EKS-XET-00482

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00482

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	446.0	3.8E-134	268	517	250

Status

Unreviewed

Ensembl Protein

ENSXETP00000037721

UniProt Accession

F7DXH6;

Protein Name

Protein Synonyms/Alias

Gene Name

src

Gene Synonyms/Alias

src;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000017318	ENSXETP00000037721	ENSXETT00000037721

Organism

Xenopus tropicalis

Functional Description

Protein Length

534

Protein Sequence
(FASTA)

MGATKSKPRE GGPRSRSLDI AEGSHQPFTS LSASQTPSKS LDSHRQPAQP FGGNCDLTPF 60

GGVNFSDTIT SPQRIGPLAG GVTTFVALYD YESRTETDLS FKKGERLQIV NNTEGDWWLA 120

RSLSSGQTGY IPSNYVAPSD SIQAEEWYLG KITRREAERL LLSLENPRGT FLVRESETTK 180

ATGAYCLSVS DYDANRGLNV KHYKIRKLDS GGFYITSRTQ FSSLQQLVAY YSKHADGLCH 240

RLTTVCPTAK PQTQGLSKDA WEIPRDSLRL ELKLGQGCFG EVWMGTWNGT TRVAIKTLKP 300

GTMSPEAFLQ EAQVMKKLRH EKLVQLYAVV SEEPIYIVTE YMSKGSLLDF LKGEMGRYLR 360

LPQLVDMAAQ IASGMAYVER MNYVHRDLRA ANILVGENLV CKVADFGLAR LIEDNEYTAR 420

QGAKFPIKWT APEAALYGRF TIKSDVWSFG ILLTELTTKG RVPYPGMVNR EVLDQVERGY 480

RMPCPPDCPE SLHDLMCQCW RKDPEERPTF EYLQAFLEDY FTATEPQYQP GDNL 534

Nucleotide Sequence
(FASTA)

ATGGGTGCCA CTAAAAGCAA GCCGCGAGAA GGTGGCCCCC GGAGCCGCAG CCTGGACATT 60

GCTGAGGGGT CCCACCAGCC TTTTACCTCC CTTTCTGCCT CTCAGACCCC CAGCAAGAGC 120

CTGGATTCCC ACCGGCAACC TGCACAGCCA TTTGGGGGCA ACTGTGACCT GACGCCTTTT 180

GGAGGGGTGA ATTTCTCTGA TACCATCACT TCCCCCCAGC GGATAGGACC GCTAGCAGGG 240

GGCGTCACCA CCTTTGTCGC TTTGTACGAC TATGAATCTC GCACCGAGAC AGACTTGTCC 300

TTTAAGAAGG GGGAGAGACT ACAGATCGTC AATAACACGG AAGGCGACTG GTGGTTGGCA 360

CGTTCCCTGA GCTCTGGGCA GACTGGCTAC ATTCCAAGCA ACTACGTAGC TCCTTCGGAC 420

TCCATTCAAG CTGAAGAGTG GTATTTGGGG AAGATAACGC GCCGAGAAGC AGAGCGTCTG 480

CTTCTGAGCC TTGAGAACCC TCGAGGGACT TTCCTGGTGA GAGAGAGTGA AACTACCAAA 540

GCCACAGGTG CATACTGCTT GTCTGTCTCT GACTATGATG CCAATCGTGG CCTCAATGTG 600

AAGCATTACA AGATCCGCAA GTTAGACAGT GGAGGATTTT ACATCACGTC TCGCACTCAG 660

TTCAGCAGCC TGCAGCAACT TGTGGCCTAC TATAGCAAGC ACGCAGATGG CCTGTGTCAC 720

CGCCTGACCA CTGTTTGTCC CACTGCCAAG CCCCAAACTC AGGGCCTGTC CAAAGATGCC 780

TGGGAAATAC CGCGCGACTC TCTGCGCTTG GAGCTCAAGC TGGGACAGGG TTGCTTCGGA 840

GAAGTGTGGA TGGGCACTTG GAACGGAACC ACACGAGTTG CCATCAAGAC TCTGAAGCCT 900

GGCACAATGT CACCGGAAGC CTTTCTGCAG GAAGCACAGG TCATGAAGAA ACTTAGGCAT 960

GAGAAGCTGG TACAGCTTTA TGCTGTGGTG TCTGAGGAAC CCATCTACAT AGTAACCGAG 1020

TATATGAGCA AAGGCAGTCT ACTGGATTTC CTAAAGGGTG AAATGGGGCG GTATCTACGG 1080

CTTCCCCAAC TTGTGGATAT GGCTGCCCAG ATTGCTTCCG GCATGGCGTA TGTGGAACGC 1140

ATGAATTACG TACATCGGGA TCTCAGAGCA GCCAACATCT TGGTAGGAGA GAACTTGGTG 1200

TGCAAGGTGG CTGATTTTGG CTTGGCACGA CTGATTGAAG ACAATGAATA TACAGCACGT 1260

CAAGGTGCCA AGTTCCCTAT TAAGTGGACT GCCCCTGAGG CTGCCCTGTA TGGTAGATTC 1320

ACCATTAAAT CCGACGTCTG GTCTTTTGGA ATTCTCCTGA CTGAGCTTAC CACCAAGGGC 1380

AGGGTCCCTT ACCCAGGCAT GGTTAACCGA GAGGTGTTGG ACCAAGTGGA GCGAGGATAC 1440

CGCATGCCTT GTCCCCCGGA CTGCCCAGAA TCCCTCCACG ACCTGATGTG CCAGTGCTGG 1500

AGGAAGGATC CTGAGGAGAG GCCAACCTTT GAATACCTGC AGGCGTTCCT GGAGGACTAC 1560

TTTACTGCAA CGGAACCGCA GTACCAACCT GGGGACAACC TTTAG 1605

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 268   LRLELKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  327

         57899*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk e g++l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 328   AVVSE-EPIYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERMNYVHR  386

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 387   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  446

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p +cpe+l++l+++cw+kdpee

Q: 447   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPDCPESLHDLMCQCWRKDPEE  506

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 507   RPTFEYLQAFL  517

         *******9876

Domain Sequence
(FASTA)

LRLELKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMSKGSL LDFLKGEMGR YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120

LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPD CPESLHDLMC QCWRKDPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013