EKS-XET-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	476.8	2.0E-143	339	597	259

Status

Unreviewed

Ensembl Protein

ENSXETP00000037655

UniProt Accession

F7CL97;

Protein Name

Protein kinase C

Protein Synonyms/Alias

Gene Name

prkcb

Gene Synonyms/Alias

prkcb;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000017294	ENSXETP00000037655	ENSXETT00000037655

Organism

Xenopus tropicalis

Functional Description

Protein Length

670

Protein Sequence
(FASTA)

MADPAACEPG EDTTTRFARK GALRQKNVHE VKEHKFTARF FKQPTFCSHC TDFIWGFGKQ 60

GFQCQVCCFV VHKRCHEFVT FSCPGADKGP ASDDPRSKHK FKIHTYSSPT FCDHCGSLLY 120

GLIHQGMKCE TCMMNVHKRC VMNVPSLCGT DHTERRGRIH IKAEIREEVL TVTVGDARNL 180

VPMDPNGLSD PYVKLKLIPD PKSESKQKTK TIKCSLNPTW NESFKFQLKE SDKDRRLSVE 240

IWDWDLTSRN DFMGSLSFGI SELLKAGVDG WFKLLSQEEG EYFNVPVPPE GEEGNEELRQ 300

KFERAKIGPG TKAVEEKVVN PMPKVDNNGT RDRMKVSDFN FLKVLGKGSF GKVILAERKG 360

TDELYAIKIL KKDVVIQDDD VECTMVEKRV LALSGKPPFL TQLHSCFQTM DRLYFVMEYV 420

NGGDLMYQIQ QVGRFKEPHA VFYAAEIAIG LLFLHSKGIV YRDLKLDNVM LDSEGHIKIA 480

DFGMCKENMW DGVTTKTFCG TPDYIAPEII AYQPYAKSVD WWAFGILLYE MLAGQAPFEG 540

EDEDELFQSI MEHNVAYPKS MSKEAVAICK GLMTKHPGKR LGCGPEGERD IKDHAFFRYI 600

DWEKLERNEI QPPYKPKACG RNAENFDKFF TRHPPVLTPP DHEVIRNIDQ SEFEGFSYVN 660

SDFAKEEEKD 670

Nucleotide Sequence
(FASTA)

