EKS-XET-00495

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00495

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	314.1	7.9E-94	25	272	248

Status

Unreviewed

Ensembl Protein

ENSXETP00000040587

UniProt Accession

F6U298;

Protein Name

Protein Synonyms/Alias

Gene Name

map3k7

Gene Synonyms/Alias

map3k7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000018737	ENSXETP00000040587	ENSXETT00000040587

Organism

Xenopus tropicalis

Functional Description

Protein Length

616

Protein Sequence
(FASTA)

MSAASADMIE TPPVLNFEEI DYKEIEVEEV VGRGTFGVVC KAKWRGKDVA IKQIESESER 60

KAFIVELRQL SRVNHPNIVK LYGACLNPVC LVMEYAEGGS LYNVLHGAEP LPYYTAAHAM 120

SWCLQCAQGV AYLHSMKPKA LIHRDLKPPN LLLVAGGTVL KICDFGTACD IQTHMTNNKG 180

SAAWMAPEVF EGSNYSEKCD VFSWGIILWE VITRRKPFDE IGGPAFRIMW AVHNGTRPPL 240

IKNLPKPIES LMTRCWSKDP PQRPSMEEIV KIMTHLMQYF PGADVSLQYP CQYSDEGQSN 300

SATSTGSCID ITSTNTSNKS DINIEAGDFQ ASASNDTIKR IESKLAQHLK NQSKQSGETG 360

RLSLPPSRGS SVESLSEIRG RPPSTLGTSE GKRMSADMSE LEARISASTA AYAKPKRGHR 420

KTASFGNILD VPEIIITGNG QQRRRSVQDL TIVGTESSQE SRNSSRSSSP SVRMITTSGP 480

TPDKPPRGLP WGPDESSDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA 540

QEYMKVQTEI ALLLQRKQEL IAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK 600

QLEVIRSQQQ KRQGTS 616

Nucleotide Sequence
(FASTA)

