EKS-XET-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	352.0	2.4E-105	11	298	288

Status

Unreviewed

Ensembl Protein

ENSXETP00000040108

UniProt Accession

F6YRJ4;

Protein Name

Protein Synonyms/Alias

Gene Name

cdk6

Gene Synonyms/Alias

cdk6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000018529	ENSXETP00000040108	ENSXETT00000040108

Organism

Xenopus tropicalis

Functional Description

Protein Length

325

Protein Sequence
(FASTA)

MEKDSLADQQ YECVAEIGEG AYGKVFKARD LKNGGRFVAL KRVRVQTGEE GMPLSTIREV 60

AVLRHLETFE HPNVVRLFDV CTVSRTDRET KLTLVFEHVD QDLTTYLDKV PDPGVPSEII 120

KDMMLQLLRG LDFLHSHRVV HRDLKPQNIL VTSNGQIKLA DFGLARIYSF QMALTSVVVT 180

LWYRAPEVLL QSSYATPVDL WSVGCIFAEM FRRKPLFRGN SDVDQLGKIF DVIGLPEEEE 240

WPHDVAVPRN AFHFRQPQPI ENVVPGIDEQ GKDLLIKCLT FSPANRISAY SALSHPYFHD 300

LQKGKDSVDS HRPSGQKGVD EGSAG 325

Nucleotide Sequence
(FASTA)

ATGGAGAAGG ACAGCTTGGC CGATCAGCAG TACGAGTGCG TGGCTGAGAT AGGGGAAGGG 60

GCGTACGGCA AGGTGTTCAA GGCCCGGGAC TTAAAGAACG GAGGTCGCTT CGTGGCGTTG 120

AAACGAGTGC GGGTGCAGAC CGGGGAGGAG GGCATGCCGC TCTCTACCAT CAGGGAAGTG 180

GCGGTGCTTC GGCACCTGGA GACCTTCGAG CATCCCAACG TGGTCAGATT GTTTGATGTA 240

TGTACAGTTT CACGGACAGA CAGAGAGACA AAACTTACAC TGGTGTTTGA ACATGTTGAT 300

CAAGATTTGA CCACTTACTT GGATAAAGTA CCAGATCCTG GCGTTCCGAG TGAAATTATA 360

AAGGATATGA TGCTACAGCT TCTTCGAGGA CTGGATTTTC TTCATTCCCA TAGAGTGGTT 420

CATCGAGACC TAAAGCCTCA AAACATTCTT GTCACCAGCA ATGGACAGAT AAAATTAGCA 480

GACTTTGGCC TTGCCAGAAT CTACAGTTTT CAGATGGCAC TCACATCAGT GGTGGTCACC 540

TTGTGGTACA GAGCCCCAGA AGTCTTACTT CAGTCGAGTT ACGCCACGCC AGTTGACCTT 600

TGGAGTGTTG GCTGTATATT TGCAGAAATG TTTCGACGAA AGCCACTTTT TCGTGGAAAT 660

TCAGATGTTG ATCAACTAGG AAAAATCTTT GATGTCATTG GTCTCCCAGA GGAAGAAGAG 720

TGGCCCCACG ATGTGGCTGT ACCAAGGAAT GCCTTCCATT TTAGACAGCC TCAACCCATT 780

GAAAATGTTG TTCCAGGTAT AGATGAGCAA GGCAAGGACT TACTTATTAA ATGCCTGACC 840

TTCAGTCCAG CCAACCGCAT CTCTGCATAC AGCGCCTTGT CCCACCCTTA CTTCCATGAT 900

TTACAGAAAG GCAAAGACAG TGTAGACTCT CACAGGCCAA GCGGCCAGAA GGGGGTGGAT 960

GAAGGTTCTG CTGGA 975

Domain Profile

S: 1     yeklekigeGtygkvykakd.ketgevvAlKkirlekekegvpitalrEisllkel...k  56

         ye++++igeG+ygkv+ka+d k+ g++vAlK++r+++ +eg+p +++rE+++l++l   +

Q: 11    YECVAEIGEGAYGKVFKARDlKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLetfE  70

         899*****************888999*****************************98889

S: 57    hknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleg  112

         h+n+v+L +v++     +++kl+Lvfe+++qdL+++l+k +  ++++e +k ++lqll+g

Q: 71    HPNVVRLFDVCTvsrtDRETKLTLVFEHVDQDLTTYLDKVPDPGVPSEIIKDMMLQLLRG  130

         ************99855569****************************************

S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelL  172

         l++lHs++++HRDlKpqN+L++++g++klaDfGlar +s ++  +t++vvTlwYraPe+L

Q: 131   LDFLHSHRVVHRDLKPQNILVTSNGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVL  189

         *****************************************99.****************

S: 173   lgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklp  232

         l++ +Y t vD+Wsvgci+ae+++rkplf+g+s++dql +if+++g p+e++wp+   +p

Q: 190   LQS-SYATPVDLWSVGCIFAEMFRRKPLFRGNSDVDQLGKIFDVIGLPEEEEWPHDVAVP  248

         *88.5*******************************************************

S: 233   eykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +    f+ ++++ ++++v+ ++e++ dll k+l+++p++Risa +al+h+yf

Q: 249   RNA--FHFRQPQPIENVVPGIDEQGKDLLIKCLTFSPANRISAYSALSHPYF  298

         *76..6666699***************************************9

Domain Sequence
(FASTA)

YECVAEIGEG AYGKVFKARD LKNGGRFVAL KRVRVQTGEE GMPLSTIREV AVLRHLETFE 60

HPNVVRLFDV CTVSRTDRET KLTLVFEHVD QDLTTYLDKV PDPGVPSEII KDMMLQLLRG 120

LDFLHSHRVV HRDLKPQNIL VTSNGQIKLA DFGLARIYSF QMALTSVVVT LWYRAPEVLL 180

QSSYATPVDL WSVGCIFAEM FRRKPLFRGN SDVDQLGKIF DVIGLPEEEE WPHDVAVPRN 240

AFHFRQPQPI ENVVPGIDEQ GKDLLIKCLT FSPANRISAY SALSHPYF 288

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013