EKS-XET-00335

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00335

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	423.4	3.4E-127	63	315	253

Status

Unreviewed

Ensembl Protein

ENSXETP00000040861

UniProt Accession

A4QNQ0;

Protein Name

Protein Synonyms/Alias

LOC100125189 protein;

Gene Name

plk2

Gene Synonyms/Alias

plk2; LOC100125189;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000018847	ENSXETP00000040861	ENSXETT00000040861

Organism

Xenopus tropicalis

Functional Description

Protein Length

663

Protein Sequence
(FASTA)

MELLRNIAYQ PSSGGKMCEQ ALGRVCDSNR RWKVPADGEP IHHTCSATEV SRIITDPGTG 60

RRYCRGKVLG KGGFAKCYEM TDLTTNKIYA AKIIPHSRVS KPHQREKIDK EIELHRTLNH 120

RHVVQFYHYF EDKENIYILL EYCSRRSMAH ILKTRKVLTD PEVRYYLKQI VSGLKYLHAQ 180

EILHRDLKLG NFFINENMEL KVGDFGLAAR LEPLEQRRRT ICGTPNYLSP EVLNKQGHGC 240

ESDIWALGCV MYTMLLGRPP FETTNLKETY RCIREARYSL PSSLMTSAKH LIASMLSRNP 300

EDRPNLDEIT QHDFFTQGFT PERLPPSCCH TAPDFHLSSP AKNFFKKAAA ALFGGKKEKS 360

KYLDNHNKLP KEDEEIYKLR QDLQKSSISH QLHNPRTDEE IKTISKLDVL AEKADKQQMG 420

DTIRMIVRGT LGSCSSSSEC LEDSTMGTVA DTVARVLRGC LENMPDADAI PKEQIDTSFH 480

WVTKWVDYSN KYGFGYQLSD HTVGVLFNNG AHMNLLPDKK TVHYYAELGP CSVFPATEAP 540

EQFISQVTVL KYFSHYMEEN LMDGGDLPSV TDVCRPRLYL LQWLKSDKAL MMLFNDGTFQ 600

VNFYHDHTKI IIANQNDEYL LTYINEDRMS TTFRLNTLLI SGGSSDLKNR MEYALNMLLQ 660

RCN 663

Nucleotide Sequence
(FASTA)

