EKS-XET-00153

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00153

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	377.4	3.7E-113	409	666	258

Status

Unreviewed

Ensembl Protein

ENSXETP00000042169

UniProt Accession

F6YK61;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

rps6ka4

Gene Synonyms/Alias

rps6ka4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000019458	ENSXETP00000042169	ENSXETT00000042169

Organism

Xenopus tropicalis

Functional Description

Protein Length

765

Protein Sequence
(FASTA)

QGNKDNSESE IIMLYLIEVN LTGNEDRVAM KDFELLKILG TGAYGKVFLV RKVTGPDASR 60

LYAMKVLQKC ALVKKEKTVE HTKTERNVLE HVRESPFLVT LHYAFQTDAK LHLILDYVSG 120

GELFTHLYQR DNFSEDAVRF YSGEVILALE HLHKLGIVYR DIKLENILLD SEGHVILTDF 180

GLSKEFLSEE EERTYSFCGT TEYMAPEIIR GQGGHGKIVD WWSLGILIYE LLTGASPFTL 240

EGEKNTQSEV SRRILKMDPS IPSFLSLEAR DLLQKLLRKD PKKRLGAAGA SQIKEHPFYK 300

DLDWEALSLH KVNPPFRPSI RNETDVSNFA EEFTNLDPVY SPAGTPPSGA PVFQGYSFIA 360

PSVLFGRNAV MTDMAAPSAD KPGSPTLALS AAMKDSPFFQ LYEIDLEEPA LGSGSYSLCR 420

KCQHRQTQKE YAVKIISRRM EANTQREVAA LRLCQGHPNI VTLHEVLHDQ YHSYLVMELL 480

DGGELLDRIK KQACFSEVEA SSLMRSLVSA VSHMHSVGVV HRDLKPENLL LSSPGENAVL 540

KVIDFGFARL RPPGSRPLHT PCFTLHYAAP ELFSNQGYDE LCDLWTLGVI LYTMLSGQVP 600

FQVKRGKSPH TRAADIIQKI KKGDFSMEGK CWEHVSEEAK ELVRGLLIVD PTCRLSLSEL 660

QESEWLCGGR PLSSTPLMTP DVLESSGLAT KNCVDATFMA FNRGKREGVF LKSVDNAPLA 720

KRRKLKMCST GVDTRSGSSS SSSSSSSAAA PTSSPPKSRG TPQNN 765

Nucleotide Sequence
(FASTA)

