EKS-XET-00350

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00350

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	451.0	1.8E-135	234	521	288

Status

Unreviewed

Ensembl Protein

ENSXETP00000063302

UniProt Accession

Q0IHM5;

Protein Name

Protein Synonyms/Alias

Bone morphogenetic protein receptor, type 1B;

Gene Name

bmpr1b

Gene Synonyms/Alias

bmpr1b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000019220	ENSXETP00000063302	ENSXETT00000061543
ENSXETG00000019220	ENSXETP00000041649	ENSXETT00000041649

Organism

Xenopus tropicalis

Functional Description

Protein Length

532

Protein Sequence
(FASTA)

MGWMEERNWQ LHVSLIMLLS LHTRANLLDN MLLRSSAKLN VDSRKEDTES TAPAPPQKML 60

ACYCHHHCPE DSFNNTCWTD GYCFTIVEED ESGLPVVTSG CLGLEGSDFQ CRDTPIPHQR 120

RSIECCTDED FCNRDLHPTL PPLKKPDFVD GSIHYMALLI SVTVCSIILA IILIFCYFRY 180

KRQEARPRYS IGIEQDETYI PPGESLKDLI EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI 240

GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300

SWTQLYLITD YHENGSLYDY LKSTTLDTKA MLKLAYSTVS GLCHLHTEIF GTKGKPAIAH 360

RDLKSKNILV KKNGTCCIAD LGLAVKFISD TNEVDIPPNT RVGTKRYMPP EVLDESLNRN 420

HFQSYIMADM YSFGLILWEV ARRCISGGIL EEYQLPYHDV VPSDPSYEDM REIVCIRRFR 480

PSFPNRWSSD ECLRQMGKLM TECWAHNPAS RLTALRVKKT LAKMSESQDI KL 532

Nucleotide Sequence
(FASTA)

ATGGGTTGGA TGGAAGAAAG AAATTGGCAG CTTCACGTTT CCTTGATTAT GCTGCTCTCC 60

CTGCATACAA GAGCAAATCT GCTTGATAAC ATGCTGCTAA GAAGTTCTGC AAAGCTAAAT 120

GTGGACAGCA GGAAGGAAGA CACAGAAAGC ACAGCTCCCG CTCCGCCGCA GAAGATGCTG 180

GCATGTTACT GCCATCACCA CTGTCCAGAA GACTCTTTCA ATAACACCTG CTGGACTGAT 240

GGCTATTGCT TTACTATCGT GGAAGAAGAT GAATCTGGCC TTCCCGTAGT CACTTCTGGC 300

TGCTTGGGAT TAGAGGGATC TGACTTCCAA TGTAGGGATA CACCAATACC CCATCAGCGG 360

AGATCAATTG AATGTTGCAC CGATGAAGAC TTTTGTAACA GAGATCTCCA TCCCACATTA 420

CCTCCTCTTA AAAAACCAGA TTTTGTTGAT GGGAGTATCC ACTACATGGC ATTGCTTATT 480

TCTGTGACTG TCTGCAGCAT CATCCTGGCC ATTATTCTGA TATTCTGTTA CTTCAGGTAT 540

AAGCGACAGG AAGCCAGACC CCGTTACAGC ATTGGAATTG AGCAGGATGA GACATACATT 600

CCTCCTGGAG AGTCACTGAA GGATCTCATT GAACAGTCAC AAAGCTCAGG AAGTGGCTCG 660

GGGCTCCCTC TGCTGGTCCA AAGGACAATA GCAAAGCAAA TACAGATGGT GAAGCAAATT 720

GGCAAAGGGC GGTATGGAGA GGTCTGGATG GGTAAATGGC GAGGAGAGAA GGTGGCTGTG 780

AAAGTGTTCT TCACAACAGA AGAAGCAAGT TGGTTTCGAG AGACAGAAAT CTACCAGACT 840

GTGCTTATGC GACATGAAAA CATACTGGGC TTCATTGCAG CTGATATCAA AGGGACCGGG 900

TCATGGACTC AACTCTATTT GATTACGGAC TATCATGAAA ATGGCTCTCT CTATGATTAC 960

CTGAAGTCTA CCACCCTGGA TACAAAGGCA ATGCTGAAGC TAGCCTATTC AACAGTTAGC 1020

GGCCTCTGCC ACCTGCACAC TGAAATTTTT GGAACAAAAG GAAAGCCAGC TATCGCCCAC 1080

AGGGATCTTA AAAGTAAAAA TATACTGGTG AAGAAAAACG GAACATGCTG TATTGCAGAC 1140

CTGGGACTGG CAGTAAAATT CATTAGTGAC ACAAATGAAG TGGACATTCC GCCAAACACC 1200

AGAGTTGGTA CAAAGCGCTA TATGCCTCCA GAGGTGCTTG ATGAGAGCTT AAACAGAAAT 1260

CACTTTCAGT CCTATATCAT GGCAGATATG TATAGCTTTG GACTCATCCT TTGGGAAGTA 1320

GCCAGAAGAT GCATATCAGG AGGTATATTG GAGGAATACC AGCTGCCCTA CCATGATGTG 1380

GTACCTAGCG ACCCATCTTA TGAAGACATG AGAGAAATTG TCTGTATCAG GAGGTTTCGA 1440

CCTTCATTTC CGAATAGATG GAGCAGCGAT GAGTGTTTGA GACAGATGGG AAAGCTCATG 1500

ACAGAGTGTT GGGCTCACAA TCCAGCCTCA CGCCTCACAG CTCTGCGAGT AAAGAAGACC 1560

TTAGCCAAAA TGTCAGAGTC TCAAGATATC AAGCTTTGA 1599

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 234   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  293

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++ +l+la+s++sGl+hLH+ei+gtk

Q: 294   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKAMLKLAYSTVSGLCHLHTEIFGTK  353

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 354   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  411

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++ eey+lp+++vv+sdPs+e+m

Q: 412   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCIS-GGILEEYQLPYHDVVPSDPSYEDM  470

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ ++ rP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 471   REIVCIRRFRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  521

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKAMLK LAYSTVSGLC HLHTEIFGTK 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CISGGILEEY QLPYHDVVPS DPSYEDMREI 240

VCIRRFRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

xtr:780089

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013