EKS-XET-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	321.9	4.0E-96	863	1134	272

Status

Unreviewed

Ensembl Protein

ENSXETP00000044013

UniProt Accession

F7DKS0;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

jak1

Gene Synonyms/Alias

jak1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000020396	ENSXETP00000044013	ENSXETT00000044013

Organism

Xenopus tropicalis

Functional Description

Protein Length

1141

Protein Sequence
(FASTA)

MAFCAKMRNS KKLEVGIAAK DGLEICFYLP DKSTLYHLQG EFTAEDLCIE SALHCNISPL 60

CHNLFALYNE RSQSWYSPNH NFKIDSNVSL KLHYRMRRFI FTNWHGTNEN EPSVWRHYPK 120

KRDGYDKKQI QEGTPLLDAS SLDYLFAQGQ YELVKCLAPV REPKNDQEVH EIENECLGMA 180

VLAISHYAIK RNIQLPDLPK DISYKKYIPE TLNRTIKQRN FLTRMRINNV FKNFLKEFNN 240

KTICDSSVSP HDLKVKYLST METLTKNYGA ESFETNSLII KSENEQNGFN ISDYDSMRRY 300

EVLVTGNSGI QWRRKPTCTT SEKDRKLKRK KTESKSKNSD EKGKLKDEWN CFSYYPEITH 360

IAIKEDTVII NNQDNKSMEL KLSSQEEALS FAALIDGYFR LTADAHHYLC SDVAPPLIVN 420

NIKNGCHGPI CTEYAINKLR QEGNEEGMYV LRWSCTDFNN ILMTVSCSKM SQFESKYVKQ 480

YKNFQIEVKK GRYSLLGPDR GFDSLKDLMK HLKGQVLKTD DVSFTLKKCC PPKPREISNL 540

LVATKKALEW QPVYHLSQLS FHRILKEEIT QLEHLGRGTR TQIYAGKLNY KDDNDSESYS 600

TEKEIKVILK VLDPSHRDIS LAFFETASMM RQVSHKHIVL LHGVCVRDVE NIMVEEFVDF 660

GPLDLFMHRK SEVLTTPWKF KVAKQLASAL SYLEDKDLVH GNVCTKNILL AREGIDNDCG 720

PFIKLSDPGI PITVLTRQER VERIPWIAPE CVEDSRVLSV AADKWSFGTT LWEICFNGEV 780

PLKDRTLAEK ERFYGGCFML VAPSCKELAD LINQCMNYDP LRRPFFRAIM REINKLEEQN 840

PDIVSEKTPS AEVDPTLFEK RFLKRVRDLG EGHFGKVELC RYDPEGDNTG ELVAVKSLKP 900

GTAGSHIADL KKEIEILRNL YHENIVKYKG ICEDGGSGIK LIMEYLPSGS LKEYLPRNVN 960

KINLKQQLKY ATQICKGMDY LGSRQYVHRD LAARNVLVEN EQIIKIGDFG LTKAIETDKE 1020

YYTVKDDLDS PVFWYAPECL LHCKFYIASD VWSFGVTLYE LLTYCNSEYS PMTMFLKMIG 1080

PTQGQMTVTR LVRVLEEDKR LPIPANCPKQ VYQLMLKCWE QNPSHRTTFQ DLIKGFEAII 1140

N 1141

Nucleotide Sequence
(FASTA)

