EKS-XET-00321

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00321

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	338.3	2.7E-101	48	299	252

Status

Unreviewed

Ensembl Protein

ENSXETP00000040675

UniProt Accession

F7B8H1;

Protein Name

Protein Synonyms/Alias

Gene Name

nuak1

Gene Synonyms/Alias

nuak1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000018772	ENSXETP00000040675	ENSXETT00000040675

Organism

Xenopus tropicalis

Functional Description

Protein Length

650

Protein Sequence
(FASTA)

ADAKSPVVGL AEQMHLSPCD EEDDTAGALA KQHGVKRHHH KHNLKHRYEL LETLGKGTYG 60

KVKRAIERFS GRVVAIKSIR KDKIRDEQDM VHIRREIEIM SSLNHPHIIR IYEVFENKDK 120

IVIIMEYASK GELYDYISER RRLSERETRH FFRQIVSAVH YCHKNGVVHR DLKLENILLD 180

ENGNIKIADF GLSNLYQKDK FLQTFCGSPL YASPEIVNGR PYRGPEVDSW ALGVLLYTLV 240

YGTMPFDGFD HKNLIRQISS GEYREPTQPS DARGLIRWML MVNPERRATI EDIANHWWVN 300

WSYKSSVCDC DVLRDSESPL LARFIDWHNR STTRQLEAEN KSKCLSKPSE ISLEQQRSLK 360

KSKKESDIAQ SLQDGADETS SVTTSKRPKG ILKKRNGDYR SHSAGYIEGV VSPVLSPTYN 420

TDDENGHIDL SPNSTQDLEV PIICDTKQAT PMPKKGILKK TPQRESGYYS SPERSESSEL 480

LDNDGEESIN SALVISETKR TVSHSLSYRR KGILKHNSKY SSNCIDLSVA GLTGASLDSM 540

KEGVMPGEGL SRSYSRPSSV ISDDSILSND SFDLLELKGG RSNKQRIRSC VSAENILYLQ 600

DFDGLQKSSR PQNLKRYRNR FADNSFSLLT DMDDVTQVYK KALEICNNLT 650

Nucleotide Sequence
(FASTA)

