EKS-XET-00006

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00006

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	501.8	3.0E-151	609	867	259

Status

Unreviewed

Ensembl Protein

ENSXETP00000037643

UniProt Accession

F7CRM0;

Protein Name

Protein Synonyms/Alias

Gene Name

ephb3

Gene Synonyms/Alias

ephb3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000017293	ENSXETP00000037643	ENSXETT00000037643

Organism

Xenopus tropicalis

Functional Description

Protein Length

974

Protein Sequence
(FASTA)

TLAMYCIVLS LRSVSLVTKT LMDTKWTTSE LAWVAYPDSG WEEVSGYDEA SNPIRTYQVC 60

NVRDGNQNNW LRTQFIPRQD VQRVYVELKF TVRDCNSLPN IPGSCKETFN FFYYESDSDS 120

ASADSPFWME NPYMKVDTIA PDESFSRRDS GRVNTKIRSF GPLSRTGFYL AFQDLGACVS 180

LISVRVFFKK CPRTIAGFAT FPETVTGAEA TSLVIAPGTC VPNALEVSVP LKLYCNGDGE 240

WMVPVGACTC ASGFEAAGKD TQCQACKRGT YKSKQGEGSC VPCPVNSRAI SSAATICSCQ 300

NGYYRADGES AETACTSVPS APRHVISNVN ETSVVLEWAE PGHLGGRDDI LYNVICKKCL 360

ERLCSRCDDN VQFWPRQLGV TQRRVSVSHL QAHTKYSFEI QAVNGVSGKS PHIPNYYTVN 420

ITTNQAAPSA VPMVQSHGSS ANSLTLSWAP PESPNGIILD YEIKYYPKGQ SGAGNTVTSQ 480

RTTVRMEAMT PDTVYVVQVR ARTVAGYGAY SEPREFQTIS EDGDRSSLQE QVPMVVGSVT 540

AGLIFIIAVV IIVIVCFSRK QRNDAESEYT EKLQQYMVPG MKLYIDPFTY EDPNEAVRDF 600

AKEIDISCVK IEEVIGAGEF GEVCRGRLKQ AGRREQLVAI KTLKAGYTEQ QRRDFLGEAS 660

IMGQFDHPNI IRLEGVVTRS RPVMILTEFM ENGALDSFLR MNDGQFTVIQ LVGILRGIAS 720

GMKYLSEMNY VHRDLAARNI LVNSNLVCKV SDFGLSRFLE NSRSDPTYTS SLGGKIPIRW 780

TAPEAISYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVINAIEQD YRLPPPMDCP 840

AALHQLMLDC WLRDRNLRPK FSQIVSSLDK LIRNAASLKV TSPAQAGVSQ QLLDRTVPDY 900

TTFPTVSDWL EAIKMGQYQE NFLSAGFTSF HLVAQMTAED LLRIGVTLAG HQKKLLNSVQ 960

DMRLQMSQTL PVQV 974

Nucleotide Sequence
(FASTA)

