EKS-XET-00033
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00033
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak293.51.8E-878241094271
StatusUnreviewed
Ensembl ProteinENSXETP00000035893
UniProt AccessionF7EV03;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene Namejak3
Gene Synonyms/Alias jak3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000016438ENSXETP00000035893ENSXETT00000035893
OrganismXenopus tropicalis
Functional Description
Protein Length1111
Protein Sequence
(FASTA)
MSGEESPLLW GSRSSSTSST ATGSLQLLLY HSSLSVNPPT ESQLTFPGGQ YSAEELCIAA 60
AKSCGIQPVY HSLFALACPK LKTWYNPNYV FTVDSSTSHV LVYRIRFFFP HWIGVGGQKS 120
SRCSLMKLPP DPLLSYPVID YLFAQCRSDF LSDRMKLPTS LDMQDQCLTL AVLDMMRLTQ 180
ENNKPPKQIL SMISYKQCVP QSLRQAIQKL SFFSRKRLRS RVQHSLRKIR ACTLTDPLIK 240
LKYLVDLEKL DRNFGTETFQ VQSPKGTGNN MILRVSGGGG ISWMVPETEL WQTFCDFPEI 300
VDIRITQAKF DSAISEGRIV TVTKQDNKVL TIKETQFPNL QEALSFVSLV DGYYRLTTDS 360
HHYFCEEVAS PRLRWNLENQ CHGPITSEFA VGKLKKSGSV VGSFVLRCSP QDFDKFLLTV 420
CVETSLGKDY RGCMIQKLND MFSIAAVPRH FSSLWSLLEH YQHCTLSLGG VRTKLTTCCP 480
PQPKEKSNLL ILRDSCPQRV LLPGRERRNL QSLTFHKIHL KDITFMESLG KGSFTKIFRG 540
LRTDEERDER CEVEVLLKVL DPTYGHYQES FLEAASIMNQ ISHKHHILVH GVCVGKQIIM 600
IQEFVCHGAL DLYLKRQQQK GPIAISWKLE VVRQLAYALC YLEDKQLVHG NISAKKILLS 660
REGDKGNPPF IKLSDRGVSI KVLDEELLAE RIPWLSPECV SDPNNLALES DRWSFGVTLW 720
EIFNDGHVPL SAEDPSTKLQ FYNDHKTLPS PHWIELASLE QQCMSYNPLL RPSFRSIMRE 780
LNNIIAFDYE LLVDSKGQQV KGGLRVCDHA WELQDPTVYE ERHLKYISVL GKGNFGSVEL 840
CRYDPLGDNT GELVAVKKLQ HHTVEHVRDF QRESRILRSL HSDFIVKYKG ICYSAGRRSF 900
QLIMEYLPNG SLREYLPKNQ NVLGPCHLLL YASQICKGML YLGSQRYVHR DLASRNVLVE 960
SREHVKIGDF GLTKILPQDK EYYVVREKGE SPIFWYHAPE SLSDSIYSRE SDVWSFGVLL 1020
YELFTYSQRS CSPPTEYLRM MGPHNAQQTV CSLVEFLRAG KRLCTPASCP TEVYKLMLSC 1080
WSSLPSERPS FKDLELQVEQ LQESLTNRST P 1111
Nucleotide Sequence
(FASTA)
ATGTCTGGTG AGGAAAGTCC ATTACTATGG GGGTCACGCT CATCCAGCAC CTCTTCTACT 60
GCCACAGGCT CCCTCCAGTT ACTTCTGTAT CACTCCTCTC TTTCTGTTAA TCCCCCCACT 120
GAATCCCAGC TGACCTTTCC TGGGGGCCAG TATTCCGCAG AAGAATTGTG TATTGCGGCT 180
GCCAAATCAT GTGGGATCCA GCCAGTCTAT CATTCCCTGT TTGCATTGGC ATGTCCGAAA 240
CTCAAAACCT GGTATAATCC TAATTATGTC TTTACTGTGG ACAGCAGCAC CTCTCATGTT 300
CTGGTTTATA GGATCAGATT TTTCTTTCCT CATTGGATTG GGGTAGGGGG ACAAAAATCT 360
TCTCGTTGCA GTCTTATGAA GCTCCCTCCT GACCCCCTGC TCAGCTATCC AGTTATTGAT 420
TACCTTTTTG CCCAGTGTCG CAGCGATTTT TTGAGTGATC GCATGAAGCT GCCCACCAGT 480
CTGGACATGC AGGATCAGTG TTTGACCCTG GCAGTGCTAG ATATGATGCG ACTGACTCAG 540
GAGAACAACA AACCCCCAAA GCAGATTCTC AGCATGATTA GTTATAAGCA GTGTGTCCCT 600
CAGAGCCTGC GGCAAGCCAT TCAGAAACTA AGCTTCTTTT CCCGCAAGAG ACTGCGGAGC 660
