EKS-XET-00368

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00368

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IKK	402.9	8.0E-121	15	287	273

Status

Reviewed

Ensembl Protein

ENSXETP00000038296

UniProt Accession

Q28DZ1;

Protein Name

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Protein Synonyms/Alias

I kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA;

Gene Name

chuk

Gene Synonyms/Alias

chuk; ikka; TEgg047h13.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000017643	ENSXETP00000038296	ENSXETT00000038296

Organism

Xenopus tropicalis

Functional Description

Phosphorylates inhibitors of NF-kappa-B thus leading tothe dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser- 10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines (By similarity).

Protein Length

742

Protein Sequence
(FASTA)

MEKPPVQHGA VCGPWDMKDR LGTGGFGNVC LYQNRETGEL KAIKSCRLEL SMKNKERWCQ 60

EIQIMKRLNH PNVVKACEVP PEMDFLVNDV PHLAMEYCAG GDLRKLLNKP ENCCGLKESQ 120

VLNLMSDIGS GIQYLHEKRI IHRDLKPENI VLQECNGKTV HKIIDLGYAK DLDQGSLCTS 180

FVGTLQYLAP ELFENKPYSV TVDYWSFGTM VFECIAGFRP FLHNMQPFTW HEKIKKKDHK 240

HIYAYEEMSG EIRFSSYLPQ PNNLCSIIVD KIETWLQLLL NWDPIQRGGG MDCGRPQCFV 300

LMDQILNLKI VHILNMTSAK IHSFHLQEES LHTLQSRIET ETGISTCNQE LLLEMGVSLD 360

PRKPASQCVI DGVKGWDSYM VYLFDKSKTV YEGPFQSRSL SECLNYIVQD SKVQLPIPQL 420

RKVWAEAVHY VSGLKEDYSR LFQGQRAAML SLLRFNTNLT KMKNTMVSAS QQLGAKLQFF 480

KRSIEIDLER YSDQMAYGIS SEKMLRAWKE MEDKAVCFGK AGKIHFLDET IMGLHTEIVE 540

LQKSPCARRQ GDVMEHLEQR AMELYKQLKP RSPDKAYSDS TEMVKILVQT VQGQDRVLKE 600

LFGHLSKLLG CKQKIIDLLP QIEMTVNNIK EADSSLMQMQ AKRQREIWHL LKIACTQSSA 660

RSLGPASVET PITPRTSAWP DQSSSQALFS MLTTKDKSRE ILRHTIDKNS DYQKLLSSLI 720

LQTQTTMEQN SLMSLDFSWL NK 742

Nucleotide Sequence
(FASTA)