CAGGGAAATA AGGACAATTC AGAATCAGAA ATCATCATGC TGTATCTAAT AGAAGTGAAT 60

CTGACTGGAA ACGAGGACAG AGTTGCCATG AAAGACTTTG AACTGCTGAA GATCTTGGGA 120

ACTGGAGCAT ATGGCAAGGT ATTCCTTGTA CGGAAGGTGA CTGGGCCAGA TGCCAGCCGT 180

CTCTATGCTA TGAAAGTCCT CCAGAAATGT GCACTAGTCA AGAAGGAGAA AACTGTGGAG 240

CACACTAAAA CTGAGCGCAA CGTACTAGAA CATGTGAGGG AAAGCCCCTT CCTAGTAACA 300

CTCCATTATG CCTTCCAGAC AGATGCCAAG CTCCATCTTA TACTGGATTA TGTGAGTGGC 360

GGAGAGCTTT TCACTCACCT CTATCAGCGG GATAACTTCT CTGAAGACGC AGTGCGGTTT 420

TATTCTGGAG AGGTTATTTT GGCTCTGGAG CACTTGCACA AGTTGGGCAT CGTGTACAGG 480

GACATTAAGC TGGAAAACAT CCTGTTGGAT AGTGAAGGCC ATGTGATCCT GACAGACTTT 540

GGCCTAAGCA AAGAGTTCCT TTCTGAAGAG GAGGAGCGCA CATATTCCTT CTGTGGGACG 600

ACAGAGTACA TGGCACCAGA AATTATACGT GGGCAGGGAG GCCATGGTAA GATTGTAGAT 660

TGGTGGAGTT TGGGAATCCT GATCTATGAA TTACTTACAG GAGCATCTCC TTTCACCTTA 720

GAGGGAGAAA AGAACACACA GAGTGAAGTT TCCAGGCGGA TCCTGAAAAT GGACCCCTCT 780

ATTCCCTCCT TTCTGAGTTT GGAGGCCAGG GATCTTCTCC AGAAACTGCT TCGTAAAGAC 840

CCCAAAAAAC GTTTAGGAGC TGCAGGGGCA TCCCAAATAA AGGAACACCC TTTCTATAAG 900

GATTTGGATT GGGAAGCCCT GTCACTTCAC AAGGTCAATC CTCCATTCCG CCCTTCAATA 960

AGGAATGAGA CAGATGTCAG TAATTTTGCT GAAGAATTCA CAAATCTAGA TCCTGTCTAT 1020

TCTCCAGCTG GCACACCTCC CTCTGGTGCT CCAGTCTTCC AGGGCTACTC CTTTATAGCA 1080

CCTTCTGTCC TGTTTGGCCG GAATGCTGTG ATGACAGACA TGGCAGCTCC TTCTGCCGAC 1140

AAGCCTGGAA GTCCTACTCT AGCTCTTAGT GCTGCTATGA AGGACTCCCC ATTCTTCCAG 1200

CTTTATGAAA TAGATCTTGA AGAACCAGCT CTGGGATCTG GCAGCTATTC GCTCTGCAGA 1260

AAGTGTCAGC ATAGGCAGAC CCAAAAGGAA TATGCTGTGA AAATCATAAG CAGGAGGATG 1320

GAAGCCAACA CCCAGAGGGA GGTAGCAGCA CTGAGGCTTT GTCAGGGACA CCCCAATATT 1380

GTCACACTTC ATGAGGTCCT ACATGACCAG TACCACTCAT ATTTAGTTAT GGAGCTCCTG 1440

GATGGAGGGG AGTTACTGGA CCGTATAAAA AAACAGGCCT GTTTCAGTGA AGTGGAGGCC 1500

AGCAGTCTAA TGCGTAGTCT GGTGAGCGCC GTGTCACACA TGCATTCAGT CGGAGTTGTA 1560

CATAGGGACT TAAAGCCAGA GAATCTTCTC CTGTCATCAC CTGGGGAGAA CGCCGTTCTA 1620

AAGGTCATCG ATTTTGGTTT TGCAAGGCTT CGCCCACCAG GATCCCGGCC ATTGCACACT 1680

CCATGCTTTA CCCTTCATTA TGCTGCTCCA GAACTATTTT CTAACCAGGG ATATGATGAA 1740

CTGTGTGACC TGTGGACTCT TGGAGTAATC CTGTACACCA TGCTGTCTGG CCAGGTGCCC 1800

TTCCAAGTAA AGAGAGGCAA ATCTCCTCAT ACCCGTGCTG CTGACATCAT ACAGAAAATT 1860

AAGAAAGGAG ATTTTAGCAT GGAGGGCAAG TGTTGGGAGC ATGTAAGTGA GGAGGCCAAG 1920

GAGCTGGTCA GAGGTCTTCT GATTGTGGAC CCCACTTGCA GGCTGAGTCT GAGTGAACTC 1980

CAGGAAAGTG AGTGGCTTTG CGGTGGGCGT CCTCTTTCCT CCACTCCGCT CATGACTCCA 2040

GATGTCTTGG AATCCAGTGG CCTGGCCACA AAGAACTGTG TGGATGCTAC CTTCATGGCA 2100

TTTAACCGAG GAAAGCGAGA GGGTGTATTC CTAAAGAGTG TGGATAATGC ACCCCTTGCC 2160

AAGAGACGCA AACTAAAGAT GTGCAGTACT GGGGTTGACA CACGCAGTGG TTCCTCATCA 2220

TCCTCATCTT CCTCTTCATC AGCTGCTGCA CCTACATCCT CCCCTCCAAA ATCCAGGGGC 2280

ACCCCTCAGA ACAAC 2295

Domain Profile

S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63

           lG Gsys+c++c h++t++e+avkii+++ +++t++e+++l+++++hpnivtl++v +

Q: 409   PALGSGSYSLCRKCQHRQTQKEYAVKIISRRmEANTQREVAALRLCQGHPNIVTLHEVLH  468

         579****************************9****************************

S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkpen  123

         d+ + ylv+ell GGelldrikk+ +fse eas+++r+lv+av+++h++Gvvhrdlkpen

Q: 469   DQYHSYLVMELLDGGELLDRIKKQACFSEVEASSLMRSLVSAVSHMHSVGVVHRDLKPEN  528

         ************************************************************

S: 124   ilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlwsl  183

         +l     +na  +k+idfGfa+l+++ + +l+tpc+tl+++ape++++qGyde cdlw+l

Q: 529   LLLSSPGENAV-LKVIDFGFARLRPPGSRPLHTPCFTLHYAAPELFSNQGYDELCDLWTL  587

         ***99999887.************************************************

S: 184   GvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvskll  239

         Gv+lytml+G+vpf    ++ p++ a++i++kik+G+fs++G+ w+ vseeak+lv++ll

Q: 588   GVILYTMLSGQVPFqvkrGKSPHTRAADIIQKIKKGDFSMEGKCWEHVSEEAKELVRGLL  647

         **************99888899**************************************

S: 240   tvdpakrlkleqllkhswl  258

          vdp+ rl l++l++++wl

Q: 648   IVDPTCRLSLSELQESEWL  666

         ******************7

Domain Sequence
(FASTA)

PALGSGSYSL CRKCQHRQTQ KEYAVKIISR RMEANTQREV AALRLCQGHP NIVTLHEVLH 60

DQYHSYLVME LLDGGELLDR IKKQACFSEV EASSLMRSLV SAVSHMHSVG VVHRDLKPEN 120

LLLSSPGENA VLKVIDFGFA RLRPPGSRPL HTPCFTLHYA APELFSNQGY DELCDLWTLG 180

VILYTMLSGQ VPFQVKRGKS PHTRAADIIQ KIKKGDFSME GKCWEHVSEE AKELVRGLLI 240

VDPTCRLSLS ELQESEWL 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Gasterosteus aculeatus"; ?>Macropus eugenii"; ?>Takifugu rubripes"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013