AGAGTCCAGC ATTCATTAAG GAAAATCAGG GCCTGTACAC TCACAGATCC ACTCATCAAA 720
CTCAAGTATC TGGTGGATCT TGAGAAACTG GACCGAAATT TTGGAACAGA GACCTTCCAA 780
GTACAGAGCC CAAAAGGGAC TGGAAACAAC ATGATTCTCA GAGTGTCTGG GGGAGGAGGG 840
ATCTCATGGA TGGTACCAGA AACTGAGCTG TGGCAGACGT TTTGTGATTT CCCAGAAATT 900
GTTGACATAA GGATAACACA AGCAAAGTTT GATTCCGCAA TATCAGAGGG ACGCATAGTC 960
ACAGTTACTA AGCAAGACAA CAAGGTTTTG ACAATCAAGG AGACGCAGTT CCCAAACCTG 1020
CAAGAAGCTC TTTCATTTGT CTCTCTGGTA GATGGTTACT ACCGTTTGAC TACAGATTCA 1080
CACCATTATT TCTGTGAGGA GGTGGCTTCC CCAAGGCTGC GGTGGAACCT AGAAAATCAA 1140
TGTCATGGAC CCATTACATC TGAGTTTGCT GTGGGCAAAC TGAAGAAAAG TGGGAGTGTT 1200
GTTGGCAGCT TTGTCCTACG TTGCTCCCCT CAGGACTTTG ACAAGTTTCT GCTTACAGTC 1260
TGTGTGGAGA CATCACTGGG AAAGGATTAC AGGGGCTGCA TGATCCAGAA ACTGAATGAT 1320
ATGTTTTCTA TTGCTGCTGT CCCTCGTCAT TTCTCCAGTC TATGGAGTCT CTTAGAGCAT 1380
TATCAGCACT GCACCTTGTC TTTGGGTGGA GTTCGCACAA AACTCACAAC TTGCTGCCCA 1440
CCTCAACCCA AAGAAAAATC CAACCTGTTG ATTCTACGGG ACAGCTGCCC TCAAAGAGTC 1500
CTGTTACCAG GCAGAGAAAG ACGGAACCTC CAGTCGCTCA CTTTCCATAA GATCCATCTC 1560
AAAGACATCA CTTTTATGGA AAGCCTTGGA AAAGGCTCCT TCACAAAAAT ATTTCGAGGT 1620
TTAAGAACTG ATGAAGAGAG AGACGAGCGG TGTGAGGTGG AAGTTCTGCT AAAAGTTCTG 1680
GATCCTACTT ATGGCCATTA CCAAGAGTCT TTTCTAGAAG CTGCCAGCAT AATGAACCAG 1740
ATTTCACATA AACACCACAT TCTAGTGCAT GGAGTTTGTG TGGGAAAACA AATTATCATG 1800
ATACAGGAGT TTGTGTGTCA TGGGGCCCTG GATCTCTACT TGAAACGACA GCAGCAGAAA 1860
GGACCCATTG CAATCAGCTG GAAATTGGAA GTGGTCAGAC AGTTGGCATA TGCTCTTTGC 1920
TACTTGGAGG ATAAGCAGTT GGTTCATGGG AACATTTCAG CTAAGAAAAT CCTTTTGAGC 1980
CGTGAGGGGG ATAAGGGGAA CCCTCCTTTT ATTAAACTTA GTGACCGAGG TGTGAGCATC 2040
AAAGTCCTGG ATGAAGAATT GCTGGCAGAA AGGATCCCTT GGCTAAGCCC TGAATGTGTC 2100
TCTGATCCAA ATAACCTGGC CTTGGAGTCT GACCGCTGGA GTTTTGGTGT CACATTGTGG 2160
GAGATTTTCA ATGATGGCCA TGTACCACTG AGTGCAGAGG ATCCATCCAC TAAACTGCAG 2220
TTTTATAATG ACCATAAGAC TCTGCCATCC CCACACTGGA TAGAGCTGGC AAGCCTGGAG 2280
CAGCAGTGCA TGTCCTACAA TCCCCTCCTC AGACCTTCAT TCCGATCAAT AATGCGCGAA 2340
CTGAACAATA TTATTGCATT TGATTATGAA TTACTGGTAG ATTCCAAAGG ACAACAGGTG 2400
AAGGGGGGGC TAAGAGTATG TGATCATGCC TGGGAGTTAC AGGACCCTAC TGTGTATGAG 2460
GAAAGACACC TGAAGTACAT ATCAGTGCTG GGCAAGGGAA ATTTTGGCAG TGTGGAACTG 2520
TGCCGTTATG ACCCTCTGGG AGATAACACA GGAGAGTTAG TAGCAGTGAA GAAGTTGCAG 2580
CACCATACTG TTGAACATGT CCGTGACTTC CAGCGAGAGA GTCGGATACT GCGCTCACTT 2640
CACAGTGACT TCATAGTAAA ATACAAGGGG ATCTGCTATA GTGCAGGTCG CCGTAGTTTC 2700
CAGTTGATAA TGGAGTATCT TCCAAATGGC AGTTTGCGGG AATATCTACC TAAGAACCAG 2760
AATGTACTAG GGCCTTGCCA TCTCCTGCTC TATGCCTCCC AGATCTGTAA GGGGATGTTG 2820
