EPS-XET-00038

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-XET-00038

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	563.8	9.2E-170	197	507	311

Status

Unreviewed

Ensembl Protein

ENSXETP00000039599

UniProt Accession

F6UEJ5;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

ppp5c

Gene Synonyms/Alias

ppp5c;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000018265	ENSXETP00000039599	ENSXETT00000039599

Organism

Xenopus tropicalis

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

MSQRRSVSDV FTVTGSGNMA EAERAEEAGG EPTISREKTA EELKEQANEY FRVKDYDRAV 60

QYYTQAIGLS PDTAIYYGNR SLAYLRTECY GYALADASRA IQLDAKYIKG YYRRAASNMA 120

LGKLKAALKD YETVVKVRPH DKDAQMKFQE CSKLVRQKAF ERAIACEQHN RSVVDSLDIE 180

GMTIEDEYTG PQLKDGNVTI DFMLELMQFY KDQKKLHRKC VYQMLVQVKD ILSKLPSLVE 240

ISLEKSQQVT VCGDTHGQFY DLMNIFHLNG LPSENNPYIF NGDFVDRGSF SVEVIVTLFG 300

FKLLYPAHFH LLRGNHETDT MNQMYGFEGE VKAKYSAQMF QLFSEVFQWL PLAMCVNQRV 360

LIMHGGLFSE DGVTLDQIRS IERNRQPPDS GPMCDLLWSD PQPQDGRSSS KRGVSCQFGP 420

DVTRRFLEEN GLDYIIRSHE VKPEGYEVSH NGLCVTVFSA PNYCDQMGNK GAYIHLNGSD 480

LKPKFHQFEA VPHPNVKPMM YANSLLQMGM M 511

Nucleotide Sequence
(FASTA)

