EKS-XET-00357

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00357

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	377.1	6.2E-113	178	466	289

Status

Unreviewed

Ensembl Protein

ENSXETP00000058996

UniProt Accession

F7BH92;

Protein Name

Protein Synonyms/Alias

Gene Name

acvr2b

Gene Synonyms/Alias

acvr2b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000020999	ENSXETP00000058996	ENSXETT00000062738
ENSXETG00000020999	ENSXETP00000045383	ENSXETT00000045383

Organism

Xenopus tropicalis

Functional Description

Protein Length

500

Protein Sequence
(FASTA)

GSGHDEVETR ECIYYNANWE LEKTNQSGVE SCEGEKDKRL HCYASWRNNS GFIELVKKGC 60

WLDDFNCYDR QECIAKEENP QVFFCCCEGN YCNKKFTHLP EVVHPPMIFI ETFDPKPQPP 120

ASVLNILIYS LLPIAGLSMA ILLAFWMYRH RKPPYGHVDI NEDPGPPPPS PMVGLKPLQL 180

LEIKARGRFG CVWKARLLNE YVAVKIFPIQ DKQSWQCEKE IFNTVGMKHE NLLEFIAAEK 240

RGSNLEMELW LITAFHDKGS RTDYLKGNLV TWNELCHITE TMARGLAYLH EDVPRVNVSG 300

HRWLLSERYF KSKNVLLRND LTAILADFGL AVRFEPGKPP GDTHGQVGTR RYMAPEVLEG 360

AINFQRDSFL RIDMYAMGLV LWEIVSRCTA ADGPVDEYML PFEEEIGQHP SLEDLQEVVV 420

HKKMRPVFKD HWLKHPGLAQ LCVTIEECWD HDAEARLSAG CVEERISQIR KSVNGTTSDC 480

LVSIVTSVTN VDLPPKESSI 500

Nucleotide Sequence
(FASTA)

GGCTCCGGAC ATGACGAGGT GGAGACGAGG GAGTGCATCT ATTACAATGC CAACTGGGAG 60

CTGGAGAAAA CCAACCAAAG TGGGGTAGAA AGCTGCGAAG GGGAGAAGGA CAAGCGACTC 120

CACTGTTATG CATCTTGGAG GAACAACTCG GGCTTCATAG AGCTGGTGAA GAAAGGGTGC 180

TGGCTGGATG ATTTCAACTG TTACGACAGA CAGGAATGTA TTGCCAAGGA AGAAAACCCC 240

CAAGTGTTTT TCTGCTGCTG CGAAGGAAAC TACTGCAACA AGAAATTTAC TCATTTGCCT 300

GAAGTCGTTC ATCCTCCCAT GATCTTTATA GAAACATTTG ATCCGAAGCC CCAGCCTCCG 360

GCCTCTGTGC TGAACATTCT GATCTATTCC CTGCTTCCAA TCGCTGGTCT TTCCATGGCA 420

ATTCTCCTGG CGTTCTGGAT GTACCGACAT CGAAAGCCTC CCTACGGGCA CGTAGACATC 480

AATGAGGACC CAGGGCCGCC CCCTCCATCT CCCATGGTCG GGCTGAAGCC GCTGCAGTTG 540

CTGGAGATCA AGGCGCGAGG CCGGTTTGGC TGCGTGTGGA AAGCGCGCCT GCTGAATGAA 600

TACGTGGCGG TGAAAATCTT CCCCATCCAG GATAAGCAGT CGTGGCAATG TGAGAAAGAG 660

ATCTTCAACA CGGTGGGCAT GAAACACGAG AACCTCTTGG AGTTCATTGC CGCGGAGAAG 720

AGGGGGAGCA ACCTGGAGAT GGAGCTGTGG CTCATCACTG CGTTCCATGA TAAGGGTTCT 780

CGGACAGACT ACCTGAAAGG GAACTTAGTC ACCTGGAATG AACTGTGTCA CATAACAGAG 840

ACGATGGCTC GTGGGCTGGC CTACTTGCAC GAAGATGTGC CCCGGGTAAA TGTGTCAGGC 900

CATAGATGGT TATTGTCTGA GCGCTATTTT AAAAGTAAGA ATGTATTGCT GAGAAACGAC 960

CTGACGGCGA TATTAGCAGA CTTCGGGCTG GCCGTACGGT TTGAGCCTGG AAAACCGCCA 1020

GGAGATACAC ACGGGCAGGT TGGCACCAGG AGGTATATGG CCCCTGAGGT TCTGGAGGGA 1080

GCAATTAACT TTCAGCGAGA TTCCTTTCTC AGGATAGATA TGTATGCCAT GGGACTGGTG 1140

CTCTGGGAAA TAGTATCCCG ATGTACAGCA GCAGATGGCC CAGTTGATGA GTACATGCTC 1200

CCATTCGAAG AGGAGATTGG GCAACATCCT TCCCTTGAGG ACCTGCAGGA AGTTGTGGTT 1260

CACAAGAAGA TGCGCCCCGT ATTTAAAGAC CACTGGCTGA AGCACCCAGG TCTGGCCCAA 1320

CTGTGCGTGA CCATTGAGGA ATGCTGGGAC CACGACGCGG AGGCGCGGCT TTCTGCGGGC 1380

TGCGTAGAGG AACGCATTTC CCAAATCCGT AAATCAGTGA ACGGCACTAC CTCGGACTGC 1440

CTTGTATCCA TTGTTACATC TGTCACCAAT GTGGACTTGC CACCCAAAGA GTCCAGTATC 1500

TGA 1503

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw+ Ekei++tv ++hen+l+fia

Q: 178   LQLLEIKARGRFGCVWKARLLNEYVAVKIFPIQDKQSWQCEKEIFNTVGMKHENLLEFIA  237

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgs +dyLk + ++++el+++++++a+Gla+LHe+++  +

Q: 238   AEKRGSNLEMELWLITAFHDKGSRTDYLKGNLVTWNELCHITETMARGLAYLHEDVPRVN  297

         ********************************************************8776

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

            ++  ++ R +kskN+l+++dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 298   VsGHRWLLSERYFKSKNVLLRNDLTAILADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  355

         657999************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ ++f r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Psle+

Q: 356   EVLEGAINFQR-DSFLRIDMYAMGLVLWEIVSRCTAADGPVDEYMLPFEEEIGQHPSLED  414

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++evvv+kk+rP ++++w k++ l++l+ ++eecWd+d+eaRl+a +v++r+

Q: 415   LQEVVVHKKMRPVFKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERI  466

         *************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKARL LNEYVAVKIF PIQDKQSWQC EKEIFNTVGM KHENLLEFIA 60

AEKRGSNLEM ELWLITAFHD KGSRTDYLKG NLVTWNELCH ITETMARGLA YLHEDVPRVN 120

VSGHRWLLSE RYFKSKNVLL RNDLTAILAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD SFLRIDMYAM GLVLWEIVSR CTAADGPVDE YMLPFEEEIG QHPSLEDLQE 240

VVVHKKMRPV FKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEERI 289

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013