EKS-XET-00136

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00136

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	547.0	7.2E-165	474	750	277

Status

Unreviewed

Ensembl Protein

ENSXETP00000036588

UniProt Accession

Q28J96;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

fgfr1

Gene Synonyms/Alias

fgfr1; TNeu076b03.1-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000016775	ENSXETP00000036588	ENSXETT00000036588

Organism

Xenopus tropicalis

Functional Description

Protein Length

814

Protein Sequence
(FASTA)

MFSGRSLLLW GVLLGAALSV ARPPSTLPDQ VAPKTKTDVE PYSARPGDRI TLQCRLREDV 60

QSINWAKNEM QLSETNRTRI TGEEIQISNA GPEDNGVYTC VTNGPSGTYT VLFSVNVSDA 120

LPSAEDDDDD DDNSSSEEKA SENSKPNRPF WSHPEKMEKK LHAVPAAKTV KFRCPANGTP 180

QPNLRWLKNG KEFRQDQRIG GYKVRSQTWS LIMDSVVPSD KGNYTCIVEN KYGTLNHTYQ 240

LDVVERSPHR PILQAGLPAN TSVIVGSTAE FFCKVYSDPQ PHIQWLRHIE INGSRVASDG 300

FPYVEILKTA GVNTSDKDME VLHLRNVTFE DAGQYTCLAA NSIGISHHSA WLTVLEVEDD 360

KPAPLASPLQ LEIIIYCTGA AFVSAMVITI IIFKMKHPSK KSDFNSQLAV HKLAKSIPLR 420

RQVTVSGDSN SSMHSGVILV RPSRLSSSGT PMLSGVSEYE LPEDPRWEVA RDRLILGKPL 480

GEGCFGQVVM AEAIGLDKEK PNKVTKVAVK MLKSDASEKD LSDLISEMEM MKMIGKHKNI 540

INLLGACTQD GPLYVIVEYA SKGNLREYLR ARRPPGMEYC YNPTCAPDQL LSFKDLVSCA 600

YQVARGMEYL ASKKCIHRDL AARNVLVTED NVMKIADFGL ARDIHHIDYY KKTTNGRLPV 660

KWMAPEALFD RIYTHQSDVW SFGVLLWEIF TLGGSPYPGV PMEELFKLLK EGHRMDKPTT 720

CTNELYMMMK DCWHAMPSQR PTFNQLVEDL DRILALSSNQ EYLDLSMPVN QYSPCFPDTR 780

SSTCSSGEDS VFSHDPLPDE PCLPKYSNGG LKKR 814

Nucleotide Sequence
(FASTA)