ATGTCTGCCG CCTCTGCTGA CATGATTGAG ACTCCACCGG TGCTAAACTT TGAGGAGATC 60

GACTACAAGG AGATAGAGGT GGAAGAGGTA GTTGGAAGAG GAACCTTTGG TGTTGTCTGC 120

AAAGCCAAAT GGCGAGGAAA GGATGTGGCA ATTAAACAAA TTGAAAGTGA ATCTGAAAGG 180

AAAGCCTTTA TTGTTGAGCT GCGGCAGTTG TCTCGTGTTA ACCATCCCAA TATTGTCAAG 240

TTGTATGGAG CCTGCCTAAA TCCTGTATGT TTAGTAATGG AATATGCAGA AGGCGGTTCC 300

CTGTACAATG TTTTGCATGG AGCTGAACCA CTGCCGTACT ATACAGCTGC GCATGCAATG 360

AGTTGGTGTT TACAATGTGC CCAAGGAGTC GCATATTTAC ATAGCATGAA GCCAAAGGCT 420

CTAATTCACA GGGACCTCAA ACCACCAAAC TTGCTGCTGG TAGCTGGAGG CACTGTTCTT 480

AAGATTTGTG ACTTTGGTAC AGCCTGTGAT ATTCAGACTC ACATGACTAA TAACAAAGGA 540

AGCGCAGCAT GGATGGCTCC AGAAGTTTTT GAAGGTAGCA ACTACAGTGA GAAATGTGAT 600

GTATTTAGTT GGGGAATCAT TCTATGGGAA GTAATAACCC GAAGAAAACC TTTTGATGAA 660

ATTGGTGGCC CAGCATTCCG TATAATGTGG GCTGTTCACA ATGGTACTCG TCCACCATTA 720

ATTAAAAATT TGCCTAAGCC TATTGAAAGC TTAATGACTC GCTGCTGGTC CAAAGATCCC 780

CCACAAAGAC CTTCAATGGA GGAGATTGTC AAGATAATGA CACATCTTAT GCAGTATTTT 840

CCCGGAGCGG ATGTTTCCTT ACAGTATCCT TGTCAGTACT CCGATGAAGG GCAAAGCAAT 900

TCTGCCACAA GTACAGGTTC CTGCATTGAT ATTACATCTA CAAATACTAG TAACAAGAGT 960

GACATCAATA TAGAAGCTGG TGATTTCCAA GCAAGCGCAA GTAATGACAC AATCAAACGA 1020

ATTGAGTCGA AGCTGGCACA ACACTTGAAA AATCAATCCA AGCAATCGGG TGAAACTGGT 1080

CGCTTGAGTT TGCCTCCCTC TCGGGGTAGC AGCGTGGAGA GCCTGTCTGA AATACGAGGG 1140

AGGCCACCAT CTACTCTGGG TACATCTGAG GGGAAACGAA TGAGCGCTGA CATGTCTGAA 1200

TTAGAAGCAA GAATTTCTGC AAGTACAGCA GCATATGCCA AGCCTAAACG AGGCCATCGT 1260

AAAACTGCTT CATTTGGCAA CATTCTGGAT GTCCCTGAGA TCATCATTAC AGGGAACGGG 1320

CAGCAGAGGC GCAGATCTGT ACAGGACCTC ACTATTGTTG GAACAGAGTC CAGTCAGGAG 1380

AGCAGAAACA GCAGCAGATC GTCAAGTCCT AGTGTGAGGA TGATTACTAC CTCAGGACCA 1440

ACCCCAGACA AGCCCCCACG TGGTCTTCCA TGGGGCCCCG ATGAATCTTC AGATACAAAT 1500

GGATCTGATA ACTCCATACC TATGGCGTAC CTTACACTGG ATCATCAGTT ACAGCCTCTA 1560

GCACCATGTC CAAACTCTAA AGAATCTATG GCTGTGTTTG AACAACACTG CAAAATGGCA 1620

CAGGAGTACA TGAAAGTACA GACTGAAATT GCTTTATTGC TGCAAAGAAA ACAAGAACTC 1680

ATAGCAGAAC TAGATCAGGA TGAGAAAGAC CAGCAGAACA CATCTCGTCT GGTGCAAGAA 1740

CACAAAAAGC TTTTAGATGA AAATAAAAGC CTGTCAACAT ATTATCAGCA ATGTAAAAAA 1800

CAGTTGGAAG TCATCCGAAG TCAGCAGCAG AAACGACAAG GAACCTCCTG A 1851

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniie  60

         ie+ee++g+g+fg v+kakwr+k+va+K++++e+e+    +++  e+++ls+++hpni++

Q: 25    IEVEEVVGRGTFGVVCKAKWRGKDVAIKQIESESER----KAFIVELRQLSRVNHPNIVK  80

         5789****************************9888....********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhe.kskreidlevlvswalqiArGmaYLhseap  119

         l+G+cl++  ++lvmey+eggsL+nvlh+ +  + ++ ++++sw+lq+A+G+aYLhs++p

Q: 81    LYGACLNP--VCLVMEYAEGGSLYNVLHGaEPLPYYTAAHAMSWCLQCAQGVAYLHSMKP  138

         *******9..89*****************778899*************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         k++ihrdLk++n+Ll +  ++lkicdFGta++++ +++++++g++awmaPEv++ +++se

Q: 139   KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAPEVFEGSNYSE  197

         ********************************99.9************************

S: 180   ksDvwSygvvLWelltrevPykdlse..laiaykvalkglrlpipsscpeklkkLmkecw  237

         k+Dv+S+g++LWe++tr++P++++    ++i+++v ++g+r+p+++++p+++++Lm++cw

Q: 198   KCDVFSWGIILWEVITRRKPFDEIGGpaFRIMWAV-HNGTRPPLIKNLPKPIESLMTRCW  256

         **********************9987447889999.99**********************

S: 238   nedpekRpsfseivks  253

         ++dp +Rps++eivk+

Q: 257   SKDPPQRPSMEEIVKI  272

         *************986

Domain Sequence
(FASTA)

IEVEEVVGRG TFGVVCKAKW RGKDVAIKQI ESESERKAFI VELRQLSRVN HPNIVKLYGA 60

CLNPVCLVME YAEGGSLYNV LHGAEPLPYY TAAHAMSWCL QCAQGVAYLH SMKPKALIHR 120

DLKPPNLLLV AGGTVLKICD FGTACDIQTH MTNNKGSAAW MAPEVFEGSN YSEKCDVFSW 180

GIILWEVITR RKPFDEIGGP AFRIMWAVHN GTRPPLIKNL PKPIESLMTR CWSKDPPQRP 240

SMEEIVKI 248

Keyword

Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0048514	; P:blood vessel morphogenesis
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017421	; MAPKKK7.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013