GCTGATGCCA AGAGCCCTGT TGTGGGGCTA GCAGAGCAAA TGCACCTTTC CCCTTGTGAC 60

GAGGAGGACG ACACAGCCGG GGCTCTAGCC AAGCAGCATG GGGTGAAGAG GCACCATCAT 120

AAGCACAACC TGAAGCACAG GTACGAGCTG CTGGAGACCC TGGGCAAGGG CACCTATGGG 180

AAGGTCAAGC GAGCCATCGA GAGGTTTTCA GGCAGAGTGG TTGCCATAAA ATCCATTCGT 240

AAAGACAAAA TCAGAGATGA GCAAGATATG GTTCACATCA GAAGAGAAAT TGAGATCATG 300

TCATCCCTCA ACCACCCGCA TATCATAAGA ATTTATGAAG TTTTTGAAAA TAAGGACAAA 360

ATTGTGATTA TAATGGAATA TGCAAGCAAA GGCGAGCTGT ATGATTATAT CAGCGAGAGA 420

CGAAGACTGA GTGAAAGGGA AACCAGACAC TTCTTTCGTC AGATTGTCTC GGCTGTGCAC 480

TACTGCCACA AGAATGGTGT TGTACATAGA GATTTAAAAC TGGAGAATAT TCTTCTTGAT 540

GAAAACGGTA ACATAAAGAT TGCTGACTTT GGTCTTTCAA ACCTTTATCA AAAAGATAAA 600

TTTCTGCAAA CATTCTGTGG GAGCCCTCTT TATGCTTCTC CGGAAATAGT CAACGGGAGA 660

CCATATCGAG GTCCTGAGGT TGACAGCTGG GCCCTTGGAG TACTTCTATA CACTCTAGTT 720

TATGGAACGA TGCCCTTTGA TGGTTTTGAT CACAAAAACC TAATCAGACA AATAAGCAGT 780

GGAGAATACC GTGAGCCAAC ACAACCATCA GATGCTCGTG GGCTGATCAG ATGGATGCTC 840

ATGGTCAATC CTGAGCGTCG AGCAACAATT GAGGATATTG CAAACCACTG GTGGGTTAAC 900

TGGAGCTATA AAAGTAGTGT ATGTGACTGT GATGTTTTAA GAGACTCTGA ATCTCCTCTC 960

CTTGCGAGGT TTATCGATTG GCATAATCGT TCTACCACCA GACAGCTCGA GGCTGAAAAC 1020

AAAAGCAAGT GCCTTTCAAA ACCATCTGAA ATATCATTAG AACAGCAGAG ATCTTTAAAG 1080

AAATCGAAGA AAGAAAGCGA CATTGCACAG TCTTTGCAAG ATGGCGCTGA TGAAACATCA 1140

TCAGTGACAA CATCAAAGAG ACCCAAAGGA ATATTAAAGA AAAGAAATGG TGATTATCGT 1200

TCACATAGTG CTGGCTATAT TGAAGGTGTT GTTAGTCCTG TTTTGTCTCC AACATACAAC 1260

ACTGATGATG AAAACGGGCA CATAGATCTA TCTCCCAACA GCACACAAGA CCTTGAAGTT 1320

CCTATTATAT GTGATACCAA ACAGGCAACG CCAATGCCAA AAAAGGGCAT TTTAAAAAAG 1380

ACACCACAAA GAGAGTCTGG CTATTACTCT TCTCCTGAAC GAAGTGAGTC ATCTGAACTG 1440

TTAGACAATG ATGGAGAAGA AAGTATCAAT TCTGCACTTG TCATCAGTGA GACAAAAAGA 1500

ACGGTTTCTC ATAGTCTGTC ATATAGGAGA AAGGGCATCT TAAAGCATAA TAGCAAATAT 1560

TCCAGCAACT GCATAGATTT GTCAGTGGCT GGTCTCACAG GAGCTTCACT GGACTCTATG 1620

AAAGAAGGTG TTATGCCTGG AGAAGGATTG TCTCGAAGCT ACAGTCGTCC CTCCAGTGTC 1680

ATTAGTGATG ACAGCATTCT TTCCAATGAC TCCTTTGATT TGCTTGAATT AAAAGGTGGT 1740

AGATCAAACA AGCAGAGAAT ACGCAGTTGT GTTTCTGCTG AAAATATCTT GTATCTGCAG 1800

GATTTCGATG GACTTCAGAA AAGCTCTCGT CCGCAAAACC TGAAACGCTA CCGTAACCGT 1860

TTTGCAGACA ATAGCTTTTC TTTACTTACA GATATGGATG ATGTGACTCA GGTTTATAAA 1920

AAAGCATTGG AGATCTGTAA CAATCTTACT TAA 1953

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y+ll+tlG+g++gkVk a+++  ++ va+K i+k+k+ +e+ + +i+rEiei+++l+hp+

Q: 48    YELLETLGKGTYGKVKRAIERFSGRVVAIKSIRKDKIrDEQDMVHIRREIEIMSSLNHPH  107

         99**********************************96777788****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+k+k+++++eyas+geL+dyi+e++rl+e+e+r++f+q+vsav+Y+h++g+

Q: 108   IIRIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV  167

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld+++nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 168   VHRDLKLENILLDENGNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV  227

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D W+lGv+Ly+lv+g++Pfd+ + k+l ++i++g+++ p++  ++++ L+r +L+v+pe+

Q: 228   DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPER  286

         ***************************************99.7789**************

S: 240   Ratieeilkhewl  252

         Ratie+i +h w+

Q: 287   RATIEDIANHWWV  299

         ************6

Domain Sequence
(FASTA)

YELLETLGKG TYGKVKRAIE RFSGRVVAIK SIRKDKIRDE QDMVHIRREI EIMSSLNHPH 60

IIRIYEVFEN KDKIVIIMEY ASKGELYDYI SERRRLSERE TRHFFRQIVS AVHYCHKNGV 120

VHRDLKLENI LLDENGNIKI ADFGLSNLYQ KDKFLQTFCG SPLYASPEIV NGRPYRGPEV 180

DSWALGVLLY TLVYGTMPFD GFDHKNLIRQ ISSGEYREPT QPSDARGLIR WMLMVNPERR 240

ATIEDIANHW WV 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013