EKS-XET-00509

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00509

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	521.3	5.3E-157	464	727	264

Status

Unreviewed

Ensembl Protein

ENSXETP00000040527

UniProt Accession

A0JP83; F6YK41;

Protein Name

Protein Synonyms/Alias

Axl protein;

Gene Name

axl

Gene Synonyms/Alias

axl;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000018708	ENSXETP00000040527	ENSXETT00000040527
ENSXETG00000018708	ENSXETP00000030202	ENSXETT00000030202

Organism

Xenopus tropicalis

Functional Description

Protein Length

803

Protein Sequence
(FASTA)

KDIVLRCSVK VKETFPDVEW LHNGVPLEFA DSNQIQMPLD EDEQWLVISE LSIPSLQLSD 60

SGQYSCAVTI EGEEILSDEA YLELEGLPVF IEEPQDLDTY PNQSFNLSCY AQGPPDPVYV 120

IWLQNGAPLN SLNESAPPIL ATAGLNKSSL FSCEAHNAKG VTTSRTATIK VLPEKPRDLQ 180

LLSQSSTELE ISWQPGRSGV HPQHICTVQF MHASPMILTN ILMLYIWNLN VPPYSHVIGS 240

LTPYTTYNVR VACLSSEGVS HWTDWVAMKT TEGVPAGPPE NVTLTTNGTV TIVMWTEPQP 300

PINGILLGYK LAYRIKEMEE VVVDAGLTNK EILETANPED LTVRVASYTN AGDGPWSDPV 360

TFSSIMGTGI FAWFYTSTPF TSAAVAVAFF CAICIAIFLA RIRKKETRYG EAFEPTVEQG 420

ELVVHYRVKK SYSRRTTEAT LNRLGISNDL KEKLRDVMVD RHKLALGKTL GEGEFGSVME 480

GQLNQDDYIL KVAVKTMKIA ICTRTEMEDF LSEAVCMKEF DHPNVMRLIG VCLQNTENEG 540

YPSPVVILPF MKHGDLHSFL LYSRLGDTPL FLPTQTLVKF MTDIASGMAY LSSKNFIHRD 600

LAARNCMLNE NMNVSVADFG LSKKIYNGDY YRQGRIAKMP VKWIAIESLA DRVYTTKSDV 660

WSFGVTMWEI ATRGQTPYPG VENSEIYDYL QQGNRLKQPP DCLDGLYELM SSCWQLNAKD 720

RPCFDTLYRE LEKISKNLPP IKDPEEILYV NMEDASSPLS EDFGELGAVG GQDAKDLGDD 780

IFFKAGPVTA EVHHSENSNR YVM 803

Nucleotide Sequence
(FASTA)