ATGTCGCAGC GTCGCTCTGT TAGTGACGTC TTCACAGTAA CCGGCAGCGG GAACATGGCA 60

GAGGCAGAGC GAGCTGAGGA GGCCGGAGGA GAACCAACAA TTAGCAGGGA GAAGACTGCT 120

GAAGAGCTAA AGGAACAAGC GAATGAATAC TTCAGGGTAA AAGATTATGA CCGTGCTGTG 180

CAGTATTACA CCCAAGCCAT TGGTCTTAGT CCAGACACTG CTATTTACTA TGGGAATCGC 240

AGTCTGGCAT ATCTCCGAAC TGAATGTTAT GGCTATGCCC TTGCGGATGC TTCCCGTGCC 300

ATCCAGCTGG ATGCCAAATA CATCAAAGGT TACTACAGAA GGGCAGCCAG TAATATGGCC 360

CTGGGGAAGC TGAAAGCTGC TCTAAAGGAC TATGAGACGG TAGTTAAAGT TCGCCCTCAT 420

GACAAAGATG CCCAAATGAA GTTTCAAGAG TGCAGTAAGC TGGTCCGGCA GAAAGCTTTT 480

GAAAGAGCTA TCGCTTGTGA ACAGCACAAC CGTTCAGTGG TGGACTCACT TGATATTGAA 540

GGAATGACTA TAGAAGATGA GTATACAGGT CCACAGTTAA AGGATGGGAA TGTCACCATA 600

GATTTTATGT TGGAGTTGAT GCAGTTTTAT AAAGATCAGA AAAAACTTCA TCGGAAATGT 660

GTTTATCAGA TGTTGGTACA AGTGAAAGAT ATTTTGTCTA AGCTTCCCAG TCTGGTAGAG 720

ATCTCTCTGG AAAAGTCTCA GCAGGTAACA GTGTGTGGTG ACACACATGG TCAGTTTTAC 780

GACTTAATGA ACATTTTTCA TCTAAACGGT CTCCCGTCTG AGAATAATCC ATATATATTT 840

AATGGTGACT TTGTTGATCG TGGTTCATTC TCAGTGGAAG TCATAGTGAC CCTCTTTGGG 900

TTCAAATTGC TTTATCCAGC CCACTTTCAT CTGCTTAGAG GTAACCATGA AACAGACACT 960

ATGAATCAGA TGTATGGATT TGAAGGGGAA GTAAAGGCTA AATACTCAGC TCAAATGTTC 1020

CAGCTATTTA GTGAAGTTTT TCAGTGGCTG CCGTTGGCAA TGTGTGTAAA CCAACGAGTC 1080

CTGATTATGC ATGGAGGTCT CTTCTCAGAG GATGGTGTAA CTTTGGATCA GATTCGTAGC 1140

ATTGAAAGAA ATAGACAGCC ACCAGACTCA GGCCCAATGT GTGACTTGTT ATGGTCGGAT 1200

CCACAGCCTC AGGATGGACG CTCTTCTAGT AAACGTGGTG TCAGCTGTCA GTTTGGTCCT 1260

GATGTCACAC GACGGTTTTT GGAAGAAAAT GGACTAGATT ACATTATCCG CAGCCATGAA 1320

GTGAAGCCAG AAGGATATGA AGTGTCTCAC AATGGTTTAT GTGTTACAGT ATTCTCTGCA 1380

CCTAACTACT GTGATCAGAT GGGTAATAAA GGAGCATACA TACATCTCAA TGGATCAGAT 1440

TTGAAACCTA AGTTTCATCA GTTTGAGGCA GTGCCACACC CGAATGTAAA ACCAATGATG 1500

TATGCAAATT CTCTGCTTCA GATGGGAATG ATGTAA 1536

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         +v+i+f+ +l++ +k++kkl+rk+++++lv+v+d+l+kl  ++e ++++++++tvcGdth

Q: 197   NVTIDFMLELMQFYKDQKKLHRKCVYQMLVQVKDILSKLPSLVEISLEKSQQVTVCGDTH  256

         899*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         Gqfydl+nif+lnGlpse+npy+fnGdfvdrGsfsvevi+tlfg+kllyP hf+llrGnh

Q: 257   GQFYDLMNIFHLNGLPSENNPYIFNGDFVDRGSFSVEVIVTLFGFKLLYPAHFHLLRGNH  316

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+d mn++yGfegevkaky+a++++lf+evf+wlPla ++n++vl+mhGGlfsedgvtld

Q: 317   ETDTMNQMYGFEGEVKAKYSAQMFQLFSEVFQWLPLAMCVNQRVLIMHGGLFSEDGVTLD  376

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         +ir iern+qPP++G++c+llWsdPq++ Gr+ skrGv++qfGpdvt rfleen ldyii

Q: 377   QIRSIERNRQPPDSGPMCDLLWSDPQPQDGRSSSKRGVSCQFGPDVTRRFLEENGLDYII  436

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevk eg+ev+++g +vtvfsapnycd++gn++++ih++++dl++++++feav+hp+v

Q: 437   RSHEVKPEGYEVSHNGLCVTVFSAPNYCDQMGNKGAYIHLNGSDLKPKFHQFEAVPHPNV  496

         ************************************************************

S: 302   kpmaysngllg  312

         kpm y+n+ll+

Q: 497   KPMMYANSLLQ  507

         ********998

Domain Sequence
(FASTA)

NVTIDFMLEL MQFYKDQKKL HRKCVYQMLV QVKDILSKLP SLVEISLEKS QQVTVCGDTH 60

GQFYDLMNIF HLNGLPSENN PYIFNGDFVD RGSFSVEVIV TLFGFKLLYP AHFHLLRGNH 120

ETDTMNQMYG FEGEVKAKYS AQMFQLFSEV FQWLPLAMCV NQRVLIMHGG LFSEDGVTLD 180

QIRSIERNRQ PPDSGPMCDL LWSDPQPQDG RSSSKRGVSC QFGPDVTRRF LEENGLDYII 240

RSHEVKPEGY EVSHNGLCVT VFSAPNYCDQ MGNKGAYIHL NGSDLKPKFH QFEAVPHPNV 300

KPMMYANSLL Q 311

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013