TATTTGGGAT CCCAGCGATA TGTGCACAGG GATTTGGCCA GTCGCAATGT CTTGGTGGAG 2880
AGCAGGGAAC ATGTAAAGAT TGGAGACTTT GGCTTGACCA AAATCTTGCC ACAGGACAAA 2940
GAGTACTATG TAGTTCGTGA AAAAGGAGAA AGTCCGATTT TCTGGTATCA TGCCCCTGAG 3000
TCTCTTTCTG ATAGTATTTA CTCTCGAGAA TCAGATGTCT GGAGCTTTGG AGTTCTGCTG 3060
TATGAGCTTT TCACTTACAG CCAAAGGAGT TGTAGCCCCC CCACTGAGTA TCTGCGTATG 3120
ATGGGGCCTC ACAATGCTCA GCAAACTGTG TGTAGCTTGG TAGAGTTTTT ACGAGCAGGG 3180
AAACGACTTT GCACACCTGC CTCTTGCCCA ACTGAGGTGT ATAAACTAAT GCTTTCTTGT 3240
TGGTCTTCAC TTCCCTCTGA GCGGCCATCA TTTAAAGACT TGGAGTTGCA GGTTGAGCAG 3300
TTGCAAGAGT CACTTACCAA TAGGAGCACA CCATAA 3336
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk+i+ Lgkg+f++v+++r+d+ gd+t+e va+k L++ + ++ rdf+re+ il++l+++
Q: 824   LKYISVLGKGNFGSVELCRYDPLGDNTGELVAVKKLQHHTVEHVRDFQRESRILRSLHSD  883
         799*********************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk+kg+c++ g++  +l+mey+++GsL++yL+k+++ l    ll +a+q++k+m YL+
Q: 884   FIVKYKGICYSAGRRsfQLIMEYLPNGSLREYLPKNQNVLGPCHLLLYASQICKGMLYLG  943
         *************999********************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl.  176
         ++++vhrd+a rnvLve+ ++      vk++d+gl+k ++qd eYy+vre+++s+i+w+ 
Q: 944   SQRYVHRDLASRNVLVESREH------VKIGDFGLTKILPQDkEYYVVREKGESPIFWYh  997
         *********************......*******************************95
S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224
         ape+ls++   s++sdvWsFgv lyel+t  ++++sp    lr+++++        ++e+
Q: 998   APESLSDSI-YSRESDVWSFGVLLYELFTySQRSCSPpteyLRMMGPHnaqqtvcSLVEF  1056
         5********.*******************88899999**********9999*9999****
S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrai  261
         l  ++rl +p  cp+e+++lm  c+s  ps+rpsF+++
Q: 1057  LRAGKRLCTPAsCPTEVYKLMLSCWSSLPSERPSFKDL  1094
         ***********************************998
Domain Sequence
(FASTA)
LKYISVLGKG NFGSVELCRY DPLGDNTGEL VAVKKLQHHT VEHVRDFQRE SRILRSLHSD 60
FIVKYKGICY SAGRRSFQLI MEYLPNGSLR EYLPKNQNVL GPCHLLLYAS QICKGMLYLG 120
SQRYVHRDLA SRNVLVESRE HVKIGDFGLT KILPQDKEYY VVREKGESPI FWYHAPESLS 180
DSIYSRESDV WSFGVLLYEL FTYSQRSCSP PTEYLRMMGP HNAQQTVCSL VEFLRAGKRL 240
CTPASCPTEV YKLMLSCWSS LPSERPSFKD L 271
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Mustela putorius furo"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00027
EKS-BOT-00033
EKS-CAF-00032
EKS-CAP-00034
EKS-FEC-00029
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-MUP-00033
EKS-OTG-00032
EKS-PAT-00027
EKS-PTV-00031
EKS-SAH-00030
EKS-SUS-00027
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
Created Date20-Feb-2013