ATGGCCTTTT GTGCAAAAAT GAGGAATTCA AAGAAGTTAG AAGTAGGTAT AGCTGCAAAA 60

GATGGCCTGG AAATCTGCTT TTACTTGCCT GACAAGTCAA CTCTCTATCA TCTCCAAGGA 120

GAATTTACTG CTGAGGATTT GTGCATTGAG TCTGCTTTGC ACTGCAATAT ATCTCCCCTT 180

TGCCACAATC TGTTTGCTCT GTATAATGAG AGAAGCCAAA GCTGGTATTC ACCGAATCAT 240

AACTTCAAGA TAGATTCTAA TGTTTCACTG AAACTTCATT ATCGTATGAG AAGGTTCATT 300

TTTACAAACT GGCATGGGAC AAATGAAAAT GAGCCATCCG TTTGGAGACA TTATCCTAAG 360

AAAAGAGATG GTTATGATAA AAAACAAATC CAGGAAGGTA CCCCTCTTCT TGATGCCAGC 420

TCACTGGATT ACCTATTTGC CCAGGGCCAG TATGAATTGG TGAAATGCCT AGCTCCAGTC 480

AGAGAGCCAA AAAACGATCA AGAGGTTCAC GAAATAGAGA ATGAGTGCCT GGGCATGGCG 540

GTTTTGGCAA TTTCTCATTA TGCCATAAAA AGAAATATAC AGCTTCCGGA TCTTCCCAAG 600

GACATCAGCT ACAAGAAATA TATTCCAGAA ACACTTAACA GAACCATCAA ACAAAGGAAT 660

TTCCTAACCC GGATGCGGAT AAACAACGTT TTTAAGAATT TCCTCAAAGA ATTTAACAAT 720

AAAACCATAT GTGACAGTAG TGTTTCTCCA CATGACCTGA AGGTTAAATA CTTATCAACC 780

ATGGAGACGT TAACCAAGAA TTACGGCGCA GAAAGCTTTG AGACAAATTC GCTGATTATC 840

AAATCAGAGA ACGAACAAAA TGGCTTCAAT ATAAGTGACT ATGACAGTAT GCGTCGTTAT 900

GAAGTCTTGG TCACTGGAAA CTCAGGAATA CAGTGGAGAC GTAAACCAAC CTGTACCACA 960

TCAGAAAAAG ACAGGAAACT AAAACGGAAA AAAACAGAAA GCAAAAGTAA GAACTCAGAT 1020

GAAAAGGGAA AACTAAAAGA TGAATGGAAC TGCTTCTCGT ATTATCCTGA AATCACACAT 1080

ATTGCCATAA AGGAGGATAC CGTCATAATT AATAATCAGG ATAACAAGAG CATGGAGCTG 1140

AAGCTTTCCT CACAAGAAGA GGCGCTTTCC TTCGCTGCAC TGATTGATGG ATACTTCCGT 1200

CTTACAGCAG ATGCACATCA TTACCTTTGC TCTGATGTTG CGCCACCTTT GATAGTAAAT 1260

AACATAAAAA ATGGATGTCA TGGACCAATA TGCACAGAAT ATGCAATAAA CAAATTACGG 1320

CAAGAAGGAA ATGAGGAGGG AATGTATGTG TTGAGATGGA GCTGTACAGA TTTTAACAAT 1380

ATTCTTATGA CGGTGTCATG CAGTAAAATG TCACAGTTTG AGTCCAAATA TGTGAAACAG 1440

TACAAAAACT TTCAGATCGA AGTAAAAAAA GGTAGATACT CTTTGCTTGG TCCAGATCGT 1500

GGCTTTGACT CACTGAAAGA TCTGATGAAG CATTTGAAAG GACAAGTGCT GAAGACAGAT 1560

GATGTCAGCT TTACATTAAA AAAATGCTGT CCACCAAAAC CAAGAGAAAT TTCAAACTTG 1620

TTGGTTGCAA CAAAAAAAGC ATTAGAGTGG CAGCCGGTCT ACCACCTGAG TCAACTGAGT 1680

TTCCATAGAA TACTGAAAGA AGAAATCACA CAACTGGAAC ATTTGGGTAG AGGAACTAGG 1740

ACCCAAATCT ATGCTGGAAA ACTAAACTAC AAAGATGACA ATGATAGTGA AAGCTATTCT 1800

ACAGAAAAGG AGATAAAAGT CATACTAAAA GTGCTGGATC CAAGTCATAG AGACATCTCT 1860

TTGGCATTTT TTGAGACTGC AAGTATGATG AGGCAGGTTT CACACAAGCA CATTGTATTG 1920

CTTCACGGTG TATGTGTCAG AGATGTCGAA AATATAATGG TTGAAGAATT TGTGGACTTT 1980

GGCCCGCTTG ATCTGTTCAT GCATCGTAAA AGTGAGGTTC TGACCACCCC ATGGAAATTT 2040

AAAGTTGCCA AGCAACTCGC TAGTGCCCTG AGCTACTTGG AAGATAAAGA TTTAGTGCAT 2100

GGAAATGTTT GTACTAAAAA TATTTTACTG GCGAGAGAAG GAATTGACAA TGATTGTGGT 2160

CCATTCATAA AGCTTAGTGA TCCTGGAATC CCGATTACTG TGTTAACAAG GCAAGAGCGT 2220

GTAGAGCGGA TTCCATGGAT TGCTCCTGAA TGTGTTGAGG ATTCCAGAGT ATTAAGTGTT 2280

GCTGCTGACA AGTGGAGCTT TGGAACCACT TTATGGGAAA TCTGTTTCAA TGGAGAAGTG 2340

CCTCTTAAAG ACCGGACGCT AGCAGAGAAA GAAAGATTTT ATGGAGGCTG CTTTATGTTA 2400

