EKS-XET-00311

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00311

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	362.8	1.1E-108	50	332	283

Status

Unreviewed

Ensembl Protein

ENSXETP00000058994

UniProt Accession

F7BHB0;

Protein Name

Protein Synonyms/Alias

MAP kinase-interacting serine/threonine-protein kinase 1;

Gene Name

mknk1

Gene Synonyms/Alias

mknk1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000016357	ENSXETP00000058994	ENSXETT00000060916
ENSXETG00000016357	ENSXETP00000035708	ENSXETT00000035708

Organism

Xenopus tropicalis

Functional Description

Protein Length

427

Protein Sequence
(FASTA)

LVDSPWLEFV LKMVSSQPVP IDDGGKRRKK KRRTRAMESF TGKFADLYRL TDELLGEGAY 60

AKVQGCVSLQ NGKDYAVKIV EKKAGHSRSR VFREVETLYQ CQGNKNILEL IEFCEDDARF 120

YLVFEKLRGV GLIKHISREP HTQGLCKKIK RDIASALDFL HTKGIAHRDL KPENILCEFK 180

DKVSPVKICD FDLGSGVKLN SACTPITTPE LTTPCGSAEY MAPEVVEVFT EEATFYDKRC 240

DLWSLGVILY IMLSGYPPFV GNCGADCGWD RGEMCRVCQN KLFESIQEGK YEFPEKDWSH 300

ISNSAKDLIS KLLVRDAKER LSAAQVLQHP WLQGDAPERG LPTPLVLQRN SSTKDLTIFA 360

AEAVALNRQL SQHDSDLNEE HESFIHTVCS MRLSPPSKSR LAKRRAQAHA RKGGSHLTHT 420

TVTSQGA 427

Nucleotide Sequence
(FASTA)

CTAGTTGATT CACCTTGGTT GGAGTTTGTG TTAAAAATGG TGAGCAGTCA GCCTGTCCCA 60

ATCGATGATG GAGGCAAAAG GAGAAAGAAG AAGCGGAGGA CTAGAGCAAT GGAGAGCTTT 120

ACCGGGAAGT TTGCAGATCT GTACAGACTG ACTGACGAGC TACTTGGAGA GGGAGCTTAT 180

GCTAAAGTTC AAGGCTGTGT CAGTTTACAG AATGGAAAAG ATTACGCTGT CAAGATCGTC 240

GAAAAGAAGG CTGGGCACAG TCGCAGTAGA GTATTTAGAG AAGTGGAAAC GCTATACCAG 300

TGCCAAGGCA ACAAGAACAT CTTGGAGTTA ATAGAATTCT GTGAAGATGA TGCTCGTTTT 360

TATCTGGTCT TTGAAAAGCT GCGAGGAGTG GGTTTAATTA AACATATAAG CAGAGAGCCG 420

CACACACAGG GACTTTGCAA AAAGATAAAG CGTGATATAG CCTCTGCCCT TGATTTCCTT 480

CATACGAAAG GTATTGCTCA TCGTGACTTA AAACCAGAAA ACATATTGTG TGAATTCAAA 540

GATAAGGTGT CACCTGTGAA AATCTGTGAC TTTGATCTTG GAAGCGGTGT AAAACTAAAC 600

AGTGCATGCA CCCCTATAAC CACGCCTGAG TTAACAACAC CTTGTGGGTC AGCAGAGTAC 660

ATGGCTCCAG AAGTGGTGGA AGTTTTCACG GAGGAAGCTA CTTTTTATGA CAAGCGCTGT 720

GATTTGTGGA GTCTGGGCGT AATTTTATAC ATTATGCTTA GCGGGTATCC TCCTTTTGTG 780

GGCAACTGTG GGGCAGACTG TGGTTGGGAT CGAGGAGAAA TGTGCAGAGT TTGCCAGAAC 840

AAGCTATTTG AAAGTATCCA AGAAGGCAAG TATGAATTTC CAGAAAAGGA CTGGTCCCAT 900

ATTTCCAACT CTGCTAAAGA TTTGATCTCC AAGCTTCTTG TTCGGGATGC CAAAGAGCGA 960

CTGAGCGCTG CTCAGGTTTT GCAGCACCCA TGGTTGCAAG GGGATGCTCC AGAGCGAGGA 1020

CTGCCCACCC CACTGGTGCT TCAGAGAAAC AGCAGTACAA AGGACCTGAC TATCTTTGCA 1080

GCAGAAGCAG TTGCCTTAAA CCGTCAGCTC TCACAGCATG ACAGTGATCT GAATGAGGAG 1140

CACGAAAGCT TCATCCACAC AGTCTGCTCT ATGAGACTCT CACCGCCATC AAAATCTCGA 1200

CTTGCAAAGC GTCGGGCCCA GGCCCATGCA CGCAAGGGTG GCTCCCATCT TACCCATACT 1260

ACTGTGACAA GCCAAGGGGC A 1281

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghknive  56

         lt+e+lGeG+++kv+ cv+ ++g++ya+ki+     ++r++v+reve+++q++g+kni+e

Q: 50    LTDELLGEGAYAKVQGCVSLQNGKDYAVKIVekkagHSRSRVFREVETLYQCQGNKNILE  109

         7899********************************************************

S: 57    lidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhskn  116

         li++ e    d++r++lv+ekl+G  l+++i+ r+ +t+   +++ +diasal+flh+k+

Q: 110   LIEFCE----DDARFYLVFEKLRGVGLIKHIS-REPHTQGLCKKIKRDIASALDFLHTKG  164

         ******....*********************7.56789999*******************

S: 117   iahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyvaPe  168

         iahrDlkpen+L+e k+k++pvk+cDf+l+++++ +        +el+tpc++aey+aPe

Q: 165   IAHRDLKPENILCEFKDKVSPVKICDFDLGSGVKLNsactpittPELTTPCGSAEYMAPE  224

         *******************************9954457889999****************

S: 169   vleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklke  217

         v+e+++eea++ydk+CDlWslGvilyi+l+GypPf++++g           r +++kl+e

Q: 225   VVEVFTEEATFYDKRCDLWSLGVILYIMLSGYPPFVGNCGadcgwdrgemcRVCQNKLFE  284

         ***************************************99*******************

S: 218   riqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         +iqegkyefPe++Ws++s++akdli+klL+rd+kerl++++vl+hpw+

Q: 285   SIQEGKYEFPEKDWSHISNSAKDLISKLLVRDAKERLSAAQVLQHPWL  332

         ***********************************************6

Domain Sequence
(FASTA)

LTDELLGEGA YAKVQGCVSL QNGKDYAVKI VEKKAGHSRS RVFREVETLY QCQGNKNILE 60

LIEFCEDDAR FYLVFEKLRG VGLIKHISRE PHTQGLCKKI KRDIASALDF LHTKGIAHRD 120

LKPENILCEF KDKVSPVKIC DFDLGSGVKL NSACTPITTP ELTTPCGSAE YMAPEVVEVF 180

TEEATFYDKR CDLWSLGVIL YIMLSGYPPF VGNCGADCGW DRGEMCRVCQ NKLFESIQEG 240

KYEFPEKDWS HISNSAKDLI SKLLVRDAKE RLSAAQVLQH PWL 283

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013