EKS-XET-00512
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00512
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR579.92.2E-174596955360
StatusUnreviewed
Ensembl ProteinENSXETP00000045488
UniProt AccessionF6RSC1;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene Namepdgfra
Gene Synonyms/Alias pdgfra;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000021035ENSXETP00000045488ENSXETT00000045488
OrganismXenopus tropicalis
Functional Description
Protein Length1092
Protein Sequence
(FASTA)
MMPTTRASLV LGCLLIIGPW VILAQNPLPS IFPEKDELVQ RLHSSFSLTC TGESELSWQH 60
PHSESELGNV VIGSEENNSG LFVSVLEVTN ASASNTGLYT CYYNHTQTED SEIEGTDIYI 120
YVPDTNVPFV PPGLFDHIIV VEEDESAFIP CRTTDPSSQV TLKSIENSKT VSAFYDSKQG 180
FVGNFQPGSY ICETVSNKMV YQTDLYILQT WKATHNISVE MEAPQTVFRT GETITISCIV 240
LENEVVELKW YYPGQQRGVG KRNVEESRVP SQRLVYTLTI ANATADDSGE YQCAVLHATL 300
DNKVIKKTNI TVHEKGFINL EPMFGSEEYA NLHEVKSFIV DLHAYPCPRV FWLKDNRTLS 360
ENLTEITTST VTTKETRFQS KLKLIRAKEE DSGLYTLVAQ NDAESKSYSF ILQIKVPALI 420
LELVDEHHGT SGEQTVGCLA KGMPVPDVEW LVCKDIKRCN NDTLWSLLAI NGSEISMETH 480
QDYENTIESQ VTFKKVEETM AIRCIARNDL GVVARELKLV APTLRSELTV AAAVLVLLVI 540
VIISLIVLVI IWKQKPRYEI RWRVIESISP DGHEYIYVDP MQLPYDSRWE FQRDGLVLGR 600
ILGSGAFGKV VEGTAYGLSR SQPVMKVAVK MLKPTARSSE KQALMSELKI MTHLGAHLNI 660
VNLLGACTKS GPIYIITEYC FYGDLVNYLH KNRDNFQSRH PEKSKKDLDI FGLNPADEST 720
RSYVILSFEN NGDYMDMKQA DTMQYVPMLE MKEPSKYSDI QRSLYDRPAS YKKKPLSEVK 780
NILSDDGFDG FDGLTVLDLL SFTYQVARGM EFLASKNCVH RDLAARNVLL AHGKIVKICD 840
FGLARDIMHD SNYVSKGSTF LPVKWMAPES IFDNLYTTLS DVWSFGILLW EIFSLEGGTP 900
YPGMIVDSTF YNKIKSGYRM AKPDHATHEV YDIMVKCWNS EPEKRPSFRH LSDIVESLLP 960
MEYKRCYETV LHDFLKSDHP AVTRMRSDSD NSYIGVTYKN ENKMKDRESG FDEQRLSADS 1020
GYIIPLPDID PVSEDESSKR NRHSSQTSEE SAIETGSSSS TFIKREDETI EDIEMMDDIG 1080
IDSSDLVEDS FL 1092
Nucleotide Sequence
(FASTA)
ATGATGCCTA CCACGAGGGC ATCCCTTGTT TTGGGGTGTC TCCTGATTAT AGGTCCGTGG 60
GTCATTCTTG CTCAAAATCC CCTGCCCTCA ATATTTCCTG AAAAGGATGA GTTGGTTCAG 120
AGGTTGCACT CCTCCTTTTC ACTAACGTGC ACTGGTGAGA GCGAACTGAG CTGGCAGCAC 180
CCCCATTCCG AATCTGAACT GGGGAATGTA GTCATTGGAA GCGAAGAAAA CAACAGCGGC 240
CTCTTTGTGT CTGTTCTGGA AGTGACCAAC GCTTCCGCCT CCAATACGGG CCTCTACACC 300
TGCTACTACA ATCACACCCA GACTGAGGAC AGTGAGATTG AAGGCACTGA TATCTACATC 360
TATGTCCCAG ACACCAATGT CCCTTTTGTT CCCCCCGGGT TGTTTGACCA TATCATTGTG 420
GTTGAGGAAG ATGAATCTGC TTTCATACCT TGTCGCACTA CCGACCCTTC CAGCCAAGTG 480
ACCCTAAAAA GTATCGAAAA TTCTAAGACT GTCAGTGCCT TTTATGACAG CAAGCAAGGA 540
TTTGTTGGAA ACTTCCAACC AGGATCATAC ATCTGTGAAA CCGTCTCTAA CAAAATGGTC 600
TACCAGACAG ACCTTTACAT TCTACAGACA TGGAAAGCAA CGCACAACAT TTCCGTTGAG 660