AAAGACATAG TTCTTAGGTG CAGTGTGAAA GTAAAAGAGA CTTTTCCTGA TGTGGAATGG 60

TTGCATAATG GAGTGCCATT AGAATTTGCT GATAGCAATC AGATCCAGAT GCCCTTGGAT 120

GAAGATGAGC AATGGCTAGT CATCAGTGAA TTGAGCATTC CCTCCCTGCA GTTGTCAGAC 180

TCAGGGCAAT ATAGCTGTGC AGTAACTATT GAAGGAGAGG AGATTCTATC TGACGAGGCC 240

TACTTGGAGC TGGAAGGTTT GCCAGTTTTT ATTGAAGAAC CCCAAGATCT AGATACTTAC 300

CCTAATCAAT CATTCAACCT CAGCTGTTAT GCCCAGGGTC CCCCTGATCC AGTTTATGTG 360

ATATGGCTGC AGAATGGGGC CCCCCTAAAC TCTCTCAATG AAAGTGCACC ACCCATTTTG 420

GCCACTGCAG GCCTCAATAA ATCTTCCTTG TTCTCTTGTG AAGCTCATAA TGCTAAAGGA 480

GTCACTACAT CGAGAACTGC AACCATTAAA GTACTACCAG AGAAGCCAAG AGACTTGCAG 540

CTACTGTCCC AGAGTTCTAC AGAACTTGAG ATATCATGGC AGCCTGGAAG AAGTGGGGTC 600

CACCCACAAC ATATTTGCAC CGTACAGTTC ATGCATGCTA GCCCAATGAT CTTGACCAAT 660

ATCTTAATGC TATATATATG GAACCTTAAT GTGCCCCCTT ATAGCCATGT GATTGGTAGC 720

CTGACCCCAT ACACCACCTA CAATGTCCGT GTTGCCTGCC TGAGCAGTGA GGGTGTATCC 780

CATTGGACTG ACTGGGTTGC CATGAAAACC ACAGAAGGAG TTCCAGCAGG ACCTCCTGAA 840

AATGTCACTT TAACAACAAA CGGAACTGTA ACCATTGTGA TGTGGACAGA ACCGCAGCCA 900

CCCATTAATG GAATTTTGCT AGGATATAAA CTGGCATATA GAATAAAAGA AATGGAAGAG 960

GTTGTAGTTG ATGCAGGTTT GACCAATAAA GAAATACTTG AGACAGCAAA TCCTGAAGAT 1020

CTGACTGTAA GGGTGGCTTC ATATACAAAT GCTGGTGATG GACCCTGGAG TGATCCTGTA 1080

ACTTTTTCTT CTATTATGGG TACAGGCATT TTTGCTTGGT TTTATACATC AACACCTTTT 1140

ACTTCTGCAG CCGTCGCTGT AGCATTTTTC TGTGCTATAT GTATTGCTAT TTTCCTGGCA 1200

CGCATAAGGA AGAAGGAGAC ACGCTACGGA GAGGCTTTTG AGCCGACCGT GGAACAAGGG 1260

GAGCTTGTAG TGCATTACAG AGTAAAGAAA TCATACAGCC GGCGCACTAC TGAAGCTACA 1320

TTAAACCGAC TGGGTATCAG CAATGATCTA AAAGAGAAGT TACGTGATGT CATGGTAGAT 1380

AGGCACAAGC TGGCACTTGG CAAGACTCTT GGGGAAGGAG AGTTTGGCTC AGTCATGGAA 1440

GGACAGTTAA ACCAAGATGA CTACATCCTT AAAGTGGCTG TGAAAACAAT GAAAATTGCT 1500

ATCTGCACCC GCACAGAGAT GGAAGATTTT CTGAGCGAGG CTGTCTGTAT GAAAGAATTT 1560

GACCATCCAA ATGTCATGAG ACTTATAGGT GTTTGTCTGC AGAATACTGA GAACGAGGGA 1620

TACCCATCAC CTGTGGTCAT CTTGCCCTTT ATGAAGCATG GAGACTTACA TAGCTTTCTC 1680

CTTTACTCAC GACTGGGTGA TACACCTCTT TTCCTACCCA CGCAAACACT GGTGAAGTTC 1740

ATGACAGATA TTGCAAGTGG CATGGCCTAC CTGAGCAGCA AGAACTTCAT TCACAGAGAC 1800

CTCGCAGCCA GGAACTGCAT GCTAAATGAG AACATGAACG TCTCTGTGGC AGATTTTGGC 1860

CTCTCCAAGA AAATCTACAA TGGAGACTAT TACAGGCAAG GCCGTATCGC AAAAATGCCT 1920

GTAAAATGGA TTGCAATAGA GAGCCTAGCA GACAGAGTCT ATACAACAAA AAGTGATGTG 1980

TGGTCTTTTG GGGTGACTAT GTGGGAGATT GCTACTCGAG GTCAGACACC ATACCCTGGT 2040

GTGGAGAATA GTGAAATATA CGACTACCTG CAGCAGGGGA ACCGTCTGAA GCAGCCTCCG 2100

GATTGTCTTG ATGGATTGTA TGAGCTGATG TCCAGCTGTT GGCAGCTGAA TGCCAAAGAC 2160

CGTCCATGTT TTGATACACT GTATAGAGAG CTGGAGAAAA TTTCCAAGAA CCTCCCTCCA 2220

ATTAAGGATC CTGAGGAGAT TCTGTATGTT AATATGGAAG ATGCCTCTTC TCCTTTGTCT 2280

GAAGATTTTG GTGAGTTAGG TGCAGTAGGT GGTCAAGATG CCAAGGATCT TGGAGACGAT 2340

ATTTTCTTCA AAGCTGGTCC AGTCACTGCA GAGGTTCACC ACTCCGAAAA TTCTAATCGA 2400

TATGTTATG 2409

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         l+lgk+lgegefgsvmegql+q+d  ilkvavkt+k++i++r+e+e+flsea+cmkefdh

Q: 464   LALGKTLGEGEFGSVMEGQLNQDD-YILKVAVKTMKIAICTRTEMEDFLSEAVCMKEFDH  522

         68**********************.9**********************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         pnv+rl+gv+l+++e++  p pvvilpfmk+gdlh+fllysrlg+ p +lp+qtlvkfm

Q: 523   PNVMRLIGVCLQNTENEGYPSPVVILPFMKHGDLHSFLLYSRLGDTPLFLPTQTLVKFMT  582

         ************************************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         diasgm ylss+nfihrdlaarncml+e+m v vadfglskkiy+gdyyrqgriak+pvk

Q: 583   DIASGMAYLSSKNFIHRDLAARNCMLNENMNVSVADFGLSKKIYNGDYYRQGRIAKMPVK  642

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         wiaiesladrvyt+ksdvw+fgvtmweiatrgqtpy+gven+eiydyl+qgnrlkqp+dc

Q: 643   WIAIESLADRVYTTKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLQQGNRLKQPPDC  702

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvl  265

         ld+ly+lm++cw+++ kdrp+f +l

Q: 703   LDGLYELMSSCWQLNAKDRPCFDTL  727

         **********************876

Domain Sequence
(FASTA)

LALGKTLGEG EFGSVMEGQL NQDDYILKVA VKTMKIAICT RTEMEDFLSE AVCMKEFDHP 60

NVMRLIGVCL QNTENEGYPS PVVILPFMKH GDLHSFLLYS RLGDTPLFLP TQTLVKFMTD 120

IASGMAYLSS KNFIHRDLAA RNCMLNENMN VSVADFGLSK KIYNGDYYRQ GRIAKMPVKW 180

IAIESLADRV YTTKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLQQG NRLKQPPDCL 240

DGLYELMSSC WQLNAKDRPC FDTL 264

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

xtr:100036629	;
xtr:100497963	;

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00409	; IG; 2.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013