EKS-XET-00090
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00090
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec440.81.5E-132393646254
StatusUnreviewed
Ensembl ProteinENSXETP00000039378
UniProt AccessionF6V9R3;
Protein Name
Protein Synonyms/Alias
Gene Namebtk
Gene Synonyms/Alias btk;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000018152ENSXETP00000039378ENSXETT00000039378
OrganismXenopus tropicalis
Functional Description
Protein Length653
Protein Sequence
(FASTA)
MAATASILES IFLKRSQQKR KTSPLNFKKR LFVLTDTKII YYEYDFDRGR RGSKKGSVDL 60
DKVICVECVE PEENPPPERQ IPNREEFDTE QMTIIERFPY PFQIVYDDGP LYVFAPTEEL 120
RKRWIHQLKH VIRFNSDVAQ KYHPRFYQDG QYLCCAQTAK NAMGCQPLGN ANGFIRTERS 180
QRRSRKPLPP PPPQESQKPL PPTPCLSLHK VVAMYDFTPL NAQDLPLHKG EEYVLLEEGT 240
GNPWLRARDK NGLEGYIPGN YVTEAQDPLE IYEWYSKNMT RSQAEKLLRA EDKEGGFIVR 300
DSSKAGKYTV SVYAKSSGEG IIRHYVVCEA PGNQYYLAEK HLYSSIPELI TYHQHNAAGL 360
ISRLKYPVCS LRKTAPSTAG LGYGSWEIDP KDLTFLKELG NGQFGVVKYG KWRGQHDVAI 420
KMIKEGSMSE DEFIEEAKCM MKLSHQNLVQ LYGVCTKQRP IFIITEFLSN GCLLNYLKDL 480
RGRVSQGDLL SMCSDVCAAM TYLESKQYLH RDLAARNCLV AADGIVKVSD FGLSRYVLDD 540
EYTSSLGSKF PVRWSSPEVL LYCRFSSKSD VWSFVLAPGV LMWEVFTLGR MPYDRFTNNE 600
IVEQITRGVR LYRPQNATDR VYSIMVSCWA EKADDRPTFR ILHNTILEVL EDS 653
Nucleotide Sequence
(FASTA)
ATGGCTGCCA CTGCCAGTAT ATTAGAGAGT ATTTTTTTGA AAAGATCCCA GCAGAAGCGA 60
AAAACATCAC CTCTTAACTT TAAGAAGAGA CTATTTGTGC TAACAGACAC CAAAATCATC 120
TATTATGAGT ATGACTTTGA CAGAGGGCGT CGGGGCAGCA AAAAAGGATC TGTGGATCTA 180
GACAAAGTGA TTTGTGTGGA GTGTGTTGAG CCTGAGGAAA ACCCACCACC AGAGAGGCAA 240
ATACCAAACA GAGAAGAATT TGACACAGAG CAGATGACTA TCATAGAGAG ATTTCCATAC 300
CCATTCCAGA TAGTGTATGA TGATGGGCCG CTCTACGTCT TTGCTCCTAC AGAAGAACTG 360
CGAAAACGCT GGATTCACCA GTTGAAGCAT GTTATTCGTT TTAACAGCGA TGTGGCTCAG 420
AAATATCACC CTCGGTTTTA CCAAGATGGG CAATATCTTT GCTGTGCCCA AACAGCCAAA 480
AATGCAATGG GATGCCAGCC ACTGGGGAAT GCCAATGGAT TTATAAGAAC AGAACGCTCC 540
CAGCGAAGGT CCAGAAAGCC ACTCCCTCCT CCACCACCCC AAGAGAGCCA GAAGCCATTG 600
CCACCTACAC CATGTTTATC ACTACACAAG GTTGTAGCCA TGTATGATTT TACTCCATTA 660
AATGCCCAAG ATTTGCCGCT GCATAAGGGT GAGGAGTATG TATTGCTGGA GGAAGGCACT 720
GGGAATCCCT GGCTGAGAGC ACGGGATAAA AATGGGCTGG AAGGATACAT ACCTGGTAAT 780
TATGTTACAG AAGCTCAAGA TCCACTGGAA ATATATGAGT GGTACTCCAA AAACATGACA 840
AGAAGTCAGG CTGAAAAACT GCTACGAGCA GAGGATAAAG AAGGTGGCTT TATCGTGAGA 900
GATTCCAGCA AGGCCGGAAA GTACACTGTA TCCGTATATG CAAAATCATC TGGGGAAGGT 960
ATTATACGCC ATTATGTGGT GTGTGAGGCG CCTGGAAATC AATATTATTT GGCAGAGAAA 1020
CATCTGTATT CCTCAATACC AGAACTGATC ACATATCATC AACACAATGC TGCAGGCCTA 1080
ATATCAAGGT TGAAATATCC TGTCTGCTCT TTGAGAAAAA CTGCTCCTTC CACAGCAGGC 1140
CTTGGCTATG GCTCATGGGA GATTGACCCA AAGGACCTGA CATTCCTGAA GGAGTTAGGC 1200