ATGGAATTAC TGAGGAATAT CGCTTATCAA CCAAGCAGCG GGGGCAAGAT GTGCGAACAG 60

GCGCTGGGCA GGGTGTGTGA CAGCAACAGG AGGTGGAAGG TACCGGCCGA TGGGGAGCCC 120

ATTCATCACA CCTGCTCTGC CACTGAGGTC TCCAGGATTA TAACCGACCC TGGCACAGGG 180

AGGCGCTACT GCAGGGGCAA AGTGCTTGGC AAGGGTGGAT TTGCGAAATG CTATGAAATG 240

ACAGATTTGA CAACAAACAA AATATATGCT GCTAAAATCA TCCCGCACAG CAGAGTGTCC 300

AAGCCTCACC AAAGGGAAAA GATTGATAAA GAGATCGAAT TGCACAGAAC CCTGAATCAC 360

CGGCACGTCG TACAGTTCTA TCACTATTTT GAAGACAAAG AGAACATCTA CATATTACTG 420

GAGTACTGCA GTAGACGGTC CATGGCCCAC ATTCTAAAGA CAAGAAAAGT GTTGACAGAC 480

CCTGAAGTGA GATACTACCT CAAGCAAATT GTCTCTGGTC TGAAATATCT CCATGCGCAA 540

GAGATCCTCC ACCGGGATTT AAAATTAGGA AACTTTTTTA TTAATGAGAA CATGGAACTG 600

AAAGTGGGTG ACTTTGGCCT TGCAGCCAGA CTGGAGCCTC TGGAGCAGAG AAGAAGAACG 660

ATTTGTGGCA CGCCAAATTA CCTCTCCCCC GAAGTGCTTA ACAAACAAGG GCACGGCTGT 720

GAATCAGACA TCTGGGCACT GGGTTGTGTA ATGTATACAA TGCTGCTTGG AAGGCCGCCG 780

TTTGAAACCA CAAATCTTAA AGAAACATAC AGGTGTATTC GGGAAGCAAG ATATTCCCTG 840

CCTTCATCGT TGATGACGTC TGCAAAGCAT CTCATAGCAA GCATGTTATC CAGGAATCCT 900

GAGGACAGGC CCAACCTAGA TGAAATTACG CAACATGACT TTTTCACACA GGGTTTCACA 960

CCAGAGCGAC TGCCACCTAG CTGCTGCCAC ACGGCTCCTG ATTTCCACTT ATCAAGTCCA 1020

GCTAAGAATT TCTTTAAAAA GGCCGCTGCA GCACTGTTTG GAGGGAAGAA AGAAAAGTCA 1080

AAGTATTTGG ATAATCACAA TAAACTGCCA AAGGAAGATG AGGAAATATA CAAGCTGAGA 1140

CAGGACCTAC AGAAAAGCTC CATATCTCAT CAGCTGCACA ATCCCAGAAC GGATGAGGAG 1200

ATCAAAACCA TCTCCAAATT AGATGTTCTT GCAGAGAAGG CAGACAAACA GCAGATGGGA 1260

GATACCATCC GCATGATTGT TAGAGGAACA CTTGGAAGCT GCAGTAGCAG TAGTGAATGT 1320

TTGGAAGATA GCACGATGGG AACTGTGGCA GATACTGTTG CTCGGGTTCT AAGAGGCTGT 1380

TTAGAAAACA TGCCTGACGC TGATGCTATC CCTAAGGAAC AGATTGACAC TTCCTTCCAC 1440

TGGGTTACAA AATGGGTGGA CTACTCCAAC AAGTACGGCT TTGGTTACCA GCTGTCGGAT 1500

CACACAGTTG GCGTATTGTT CAACAACGGA GCACACATGA ATTTGCTGCC TGACAAAAAA 1560

ACTGTGCATT ACTATGCCGA GCTTGGACCA TGCTCTGTGT TTCCTGCCAC TGAGGCCCCT 1620

GAACAGTTCA TCAGTCAAGT GACAGTTCTG AAGTACTTCT CCCATTACAT GGAAGAGAAT 1680

CTGATGGATG GTGGTGACTT GCCAAGTGTA ACAGATGTTT GCCGGCCTAG GCTGTATCTC 1740

CTTCAGTGGC TTAAATCTGA CAAGGCTCTT ATGATGCTCT TCAATGATGG CACATTTCAG 1800

GTCAACTTTT ATCACGATCA CACGAAAATC ATAATCGCAA ACCAGAACGA TGAATACTTG 1860

CTAACCTATA TCAACGAGGA CAGGATGTCT ACGACATTCC GCCTGAACAC CCTTCTGATA 1920

TCTGGTGGCT CCAGTGATCT GAAGAACAGA ATGGAATATG CATTGAACAT GCTGCTGCAA 1980

AGATGCAATT AA 1992

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl+t++++a+k++p+s++ k++qrek++keie+hr+l+h++

Q: 63    YCRGKVLGKGGFAKCYEMTDLTTNKIYAAKIIPHSRVSKPHQREKIDKEIELHRTLNHRH  122

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fedken+y++le+csrrs+a++lk+rk+lt+pevryyl+qivsglkylh ++i

Q: 123   VVQFYHYFEDKENIYILLEYCSRRSMAHILKTRKVLTDPEVRYYLKQIVSGLKYLHAQEI  182

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 183   LHRDLKLGNFFINENMELKVGDFGLAARLEPLEQRRRTICGTPNYLSPEVLNKQGHGCES  242

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+yslPssl ++ak+lia++l+++Pe+

Q: 243   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYSLPSSLMTSAKHLIASMLSRNPED  302

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+l+e+ +++f+

Q: 303   RPNLDEITQHDFF  315

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTTNKIYAAK IIPHSRVSKP HQREKIDKEI ELHRTLNHRH 60

VVQFYHYFED KENIYILLEY CSRRSMAHIL KTRKVLTDPE VRYYLKQIVS GLKYLHAQEI 120

LHRDLKLGNF FINENMELKV GDFGLAARLE PLEQRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYSLPS SLMTSAKHLI ASMLSRNPED 240

RPNLDEITQH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

xtr:100125189

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013