EKS-XET-00133

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00133

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	432.2	5.1E-130	195	442	248

Status

Unreviewed

Ensembl Protein

ENSXETP00000045692

UniProt Accession

F6UTP2;

Protein Name

Protein Synonyms/Alias

Gene Name

csk

Gene Synonyms/Alias

csk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000021139	ENSXETP00000045692	ENSXETT00000045692

Organism

Xenopus tropicalis

Functional Description

Protein Length

452

Protein Sequence
(FASTA)

MSVVQAPWQA GTECIANYDF QGKAEQDLHF SKGEVLTIVA VTKDPNWYKA KNKVGRVGFI 60

PANYVQKREG VKSGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

SCEGKVEHYR IIYSSGKLSI DEEEYFENLM QLVEHYTNDA DGLCTNLMKP KLVEGTVAAQ 180

DEFSRSGWAL KMRDLKLLHT IGKGEFGDVM LGEHQGVKVA VKCIKNDATA QAFVAEAMVM 240

TQLQHNNLVQ LLGVIVEDKS GLFIVTEFMA KGSLVDYLRS RGRSVLGGEC LLKFSLDVSE 300

GMAYLESNNF VHRDLAARNV LVSEENIAKV SDFGLTKEAS AIQDTSKLPV KWTAPEALRD 360

KASLFSTKSD VWSFGILLWE IYSFGRVPYP RIALKDVVPK VENGYKMDAP DGCPPVVYDL 420

MKQCWHLDPK QRPTFRNLRE QLEHIKAKEL FH 452

Nucleotide Sequence
(FASTA)

ATGTCAGTGG TGCAGGCCCC TTGGCAAGCT GGCACAGAAT GCATTGCTAA CTATGACTTC 60

CAGGGTAAAG CTGAGCAGGA CCTGCATTTT AGTAAAGGTG AAGTGCTGAC CATTGTGGCT 120

GTGACAAAGG ATCCAAATTG GTACAAGGCA AAAAACAAAG TAGGGAGAGT GGGATTCATC 180

CCTGCAAACT ATGTCCAAAA GAGAGAAGGA GTGAAATCTG GAACCAAACT CAGCCTTATG 240

CCGTGGTTTC ATGGCAAGAT AACCCGAGAG CAGGCTGAGC GTCTCTTGTA TCCACCTGAA 300

ACGGGCTTAT TCCTTGTACG GGAGAGTACA AACTACCCTG GAGATTATAC TCTGTGTGTG 360

AGCTGTGAAG GGAAAGTGGA GCATTACCGC ATTATCTATT CTTCTGGCAA GCTGAGCATT 420

GATGAAGAGG AATACTTTGA AAATCTCATG CAGCTGGTGG AGCACTATAC CAATGATGCA 480

GATGGCCTGT GCACAAATTT GATGAAGCCC AAATTGGTGG AGGGAACTGT AGCTGCCCAG 540

GATGAATTCT CCCGGAGTGG CTGGGCCCTC AAGATGAGAG ATCTCAAACT GCTGCACACC 600

ATTGGCAAGG GGGAATTTGG AGATGTCATG CTTGGTGAAC ATCAAGGAGT GAAAGTAGCT 660

GTGAAATGTA TCAAGAACGA TGCCACGGCA CAAGCATTTG TAGCAGAAGC TATGGTGATG 720

ACGCAATTGC AACATAACAA TCTTGTGCAG CTACTTGGAG TGATTGTTGA AGATAAAAGT 780

GGTTTGTTTA TCGTCACAGA ATTTATGGCA AAGGGAAGCC TAGTGGATTA TTTGAGGTCT 840

CGGGGAAGGT CAGTGCTAGG TGGCGAATGT CTACTAAAGT TCTCACTGGA TGTATCAGAA 900

GGTATGGCAT ATCTTGAGAG TAATAACTTT GTGCACAGAG ATCTAGCGGC ACGCAATGTG 960

TTGGTATCAG AAGAAAATAT TGCTAAGGTC AGTGACTTTG GACTCACCAA GGAAGCATCC 1020

GCCATACAGG ACACAAGCAA ACTGCCTGTT AAGTGGACAG CACCAGAAGC GTTGCGGGAT 1080

AAGGCAAGTC TATTTTCAAC CAAGTCTGAT GTTTGGAGCT TTGGAATTCT GTTATGGGAG 1140

ATCTATTCCT TTGGGCGAGT GCCTTATCCA CGCATTGCCC TCAAAGATGT GGTACCAAAG 1200

GTGGAGAATG GGTATAAAAT GGACGCACCC GATGGATGTC CTCCTGTTGT ATATGATTTG 1260

ATGAAGCAGT GTTGGCATCT GGACCCAAAA CAGCGACCCA CTTTTAGGAA TCTGCGAGAA 1320

CAGCTAGAGC ATATCAAAGC GAAGGAACTG TTTCACTGA 1359

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lkl +tigkgefgdv+lge++g kvavk+ikndataqaf++ea vmt+l+h+nlv+llgv

Q: 195   LKLLHTIGKGEFGDVMLGEHQGVKVAVKCIKNDATAQAFVAEAMVMTQLQHNNLVQLLGV  254

         6899********************************************************

S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119

         i+e+k gl++vte++akgslvdylrsrgr++l+ ++llkf+ldv+egm yles+++vhrd

Q: 255   IVEDKsGLFIVTEFMAKGSLVDYLRSRGRSVLGGECLLKFSLDVSEGMAYLESNNFVHRD  314

         ****999*****************************************************

S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekk..fstksdvwsf  177

         laarnvlvse+++akvsdfgl+ke+s  +d++klpvkwtapeal++k   fstksdvwsf

Q: 315   LAARNVLVSEENIAKVSDFGLTKEASAIQDTSKLPVKWTAPEALRDKAslFSTKSDVWSF  374

         ********************************************986444**********

S: 178   gillweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrps  237

         gillwei+sfgrvpypri+lkdvv++ve+gykm+ap+gcpp vy+lmk++w+l++++rp+

Q: 375   GILLWEIYSFGRVPYPRIALKDVVPKVENGYKMDAPDGCPPVVYDLMKQCWHLDPKQRPT  434

         ************************************************************

S: 238   faklkekl  245

         f++l+e+l

Q: 435   FRNLREQL  442

         *****997

Domain Sequence
(FASTA)

LKLLHTIGKG EFGDVMLGEH QGVKVAVKCI KNDATAQAFV AEAMVMTQLQ HNNLVQLLGV 60

IVEDKSGLFI VTEFMAKGSL VDYLRSRGRS VLGGECLLKF SLDVSEGMAY LESNNFVHRD 120

LAARNVLVSE ENIAKVSDFG LTKEASAIQD TSKLPVKWTA PEALRDKASL FSTKSDVWSF 180

GILLWEIYSF GRVPYPRIAL KDVVPKVENG YKMDAPDGCP PVVYDLMKQC WHLDPKQRPT 240

FRNLREQL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013