ATGGAGAAGC CCCCAGTCCA ACATGGAGCT GTTTGTGGGC CATGGGACAT GAAAGACCGC 60

CTAGGAACAG GAGGTTTTGG AAATGTTTGC TTGTACCAGA ATCGGGAAAC AGGAGAGCTG 120

AAAGCCATCA AATCCTGTAG GTTGGAACTG AGTATGAAAA ACAAAGAGAG ATGGTGTCAA 180

GAAATTCAGA TTATGAAGAG GTTAAATCAT CCAAATGTTG TGAAAGCTTG TGAAGTTCCA 240

CCGGAGATGG ATTTCCTTGT TAATGACGTC CCTCACCTAG CCATGGAATA CTGTGCTGGA 300

GGGGATTTGC GAAAGCTTCT AAATAAACCA GAAAACTGCT GTGGTTTGAA GGAAAGTCAA 360

GTGCTAAATT TAATGAGTGA CATAGGTTCT GGAATACAAT ATCTGCATGA GAAGAGGATC 420

ATACACAGAG ACCTCAAACC AGAAAACATA GTGCTGCAAG AATGTAATGG GAAGACTGTT 480

CACAAAATCA TCGACTTGGG ATATGCCAAA GACTTAGATC AGGGAAGTCT TTGTACATCC 540

TTTGTAGGAA CACTGCAGTA CCTGGCTCCT GAACTCTTTG AGAACAAACC TTACAGCGTT 600

ACAGTTGACT ATTGGAGTTT CGGCACCATG GTTTTTGAGT GCATAGCAGG CTTCAGACCA 660

TTTCTGCACA ACATGCAGCC ATTCACCTGG CATGAGAAGA TTAAGAAGAA AGATCACAAA 720

CATATCTATG CTTATGAAGA GATGTCTGGA GAAATTAGAT TCAGCTCATA TCTTCCACAA 780

CCCAACAATC TTTGCAGCAT AATTGTAGAC AAGATAGAGA CATGGTTGCA GCTTTTGTTA 840

AACTGGGACC CTATACAACG GGGAGGAGGA ATGGACTGCG GTCGTCCACA ATGTTTTGTG 900

CTAATGGACC AGATCCTCAA CTTGAAGATA GTTCACATTT TGAATATGAC ATCTGCCAAG 960

ATTCATTCTT TTCACCTGCA GGAGGAGAGC CTACACACCC TGCAGTCTCG CATTGAGACA 1020

GAGACTGGCA TTAGCACATG TAATCAAGAG TTACTTCTAG AGATGGGGGT ATCCCTTGAT 1080

CCAAGAAAAC CAGCATCCCA ATGTGTTATA GATGGAGTGA AAGGATGGGA TAGCTATATG 1140

GTTTATTTGT TTGATAAAAG CAAGACTGTT TATGAAGGAC CATTTCAGTC AAGAAGCCTC 1200

TCGGAATGCC TTAATTACAT AGTACAGGAC AGTAAAGTCC AACTCCCCAT TCCACAACTG 1260

CGTAAAGTGT GGGCTGAGGC TGTCCATTAT GTTTCTGGCT TGAAGGAAGA TTACAGCCGC 1320

CTTTTCCAGG GCCAGAGGGC CGCTATGCTC AGCCTTCTGC GCTTTAATAC GAATCTCACC 1380

AAGATGAAGA ACACCATGGT GTCTGCCTCA CAGCAGCTAG GAGCAAAGTT ACAGTTCTTC 1440

AAGCGAAGCA TTGAGATAGA CTTGGAACGC TATAGTGATC AAATGGCCTA TGGAATTTCT 1500

TCAGAGAAAA TGCTGAGAGC TTGGAAGGAA ATGGAAGACA AAGCGGTTTG CTTTGGGAAG 1560

GCTGGAAAGA TCCATTTCTT AGATGAGACT ATAATGGGAC TTCATACAGA GATAGTAGAA 1620

CTGCAGAAAA GTCCTTGTGC CCGTAGACAA GGAGATGTGA TGGAGCACCT AGAACAGAGA 1680

GCAATGGAAT TGTACAAGCA ACTGAAGCCT CGCTCTCCAG ATAAAGCTTA TAGTGACAGT 1740

ACTGAAATGG TGAAAATTCT TGTACAGACG GTGCAAGGAC AAGACCGAGT GCTAAAGGAA 1800

CTATTTGGCC ACTTAAGCAA GCTTCTAGGT TGCAAGCAGA AAATCATTGA TCTACTTCCT 1860

CAGATTGAGA TGACTGTGAA TAATATCAAG GAAGCAGACA GTTCTCTCAT GCAGATGCAA 1920

GCCAAGCGAC AGAGGGAGAT ATGGCATTTA CTAAAAATTG CATGTACTCA GAGCTCCGCC 1980

CGCTCATTGG GACCTGCAAG TGTGGAAACA CCAATTACTC CTCGCACATC AGCCTGGCCT 2040

GATCAAAGCT CTTCGCAGGC ACTTTTCTCC ATGCTAACAA CTAAAGACAA GAGCAGAGAA 2100

ATATTAAGGC ATACTATTGA CAAGAACTCA GATTATCAGA AACTGCTGAG CAGCTTAATA 2160

CTGCAGACAC AGACAACAAT GGAGCAAAAC AGTCTAATGA GTCTGGATTT CAGCTGGCTA 2220

AACAAATGA 2229

Domain Profile

S: 1     WelkelLGeGafgnvikarnkktgekiavkvikeesslrprevqvrelevlrklnhkniv  60

         W +k++LG+G+fgnv+ ++n++tge  a+k+++ e+s++++e++++e++++++lnh+n+v

Q: 15    WDMKDRLGTGGFGNVCLYQNRETGELKAIKSCRLELSMKNKERWCQEIQIMKRLNHPNVV  74

         9***********************************************************

S: 61    klvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvLsdvvaglry  120

         k+++v+ e++++ ++++ l++eyC gGdlrk+L++pen++GLkes+vl ++sd+ +g++y

Q: 75    KACEVPPEMDFLVNDVPHLAMEYCAGGDLRKLLNKPENCCGLKESQVLNLMSDIGSGIQY  134

         ************************************************************

S: 121   LrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGteeYlaPely  180

         L+e++i+hRDlkPenivl++  +gk+++k++DlG+a++ld++++++s+vGt++YlaPel+

Q: 135   LHEKRIIHRDLKPENIVLQEC-NGKTVHKIIDLGYAKDLDQGSLCTSFVGTLQYLAPELF  193

         ********************9.**************************************

S: 181   eqkkytatvDlWsiGvllyeaitGslPflpfegprrlykkitkkpakaiagtekangeve  240

         e+k y++tvD+Ws+G++++e+i+G++Pfl++++p+++++ki+kk++k i + e+++ge++

Q: 194   ENKPYSVTVDYWSFGTMVFECIAGFRPFLHNMQPFTWHEKIKKKDHKHIYAYEEMSGEIR  253

         ************************************************************

S: 241   fssslPlsaslssglqeklekllanllevdeekr  274

         fss lP++++l+s++++k+e +l++ll++d+ +r

Q: 254   FSSYLPQPNNLCSIIVDKIETWLQLLLNWDPIQR  287

         ******************************9887

Domain Sequence
(FASTA)

WDMKDRLGTG GFGNVCLYQN RETGELKAIK SCRLELSMKN KERWCQEIQI MKRLNHPNVV 60

KACEVPPEMD FLVNDVPHLA MEYCAGGDLR KLLNKPENCC GLKESQVLNL MSDIGSGIQY 120

LHEKRIIHRD LKPENIVLQE CNGKTVHKII DLGYAKDLDQ GSLCTSFVGT LQYLAPELFE 180

NKPYSVTVDY WSFGTMVFEC IAGFRPFLHN MQPFTWHEKI KKKDHKHIYA YEEMSGEIRF 240

SSYLPQPNNL CSIIVDKIET WLQLLLNWDP IQR 273

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>