EKS-XET-00075

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00075

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	450.3	2.9E-135	41	325	285

Status

Unreviewed

Ensembl Protein

ENSXETP00000039075

UniProt Accession

F7ACT4;

Protein Name

Protein Synonyms/Alias

Gene Name

gsk3b

Gene Synonyms/Alias

gsk3b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000018019	ENSXETP00000039075	ENSXETT00000039075

Organism

Xenopus tropicalis

Functional Description

Protein Length

405

Protein Sequence
(FASTA)

CIRVPDPSFS SLSPGDKDGS KVTTVVATPG QGPDRQQEVS YTDTKVIGNG SFGVVYQAKL 60

CDTGELVAIK KVLQDKRFKN RELQIMRKLD HCNIVRLRYF FYSSGEKKDE VYLNLVLDYV 120

PETVYRVARH YSRAKQALPM IYVKLYMYQL FRSLAYIHSF GICHRDIKPQ NLLLDPETAV 180

LKLCDFGSAK QLVRGEPNVS YICSRYYRAP ELIFGATDYT SSIDVWSAGC VLAELLLGQP 240

IFPGDSGVDQ LVEIIKVLGT PTREQIREMN PNYTEFKFPQ IKAHPWTKVF RARTPPEAIA 300

LCSRLLEYTP TARLTPLDAC AHSFFDELRD PNLKLPNGRE FPALFNFTTQ ELSSNPSLSS 360

ILIPAHARNQ ASVPTPSNST SASETSTGER CTSTNAASAS ASNSS 405

Nucleotide Sequence
(FASTA)

TGTATACGTG TTCCTGATCC TTCTTTCTCT TCTCTCTCCC CAGGAGACAA AGATGGCAGC 60

AAGGTGACCA CAGTAGTAGC GACCCCCGGC CAGGGGCCCG ACCGGCAGCA AGAAGTCAGC 120

TACACGGACA CCAAGGTTAT TGGCAACGGG TCCTTTGGGG TTGTGTACCA GGCCAAACTG 180

TGCGACACGG GGGAGCTGGT GGCTATCAAG AAGGTGCTAC AGGACAAGAG ATTTAAGAAC 240

CGAGAACTGC AGATCATGAG AAAACTGGAT CACTGCAACA TTGTGCGTCT GCGCTACTTC 300

TTCTACTCCA GCGGGGAGAA GAAGGACGAA GTGTACCTCA ACTTGGTGCT GGACTACGTT 360

CCCGAAACTG TGTACAGAGT GGCCAGACAT TACAGCCGGG CTAAGCAGGC GCTCCCCATG 420

ATCTATGTCA AGTTGTACAT GTACCAGCTG TTCCGCAGTT TAGCCTACAT CCATTCCTTT 480

GGGATCTGCC ACCGGGATAT CAAACCACAG AACCTTCTGC TGGACCCAGA AACTGCTGTA 540

CTCAAGCTGT GTGACTTTGG CAGTGCCAAG CAGCTGGTAC GCGGAGAGCC CAACGTGTCC 600

TACATCTGCT CCCGGTACTA CAGGGCCCCA GAGTTGATCT TTGGAGCCAC CGATTACACT 660

TCCAGTATTG ACGTGTGGTC AGCAGGCTGC GTATTGGCCG AGCTGCTGCT GGGTCAGCCC 720

ATCTTCCCTG GGGACAGCGG CGTGGATCAG CTGGTTGAGA TAATCAAGGT TCTGGGTACC 780

CCGACTCGAG AGCAGATCCG AGAAATGAAC CCCAACTACA CTGAATTCAA GTTCCCACAG 840

ATTAAGGCGC ATCCTTGGAC AAAGGTGTTC CGGGCGCGCA CCCCTCCCGA GGCCATCGCC 900

CTGTGCAGTC GGCTGCTGGA GTACACGCCC ACTGCCCGCC TCACCCCATT GGATGCCTGC 960

GCCCACTCCT TCTTCGACGA ACTGCGGGAC CCCAATCTGA AACTGCCCAA CGGGCGCGAA 1020

TTCCCTGCTC TCTTCAACTT TACCACTCAA GAGCTGTCAA GCAATCCTTC CCTCTCTTCT 1080

ATTCTCATCC CTGCCCATGC TCGGAACCAG GCCTCCGTGC CCACGCCGTC AAACTCGACA 1140

TCGGCATCAG AGACGAGCAC CGGGGAGCGC TGTACGAGCA CCAACGCAGC CTCCGCGTCG 1200

GCCTCCAATT CCTCCTGA 1218

Domain Profile

S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLly  60

         ++++k+ig+GsFg+Vyqa+l+++ e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+y

Q: 41    YTDTKVIGNGSFGVVYQAKLCDTGEL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRY  99

         5789**********************.*********************************

S: 61    ffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhs  120

         ff++s ekkd+vylnlvl+y+Pet+++v+r+++++k++l++++vkly+yQlfr+lay+hs

Q: 100   FFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHS  159

         ************************************************************

S: 121   leivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakey  180

         ++i+HrDiKPqNll+d+et+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++y

Q: 160   FGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDY  219

         ************************************************************

S: 181   ttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfk  240

         t++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf+

Q: 220   TSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFP  279

         ************************************************************

S: 241   kikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         +ik+++++kv++ ++++ea++l++++l+y+p++Rl++l+++ah+ff

Q: 280   QIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFF  325

         *********************************************9

Domain Sequence
(FASTA)

YTDTKVIGNG SFGVVYQAKL CDTGELVAIK KVLQDKRFKN RELQIMRKLD HCNIVRLRYF 60

FYSSGEKKDE VYLNLVLDYV PETVYRVARH YSRAKQALPM IYVKLYMYQL FRSLAYIHSF 120

GICHRDIKPQ NLLLDPETAV LKLCDFGSAK QLVRGEPNVS YICSRYYRAP ELIFGATDYT 180

SSIDVWSAGC VLAELLLGQP IFPGDSGVDQ LVEIIKVLGT PTREQIREMN PNYTEFKFPQ 240

IKAHPWTKVF RARTPPEAIA LCSRLLEYTP TARLTPLDAC AHSFF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013