ATGTTCTCCG GAAGGTCCCT CCTCCTGTGG GGTGTCCTGC TCGGCGCTGC TCTATCAGTT 60

GCCCGGCCCC CTTCCACCCT CCCCGACCAA GTCGCCCCTA AAACCAAAAC AGACGTGGAG 120

CCATATTCAG CTCGGCCAGG AGACAGGATA ACTTTGCAGT GCAGGCTACG AGAAGATGTT 180

CAGAGCATCA ACTGGGCGAA AAATGAAATG CAGCTTTCGG AGACTAACCG CACGCGCATA 240

ACGGGGGAGG AGATCCAAAT TTCCAACGCA GGGCCGGAGG ACAATGGGGT GTATACCTGT 300

GTTACTAACG GGCCTTCTGG AACATATACA GTTTTATTCT CCGTTAATGT ATCAGATGCA 360

CTGCCTTCAG CCGAGGATGA TGATGACGAT GATGACAACT CATCCTCTGA GGAGAAAGCT 420

TCTGAGAATT CCAAACCGAA CCGTCCATTT TGGTCACACC CAGAAAAAAT GGAGAAAAAG 480

CTTCATGCGG TGCCAGCGGC AAAAACGGTG AAATTCAGGT GCCCAGCAAA TGGAACTCCG 540

CAGCCAAATC TTCGCTGGCT GAAGAACGGC AAGGAGTTCC GGCAGGATCA GCGCATTGGT 600

GGATATAAGG TTCGTTCTCA AACATGGAGC CTTATTATGG ATTCCGTTGT CCCATCTGAT 660

AAAGGCAATT ACACTTGTAT TGTGGAGAAC AAGTATGGCA CCCTCAACCA CACCTACCAG 720

TTGGATGTAG TCGAACGTTC GCCACATCGC CCAATCCTAC AGGCCGGTCT CCCAGCGAAT 780

ACGAGTGTTA TTGTGGGAAG CACTGCTGAA TTTTTCTGCA AAGTGTACAG CGACCCCCAG 840

CCTCACATCC AATGGCTCAG GCACATTGAA ATTAATGGCA GCAGAGTGGC CTCGGATGGC 900

TTCCCGTATG TGGAAATCCT CAAGACTGCA GGAGTCAACA CCTCGGACAA GGATATGGAG 960

GTTCTCCACC TGAGAAATGT TACTTTTGAG GATGCTGGCC AGTATACCTG CTTGGCCGCT 1020

AACTCCATTG GGATATCTCA TCATTCTGCA TGGTTGACCG TTCTTGAAGT GGAGGACGAT 1080

AAACCTGCGC CTCTGGCCTC CCCTTTACAA CTGGAGATTA TAATCTACTG CACGGGGGCC 1140

GCCTTCGTGT CCGCCATGGT AATCACCATC ATTATCTTTA AAATGAAGCA TCCGTCGAAG 1200

AAGTCGGACT TCAACAGCCA GCTGGCCGTG CACAAGCTTG CCAAGAGCAT CCCGCTGCGC 1260

AGACAGGTAA CAGTTTCAGG GGACTCCAAC TCATCAATGC ACTCTGGAGT GATATTGGTC 1320

AGACCCTCAC GCCTCTCATC CAGTGGGACG CCTATGTTGT CTGGAGTCTC GGAATACGAG 1380

CTTCCGGAAG ATCCACGTTG GGAAGTGGCA AGAGACAGGT TGATCCTTGG GAAACCTCTC 1440

GGAGAAGGCT GCTTTGGGCA AGTAGTAATG GCAGAGGCTA TCGGCCTGGA TAAGGAGAAG 1500

CCTAACAAAG TGACAAAAGT TGCCGTGAAG ATGTTAAAGT CTGATGCAAG TGAAAAGGAC 1560

CTGTCTGATC TGATTTCCGA GATGGAAATG ATGAAAATGA TTGGAAAACA CAAAAATATC 1620

ATCAATTTAC TTGGTGCCTG CACCCAAGAT GGTCCACTCT ATGTAATTGT GGAATATGCT 1680

TCCAAGGGGA ACCTTAGAGA GTACTTGCGA GCCAGGCGCC CCCCGGGCAT GGAGTACTGC 1740

TACAACCCTA CCTGTGCCCC CGATCAGCTG CTCTCCTTCA AGGATCTGGT GTCGTGTGCT 1800

TACCAGGTGG CGCGTGGGAT GGAGTACCTT GCCTCTAAAA AGTGTATCCA CCGAGACCTG 1860

GCTGCAAGGA ATGTCTTGGT AACAGAGGAC AATGTGATGA AGATTGCCGA CTTCGGCTTA 1920

GCCCGTGATA TCCATCACAT TGACTATTAC AAGAAGACCA CAAACGGACG GCTGCCTGTA 1980

AAATGGATGG CCCCAGAAGC CCTTTTTGAC CGGATTTACA CTCATCAGAG TGATGTCTGG 2040

TCGTTCGGTG TGCTGCTGTG GGAGATTTTC ACGCTCGGGG GCTCCCCGTA TCCTGGTGTC 2100

CCCATGGAAG AGCTCTTTAA GTTACTTAAG GAAGGGCACA GAATGGATAA ACCCACTACC 2160

TGCACCAATG AGTTGTATAT GATGATGAAG GACTGCTGGC ATGCCATGCC TTCTCAAAGA 2220

CCAACATTCA ATCAGCTGGT TGAAGATCTT GACCGAATTC TTGCTCTGAG TTCCAATCAG 2280

GAGTATCTCG ATCTTTCCAT GCCAGTGAAT CAGTATTCTC CATGTTTCCC AGACACTCGA 2340

AGTTCCACGT GTTCTTCAGG CGAGGACTCT GTGTTCTCTC ATGACCCCCT CCCTGATGAA 2400

CCTTGCCTTC CCAAATACTC CAATGGTGGA CTTAAAAAAC GCTGA 2445

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l lgk+lGeG+fGqvv+aeaigldk+k++k ++vavkmlk+da++kdl+dl+seme++k+

Q: 474   LILGKPLGEGCFGQVVMAEAIGLDKEKPNKVTKVAVKMLKSDASEKDLSDLISEMEMMKM  533

         689*********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e++++++ a+++ l++

Q: 534   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYCYNPTCAPDQLLSF  593

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 594   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  653

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg+++eelfkllkeGh

Q: 654   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPMEELFKLLKEGH  713

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++m++cwha +s+rptf+qlvedl

Q: 714   RMDKPTTCTNELYMMMKDCWHAMPSQRPTFNQLVEDL  750

         ***********************************97

Domain Sequence
(FASTA)

LILGKPLGEG CFGQVVMAEA IGLDKEKPNK VTKVAVKMLK SDASEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYCYNP TCAPDQLLSF 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPME ELFKLLKEGH 240

RMDKPTTCTN ELYMMMKDCW HAMPSQRPTF NQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

xtr:548648

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013