ACCCTAGCTA TGTATTGTAT AGTTCTTTCC CTCAGAAGCG TGAGCTTGGT CACTAAGACT 60

CTGATGGACA CAAAATGGAC AACATCAGAA TTAGCATGGG TTGCATACCC AGATTCAGGG 120

TGGGAGGAAG TAAGTGGATA CGATGAAGCC TCAAACCCAA TCCGGACGTA TCAGGTTTGT 180

AATGTACGGG ATGGTAATCA GAATAATTGG CTACGTACGC AGTTTATTCC ACGGCAAGAT 240

GTTCAGCGCG TGTATGTGGA GTTGAAGTTT ACTGTCAGAG ACTGTAACAG CCTGCCGAAT 300

ATCCCAGGAT CTTGCAAAGA GACCTTTAAT TTCTTCTACT ATGAATCGGA CTCTGACTCT 360

GCTTCTGCTG ACAGCCCATT CTGGATGGAA AACCCATACA TGAAGGTGGA TACCATAGCT 420

CCAGATGAGA GCTTTTCACG ACGGGATTCT GGGCGTGTCA ACACAAAGAT ACGTAGCTTT 480

GGACCTTTAT CCCGTACAGG TTTCTACTTG GCTTTTCAGG ACCTGGGTGC CTGTGTATCC 540

CTAATTTCAG TTCGTGTCTT CTTTAAAAAG TGTCCTCGAA CCATTGCTGG ATTTGCCACT 600

TTTCCCGAGA CAGTTACAGG GGCTGAAGCA ACATCACTTG TTATTGCACC AGGTACATGT 660

GTGCCGAATG CCCTAGAAGT TTCTGTGCCT CTCAAGCTGT ACTGCAATGG AGATGGAGAA 720

TGGATGGTGC CTGTGGGTGC CTGTACATGC GCATCTGGGT TTGAAGCAGC TGGGAAGGAC 780

ACTCAATGCC AAGCATGCAA ACGTGGAACA TACAAGTCAA AGCAGGGAGA GGGAAGCTGT 840

GTGCCTTGCC CCGTTAACAG CAGAGCCATT TCTTCAGCAG CCACTATCTG TTCCTGTCAG 900

AATGGATACT ACCGTGCTGA CGGAGAGAGT GCTGAGACTG CGTGTACCTC TGTGCCCTCG 960

GCACCACGAC ATGTTATCTC CAATGTAAAT GAAACCTCTG TGGTCCTTGA ATGGGCAGAG 1020

CCTGGTCATT TGGGCGGTCG GGATGACATT CTATACAATG TGATCTGTAA GAAATGCTTG 1080

GAGCGACTGT GTTCTCGCTG TGATGATAAT GTTCAGTTCT GGCCACGGCA GCTTGGTGTC 1140

ACCCAGAGGC GAGTCTCAGT CAGTCATCTC CAGGCCCACA CCAAGTATAG CTTTGAAATC 1200

CAGGCGGTCA ACGGAGTGTC TGGCAAAAGT CCACACATCC CCAACTACTA TACTGTGAAT 1260

ATTACAACTA ACCAGGCAGC CCCTTCAGCT GTGCCAATGG TGCAGTCTCA TGGAAGTTCG 1320

GCAAACTCTC TAACTCTGTC TTGGGCACCT CCAGAGAGCC CCAATGGCAT CATATTAGAC 1380

TATGAAATAA AATACTATCC CAAAGGCCAA AGCGGTGCAG GTAACACAGT GACCAGCCAG 1440

CGCACAACTG TGCGAATGGA AGCAATGACC CCAGATACAG TGTATGTTGT TCAGGTTCGA 1500

GCCCGTACTG TGGCTGGATA TGGAGCCTAT AGTGAACCTA GAGAGTTCCA GACAATCTCT 1560

GAAGATGGTG ACCGGAGCAG TCTGCAGGAA CAAGTCCCGA TGGTTGTTGG CTCTGTAACA 1620

GCCGGACTCA TTTTTATCAT TGCAGTGGTC ATTATAGTAA TAGTTTGTTT CAGCCGCAAG 1680

CAAAGGAATG ATGCTGAATC TGAATACACT GAAAAGCTGC AGCAGTACAT GGTGCCTGGC 1740

ATGAAGCTTT ACATTGATCC ATTTACGTAT GAGGATCCTA ATGAAGCTGT GCGAGACTTT 1800

GCTAAAGAAA TTGACATTTC CTGTGTGAAG ATTGAAGAAG TGATTGGTGC AGGTGAATTT 1860

GGGGAAGTGT GCCGGGGGAG ACTAAAGCAA GCAGGTCGCA GAGAACAGCT TGTAGCTATT 1920

AAGACATTGA AGGCAGGTTA CACAGAACAA CAAAGAAGAG ACTTTCTCGG TGAGGCCAGC 1980

ATCATGGGAC AGTTTGATCA TCCAAACATC ATTCGACTGG AAGGAGTTGT GACAAGGAGC 2040

CGGCCTGTCA TGATCTTGAC TGAATTTATG GAGAATGGAG CCCTTGACTC ATTTCTAAGG 2100

ATGAACGATG GACAGTTCAC AGTTATCCAG CTGGTTGGGA TACTCCGTGG CATTGCATCT 2160