AATGGGCAGT TTGGGGTGGT AAAGTACGGA AAGTGGAGAG GTCAGCATGA TGTGGCTATT 1260
AAGATGATTA AAGAGGGTTC CATGTCTGAA GATGAATTCA TAGAAGAGGC CAAATGTATG 1320
ATGAAGTTGT CCCATCAAAA TCTGGTGCAG TTGTACGGTG TCTGTACTAA GCAGCGTCCT 1380
ATTTTTATAA TTACCGAGTT CCTGTCGAAC GGCTGCCTGC TCAATTACCT GAAGGATCTG 1440
CGTGGGAGGG TCTCTCAGGG AGATCTGCTA TCCATGTGCA GTGATGTCTG CGCAGCAATG 1500
ACATATCTTG AATCGAAGCA ATATCTGCAC CGTGACTTGG CTGCAAGAAA TTGCTTAGTT 1560
GCTGCAGATG GAATAGTAAA GGTTTCTGAT TTCGGTCTTT CAAGATATGT TCTAGATGAT 1620
GAATATACAA GTTCTTTGGG TTCTAAGTTT CCTGTCCGCT GGTCATCTCC AGAGGTTCTT 1680
CTGTACTGCA GGTTCAGTAG CAAGTCTGAT GTGTGGTCAT TTGTTCTCGC CCCAGGGGTC 1740
TTAATGTGGG AAGTGTTTAC TCTTGGAAGG ATGCCATATG ACAGATTCAC TAATAATGAA 1800
ATTGTGGAAC AGATAACAAG GGGTGTCCGT CTGTACAGAC CCCAAAATGC CACAGATAGA 1860
GTGTACAGCA TCATGGTCAG TTGCTGGGCA GAGAAAGCTG ATGACAGACC AACCTTCCGA 1920
ATTCTACATA ATACCATCTT GGAAGTTCTG GAGGACTCCT GA 1962
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeak mmklsh++lvqly
Q: 393   LTFLKELGNGQFGVVKYGKWRGQHDVAIKMIKEGSMSEDEFIEEAKCMMKLSHQNLVQLY  452
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+te+l+ngcllnyl++ ++++++  ll+mc dvc +m+yle+k+++hrd
Q: 453   GVCTKQRPIFIITEFLSNGCLLNYLKDLRGRVSQGDLLSMCSDVCAAMTYLESKQYLHRD  512
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv  + +vkvsdfgl+ryvldd+y+ss g+kfpv+ws+pevl y ++ssksdvw
Q: 513   LAARNCLVAADGIVKVSDFGLSRYVLDDEYTSSLGSKFPVRWSSPEVLLYCRFSSKSDVW  572
         ************************************************************
S: 181   af....gvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkek  236
         +f    gvlmwevf++g++py++++n+e+ve+++rg+rlyrp+ a+++vy++m scw ek
Q: 573   SFvlapGVLMWEVFTLGRMPYDRFTNNEIVEQITRGVRLYRPQNATDRVYSIMVSCWAEK  632
         *999999*****************************************************
S: 237   peerptfkellsal  250
         +++rptf+ l +++
Q: 633   ADDRPTFRILHNTI  646
         ********999887
Domain Sequence
(FASTA)
LTFLKELGNG QFGVVKYGKW RGQHDVAIKM IKEGSMSEDE FIEEAKCMMK LSHQNLVQLY 60
GVCTKQRPIF IITEFLSNGC LLNYLKDLRG RVSQGDLLSM CSDVCAAMTY LESKQYLHRD 120
LAARNCLVAA DGIVKVSDFG LSRYVLDDEY TSSLGSKFPV RWSSPEVLLY CRFSSKSDVW 180
SFVLAPGVLM WEVFTLGRMP YDRFTNNEIV EQITRGVRLY RPQNATDRVY SIMVSCWAEK 240
ADDRPTFRIL HNTI 254
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-CIS-00119
EKS-DAR-00355
EKS-DAN-00037
EKS-DRM-00050
EKS-EQC-00104
EKS-ERE-00053
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-TUT-00096
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0009952; P:anterior/posterior pattern specification
GO:0035556; P:intracellular signal transduction
GO:0030178; P:negative regulation of Wnt receptor signaling pathway
GO:0060828; P:regulation of canonical Wnt receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013