCT AATTCAAGAA CACCTTTACT GAGCACTATG 3120

AGTTCTACTA GCAACAACTC ACCTGTCATC TGTACCATGC GAAATGGGGG ACCACCTGTT 3180

AGAGAAGACA GCTTTGTACA AAGATACAGC ACAGATCCAA CAGTCATTTT GGAAGACAGC 3240

ATTGATGATG AGTTCCTGCC TGTGCCAGAA TATGTGAATC AGATGGTTCC AAAACCAATT 3300

GTGGAGACAC AGACAAATGC AGTATATCAA AATTTGGTTC CACTGGGGAA TACTGTGTCT 3360

CCTAAAGAGA CCCTTTACCA GAATTCTCAC AGCAATGGCC TTAATAACCC AGAGTATCTG 3420

AACACAGGCC ATACCCTTGT ACCCAAAACT GACTTTGACT ATTCCTCCAT CTGGGACCAA 3480

AAGGCTAACC TTCAGATTAA CCTGGATAAC CCTGACTATC AACAGGACTT CTTTCCAAAA 3540

GAACCTAAAA CCAATGGACA TTTTAAAATT CCTGCAGCGC AAAACCCTGA ATACTTGGGG 3600

TTGGCACCTG TGAGCGATTA TATTGAAGCT TCA 3633

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvy+G+wipege +kipvaik+l+e+t++kanke+ldea+v+as+++

Q: 715   FKKIKVLGSGAFGTVYQGLWIPEGEGIKIPVAIKELREATSPKANKEILDEAYVMASVEN  774

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldyvr++kd++Gsq+llnwcvqiakGm+ylee+

Q: 775   PYVCRLLGICLTSTVQLITQLMPFGCLLDYVRDNKDNIGSQHLLNWCVQIAKGMNYLEER  834

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk p+hvkitdfGlakll adek ++aeggkvpikw+alesil+r+y

Q: 835   RLVHRDLAARNVLVKGPQHVKITDFGLAKLLGADEKAYHAEGGKVPIKWMALESILHRTY  894

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG kpydgipa+ei+++lekGerl+qppictidvym++vkcw

Q: 895   THQSDVWSYGVTVWELMTFGLKPYDGIPASEISNILEKGERLPQPPICTIDVYMIMVKCW  954

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         midaesrpkf+el +ef

Q: 955   MIDAESRPKFRELSAEF  971

         ***************99

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYQGLW IPEGEGIKIP VAIKELREAT SPKANKEILD EAYVMASVEN 60

PYVCRLLGIC LTSTVQLITQ LMPFGCLLDY VRDNKDNIGS QHLLNWCVQI AKGMNYLEER 120

RLVHRDLAAR NVLVKGPQHV KITDFGLAKL LGADEKAYHA EGGKVPIKWM ALESILHRTY 180

THQSDVWSYG VTVWELMTFG LKPYDGIPAS EISNILEKGE RLPQPPICTI DVYMIMVKCW 240

MIDAESRPKF RELSAEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013