EKS-XET-00128

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00128

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	498.8	3.8E-150	156	413	258

Status

Unreviewed

Ensembl Protein

ENSXETP00000037022

UniProt Accession

B1WB72;

Protein Name

Protein Synonyms/Alias

Akt2 protein;

Gene Name

akt2

Gene Synonyms/Alias

akt2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000016986	ENSXETP00000037022	ENSXETT00000037022

Organism

Xenopus tropicalis

Functional Description

Protein Length

485

Protein Sequence
(FASTA)

MNEVMVIKEG WLQKRGEYIK TWRPRYFLLK SDGSFIGYKE KPESTEHSSI PPLNNFSVAE 60

CQLMKTERPR PNTFVIRCLQ WTTVIERTFH VDTPEEREEW IIAIQTVANG LKNQVAEDEE 120

EEAMEVKYGS PSDVSSAEQM DVAMSKGRPK VTMNDFDYLK LLGKGTFGKV ILVREKSSGR 180

YYAMKILRKE VIIAKDEVAH TLTESRVLQN TKHPFLTALK YAFQTSDRLC FVMEYANGGE 240

LFFHLSRERV FTEDRARFYG AEIVSALEYL HSRNVVYRDI KLENLMLDKD GHVKITDFGL 300

CKEGITDGAT MRTFCGTPEY LAPEVLEDND YGRAVDWWGL GVVMYEMMCG RLPFYNQDHE 360

RLFELILMEE IRFPRTLSPE AKSLLAGLLK KDPKQRLGGG PNDAQEVMSH RFFASINWQD 420

VTERKLTPPF KPQVTSEIDT RYFDDEFTAQ SITLTPPDRY DNLDALESDQ RPHFPQFSYS 480

ASIRE 485

Nucleotide Sequence
(FASTA)

ATGAATGAAG TGATGGTGAT TAAAGAAGGT TGGCTTCAGA AAAGAGGGGA GTATATCAAA 60

ACATGGAGAC CACGATATTT CCTTCTAAAA AGTGATGGTT CATTTATTGG CTATAAGGAA 120

AAGCCAGAGT CCACAGAGCA CAGTTCGATT CCGCCCCTCA ATAACTTCTC AGTTGCAGAA 180

TGTCAGCTAA TGAAGACAGA GCGTCCTAGG CCCAACACAT TTGTAATTCG CTGCCTACAA 240

TGGACTACAG TTATTGAACG GACTTTTCAT GTTGACACAC CAGAGGAAAG GGAAGAATGG 300

ATTATTGCCA TCCAGACAGT GGCCAATGGC CTGAAGAACC AGGTGGCCGA AGATGAGGAG 360

GAGGAAGCCA TGGAAGTTAA GTATGGCTCC CCCAGTGATG TCTCAAGCGC AGAGCAGATG 420

GATGTTGCAA TGTCCAAAGG GCGCCCCAAA GTGACCATGA ATGATTTTGA CTACCTCAAA 480

TTGCTGGGAA AAGGGACCTT TGGAAAGGTT ATTCTGGTCC GAGAGAAATC TAGTGGACGT 540

TACTACGCTA TGAAGATCCT TCGAAAAGAG GTCATAATCG CTAAGGATGA AGTTGCTCAT 600

ACACTTACAG AAAGCAGAGT TTTGCAGAAC ACAAAACACC CCTTTTTGAC GGCATTAAAG 660

TATGCATTTC AGACCAGTGA CAGACTCTGC TTTGTTATGG AATATGCTAA TGGTGGAGAG 720

CTTTTTTTCC ACCTTTCACG AGAACGAGTT TTTACCGAGG ACAGAGCACG CTTTTATGGA 780

GCAGAGATTG TGTCTGCTTT AGAATATCTA CATTCTCGAA ATGTGGTATA CAGAGACATC 840

AAGCTGGAGA ATCTCATGCT GGATAAGGAT GGTCATGTCA AAATTACAGA TTTTGGTTTG 900

TGTAAGGAAG GCATCACAGA TGGAGCTACC ATGAGGACTT TCTGTGGCAC ACCAGAGTAC 960

CTTGCCCCTG AGGTGCTTGA AGATAATGAC TATGGCCGAG CTGTGGACTG GTGGGGTCTT 1020

GGAGTTGTGA TGTATGAAAT GATGTGTGGC CGATTGCCCT TTTATAACCA AGACCATGAG 1080

AGGTTATTTG AACTTATCCT TATGGAGGAG ATCCGCTTTC CCCGTACATT AAGCCCAGAG 1140

GCCAAGTCTC TGCTTGCTGG GCTCTTGAAA AAGGATCCTA AGCAAAGATT AGGTGGGGGC 1200

CCAAATGATG CCCAGGAGGT CATGTCACAT CGATTCTTTG CTTCTATCAA TTGGCAAGAT 1260

GTAACAGAAA GAAAGCTTAC TCCTCCTTTC AAGCCACAAG TCACATCAGA GATTGACACA 1320

AGATATTTTG ATGATGAATT TACAGCTCAG TCTATAACTT TGACGCCTCC TGACAGATAT 1380

GATAACCTCG ATGCCTTAGA GTCAGATCAG CGCCCTCACT TTCCTCAATT CTCATATTCT 1440

GCAAGCATAC GGGAATAA 1458

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvrek+++++ya+kil+kevi+akdevahtlte+rvl++tkhpf

Q: 156   FDYLKLLGKGTFGKVILVREKSSGRYYAMKILRKEVIIAKDEVAHTLTESRVLQNTKHPF  215

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l+alky+fqt+++lc+v+ey+nGGelffhls+ervf+edrarfygaeivsal+ylhs++v

Q: 216   LTALKYAFQTSDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRNV  275

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrd+klenl+ldkdGh+kitdfGlcke+i+dg++++tfcGtpeylapevled+dyg+av

Q: 276   VYRDIKLENLMLDKDGHVKITDFGLCKEGITDGATMRTFCGTPEYLAPEVLEDNDYGRAV  335

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dhe+lfelil+ee++fpr+ls+eaksll+Gllkkdpk+

Q: 336   DWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQ  395

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg++da+e+++h+ff

Q: 396   RLGGGPNDAQEVMSHRFF  413

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KSSGRYYAMK ILRKEVIIAK DEVAHTLTES RVLQNTKHPF 60

LTALKYAFQT SDRLCFVMEY ANGGELFFHL SRERVFTEDR ARFYGAEIVS ALEYLHSRNV 120

VYRDIKLENL MLDKDGHVKI TDFGLCKEGI TDGATMRTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHERLFEL ILMEEIRFPR TLSPEAKSLL AGLLKKDPKQ 240

RLGGGPNDAQ EVMSHRFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

xtr:100144709

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013