EKS-XET-00483

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00483

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	444.2	1.4E-133	269	516	248

Status

Unreviewed

Ensembl Protein

ENSXETP00000046165

UniProt Accession

F6S8L5;

Protein Name

Protein Synonyms/Alias

Gene Name

fyn

Gene Synonyms/Alias

fyn;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000021344	ENSXETP00000046165	ENSXETT00000046165

Organism

Xenopus tropicalis

Functional Description

Protein Length

534

Protein Sequence
(FASTA)

MGCVQCKDKE ATKLTDERDN SLTQSLGYRY GTDPTPQHYP SFTVTTIPNY NNFHTNAGQG 60

LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFQKGEKFQ ILNSSEGDWW 120

EARSLTTGGT GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTYLIRESET 180

TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSEKADGLCF 240

NLTLIAPNYT PQTVGLAKDA WEVARNTISL EQKLGQGCFA EVWFGTWNGN TKVAIKTLKP 300

GTMSPESFLE EAQIMKKLKH DKLVQLYAVV SEEPIYIVTE YMSKGSLLDF LKDGEGRALK 360

LPNLVDMAAQ VAAGMAYIER MNYIHRDLRS ANILVGNGLI CKIADFGLAR LIEDNEYTAR 420

QGAKFPIKWT APEAALYGRF TIKSDVWSFG ILLTELVTKG RVPYPGMNNR EVLEQVERGY 480

RMPCPQDCPN SLHELMLNCW KKDPEERPTF EYLQGFLEDY FTATEPQYQP GDNL 534

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TGCAATGCAA GGATAAAGAA GCAACAAAAC TGACAGATGA GAGGGACAAC 60

AGTTTAACTC AGAGTTTAGG ATACCGCTAT GGGACGGATC CCACCCCACA GCATTATCCC 120

AGCTTTACTG TGACTACCAT TCCAAACTAT AACAACTTCC ATACAAATGC AGGGCAGGGG 180

CTTACAGTGT TTGGCGGGGT GAACTCTTCA TCACACACAG GCACCTTGCG CACAAGGGGC 240

GGAACAGGAG TGACACTTTT TGTGGCTCTG TATGACTATG AAGCCAGAAC AGAAGATGAT 300

TTAAGTTTTC AGAAAGGAGA AAAATTTCAA ATACTCAATA GCTCGGAAGG GGATTGGTGG 360

GAAGCTCGTT CTTTAACCAC TGGTGGCACA GGTTACATCC CCAGTAATTA TGTTGCACCG 420

GTGGATTCCA TACAAGCAGA GGAATGGTAC TTTGGCAAAC TGGGCAGAAA AGATGCAGAA 480

AGGCAATTAC TATCTTTTGG GAACCCAAGG GGTACTTATC TAATACGTGA AAGTGAAACT 540

ACCAAAGGTG CCTATTCCTT GTCTATTCGT GACTGGGACG ATATGAAGGG AGACCACGTT 600

AAGCATTATA AGATACGAAA ACTTGATAAT GGGGGTTATT ATATTACAAC TAGAGCCCAG 660

TTTGAAACCC TACAGCAACT GGTTCAACAT TATTCAGAGA AAGCTGATGG TTTGTGTTTT 720

AATTTAACTC TGATTGCACC GAATTATACT CCACAAACTG TTGGACTGGC TAAGGATGCA 780

TGGGAGGTTG CACGGAATAC AATATCTTTG GAGCAGAAGC TTGGTCAGGG CTGTTTCGCT 840

GAAGTGTGGT TTGGTACATG GAATGGAAAC ACAAAGGTGG CGATAAAGAC ACTGAAGCCA 900

GGCACCATGT CTCCAGAATC TTTCTTAGAA GAAGCACAGA TCATGAAGAA ACTGAAGCAT 960

GATAAGCTTG TGCAGCTCTA TGCTGTAGTG TCTGAGGAGC CCATTTATAT TGTCACCGAG 1020

TACATGAGCA AAGGTAGTTT ACTAGATTTC CTAAAGGATG GAGAAGGAAG AGCCTTGAAG 1080

TTGCCAAATT TAGTAGACAT GGCTGCCCAG GTTGCTGCTG GCATGGCTTA TATTGAGAGA 1140

ATGAATTATA TACACAGAGA TTTGAGATCT GCAAATATTT TGGTTGGAAA TGGCCTTATT 1200

TGCAAAATTG CTGATTTTGG CCTTGCTAGA TTGATTGAAG ACAATGAGTA CACTGCAAGG 1260

CAAGGTGCAA AGTTTCCCAT AAAATGGACA GCTCCTGAAG CAGCGCTCTA TGGAAGGTTC 1320

ACAATAAAGT CAGATGTGTG GTCATTTGGA ATTTTACTGA CAGAGCTTGT TACAAAGGGA 1380

AGAGTTCCCT ATCCAGGAAT GAACAACCGG GAGGTCTTGG AGCAAGTTGA GCGCGGTTAC 1440

AGAATGCCAT GTCCACAGGA CTGTCCAAAC TCCCTCCATG AGCTTATGCT GAACTGCTGG 1500

AAAAAGGACC CAGAGGAACG CCCAACTTTT GAGTATCTAC AGGGTTTCCT GGAGGATTAC 1560

TTCACTGCCA CCGAGCCCCA ATATCAGCCC GGAGACAACC TGTAA 1605

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

          l++klG+G+f evw g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+lya

Q: 269   SLEQKLGQGCFAEVWFGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYA  328

         7899********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         vvse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihrd

Q: 329   VVSE-EPIYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRD  387

         ***9.*******************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         l+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdvW

Q: 388   LRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW  447

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         sfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp++l+el+l+cwkkdpeer

Q: 448   SFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPNSLHELMLNCWKKDPEER  507

         ************************************************************

S: 242   Ptfetlqev  250

         Ptfe+lq +

Q: 508   PTFEYLQGF  516

         ******976

Domain Sequence
(FASTA)

SLEQKLGQGC FAEVWFGTWN GNTKVAIKTL KPGTMSPESF LEEAQIMKKL KHDKLVQLYA 60

VVSEEPIYIV TEYMSKGSLL DFLKDGEGRA LKLPNLVDMA AQVAAGMAYI ERMNYIHRDL 120

RSANILVGNG LICKIADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALYG RFTIKSDVWS 180

FGILLTELVT KGRVPYPGMN NREVLEQVER GYRMPCPQDC PNSLHELMLN CWKKDPEERP 240

TFEYLQGF 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

xtr:100488004

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013