EKS-XET-00619

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00619

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	342.5	2.0E-102	20	316	297

Status

Unreviewed

Ensembl Protein

ENSXETP00000044832

UniProt Accession

F7EB99;

Protein Name

Protein Synonyms/Alias

Gene Name

mapk6

Gene Synonyms/Alias

mapk6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000020744	ENSXETP00000044832	ENSXETT00000044832

Organism

Xenopus tropicalis

Functional Description

Protein Length

720

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGYGG NGLVFSAVDN DCDKRVAVKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPNGRQ LTDDVSSLTE LNCVYIVQDY METDLAKLLE 120

QGPLREEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVVKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL NVIPVYIKND MSEPHKPLTQ LLPGISSEAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDDSHSQ VYNWERYHES 360

DFSDHDWPIH NNFEVDEVQR DPRALSDGSD DEEVQVDPRK YLDGDREKYL EDPAFDPHFS 420

TEPCWQYLDH HENKYCDLEC SHTCNYKMRS SSYLDNLVWK ESEVNHYYEP KLIIDLSNWK 480

EQNKEKADKK GKSKCERNGL VKAQLALAEA SQQLVEKERE KHKEFDFDSF IAGTIELSLQ 540

HDSSCVDKLN DLNSSVTQLE LKNLISKSVS MEKQEKGMAN LAQLGARNQN SWDSQIVSGE 600

DCFLKDQFCC DVRKDDHVEK ETSYTSYLDD FFSKKEETEV TETEISGDGK VGVKDYDDGL 660

LSFNGDLILN KQLDCIGIPQ FHNPVGSPLK SIQATLAPST MKSSPQIPHK TYSSILKHLN 720

Nucleotide Sequence
(FASTA)

ATGGCAGAAA AGTTTGAAAG CCTCATGAAC ATTCATGGAT TTGATTTGGG ATCCAGATAT 60

ATGGACTTAA AACCTCTTGG CTATGGTGGG AATGGCTTAG TTTTTTCTGC TGTTGATAAT 120

GACTGTGATA AGCGGGTGGC TGTGAAGAAA ATCGTTCTGA CCGATCCTCA GAGTGTCAAA 180

CATGCTCTGC GAGAGATCAA AATTATCCGG AGACTTGACC ATGATAACAT TGTGAAAGTT 240

TTTGAAATCC TCGGTCCTAA TGGAAGACAG TTAACAGATG ATGTGAGCTC TTTAACAGAG 300

TTGAACTGCG TTTACATTGT CCAAGACTAC ATGGAAACTG ATCTTGCGAA GCTGCTAGAG 360

CAGGGCCCCT TAAGAGAAGA GCATGCAAGG CTCTTCATGT ACCAGCTGCT ACGTGGGCTT 420

AAGTATATCC ATTCTGCTAA TGTGCTGCAC AGAGATCTTA AACCAGCAAA CCTTTTCATA 480

AACACAGAAG ATCTAGTGGT AAAAATTGGA GATTTTGGTC TTGCGCGTAT TATGGATCCC 540

CATTATTCTC ATAAGGGACA TCTATCTGAA GGACTTGTAA CAAAATGGTA CAGATCTCCC 600

CGACTTCTTC TCTCTCCCAA CAATTACACT AAAGCAATTG ACATGTGGGC TGCTGGATGC 660

ATCTTTGCAG AAATGTTAAC TGGAAAAACG CTTTTTGCAG GTGCACATGA GCTTGAACAG 720

ATGCAGCTGA TCCTGGAATC AATACCTGTT GTGCATGAAG AAGACCGCCA AGAGCTCCTC 780

AATGTAATCC CAGTGTATAT CAAAAATGAT ATGTCAGAGC CGCATAAGCC TTTAACACAA 840

CTGCTTCCAG GCATCAGCTC AGAGGCGCTG GATTTTCTGG AACAAATATT AACATTCAGT 900

CCCATGGACA GACTAACAGC AGAAGAAGCT TTGTCTCACC CATACATGAG CATTTACTCT 960

TTCCCAATGG ATGAGCCAAT TTCAAGCCAT CCTTTTCACA TTGAGGATGA GGTAGATGAT 1020

ATATTATTGA TGGATGACAG CCACAGCCAA GTGTATAACT GGGAAAGATA CCATGAAAGC 1080

GATTTTTCAG ACCATGATTG GCCTATACAT AATAATTTTG AAGTTGATGA AGTTCAGCGT 1140

GACCCTAGGG CACTGTCTGA TGGTAGTGAT GATGAAGAAG TACAAGTGGA CCCCCGCAAA 1200

TACCTTGATG GAGACCGGGA AAAGTATCTT GAAGATCCTG CATTCGATCC CCACTTTTCT 1260

ACTGAGCCTT GCTGGCAATA TCTAGATCAC CATGAAAATA AATATTGTGA TCTGGAATGT 1320

AGCCATACAT GTAATTATAA AATGAGGTCT TCCTCTTATT TAGATAACTT AGTATGGAAG 1380

GAGAGTGAAG TTAACCATTA TTATGAGCCA AAACTTATCA TTGATCTTTC TAACTGGAAG 1440

GAACAAAATA AGGAGAAGGC AGATAAGAAG GGGAAATCCA AATGTGAAAG GAATGGTTTA 1500

GTAAAAGCTC AGTTAGCGCT AGCAGAAGCT TCACAGCAAC TGGTTGAGAA GGAAAGGGAA 1560

AAGCACAAAG AATTTGACTT TGATTCATTT ATTGCAGGTA CTATTGAGCT TAGTTTGCAG 1620

CATGATTCCT CTTGTGTAGA CAAACTCAAT GACTTAAATA GCTCAGTGAC ACAACTTGAA 1680

TTGAAGAATT TGATCTCAAA GTCAGTTAGC ATGGAGAAAC AAGAGAAAGG AATGGCCAAC 1740

TTAGCACAGT TGGGTGCCAG AAATCAGAAT TCTTGGGACA GCCAGATTGT AAGTGGGGAA 1800

GACTGCTTTC TGAAAGACCA GTTTTGTTGT GATGTAAGGA AAGATGATCA TGTTGAGAAG 1860

GAAACCAGCT ATACAAGTTA CTTAGATGAT TTTTTTAGCA AAAAAGAAGA GACAGAGGTG 1920

ACAGAAACAG AGATATCAGG AGATGGAAAG GTCGGTGTTA AAGATTATGA TGATGGCCTG 1980

TTGAGTTTTA ATGGAGACCT CATCCTTAAC AAGCAACTGG ATTGCATAGG TATTCCTCAG 2040

TTTCATAATC CTGTTGGCTC CCCACTAAAA TCTATACAAG CCACGTTGGC TCCCTCTACC 2100

ATGAAATCCT CCCCTCAAAT TCCTCACAAA ACCTACAGCA GCATTCTGAA ACATCTGAAC 2160

TAA 2163

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rva+kk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGYGGNGLVFSAVDNDCDKRVAVKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el+ vY+v+++metdL+k++++  l++eh++l++yq+l

Q: 78    VKVFEILGPNGrqltddvsSLTELNCVYIVQDYMETDLAKLLEQGPLREEHARLFMYQLL  137

         *********99999999989999*************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   +ki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvVKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876539**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ +  +  yik+ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLNV-IPVYIKNDMSEPHKPLTQLLPGISSEALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGYG GNGLVFSAVD NDCDKRVAVK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPNGR QLTDDVSSLT ELNCVYIVQD YMETDLAKLL EQGPLREEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVVKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LNVIPVYIKN DMSEPHKPLT QLLPGISSEA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

xtr:100494114

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013