ATGGAAGCCC CCCAAACTGT ATTTCGAACT GGGGAAACCA TTACCATTTC CTGCATTGTG 720
CTGGAGAATG AGGTGGTAGA ATTGAAGTGG TACTACCCTG GACAACAGAG AGGCGTTGGC 780
AAAAGAAATG TTGAAGAAAG CAGGGTTCCA TCTCAGAGAC TGGTGTACAC CTTAACCATT 840
GCAAATGCCA CTGCGGATGA CTCAGGAGAG TACCAGTGTG CCGTTCTACA TGCAACACTA 900
GATAACAAGG TCATCAAGAA GACAAATATA ACAGTTCATG AAAAGGGATT CATCAATCTG 960
GAGCCCATGT TTGGATCTGA GGAATATGCC AACCTCCATG AAGTGAAGAG CTTTATAGTA 1020
GACTTGCATG CCTATCCCTG CCCTAGGGTC TTCTGGTTGA AGGACAACCG GACACTGAGT 1080
GAAAATCTGA CAGAGATCAC GACTAGCACT GTTACAACTA AAGAAACCAG GTTTCAGAGT 1140
AAACTTAAAC TGATCCGGGC CAAAGAAGAA GACAGCGGAC TGTACACTCT TGTGGCACAA 1200
AATGACGCAG AAAGTAAAAG CTACTCGTTT ATTTTGCAGA TAAAAGTACC CGCTTTGATA 1260
TTGGAACTGG TTGATGAACA TCATGGGACA TCTGGTGAAC AGACTGTTGG GTGCTTAGCC 1320
AAAGGGATGC CGGTCCCTGA TGTGGAATGG TTGGTCTGCA AAGACATCAA AAGATGCAAC 1380
AATGACACCT TGTGGTCCCT TCTGGCAATA AATGGGTCAG AAATCAGTAT GGAGACCCAT 1440
CAAGATTATG AGAACACAAT AGAAAGCCAG GTGACCTTTA AGAAAGTTGA GGAGACAATG 1500
GCAATCCGAT GTATCGCAAG AAACGACCTC GGTGTGGTGG CCAGGGAACT AAAGCTGGTT 1560
GCACCCACCC TACGTTCTGA ACTAACTGTG GCAGCCGCCG TCCTTGTCCT TCTGGTGATT 1620
GTCATCATAT CTCTCATTGT ACTGGTCATC ATATGGAAAC AGAAACCAAG GTATGAAATA 1680
AGATGGCGAG TGATCGAGTC CATCAGCCCA GATGGCCATG AATATATCTA TGTGGACCCA 1740
ATGCAGCTTC CTTATGACTC TCGGTGGGAG TTCCAAAGGG ATGGACTTGT TCTTGGTCGC 1800
ATCCTTGGCT CTGGGGCTTT TGGGAAAGTG GTTGAAGGCA CAGCATATGG GTTAAGTCGT 1860
TCTCAGCCAG TTATGAAAGT TGCTGTAAAA ATGTTGAAAC CTACTGCCCG GTCAAGCGAA 1920
AAGCAGGCAC TGATGTCTGA ACTGAAGATC ATGACACACC TTGGCGCACA TCTCAATATA 1980
GTCAATTTAT TAGGAGCCTG TACTAAGTCA GGACCAATTT ATATCATAAC TGAATACTGC 2040
TTCTATGGTG ACCTCGTGAA TTACCTGCAT AAGAACCGAG ATAATTTTCA GAGCCGACAC 2100
CCAGAGAAAT CAAAGAAGGA TTTGGACATC TTTGGGCTGA ACCCAGCTGA CGAGAGTACG 2160
AGAAGCTATG TTATCTTATC ATTTGAAAAC AACGGCGACT ATATGGACAT GAAACAGGCT 2220
GACACCATGC AGTATGTACC CATGCTGGAA ATGAAAGAAC CCTCCAAGTA TTCAGATATC 2280
CAGAGATCCT TGTATGACCG GCCTGCGTCG TACAAGAAGA AGCCTTTGTC AGAAGTGAAA 2340
AATATCTTGT CTGATGATGG ATTCGATGGA TTTGATGGTC TAACAGTACT GGACTTGCTC 2400
AGTTTCACAT ATCAAGTTGC AAGGGGCATG GAATTCTTAG CCTCTAAAAA TTGTGTACAT 2460
CGGGATTTGG CAGCTCGGAA TGTCCTATTA GCACATGGGA AAATTGTAAA AATCTGTGAC 2520
TTTGGCCTAG CAAGAGACAT CATGCACGAC TCCAACTATG TATCCAAAGG CAGCACTTTC 2580
CTTCCAGTAA AGTGGATGGC GCCCGAAAGC ATCTTCGATA ACCTGTACAC AACTCTCAGC 2640
GATGTGTGGT CATTTGGAAT CCTGCTGTGG GAAATATTTT CTCTTGAAGG GGGCACACCG 2700
TATCCTGGCA TGATTGTAGA TTCAACCTTC TATAATAAGA TAAAAAGTGG CTACAGAATG 2760
GCAAAACCTG ACCATGCCAC CCATGAAGTG TACGACATCA TGGTAAAATG TTGGAACAGT 2820
GAACCAGAAA AAAGGCCATC ATTTCGCCAT CTGAGTGACA TTGTGGAAAG TCTACTTCCT 2880