GTCGCCCCTT CATGCAAAGA GTTAGCAGAT CTAATTAATC AATGCATGAA TTATGACCCC 2460

CTCAGAAGAC CATTTTTTAG GGCAATTATG AGAGAAATCA ACAAGCTGGA AGAGCAAAAT 2520

CCAGACATTG TCTCTGAAAA GACCCCATCT GCAGAAGTGG ACCCTACTTT ATTTGAGAAA 2580

AGATTCTTGA AGAGAGTAAG AGATCTAGGA GAGGGCCACT TTGGAAAAGT TGAGTTGTGT 2640

AGGTATGACC CAGAAGGCGA CAACACCGGG GAACTGGTTG CTGTGAAATC ACTAAAGCCT 2700

GGCACAGCGG GCAGTCACAT TGCTGATCTG AAAAAGGAGA TTGAAATCCT GAGAAATCTG 2760

TATCATGAGA ACATTGTAAA ATACAAAGGA ATTTGTGAAG ATGGAGGCAG TGGAATAAAA 2820

TTGATCATGG AATATCTCCC ATCAGGGAGT CTAAAGGAGT ACCTTCCAAG AAATGTGAAC 2880

AAAATCAATC TGAAACAGCA GTTGAAATAT GCTACACAAA TATGCAAGGG AATGGACTAT 2940

TTGGGTTCAC GTCAGTATGT CCATCGAGAC TTGGCTGCAA GGAATGTTCT TGTTGAAAAT 3000

GAACAAATAA TAAAGATTGG AGATTTTGGA TTGACCAAGG CTATTGAAAC TGATAAGGAA 3060

TATTATACTG TCAAAGATGA CCTGGATAGT CCTGTTTTCT GGTATGCTCC AGAATGTTTG 3120

CTGCACTGCA AGTTTTACAT TGCCTCTGAT GTCTGGTCAT TTGGAGTAAC CTTGTATGAA 3180

CTGCTCACAT ACTGCAATTC AGAATACAGT CCTATGACGA TGTTTTTGAA AATGATTGGC 3240

CCAACACAAG GACAAATGAC GGTTACGAGA CTTGTACGCG TGTTGGAAGA GGACAAGCGT 3300

TTGCCAATAC CAGCAAACTG CCCAAAGCAG GTGTACCAGC TCATGCTCAA ATGCTGGGAA 3360

CAAAATCCAA GCCACCGCAC CACTTTTCAG GACCTAATTA AAGGCTTTGA AGCTATTATA 3420

AAT 3423

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+ ++Lg+g+f+kv+++r+d+egd+t+e va+k Lk      +++d+k+e+eil++l+h

Q: 863   LKRVRDLGEGHFGKVELCRYDPEGDNTGELVAVKSLKpGTAGSHIADLKKEIEILRNLYH  922

         67889********************************6667789****************

S: 60    ehivklkgvcvaegen.rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         e+ivk+kg+c ++g+  +l+mey++sGsL++yL+++ ++++l+++l++a q++k+m+YL+

Q: 923   ENIVKYKGICEDGGSGiKLIMEYLPSGSLKEYLPRNVNKINLKQQLKYATQICKGMDYLG  982

         ************************************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         ++++vhrd+aarnvLve+e+       +k++d+gl+ka+++d eYy+v+++ ds+++w+a

Q: 983   SRQYVHRDLAARNVLVENEQI------IKIGDFGLTKAIETDkEYYTVKDDLDSPVFWYA  1036

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklell  225

         pecl ++k +++asdvWsFgvtlyellt c+++ sp    l++++++       r++++l

Q: 1037  PECLLHCK-FYIASDVWSFGVTLYELLTyCNSEYSPmtmfLKMIGPTqgqmtvtRLVRVL  1095

         ********.***************************9999999999999***********

S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         ee +rlp p  cp+++++lm +c++++ps+r++F+++++

Q: 1096  EEDKRLPIPAnCPKQVYQLMLKCWEQNPSHRTTFQDLIK  1134

         ************************************986

Domain Sequence
(FASTA)

LKRVRDLGEG HFGKVELCRY DPEGDNTGEL VAVKSLKPGT AGSHIADLKK EIEILRNLYH 60

ENIVKYKGIC EDGGSGIKLI MEYLPSGSLK EYLPRNVNKI NLKQQLKYAT QICKGMDYLG 120

SRQYVHRDLA ARNVLVENEQ IIKIGDFGLT KAIETDKEYY TVKDDLDSPV FWYAPECLLH 180

CKFYIASDVW SFGVTLYELL TYCNSEYSPM TMFLKMIGPT QGQMTVTRLV RVLEEDKRLP 240

IPANCPKQVY QLMLKCWEQN PSHRTTFQDL IK 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013