EPS-XET-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-XET-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	278.8	5.6E-83	23	289	267

Status

Unreviewed

Ensembl Protein

ENSXETP00000036927

UniProt Accession

A4IHV9;

Protein Name

Protein Synonyms/Alias

Ppm1a protein;

Gene Name

ppm1a

Gene Synonyms/Alias

ppm1a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000016952	ENSXETP00000036927	ENSXETT00000036927

Organism

Xenopus tropicalis

Functional Description

Protein Length

383

Protein Sequence
(FASTA)

MGAFLDKPKM EKHNAHGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPNGL DAWSFFAVYD 60

GHAGSQVAKY CCEHLLDHIT SNQDFKGTDG HLSVWSVKNG IRTGFLQIDE HMRVISEKKH 120

GADRSGSTAV GVMTSPNHIY FINCGDSRGL LCRSKKVHFF TQDHKPSNPL EKERIQNAGG 180

SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VYEIERSEED DQFIILACDG 240

IWDVMGNEEL CDFVWSRLEV TDDLERVCNE IVDTCLYKGS RDNMSVILIC FPSAPKVLPE 300

AVKREAELDK YLEGRVEDII KKQGEEGVPD LVHVMRTLAS ENIPNLPPGG ELASKRSVIE 360

AVYNRLNPYR NDDTDSASTD DMW 383

Nucleotide Sequence
(FASTA)

ATGGGAGCAT TTTTAGACAA GCCAAAGATG GAGAAGCATA ATGCTCATGG GCAGGGTAAT 60

GGACTGCGAT ATGGGCTTAG TAGTATGCAA GGTTGGCGTG TTGAAATGGA AGATGCTCAT 120

ACTGCTGTTA TTGGGCTGCC AAATGGACTT GATGCATGGT CATTTTTTGC TGTTTATGAT 180

GGTCATGCGG GATCCCAGGT TGCCAAATAC TGCTGTGAGC ATTTGCTGGA TCACATCACT 240

AGCAACCAGG ATTTCAAAGG GACAGATGGA CATCTGTCTG TGTGGAGTGT AAAAAATGGA 300

ATCAGAACAG GATTTCTCCA GATTGACGAA CATATGAGGG TAATCTCAGA GAAGAAACAT 360

GGTGCTGACA GAAGTGGATC AACGGCTGTT GGGGTTATGA CCTCCCCAAA CCACATTTAC 420

TTCATCAACT GTGGAGACTC CAGAGGTTTA CTTTGCAGGA GCAAGAAAGT GCATTTCTTT 480

ACACAGGATC ATAAACCAAG CAATCCACTT GAAAAGGAGC GTATACAAAA CGCTGGGGGC 540

TCTGTGATGA TTCAGCGTGT AAATGGGTCA CTTGCTGTTT CAAGGGCTCT GGGTGACTTT 600

GATTACAAAT GTGTCCATGG AAAAGGCCCT ACAGAGCAGC TTGTTTCACC TGAGCCTGAA 660

GTTTATGAAA TTGAGCGTTC AGAAGAAGAT GACCAGTTTA TAATTTTGGC ATGTGATGGT 720

ATTTGGGATG TCATGGGGAA CGAAGAGCTA TGTGATTTTG TGTGGTCAAG ACTTGAAGTT 780

ACTGATGACC TTGAAAGGGT GTGCAATGAA ATAGTGGACA CCTGCTTGTA CAAGGGAAGC 840

AGAGACAACA TGAGTGTCAT ACTGATCTGT TTTCCAAGTG CTCCAAAAGT ATTGCCTGAG 900

GCAGTGAAAA GGGAGGCGGA ACTGGACAAG TACCTGGAAG GCAGAGTAGA AGACATCATA 960

AAGAAGCAGG GTGAAGAAGG GGTACCAGAC TTAGTCCATG TGATGCGTAC ATTAGCCTCT 1020

GAGAACATCC CTAATCTCCC ACCTGGTGGA GAATTGGCAA GCAAACGGAG TGTGATTGAA 1080

GCTGTGTACA ACAGATTGAA TCCATATAGA AATGATGACA CTGATTCGGC ATCAACAGAT 1140

GATATGTGGT AA 1152

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t+   ++  p+  d ++ff+vyDGh+gs+vak+c e+l +++

Q: 23    RYGLSSMQGWRVEMEDAHTA---VIGLPNGLDAWSFFAVYDGHAGSQVAKYCCEHLLDHI  79

         69****************98...5555566667***************************

S: 62    aeele....sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdskl  117

         + + +    ++  +   vk+ ++++Fl++de+++v++ek++  d+sGstav ++ +++++

Q: 80    TSNQDfkgtDGHLSVWSVKNGIRTGFLQIDEHMRVISEKKHGADRSGSTAVGVMTSPNHI  139

         ***9977655556666778*****************************************

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRa  177

         y++n+GdSr +Lcr++k++  ++dHkps++ E+eRi++aggsv+ +   Rv+G+LavsRa

Q: 140   YFINCGDSRGLLCRSKKVHFFTQDHKPSNPLEKERIQNAGGSVMIQ---RVNGSLAVSRA  196

         **********************************************...***********

S: 178   lGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrd  227

         lGd+++k         ++v+pePev+++++++ed+ f+iLa+DG+wdv+ nee++++v +

Q: 197   LGDFDYKcvhgkgpteQLVSPEPEVYEIERSEEDDqFIILACDGIWDVMGNEELCDFVWS  256

         ******************************999999************************

S: 228   vlekkeaeqeaakkLvklalargskdnvsaivv  260

         +le +++++ +++++v+++l +gs+dn+s+i++

Q: 257   RLEVTDDLERVCNEIVDTCLYKGSRDNMSVILI  289

         ****************************99976

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VIGLPNGLDA WSFFAVYDGH AGSQVAKYCC EHLLDHITSN 60

QDFKGTDGHL SVWSVKNGIR TGFLQIDEHM RVISEKKHGA DRSGSTAVGV MTSPNHIYFI 120

NCGDSRGLLC RSKKVHFFTQ DHKPSNPLEK ERIQNAGGSV MIQRVNGSLA VSRALGDFDY 180

KCVHGKGPTE QLVSPEPEVY EIERSEEDDQ FIILACDGIW DVMGNEELCD FVWSRLEVTD 240

DLERVCNEIV DTCLYKGSRD NMSVILI 267

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

xtr:548912

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013