GGAATGAAAT ATTTGTCTGA GATGAACTAT GTACATCGGG ATCTTGCTGC AAGGAACATC 2220

CTGGTGAACA GTAACCTTGT CTGCAAAGTG TCTGATTTTG GTCTGTCTAG ATTTTTGGAA 2280

AACAGTCGCT CTGATCCAAC GTACACAAGT TCATTGGGAG GAAAGATTCC AATTCGTTGG 2340

ACTGCTCCAG AGGCTATCTC ATACAGAAAG TTCACTTCTG CAAGCGATGT CTGGAGTTAT 2400

GGCATTGTCA TGTGGGAGGT TATGTCTTAC GGAGAGCGGC CATATTGGGA CATGTCAAAT 2460

CAAGATGTAA TTAATGCAAT TGAGCAAGAC TATCGGCTGC CACCTCCTAT GGATTGTCCT 2520

GCTGCTCTAC ACCAGCTCAT GCTGGACTGC TGGCTCCGTG ACCGCAACTT AAGACCCAAA 2580

TTCTCACAGA TCGTTAGTTC ACTTGACAAG CTAATACGTA ATGCAGCAAG TTTAAAGGTG 2640

ACCAGCCCAG CACAGGCAGG AGTATCTCAG CAGCTTCTAG ATCGCACTGT TCCTGATTAC 2700

ACTACTTTTC CCACTGTGAG CGATTGGTTG GAAGCCATTA AGATGGGGCA GTATCAAGAG 2760

AATTTTCTAA GCGCTGGCTT CACTTCTTTC CACTTGGTAG CACAAATGAC AGCTGAGGAC 2820

TTGCTCCGTA TCGGGGTGAC GCTGGCTGGT CACCAGAAAA AACTTCTCAA TAGTGTTCAG 2880

GACATGAGAC TGCAAATGAG TCAGACACTT CCTGTCCAGG TGTGA 2925

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGevc+Grlk++g+re+ vaiktlkag+te+qrrdfl easi+Gqfdhp

Q: 609   VKIEEVIGAGEFGEVCRGRLKQAGRREQLVAIKTLKAGYTEQQRRDFLGEASIMGQFDHP  668

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvvt+s+pvmi+te+mengaldsflr +dgqftviqlvg+lrGiasgmkyls+m

Q: 669   NIIRLEGVVTRSRPVMILTEFMENGALDSFLRMNDGQFTVIQLVGILRGIASGMKYLSEM  728

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178

         +yvhrdlaarnilvnsnlvckvsdfGlsr+le+++ +++yt+s ggkipirwtapeai+y

Q: 729   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLENSRsDPTYTSSlGGKIPIRWTAPEAISY  788

         *********************************999*****999****************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasdvwsyGiv+wev+syGerpywdmsnqdvi+aie++yrlpppmdcpaal+qlml

Q: 789   RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML  848

         ************************************************************

S: 239   dcwqkdraerpkfeqivsi  257

         dcw +dr+ rpkf+qivs

Q: 849   DCWLRDRNLRPKFSQIVSS  867

         *****************97

Domain Sequence
(FASTA)

VKIEEVIGAG EFGEVCRGRL KQAGRREQLV AIKTLKAGYT EQQRRDFLGE ASIMGQFDHP 60

NIIRLEGVVT RSRPVMILTE FMENGALDSF LRMNDGQFTV IQLVGILRGI ASGMKYLSEM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LENSRSDPTY TSSLGGKIPI RWTAPEAISY 180

RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVINAIE QDYRLPPPMD CPAALHQLML 240

DCWLRDRNLR PKFSQIVSS 259

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR011510	; SAM_2.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF07647	; SAM_2; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013