ATGGAATACA AAAGGTGCTA CGAGACAGTT CTTCACGATT TCCTTAAAAG TGACCACCCT 2940
GCAGTTACTC GCATGAGAAG TGACAGTGAC AATTCCTACA TTGGGGTGAC GTATAAGAAT 3000
GAAAACAAAA TGAAGGACAG AGAGAGTGGG TTTGATGAGC AAAGGCTGAG CGCTGACAGC 3060
GGTTACATTA TTCCCCTTCC TGATATTGAT CCCGTTTCAG AAGATGAGTC CAGCAAGAGG 3120
AACAGGCACA GTTCTCAAAC ATCAGAAGAA AGTGCAATCG AGACCGGGTC CAGCAGTTCC 3180
ACTTTTATAA AGAGGGAGGA CGAGACCATT GAAGACATTG AGATGATGGA CGACATTGGG 3240
ATCGATTCCT CGGATCTAGT GGAGGACAGT TTCCTGTAA 3279
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 596   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  655
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
          h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r++f +++ ek   ++++ld+++
Q: 656   AHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFQSRHPEK---SKKDLDIFG  712
         *********************************************999...788999999
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 713   LnPADESTRSYVILSFENNGDYMDMKQAdtmqyvpmlemkepskYSDIQRSLYDRPASYK  772
         99*************************9*******************************9
S: 164   kksalerevkaaleee...dsevleledllsfsyqvakGmeflaskncvhrdlaarnvll  220
         kk + e  vk+ l+++     ++l++ dllsf+yqva+Gmeflaskncvhrdlaarnvll
Q: 773   KKPLSE--VKNILSDDgfdGFDGLTVLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL  830
         877655..5666666511156789************************************
S: 221   teGkvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillw  280
         ++Gk+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvws+Gillw
Q: 831   AHGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSFGILLW  890
         ************************************************************
S: 281   eifsl.GstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkq  339
         eifsl G+tpypg++vds+fy++ik+Gyrma+p++at+e+y+im+kcw++epekrpsf++
Q: 891   EIFSLeGGTPYPGMIVDSTFYNKIKSGYRMAKPDHATHEVYDIMVKCWNSEPEKRPSFRH  950
         ****9899****************************************************
S: 340   lvell  344
         l+ ++
Q: 951   LSDIV  955
         *9875
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
AHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDN FQSRHPEKSK KDLDIFGLNP 120
ADESTRSYVI LSFENNGDYM DMKQADTMQY VPMLEMKEPS KYSDIQRSLY DRPASYKKKP 180
LSEVKNILSD DGFDGFDGLT VLDLLSFTYQ VARGMEFLAS KNCVHRDLAA RNVLLAHGKI 240
VKICDFGLAR DIMHDSNYVS KGSTFLPVKW MAPESIFDNL YTTLSDVWSF GILLWEIFSL 300
EGGTPYPGMI VDSTFYNKIK SGYRMAKPDH ATHEVYDIMV KCWNSEPEKR PSFRHLSDIV 360
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-DAR-00792
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013