ATGGCTGACC CCGCAGCCTG CGAGCCTGGG GAGGACACCA CCACTCGCTT TGCCAGGAAG 60

GGGGCTCTGC GGCAGAAGAA TGTGCATGAG GTGAAGGAGC ACAAGTTCAC AGCCCGCTTC 120

TTCAAGCAGC CCACCTTCTG CAGCCACTGC ACCGACTTCA TCTGGGGTTT TGGCAAACAG 180

GGATTCCAGT GTCAAGTTTG CTGTTTCGTG GTGCACAAGC GGTGTCATGA GTTTGTCACG 240

TTTTCCTGCC CGGGCGCAGA TAAAGGGCCA GCATCTGATG ACCCCCGCAG CAAACACAAG 300

TTCAAAATTC ACACGTACTC CAGCCCGACG TTCTGTGACC ACTGCGGCTC ATTGCTGTAC 360

GGCCTCATTC ACCAGGGGAT GAAATGTGAA ACCTGCATGA TGAATGTCCA CAAGCGCTGC 420

GTAATGAACG TGCCAAGTCT GTGTGGCACC GACCACACCG AGCGAAGAGG AAGGATACAC 480

ATCAAGGCGG AGATCCGCGA GGAAGTACTG ACAGTCACTG TCGGGGATGC GAGAAACCTA 540

GTTCCAATGG ACCCAAATGG ACTGTCTGAC CCGTACGTAA AGCTAAAGCT CATCCCAGAC 600

CCAAAGAGCG AGAGCAAACA AAAGACCAAG ACTATCAAGT GTTCCCTGAA CCCAACCTGG 660

AATGAGAGCT TTAAATTCCA GCTGAAGGAG TCCGATAAAG ATCGCAGGCT GTCCGTGGAA 720

ATCTGGGACT GGGACTTAAC CAGTAGGAAT GATTTCATGG GGTCCCTGTC GTTTGGTATC 780

TCGGAGCTAC TGAAGGCCGG CGTAGACGGT TGGTTCAAGT TGCTCAGCCA AGAGGAGGGA 840

GAATACTTTA ACGTACCTGT GCCACCTGAA GGAGAAGAAG GCAACGAAGA GCTACGCCAG 900

AAGTTTGAGA GAGCTAAAAT TGGCCCCGGG ACCAAAGCCG TTGAAGAGAA AGTGGTGAAC 960

CCAATGCCCA AGGTGGACAA CAATGGAACC AGGGACCGTA TGAAAGTGTC AGACTTTAAC 1020

TTCCTAAAGG TTCTGGGGAA AGGCAGCTTT GGGAAGGTGA TCCTGGCAGA GAGGAAAGGA 1080

ACAGATGAGC TCTATGCAAT AAAGATCCTG AAGAAGGACG TGGTGATTCA GGATGATGAT 1140

GTTGAGTGCA CAATGGTAGA GAAGAGGGTC TTGGCTCTGT CTGGGAAGCC CCCATTCCTC 1200

ACTCAGCTGC ACTCCTGTTT CCAGACAATG GATCGCCTTT ACTTTGTCAT GGAGTACGTC 1260

AATGGTGGAG ACCTCATGTA CCAGATCCAG CAGGTCGGCC GATTCAAGGA ACCACATGCA 1320

GTATTCTACG CAGCAGAGAT AGCCATCGGC CTGCTATTCC TGCACAGCAA AGGCATCGTG 1380

TATAGGGACC TCAAGCTGGA TAACGTCATG CTGGATTCAG AGGGACACAT AAAGATCGCA 1440

GATTTCGGCA TGTGTAAGGA GAACATGTGG GACGGGGTAA CGACAAAGAC CTTCTGCGGC 1500

ACGCCAGACT ACATAGCGCC CGAGATTATA GCTTACCAGC CTTACGCCAA GTCAGTGGAT 1560

TGGTGGGCAT TCGGGATCCT TCTTTACGAG ATGTTAGCCG GGCAGGCTCC GTTCGAAGGG 1620

GAAGATGAGG ATGAGTTATT CCAGTCCATC ATGGAGCATA ATGTAGCATA TCCCAAATCA 1680

ATGTCCAAGG AAGCTGTGGC CATCTGTAAA GGGCTGATGA CAAAGCATCC TGGGAAGCGG 1740

CTGGGCTGTG GCCCAGAGGG GGAGCGAGAC ATTAAGGACC ATGCCTTTTT CCGATACATA 1800

GACTGGGAGA AGCTGGAAAG GAACGAGATC CAACCCCCCT ACAAGCCAAA GGCGTGCGGC 1860

CGAAATGCTG AGAACTTCGA CAAGTTTTTT ACCCGCCACC CACCAGTGCT CACGCCACCC 1920

GACCATGAGG TCATCCGGAA CATTGACCAA TCAGAATTTG AAGGCTTTTC CTATGTTAAC 1980

TCTGATTTTG CAAAAGAGGA GGAGAAGGAC TAA 2013

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++lkvlGkGsfgkv+lae+k+tdelyaik+lkkdvv+qdddve+t+vekrvlal+ k+p

Q: 339   FNFLKVLGKGSFGKVILAERKGTDELYAIKILKKDVVIQDDDVECTMVEKRVLALSGKPP  398

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+ql+scfqt+drl+fv+eyvnGGdlm++iq+++++ke++a+fyaaei+++l flh+kg

Q: 399   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYQIQQVGRFKEPHAVFYAAEIAIGLLFLHSKG  458

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         i+yrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPei+++++y+ks

Q: 459   IVYRDLKLDNVMLDSEGHIKIADFGMCKENMWDGVTTKTFCGTPDYIAPEIIAYQPYAKS  518

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+G+llyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p

Q: 519   VDWWAFGILLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  578

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+ +ege+dik+haff

Q: 579   KRLGCGPEGERDIKDHAFF  597

         ******************9

Domain Sequence
(FASTA)

FNFLKVLGKG SFGKVILAER KGTDELYAIK ILKKDVVIQD DDVECTMVEK RVLALSGKPP 60

FLTQLHSCFQ TMDRLYFVME YVNGGDLMYQ IQQVGRFKEP HAVFYAAEIA IGLLFLHSKG 120

IVYRDLKLDN VMLDSEGHIK IADFGMCKEN MWDGVTTKTF CGTPDYIAPE IIAYQPYAKS 180

VDWWAFGILL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240

KRLGCGPEGE RDIKDHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0008270	; F:zinc ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013